The present invention relates to compounds suitable as modulators of protein misfolding and/or protein aggregation. The compounds are particularly suitable as inhibitors of amyloid aggregate formation and/or modulators of amyloid surface properties, and/or as activators of degradation or reduction of amyloid aggregates.

The present invention concerns a Ga68 complex of formula FOLATE-(LINKER)i-NOTA-Ga68 in which: 1) FOLATE is a folate compound or a derivative thereof capable of targeting a folate receptor,2) NOTA is a chelate capable of complexing Ga68 having a NOTA scaffold or derivatives thereof3) LINKER is a chemical group linking FOLATE and NOTA4) i is an integer chosen between 0 and 1 wherein NOTA is complexing Ga68.

The present invention is directed to novel organometallic complexes as catalysts for the reaction of compounds with isocyanate and hydroxyl functional groups to form urethane and/or polyurethane and the process employing such catalysts. More particularly, the present invention is directed to novel complexes of zinc(II) with substituted amidines. These novel catalysts are useful for the production of urethanes and polyurethanes which are important in many industrial applications.

Porphyrin compounds are provided. The compounds may further comprise a fused polycyclic aromatic hydrocarbon or a fused heterocyclic aromatic. Fused polycyclic aromatic hydrocarbon s and fused heterocyclic aromatics may extend and broaden absorption, and modify the solubility, crystallinity, and film-forming properties of the porphyrin compounds. Additionally, devices comprising porphyrin compounds are also provided. The porphyrin compounds may be used in a donor/acceptor configuration with compounds, such as C60.

Length adjustment can be performed in a simple manner and without impairment of the insulating effect in an insulation cassette for the heat insulation of elongated elements. A multilayer insulation includes flat reflection elements (21, 22). Each layer of the insulation has at least two of the flat reflection elements (21, 22), which overlap at least partly at their ends (24) facing each other.

Described herein is a composition useful for inducing expression of genes whose expression is under control of an inducible promoter sequence and methods for the compositions preparation and use.

The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.

To provide a diagnostic and therapeutic medicament, a bombesin analog peptide antagonist conjugate is provided which has general Formula (I), wherein A is a metal chelator comprising at least one radionuclide metal, B is a spacer linked to N-terminal of C or a covalent bond and C is a bombesin analog peptide antagonist having a sequence as claimed, where further x is an integer from 1 to 3 and n is an integer from 1 to 6. [A-(B)n]x—C (I)

This disclosure relates to temperature sensitive conjugates, compositions, and uses related thereto. In certain embodiments, the disclosure relates to conjugate polymers comprising a) a temperature sensitive polymer and b) an antibody. Typically the antibody has an epitope to a platelet receptor. The antibody may be a single-chain antibody wherein the platelet receptor is GPIIb/IIIa, such as an anti-GPIIb/IIIa antibody. In certain embodiments, the antibody binds specifically to the activated conformation of GPIIb/IIIa, i.e., an activation-specific GPIIb/IIIa antibody.

The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related to corresponding nucleic acid molecules encoding such a mutein and to a method for their generation. The invention further relates to a method for producing such a mutein. Furthermore, the invention is directed to a pharmaceutical composition comprising such a lipocalin mutein as well as to various uses of the mutein.

The disclosure relates to anti-glial maturation factor beta (“GMF-B”) monoclonal antibodies (mAbs) and fragments thereof, as well as hybridoma lines that secrete antibodies or fragments. Therapeutic and diagnostic uses of such antibodies, including treatment and detection of cancer and dementia, and methods and kits for detecting cells or samples expressing GMF-B, including soluble GMF-B, are also encompassed.

Three conjugation methods for use with the capsular saccharide of Streptococcus agalactiae. In the first method, reductive animation of oxidized sialic acid residue side chains is used, but the aldehyde groups are first aminated, and then the amine is coupled to a carrier via a linker. In the second method, sialic acid residues and/or N-acetyl-glucosamine residues are de-N-acetylated to give amine groups, and the amine groups are coupled to a carrier protein via a linker. In the third method, linkage is via galactose residues in the capsular saccharide rather than sialic acid residues, which can conveniently be achieved using galactose oxidase.

