This paper reports an Fe-added Y2O3 crucible which is capable of balancing the solution spontaneously and is employed to effectively enhance the homogeneity of YBa2(Cu1−xFex)3O7−δ single crystals.

Book review

The effects of relative humidity on a tetragonal crystal form of hen egg white lysozyme are studied via in situ laboratory X-ray powder diffraction.

Book review

A software package for Grazing Incident Wide Angle X-ray Scattering (GIWAXS) geared toward weakly ordered materials, including: scattering intensity normalization/uncertainty, scattering pattern indexing, and refractive shift correction.

The structure of the Pseudomonas aeruginosa T6SS PldB immunity protein PA5086 is reported at 1.9 Å resolution. Comparison of PA5086 with its homologs PA5087 and PA5088 showed great similarities in sequence and structure, but vast divergences in electrostatic potential surfaces.

The membrane protein EsaA is a conserved component of the type VIIb secretion system. Limited proteolysis of purified EsaA from Staphylococcus aureus USA300 identified a stable 48 kDa fragment, which was mapped by fingerprint mass spectrometry to an uncharacterized extracellular segment of EsaA. Analysis by circular dichroism spectroscopy showed that this fragment folds into a single stable domain made of mostly α-helices with a melting point of 34.5°C. Size-exclusion chromatography combined with multi-angle light scattering indicated the formation of a dimer of the purified extracellular domain. Octahedral crystals were grown in 0.2 M ammonium citrate tribasic pH 7.0, 16% PEG 3350 using the hanging-drop vapor-diffusion method. Diffraction data were analyzed to 4.0 Å resolution, showing that the crystals belonged to the enantiomorphic tetragonal space groups P41212 or P43212, with unit-cell parameters a = 197.5, b = 197.5, c = 368.3 Å, α = β = γ = 90°.

Cytisine, a natural product with high affinity for clinically relevant nicotinic acetylcholine receptors (nAChRs), is used as a smoking-cessation agent. The compound displays an excellent clinical profile and hence there is an interest in derivatives that may be further improved or find use in the treatment of other conditions. Here, the binding of a cytisine derivative modified by the addition of a 3-(hydroxypropyl) moiety (ligand 4) to Aplysia californica acetylcholine-binding protein (AcAChBP), a surrogate for nAChR orthosteric binding sites, was investigated. Isothermal titration calorimetry revealed that the favorable binding of cytisine and its derivative to AcAChBP is driven by the enthalpic contribution, which dominates an unfavorable entropic component. Although ligand 4 had a less unfavorable entropic contribution compared with cytisine, the affinity for AcAChBP was significantly diminished owing to the magnitude of the reduction in the enthalpic component. The high-resolution crystal structure of the AcAChBP–4 complex indicated close similarities in the protein–ligand interactions involving the parts of 4 common to cytisine. The point of difference, the 3-(hydroxypropyl) substituent, appears to influence the conformation of the Met133 side chain and helps to form an ordered solvent structure at the edge of the orthosteric binding site.

The crystal structure of MgCoGa2 (magnesium cobalt digallide) was solved by direct methods and refined in two space groups as P21/c (standard choice) and P21/n (non-standard choice). The refined lattice parameters for the standard choice are a = 5.1505 (2), b = 7.2571 (2), c = 8.0264 (3) Å and β = 125.571 (3)°, and for the non-standard choice are a = 5.1505 (2), b = 7.2571 (2), c = 6.5464 (2) Å and β = 94.217 (3)°. All parameters for MgCoGa2 refined to R1 = 0.027 and wR2 = 0.042 using 594 reflections. The crystal structure peculiarities of this compound are discussed. Particular attention has been given to relationships with other similar structures, such as YPd2Si and Fe3C. Crystallographic analysis, together with linear muffin-tin orbital electronic structure calculations, reveals the presence of three-dimensional polyatomic nets with partial covalent bonding between the Ga atoms.

Scientists from the Smithsonian Migratory Bird Center at the National Zoo have taken blood samples from thousands of birds and mosquitoes in an effort to track the progress of the West Nile Virus in the eastern United States. Come along in this video as Smithsonian scientists net birds living in downtown Washington, D.C., extract small amounts of blood, and then release them back into the "wild."

The post Video: Common birds in Washington, D.C. are helping Smithsonian scientists track intensity of the West Nile Virus appeared first on Smithsonian Insider.

Koenig and his colleagues examined an area of space called W5, which lies about 6,500 light-years away toward the constellation Cassiopeia—about 6 trillion miles. Their research indicates the prospects for hypothetical alien life there are disappointing.

The post Planets form around many star types, but intelligent life is probably rare appeared first on Smithsonian Insider.

The Stephen L. Wood collection brings the collection of bark beetles held in the Natural History Museum’s Department of Entomology to an impressive 180,000 specimens, making it one of the most extensive collections in world.

The post Eighty-thousand bark beetles enter National Museum of Natural History collections appeared first on Smithsonian Insider.

