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​Complicit: On India and the U.S and Canada cases

India must come clean on its stance on transnational killings 




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​Allow for deliberation: On the legitimate demands of Ladakh

The lack of a legislature and regional autonomy in Ladakh has led to the current protests




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What Makes <I>Andaz Apna Apna</I> Such Fun Even Today

Andaz Apna Apna is practically the most quoted film since Sholay, observes Sukanya Verma, as she celebrates 30 years of this cult classic movie.




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Alia-Ranbir's Daughter Raha Turns 2

Alia Bhatt and Ranbir Kapoor's little girl Raha turned two on November 6, and we were treated to the most adorable pictures on social media.




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Why Abhishek Missed Aishwarya's Birthday

When Aishwarya celebrated her birthday in Dubai on November 1, the speculation regarding the Abhishek-Aishwarya marital rift ran even higher.




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Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus

RSC Med. Chem., 2024, 15,3395-3417
DOI: 10.1039/D4MD00334A, Research Article
Vu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh Thanh
D-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Pyridazinone-based derivatives as anticancer agents endowed with anti-microbial activity: molecular design, synthesis, and biological investigation

RSC Med. Chem., 2024, 15,3529-3557
DOI: 10.1039/D4MD00481G, Research Article
Mohamed K. S. El-Nagar, Mai I. Shahin, Mohammed F. El-Behairy, Ehab S. Taher, Mohamed F. El-Badawy, Marwa Sharaky, Dalal A. Abou El Ella, Khaled A. M. Abouzid, Mai Adel
Discovery of novel pyridazinone derivatives with dual antimicrobial and anticancer activities.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00257A, Research Article
Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob Alam
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and in vitro and in silico investigations

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00608A, Research Article
Sunil Kumar, Bishnu Prasad Pandey, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rania B. Bakr, Hoon Kim, Bijo Mathew
A total of 18 heterocyclic derived conjugated dienones (CD1–CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis and biological evaluation of novel D-ring fused steroidal N(2)-substituted-1,2,3-triazoles

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00297K, Research Article
Branislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač, Andrea Nikolić
In this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00645C, Research Article
Geetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra Borah
Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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A decade of pyridine-containing heterocycles in US FDA approved drugs: a medicinal chemistry-based analysis

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00632A, Review Article
Ashish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder Kumar
The present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Generation and capture of naphthoquinonynes: a new frontier in the development of trypanocidal quinones via aryne chemistry

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00558A, Research Article
Laura P. R. Figueroa, Renato L. de Carvalho, Renata G. Almeida, Esther R. S. Paz, Emilay B. T. Diogo, Maria H. Araujo, Warley S. Borges, Victor F. S. Ramos, Rubem F. S. Menna-Barreto, James M. Wood, John F. Bower, Eufrânio N. da Silva Júnior
This article presents A-ring functionalized quinones via a modern and efficient new strategy involving the generation and capture of benzyne quinones and their evaluation against Trypanosoma cruzi.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Water level in Mettur Dam stands at 107.04 feet




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Data crucial for building climate resilience, says ISRO scientist




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Water level in Mettur dam stands at 106.89 feet




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Tiruchi Today (November 7, 2024)




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TNSTC Kumbakonam Division mops up ₹17.13 crore in four days




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Pumping stations to be set up in eight low-lying areas in Tiruchi to prevent inundation




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Govt. urged to extend last date to pay crop insurance premium by farmers




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Farmers demand withdrawal of Tamil Nadu Land Consolidation Act

The Coordination Committee of All Farmers’ Associations of Tamil Nadu says the State government has created a situation where industries can acquire fertile lands




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Udhayanidhi lays foundation stone for infrastructure development projects in Thanjavur district

Buildings at the Government Arts and Science College, Thirukkattupalli, construction of compound wall and an indoor stadium at the Government Rajah Serfoji College, Thanjavur, are among the projects




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Man attempts to end life, kills his wife and daughter




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Water level in Mettur Dam stands at 106.58 feet




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546: Ryan Dahl and Deno

Ryan Dahl stops by to talk about Node, Deno, JavaScript, testing, V8, and thoughts around getting started with Deno.




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550: Sanity with Simen Svale Skogsrud and Espen Hovlandsdal

Simen and Espen from Sanity stop by to talk about the origins of Sanity, how Sanity Studio works, good use cases for Sanity, how Sanity does real time updates, what Groq is, and where to start with Sanity.