The present invention relates to gastrin derivatives comprising gastrin or an analogue or fragment thereof and a derivatisation group and therapeutic use thereof.

The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis.

A method and system of providing a content guide that identifies a spatial relationship between the elements in the content guide is described. A controller receives electronic program guide data. The received electronic program guide data is parsed to identify a plurality of programs listed in the electronic program guide and data corresponding to at least one program description attribute for the identified programs. A relationship is determined between each identified program based on the at least one program description attribute. At least one cluster is generated and includes at least one of the plurality of identified programs based on the determined relationship. A user interface display processor generates a user interface display image representing a clustered content guide and including the at least one generated cluster enabling the user to view the relationship of the plurality of programs.

A display device such as a TV has both HDMI and IP network interfaces and uses the HDMI interface to exchange IP network parameters with an audio video application module (AVAM) upon HDMI connection. In this way, an IP-based peer-to-peer or client-server network connection can be automatically established to promote faster communication when sharing and executing applications between the devices than is typically available over the CEC link of HDMI.

A video-on-demand (VOD) content delivery system has a VOD Application Server which manages a database of templates ordered in a hierarchy for presentation of video content elements of different selected types categorized in hierarchical order. The templates include those for higher-order displays which have one or more links to lower-order displays of specific content. The VOD Application Server, in response to viewer request, displays a high-order templatized display, and in response to viewer selection of a link, displays the lower-order display of specific content. The hierarchical templatized displays enable viewers to navigate to an end subject of interest while having a unique visual experience of moving through a series of displays to the end subject of interest.

Disclosed is a hot-dip galvanized steel sheet or an alloyed hot-dip galvanized steel sheet, which has a tensile strength of 980 MPa or more, excellent workability, high yield ratio and high strength. The hot-dip galvanized steel sheet or the alloyed hot-dip galvanized steel sheet is characterized by containing 0.12-0.3% by mass of C, 0.1% by mass or less (excluding 0% by mass) of Si, 2.0-3.5% by mass of Mn, 0.05% by mass or less (excluding 0% by mass) of P, 0.05% by mass or less (excluding 0% by mass) of S, 0.005-0.1% by mass of Al and 0.015% by mass or less (excluding 0% by mass) of N, with the balance made up of iron and unavoidable impurities. The hot-dip galvanized steel sheet or the alloyed hot-dip galvanized steel sheet is also characterized in that the metallic structure thereof contains bainite as a matrix structure, and the area ratio of ferrite is 3-20% and the area ratio of martensite is 10-35% relative to the entire structure.

A heterocyclic compound represented by Formula 1 or Formula 2 below and an organic light-emitting device including the heterocyclic compound: wherein X1, X2, and R1 through R16 are defined as in the specification.

The present invention relates to a triphenylene-based compound represented by the following Formula 1 and an organic electroluminescent device including the same, and the compound of the present invention has excellent hole injection and/or transporting ability, electron transporting ability, and/or light emitting ability, and particularly, green and red light emitting ability, and thus in an organic electroluminescent device containing the same as a light emitting host material, characteristics such as luminous efficiency, luminance, thermal stability, driving voltage, service life and the like may be improved. In the formula, each of A, L, X and R1 to R19 is the same as those as defined in Detailed Description.

The present invention discloses a new fluorene compound and organic EL device using the compound. The organic EL device employing the new fluorene compound as host material can lower driving voltage, prolong half-lifetime. The fluorene compound can functions as blue emitting host material of a light emitting layer and improve CIE color purity in blue emitting device. The fluorene compound are represented by the following formula(A): Wherein R1 to R6 are identical or different. R1 to R6 are independently selected from the group consisting of a hydrogen atom, a halide, alkyl group having 1 to 20 carbon atoms, a substituted or unsubstituted aryl group having 6 to 30 carbon atoms, a substituted or unsubstituted aralkyl group having 6 to 30 carbon atoms, a substituted or unsubstituted heteroaryl group having 6 to 30 carbon atoms. R7˜R13 are identical or different R7 to R13 are independently selected from the group consisting of hydrogen atom, halide, alkyl group, aryl group, heteroaryl group. m and n are independently an integer of 0 to 3, X is selected from carbon or nitrogen.