This circa 1910 Yup'ik mask from Good News Bay, Alaska--made of driftwood, baleen, feathers, paint and cotton twine--is part of "Infinity of Nations: Art and History in the Collections of the National Museum of the American Indian," an exhibition at the National Museum of the American Indian, opening Saturday, Oct. 23.

The post Yup’ik mask in “Infinity of Nations” exhibition at the American Indian Museum appeared first on Smithsonian Insider.

For safety’s sake, the four eight-week-old cubs born to  National Zoo lioness Shera were given a swim test on Oct. 26  in the moat of […]

The post For safety’s sake, Zoo’s lion cubs take first swim appeared first on Smithsonian Insider.

Known as one of the greatest racehorses of his day and sire to more winning horses than any other American thoroughbred before or since, this Smithsonian loan returned the legendary Lexington's remains to the town of his birthplace some 160 years after he was born.

The post One hundred sixty years after his birth a racehorse’s bones return to Lexington appeared first on Smithsonian Insider.

Subjects watched demonstrators for varying amounts of time. When given the pipe, each of the subjects in both groups opened the door on their first attempt using the method they had seen demonstrated.

The post Lemurs exhibit ability for social learning in zoo experiment appeared first on Smithsonian Insider.

A recent experiment by scientists at the Smithsonian Tropical Research Institute in Panama has revealed just how rising atmospheric carbon dioxide will deliver a one-two […]

The post Rising ocean temperatures and acidity may deliver deadly one-two punch to the world’s corals appeared first on Smithsonian Insider.

Bats living in the dense urban area of Panama City, the scientists learned, represent just a small fraction of the roughly 25 species of high-flying insectivorous bats found in Panama’s rainforests.

The post Only large, fast-flying bats can handle life in the big city; small bats can’t adapt appeared first on Smithsonian Insider.

Astronomers are piecing together the reasons for these huge energy outputs, while sorting out why our own galaxy is so modest. The two primary suspects are bursts of star formation that produce many hot young stars, and processes associated with accretion of material onto a supermassive black hole at a galaxy's nucleus.

The post Luminosity of extreme galaxy most likely driven by star formation appeared first on Smithsonian Insider.

But a new census of all dinosaur skeletons unearthed over a large area of Eastern Montana shows that Tyrannosaurus was too numerous to have subsisted solely on the dinosaurs it tracked and killed with its scythe-like teeth.

The post Tyrannosaurus rex more hyena than lion appeared first on Smithsonian Insider.

Funded by BP through the Florida Institute of Oceanography, the scientists will make the 10-day trip aboard the institute’s 115-foot research vessel. The divers, scientists and photographers will document hard bottoms of Florida, from the Keys to the Panhandle, to gain a better understanding of these sponge- and coral-dominated communities

The post Gulf of Mexico survey will benchmark diversity of ocean floor appeared first on Smithsonian Insider.

The Harvard-Smithsonian Center for Astrophysics has been selected by the National Science Foundation as the recipient of a 12-meter (39-foot) radio antenna designed for submillimeter-wavelength astronomy. The ALMA Vertex Prototype Antenna was one of three antennas built as prototypes for the Atacama Large Millimeter Array, a 66-dish radio observatory currently being constructed in Chile.

The post Harvard-Smithsonian Center for Astrophysics to own and operate ALMA Vertex Prototype Antenna appeared first on Smithsonian Insider.

For decades, astronomers divided supernovas into two groups: one from young stars that explode and one from old stars that explode. They now have evidence for a new, third type of supernova explosion whose source is still a mystery.

The post New type of exploding star discovered appeared first on Smithsonian Insider.

One of the most challenging aspects of this research is simply studying these insects as they are falling, says Yanoviak, a tropical arthropod ecologist at the University of Arkansas, Little Rock. Small body size, rapid descent, and the long distances that they can fall, make accurate data taking a challenge.

The post Lofty experiments with gliding ants reveals secrets of their unusual flight appeared first on Smithsonian Insider.

Scientists and educators from the Smithsonian Conservation Biology Institute and George Mason University broke ground June 29 on a green-design conservation complex that embodies the concept of the living classroom.

The post Smithsonian Conservation Biology Institute and George Mason University expand partnership appeared first on Smithsonian Insider.

Researchers at the Smithsonian Conservation Biology Institute have discovered why older females are rarely able to reproduce—and hope to use this information to introduce vital […]

The post New finding may enable scientists to bolster genetic diversity of captive cheetah population appeared first on Smithsonian Insider.

Depending on where the fish disperse from, the use of ‘stepping stones', flotsam or simply being an adult can help in the journey to find a new home.

The post Ability to raft with flotsam and use non-reef habitats helps tropical fish journey to new places, study finds appeared first on Smithsonian Insider.

The first DNA barcoding survey of crustaceans living on samples of dead coral taken from the Indian, Pacific and Caribbean oceans suggests that the diversity of organisms living on the world’s coral reefs—one of the most endangered habitats on Earth—is seriously underestimated.

