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Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

Mouse studies suggest inhibiting PGF could help treat hypertension.




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Globohexaosylceramide (globo-H); stage-specific embryonic antigen-3 (SSEA-3); SSEA-4

Mouse studies suggest chemically modified carbohydrate conjugates could be useful as antigens for the development of cancer vaccines.




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Translational tidbits

Yabao and MRC Technology partner in PD; charities form Neuro-MAP to insource pharma's abandoned compounds; Singapore creates a diagnostic hub; a roundup of public-private partnerships.




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Translational balance

Moving discoveries from academia to industry requires a delicate balance of risk, reward, skill sets and personalities, according to a translational panel held at BIO-Europe's partnering conference.




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SciBX: Science-Business eXchange




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Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity




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Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling




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Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity




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In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states




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Bridging naïve and primed pluripotency




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Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis




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FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome




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Transcription factors in ferroptotic cell death




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MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




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In vivo antitumor activity by dual stromal and tumor-targeted oncolytic measles viruses




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Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




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TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials




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Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40




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UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53




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Cancer Gene Therapy




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High-purity orbital angular momentum states from a visible metasurface laser




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The rise of integrated quantum photonics




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Author Correction: Quantum wave–particle superposition in a delayed-choice experiment




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Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy




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Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism




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Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization




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Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation




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An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9




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Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy




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Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy




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Ex vivo pulsed dendritic cell vaccination against cancer




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Head-to-head trials in inflammatory bowel disease: past, present and future




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Microbiota and colorectal cancer: colibactin makes its mark




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Inducing senescence sensitizes pancreatic tumours to therapies




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Author Correction: Management of IBD during the COVID-19 outbreak: resetting clinical priorities




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Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys




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Cannabinoid CB<sub>2</sub> receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear




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A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology




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Correction: Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression




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Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity




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Δ<sup>9</sup>-Tetrahydrocannabinol (THC) impairs visual working memory performance: a randomized crossover trial




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Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation




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Obesity and impaired metabolic health in patients with COVID-19




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New insights into K<sub>ATP</sub> channel gene mutations and neonatal diabetes mellitus




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Nanoscale nights of COVID-19




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Nongjian Tao (1963–2020)




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Probing nanoscale fluctuation of ferromagnetic meta-atoms with a stochastic photonic spin Hall effect




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Author Correction: Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis




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Publisher Correction: Optomechanical detection of vibration modes of a single bacterium




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SIN List criticism based on misunderstandings