A novel substance with which an increase in life and emission efficiency of a light-emitting element can be achieved is provided. A carbazole compound having a structure represented by General Formula (G1) is provided. Note that a substituent which makes the HOMO level and the LUMO level of a compound in which a bond of the substituent is substituted with hydrogen deep and shallow, respectively is used as each of substituents in General Formula (G1) (R1, R2, Ar3, and α3). Further, a substituent which makes the band gap (Bg) and the T1 level of a compound in which a bond of the substituent is substituted with hydrogen wide and high is used as each of the substituents in General Formula (G1) (R1, R2, Ar3, and α3).

Embodiments of the present invention are directed to heterocyclic compounds and organic light-emitting devices including the heterocyclic compounds. The organic light-emitting devices using the heterocyclic compounds have high-efficiency, low driving voltages, high luminance and long lifespans.

A low profile, wrappable spacer and method for maintaining a pair of elongate members in fixed, spaced relation to one another is provided. The wrappable spacer includes a flexible elongate body having oppositely facing inner and outer faces extending along laterally spaced, lengthwise extending edges between opposite ends. The inner face has an adhesive surface. At least one member extends between the edges transversely to the lengthwise extending edges. The member extends outwardly from the adhesive surface, wherein the adhesive surface is configured for adhesion to at least one of the member, the elongate members or the outer face.

A heterocyclic compound represented by Formula 1 or Formula 2 below and an organic light-emitting device including the heterocyclic compound: wherein X1, X2, and R1 through R16 are defined as in the specification.

An organic light-emitting device, including a first electrode, the first electrode having a smaller absolute value of a work function energy level than an absolute value of a work function energy level of ITO, a second electrode facing the first electrode, and an organic layer between the first electrode and the second electrode.

A torque converter (1) connecting an engine (14) and a transmission (15) of a vehicle is provided with a lockup clutch (2), and a controller (5) is programmed to increase an engagement force of a lockup clutch (2) under open loop control before shifting to feedback control of the engaging force using a target slip rotation speed. When an engine output torque rapidly decreases during open loop control (S59, S60), the controller (5) decreases the engaging force according to a variation amount of the engine output torque (S61, S65), thereby preventing an unintentional sudden engagement of the lockup clutch (2) due to decrease in the engine output torque.

Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.

Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.

A magazine box is provided for removably storing a plurality of disc-storing magazines used in a disc apparatus for feeding a disc to each of a plurality of disc drives. The magazines each include a tray for storing the disc, a case for removably storing the tray, and a first locking mechanism for releasably locking the tray to the case. The magazine box further includes a second locking mechanism for releasably locking the case of each of the plurality of magazines to the magazine box, and the second locking mechanism maintains the locked state at least during the automatic tray-ejection from the case in the disc apparatus is conducted.

A portable portable game carcass hanger including two mounting strap with fastening devices to secure to a vertical support beam such as a tree trunk. A mounting bracket with a first leg, a second leg perpendicular to the first leg and support member are provided. A first hook is disposed on the second leg. There is a triangular hanger with an apex and a bottom end opposite the apex. The apex removably engages the second leg first hook. The bottom end of the triangular hanger has at least one second hook provided to hang at least one game carcass thereon.

Method and apparatus are provided for mechanically processing an organ or organs taken out from slaughtered poultry in a processing device or processing line, which organ or organs form part of an organ package and wherein the organ or organs are separated from the organ package. The organ package is spatially oriented by the processing device without notably breaking tissue connections in the package, and in a preselected order so as to cause the harvesting of organs from the package to occur in a preselected sequence that depends on the location of the organ package in the processing device or processing line.

Method and apparatus are provided for mechanically processing an organ or organs taken out from slaughtered poultry in a processing device or processing line, which organ or organs form part of an organ package and wherein said organ or organs are separated from the organ package. The organ package is spatially oriented by the processing device without notably breaking tissue connections in the package, and in a preselected order so as to cause harvesting of organs from the package to occur in a preselected sequence that depends on the location of the organ package in the processing device or processing line.