The post New DNA study suggests coral reef biodiversity is seriously underestimated appeared first on Smithsonian Insider.

In a new paper, Avi Loeb, of the Harvard-Smithsonian Center for Astrophysics, and Edwin Turner, Princeton University, suggest a new technique for finding aliens: look for their city lights.

The post City lights could reveal E.T. civilization appeared first on Smithsonian Insider.

Researchers who will study the microbial communities living on the skins of frogs that are surviving the fungal scourge of chytridiomycosis, deadly to the frogs.

The post Research team to explore how microbial diversity defends against disease appeared first on Smithsonian Insider.

For the first time, researchers from the Smithsonian Conservation Biology Institute’s Migratory Bird Center analyzed how songbirds are affected by both general noise and the acoustics of hard human-made surfaces in urban areas.

The post Urban songbirds adjust melodies to adapt to life in the big city, Smithsonian scientists find appeared first on Smithsonian Insider.

A new study of marmosets, small South American monkeys, indicates that obesity may begin very early in life and suggests that marmosets may be a helpful model for obesity in humans.

The post Is obesity predestined at infancy? Marmoset study may help scientists find out. appeared first on Smithsonian Insider.

Two very different models explain the possible origin of Type Ia supernovae, and different studies support each model. New evidence shows that both models are correct - some of these supernovae are created one way and some the other.

The post One supernova type, two different sources appeared first on Smithsonian Insider.

Researchers led by David Nesvorny of Southwest Research Institute and David Kipping of the Harvard-Smithsonian Center for Astrophysics has inferred an unseen planet, this time orbiting a distant star, marking the first success of this technique outside the solar system.

The post Unseen planet’s gravity allows Kepler Telescope to “see” it appeared first on Smithsonian Insider.

More than 70 scientists from 9 institutions including the Smithsonian Tropical Research Institute, sequenced the entire genome of the butterfly genus Heliconius, a brightly colored favorite of collectors and scientists since the Victorian era.

The post Heliconius butterfly genome explains wing pattern diversity appeared first on Smithsonian Insider.

Scientists have discovered an incredible story of fungal fidelity among certain species of ants.

The post Fungal fidelity: some ants have been eating the same meal for 5 million years! appeared first on Smithsonian Insider.

A July 12 news alert from NASA indicates a X1.4 class solar flare erupted from the center of the Sun, peaking July 12 at 12:52 P.M.

The post Coronal mass ejection from July 12 solar flare headed toward Earth; minor geomagnetic storm activity predicted appeared first on Smithsonian Insider.

The Smithsonian-Mason School of Conservation, a unique program in terms of its academic offerings and contributions to the field of conservation, celebrated the completion of its expansive new academic facilities today, Oct. 18, at the Smithsonian Conservation Biology Institute in Front Royal, Va.

The post Smithsonian Conservation Biology Institute and George Mason University dedicate new academic facilities in Front Royal, Va. appeared first on Smithsonian Insider.

The goal of the project—the Smithsonian’s Tennenbaum Marine Observatories—is to monitor the ocean’s coastal ecosystems over a long period of time.

The post Smithsonian launches Global Marine Biodiversity Project with $10 million donation appeared first on Smithsonian Insider.

Astronomers have discovered that one well-known elliptical galaxy has a split personality. Centaurus A is hiding a gassy spiral in its center.

The post Split-personality elliptical galaxy holds a hidden spiral appeared first on Smithsonian Insider.

This past summer, Laura Walker became the first scientist to collect slime molds from soils at the Barro Colorado Nature Monument in Panama, a reserve administered by the Smithsonain since 1946.

The post Panama’s slime molds get attention from Arkansas University grad student appeared first on Smithsonian Insider.

Covered in venomous spines the exotic and strikingly banded Indo-Pacific lionfish would be a painful mouthful to any creature that may try to catch and […]

The post Biologist Andrew Sellers turns lionfish invasion into research opportunity appeared first on Smithsonian Insider.

If you had a time machine that could take you anywhere in the past, what time would you choose? Most people would probably pick the […]

The post Young star suggests our sun was a feisty toddler appeared first on Smithsonian Insider.

The Panama Amphibian Rescue and Conservation project recently announced that the golden frog, a national icon on the brink of extinction, has been successfully raised […]

The post Success: Panama’s golden frog bred in captivity appeared first on Smithsonian Insider.

Hot spots of mercury pollution in aquatic sediments and soils can contaminate local food webs and threaten ecosystems, but cleaning them up can be expensive […]

The post Toxicity of mercury hot spots can be reduced with application of activated carbon, researchers discover appeared first on Smithsonian Insider.

A groundbreaking study by Harvard University’s Harvard Forest and the Smithsonian Conservation Biology Institute reveals that, if left unchecked, recent trends in the loss of […]

The post Sprawl threatens water quality, climate protection, and land conservation in Massachusetts appeared first on Smithsonian Insider.