The sprawling estate, which is the largest privately owned home in the country, will open its doors in November after a month-long closure

Called M136279841, the value belongs to a rare class of prime numbers called Mersenne primes and was found using a supercomputer system spread across 17 countries

Chinook salmon spark excitement among local Klamath Tribes, who have advocated for decades to restore the flow of the river in California and Oregon

A special committee has until January 15 to finalize the design, location and funding for a monument that will be erected on the lawn of the South Carolina State House

Government corruption, loved ones becoming ill or dying, cyberterrorism and nuclear weapons topped the list of Chapman University's annual survey

Colossal Biosciences reports it extracted DNA and RNA from the Tasmanian tiger specimen, a key step forward in its effort to create a modern proxy of the extinct species. Other scientists are calling for data to back up the claim

After a summer that tied for the country's hottest, meteorologists say an unusually warm autumn is delaying snowfall

A new study suggests the seismic energy traveled outward from a previously unmapped fault, emanating from the hypocenter in bouncing waves that shook distant areas

Unlike other birds, which get pigments from their diets, parrots produce their own—but scientists never fully understood the underlying mechanisms, until now

The pachyderm, named Kamala, was suffering from osteoarthritis when zoo staff chose to euthanize her

The Manhattan district attorney's office has obtained an arrest warrant for Edoardo Almagià, who has been accused of working with looters and dealing stolen artifacts for years

The farthest spacecraft in the universe went momentarily rogue, but scientists breathed a sigh of relief when it reconnected at an unexpected radio frequency

Antonia, a cloned black-footed ferret at the Smithsonian's National Zoo and Conservation Biology Institute, has produced two healthy offspring that will help build genetic diversity in their recovering population

Steve Lazarides' personal collection of prints, original works, handwritten press releases and burner phones sold at auction for around $1.4 million

On its 66th flyby of the king of planets, Juno has captured spectacular views of the stormy atmosphere, processed by citizen scientists

The beloved reptile in Australia died last weekend and was thought to be up to 120 years old, though that age is only an estimate. Research on his bones might reveal a more exact number

The robbers only made away with two of the screen prints, which they swiped from a gallery in the Netherlands. They abandoned the other artworks on the street

The viral king penguin chick at Sea Life Melbourne Aquarium is beginning to lose his youthful down, a process that will give him his distinctive and waterproof adult plumage

An increasing number of people in France espouse a clothing-free lifestyle

Mary, a 54-year-old Asian elephant at the Berlin Zoo, is the “queen of showering,” but her companion Anchali seems to have figured out how to exploit that habit to play pranks

The Cuban-American actor and producer has stars on Hollywood’s Walk of Fame, but this new honor pays tribute to his start as a musician in South Florida

Cenotes in the Yucatán Peninsula are time capsules preserving remnants of Maya culture and fossils of extinct megafauna

From Scotland to Japan, these multiday treks offer adventure and a truly immersive experience

See photographs of the beautiful natural wonders from the Smithsonian Magazine Photo Contest

See images of the American flag captured by our readers.

The surge of hungry four-legged visitors to Belushya Guba is part of a larger trend

It’s easy to write bugs off as pests, but consider the ways in which they have positively impacted our lives

Nellie Winters is 87. From the time she was a child, her hands and mind have been busy pursuing her love of Inuit art and craft.

A Labrador foster parent and head of a group working to better the Labrador foster care system is stressing the importance of keeping Indigenous children with Indigenous parents in their Indigenous communities.

The L'nu Sipuk Kina'muokuom school observed Indigenous Veterans Day with an event on Friday. Students, faculty and staff got together to honour Mi’kmaw military veterans and RCMP members.

Independent Elizabeth Smith-McCrossin is back on the campaign trail in Cumberland North, but opponents say the riding would be better represented by an MLA from an official party. 

As Nova Scotia politicians make their fall election promises, Julie Leggett is urging them to commit to helping people on income assistance stay cool during heat waves.

The Montreal English Theatre Awards ceremony is being held this evening at Le Gesù theatre. For the community, it's a time to celebrate their achievements and resilience coming out of the pandemic, together.

Dominic April fell in love with forging after his career in the military came to an end in 2015. Now operating a blacksmith studio near Quebec City, he hopes to help other veterans dealing with PTSD find creativity and purpose.

Shilei Du, 36, was charged Monday morning with the premeditated murder of his partner, Guangmei Ye, whose body was found Sunday in a residence on Fontenelle Street in Candiac, Que.

Two Falls (Nishu Takuatshina) was developed in Montreal by a local studio that collaborated closely with Indigenous designers and consultants.

Creating transgenic mosquitoes allows for mechanistic studies of basic mosquito biology and the development of novel vector control strategies. CRISPR–Cas9 gene editing has revolutionized gene editing, including in mosquitoes. This protocol details part of the gene editing process of Aedes aegypti mosquitoes via CRISPR–Cas9, through testing and validating single-guide RNAs (sgRNAs). Gene editing activity varies depending on the sequence of sgRNAs used, so validation of sgRNA activity should be done before large-scale generation of mutants or transgenics. sgRNA is designed using online tools and synthesized in <1 h. Once mutants or transgenics are generated via embryo microinjection, sgRNA activity is validated by quick genotyping polymerase chain reaction (PCR) and DNA sequencing.

Transposon-mediated transgenesis has revolutionized both basic and applied studies of mosquito vectors of disease. Currently, techniques such as enhancer traps and transposon tagging, which rely on remobilizable insertional mutagenesis, are only possible with transposon-based vector systems. Here, we provide general descriptions of methods and applications of transposon-based mosquito transgenesis. The exact procedures must be adapted to each mosquito species and comparisons of some differences among different mosquito species are outlined. A number of excellent publications showing detailed and specific protocols and methods are featured and referenced.

A Two-Day Festival in the historic Arts & Industries Building brings community, artists and scholars together for a “Culture Lab”

An unlikely friendship with Guy Burgess, the infamous British double-agent, brought unexpected joy to Stanley Weiss

The ancient burial structures, strikingly similar all across Europe and the mediterranean, have puzzled scientists and historians for centuries

Yukon appeal court Justice Karen Horsman granted a temporary stay of the requirement on Friday, the latest development in an ongoing legal battle over the property between the territorial government, cabin-owner Len Tarka and tenant Eric DeLong. 

As people across the country mourn the Honourable Justice Murray Sinclair, some in the Northwest Territories justice system are reflecting on his contributions to the country — one of those being Gladue principles. 

A Whitehorse homeowner has been charged in connection with an explosion last year that destroyed his home and killed a man in a neighbouring house. 

A group of volunteers have been providing emergency services to West Dawson residents during the periods of freeze up and break up, when there is no reliable access across the Yukon River to town.

In a new biopic starring Kate Winslet, Miller's many lives—as an artist, model, muse, cook and war correspondent—need little embellishment

An exhibition at the Huntington Library, Art Museum and Botanical Gardens explores how Western intellectuals viewed the climate crisis between 1780 and 1930

A new film revisits the 90 minutes before the first episode of "Saturday Night Live" premiered on NBC on October 11, 1975

The British explorer named dozens of geographical features and sites in the region, ignoring the traditions of the Indigenous peoples who’d lived there for millennia

When the U.S. Army massacred a Lakota village at Blue Water, dozens of plundered artifacts ended up in the Smithsonian. The unraveling of this long-buried atrocity is forging a path toward reconciliation