An energy storage composite particle is provided, which includes a carbon film, a conductive carbon component, an energy storage grain, and a conductive carbon fiber. The carbon film surrounds a space. The conductive carbon component and the energy storage grain are disposed in the space. The conductive carbon fiber is electrically connected to the conductive carbon component, the energy storage grain, and the carbon film, and the conductive carbon fiber extends from the inside of the space to the outside of the space. The energy storage composite particle has a high gravimetric capacity, a high coulomb efficiency, and a long cycle life. Furthermore, a battery negative electrode material and a battery using the energy storage composite particle are also provided.

A negative electrode active material for an electric device, including an alloy having a composition formula SixZnyAlz, where x++y=100 , 26≦x≦47, 18≦y≦44, and 22≦z≦46 are satisfied.

A gaming device having a bonus game with an adjacent selection feature. In one embodiment of the present invention, the gaming device provides a plurality of adjacent player selectable selections. An award is associated with each player selectable selection. The award associated with each selectable selection is not initially displayed or revealed to the player. The player selectable selections are arranged or grouped into a plurality of associated or related selection sets. In one embodiment, each selection set has a different number of player selectable selections. In one embodiment, the related plurality of selection sets are arranged adjacent to each other to enable each player selectable selection in one set to be adjacent to at least one player selectable selection from another selection set. The player's pick in each selection set limits the available selections in the subsequent selection sets.

A server-based video game system maintains a number of video game characters having computer-simulated genetic (“digenetic”) structures that prescribe a number of physical and cognitive performance traits and characteristics for the video game characters. The system allows end users to establish remote online access to the game characters (via, e.g., the Internet). The results of competitions and training activities are based upon the game characters' digenetics, the conditions of the game environment, and the game characters' current levels of physical and cognitive development. The game characters' performance capabilities and cognition are updated continuously in response to the results of competitions and training activities. Competition and training results can be processed by the game servers and transmitted to the end user presentation devices for graphics rendering. In this manner, the video game system need not be burdened by network latency and other delays. The game system also supports game character breeding; game character evolution based upon the digenetics; and game character buying, trading, selling, and collecting.

A method is disclosed in a gaming and media system for quickly and easily creating and sending mail communications including pre-populated, or preformed, messages. Upon receipt of a communication, a recipient may also quickly and easily download a game discussed in the message.

The Virtual Aggregation Processor enables end user devices to share a common wireless forward path of a multicast communication architecture in which the forward path delivered content is dynamically changed or modified based on a real-time, near-real-time, or delay-time basis via aggregated reverse path feedback from at least one of a plurality of end user devices. The Virtual Aggregation Processor periodically or continuously aggregates the feedback input received via the reverse path (having wired and/or wireless connectivity), modifies the forward path multi-media content, and delivers this dynamically modified multi-media content to the then connected population of end user devices via a wireless forward path multicast in a repetitive closed loop fashion.

A gaming system (10, 100) implementing a base game and a feature game. A game controller (101) controls play of the game. The gaming system has at least one display (14, 106) and a player interface (107). The feature game comprises at least one series of game events, in which a plurality of symbols from at least one predetermined symbol set that includes at least first and second symbols, are randomly selected and displayed on the at least one display (14, 106). The feature game is a challenge feature and during play of the feature game, the game controller (101) maintains in computer memory (103) counters for said at least first and second symbols, varies the value of said counters on the occurrence of the at least first and second symbols and causes the at least one display to show a value of the counters. The values of the counters are evaluated against predetermined competitive criteria to determine the outcome of the series of game events.

In contrast to slot-type gaming machines with their preset paylines designating predetermined array positions, the paylines of this novel wagering game are unknown until the indicia in the array have been selected. The indicia are selected from a variety of indicium types, each having a different number of members for identifying adjacent indicia. The randomly selected indicia determine the paylines, if any, in the array. Conditions may be imposed that limit the size and geometry of the paylines in this wagering game.

Various methods and apparatus related to gaming are described. Some embodiments relate to a multi-tiered game involving multiple participants. Some embodiments relate to players establishing gaming elements based on desired criteria. Other embodiments are described.

A gaming system used in a wager-based electronic gaming machine is described. The gaming system is configured to provide picture in a picture capabilities on the electronic gaming machine. In one embodiment, the gaming system can include a first gaming device and a second gaming device where the first gaming device controls the second gaming device. The first gaming device can be configured to receive data and/or communicate with an electronic gaming machine controller, a value input device and value output device. The second gaming device can be configured to receive touchscreen data from a touchscreen display and first video data from the first gaming device and second video data from the EGM controller. Under control of the first gaming device, the first video data and second video data can be output in various sizes and locations on the touchscreen display.

A suspension includes a positive write trace and a negative write trace. The positive write trace is separated into at least two positive write trace sections located at two different layers respectively, and the negative write trace is separated into at least two negative write trace sections located at two different layers respectively. Each positive write trace section and each negative write trace section are alternately arranged along a longitudinal direction on two different layers, and the positive write trace sections at different layers are connected together via conductive crossovers, and the negative write trace sections are connected together via conductive crossovers. The present invention can obtain balanced propagation time in the stacked trace structure to reduce signal distortion, and obtain widened frequency bandwidth.

Apparatus and method for detecting and compensating for lubrication disturbance (lube disturb) events on a rotatable data recording medium. In some embodiments, a lube disturb event is detected responsive to displacement of a data transducer away from a first memory location on a rotating data recording medium during a write operation to write data thereto. The lube disturb event arises responsive to a transfer of accumulated contamination from a data transducer to a lubrication layer on the rotating data recording medium and a smearing of the transferred accumulated contamination along the first memory location. The write data are stored to a different, second memory location instead of to the first memory location responsive to the detected lube disturb event.

The present disclosure provides for a magnetic writer pole for use in a hard drive. The magnetic writer pole comprises a first bevel formed by a non-magnetic layer, the first bevel formed at a first angle and extending to a first throat height. The magnetic writer pole further comprises a second bevel formed by the non-magnetic layer and extending distally from the first bevel at a second angle that is greater than the first angle and extending to a second throat height. The magnetic writer pole further comprises a third bevel formed by the non-magnetic layer and extending distally from the second bevel at a third angle that is greater than the second angle.

An exemplary object is to provide a library apparatus, a magazine insertion detection method, and a program that are capable of detecting whether or not a magazine is inserted for all the magazine insertion positions without using sensors for detecting insertion of magazines. A library apparatus includes: a mark reading unit which is provided in an accessor unit which transfers a plurality of media that can be read and written by a computer, and reads a predetermined mark for all insertion positions of a plurality of magazines which can be inserted into the library apparatus and can accommodate the media, the mark being stuck to each of cells accommodating the media; and a control unit which, if the mark can be read, determines that a magazine is inserted at an insertion position which includes a read position for which a reading result that the mark can be read has been obtained, and, if the mark cannot be read, determines that no magazine is inserted at an insertion position which includes a read position for which a reading result that the mark cannot be read has been obtained.

A disk drive unit includes a rotor configured to rotate a disk accommodated within a disk accommodating space and set thereon, a fixed body configured to rotatably support the rotor, a fluid dynamic pressure generating part provided between the fixed body and the rotor, and a plurality of ring-shaped members, provided in an overlapping manner along a direction of a rotational axis of the rotor within a space that communicates the disk accommodating space and a gas-liquid interface of the lubricant, and covering a gap between the rotor and the fixed body.

The present technology may determine an anomaly in a portion of a distributed business application. Data can automatically be captured and analyzed for the portion of the application associated with the anomaly. By automatically capturing data for just the portion associated with the anomaly, the present technology reduces the resource and time requirements associated with other code-based solutions for monitoring transactions. In an embodiment, a method for monitoring an application may begin with detecting a diagnostic event. A diagnostic identifier may be associated with the request in response to the diagnostic event. An outgoing call may be detected at a first server associated with processing the request. The outgoing call may be modified at the first server to include the diagnostic identifier, the outgoing call with the diagnostic identifier received by a remote computer.