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561: Web Perf News, Web Sommelier, Data Analytics, and Passkeys

Topics for this one include how do you learn about web performance news? Do you need a web components sommelier? Our thoughts on Syntax going to Sentry, and being able to focus on the things you want to focus on. Passkeys, Arc split screen, and vibe driven development.




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563: Getting Pulled by the Algorithm, AI Training Data, and SVG Drawing

There's a special guest on the show who takes aim at the billionaires in web dev, do we know better than the algorithm for news, why is AI training data such a secret, Chris and Dave discover JetBrains, monorepo struggles, and SVG drawing tools.




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570: Haircut Maintenance, Dave’s Bookshelf, Lazy Loading, and APIs

We're talking Dave's new haircut, playing Hondo, what Dave uses for images on his bookshelf page, lazy-loading thoughts, vh vw follow up, eyeball tracking updates, loading website with js, Vue transitions, charging for API access, and do you cross post, one post, or no post on social media in 2023?




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578: Customer Support, P3 Color, Dave on Productivity, and Mobile vs Desktop

Is Apple's Numbers amazing or the worst? Customer support at various levels of software, Figma and P3 color, imagining a colorspace property in CSS, what's Dave doing for productivity, how has offloading CSS Tricks affected Chris, and should we build different websites for mobile vs desktop?




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579: One Day Builds, Spicy Slugs, and What Next for CSS?

Have you ever been an auctioneer? Sometimes when God closes a shed, he opens a sauna. Dave's working on the one day build theory, how to market with fake data, an update on the Discord, marketing with a spicy slug, what we want to see next in CSS, and thoughts on component libraries.




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607: Astro Launches an Integrated Database

Fred K. Schott stops by to talk about Astro announcement of Astro DB, the pluses and minuses of it, whether you have to always use the database with Astro DB, how to migrate data, seeding your database, upgrading the database, and what about Astro DB pricing?




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614: CSS Grid Level 3 aka Masonry with Adam Argyle

Adam Argyle stops by to chat about the conversation that's happening around CSS Grid / Masonry. What do we want? What might Apple's response to Google be? And nitpicking the spec just for fun.




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615: Dave Goes Windows For Real

Dave's got job news to share, as well as insight into the process of what applying for a job in tech is like in 2024. We also talk about styling, scoping, positioning, and floating UI.




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622: Website Rendering, Updating Software, and Edge Gets Faster

We're talking website rendering, server side rendering, Astro's server islands, perf hits for navigation elements, updating software because the docs aren't available for older versions, and a new Microsoft Edge was released.




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631: Dave’s Second Brain Idea, Notion Thoughts, and Google’s LLM in Chrome

Dave's got an idea for a second brain app that's customized to his brain, where we're at with Notion and other notes apps, and accessibility on LLM's in browsers.




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632: Adam Coster on Game Development and Crashlands 2

Adam Coster talks with us about working with his family in game development, how they get started making games, what all is involved with publishing games, deciding to go Steam and Netflix only for Crashlands 2, how web tech is involved in game development, and the fun of testing and doing Q&A for games.




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639: DX, JSON, XML, HTML, and Databases! Oh My!

How important is the DX of software vs how important is the person showing off the software, Douglas Crockford and JSON, remembering XML, trying to write better HTML for email, new TC39 proposal, workshopping t-shirts, and what do you do if you want a little bit of database on your website?




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Sunny days are here again

Despite the cost, a solar energy system is a great energy saver and a boon during power cuts, says Anamika Mukherjee




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Alternatives and affordability

Each housing project has to be site-specific, culturally appropriate and climatically conforming.




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Idukki project leapfrogs ‘endangered’ list

Local enthusiasts pitch in to bring amphibian species back from the brink of extinction




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Morning runs, protein-packed breakfast, and a rest day

The daily quest to balance work, health, and personal life




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How Ratan Tata pushed for evidence-led ayurveda 

Ratan Tata sought to promote research that could validate ayurveda through contemporary science




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Jamiat cautions NDA partners, says ‘crutches’ cannot escape responsibility for Waqf Bill

The Jamiat Ulama-i-Hind urged NDA partners TDP and JD(U) to heed Muslim sentiments on the contentious issue surrounding the Waqf (Amendment) Bill, 2024




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Govt., BJP spar over Chhath planning as festivities begin today




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Attempts to douse Alipur warehouse fire continue on second day




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Delhi govt. to start drive against burning of waste in open today

Delhi, neighbouring States likely to experience ‘very poor’ quality air over next 10 days, have placed the depts. concerned on high alert: Gopal Rai




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Delhi election: AAP to hold nine-day convention for party workers




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Amit Shah to unveil Birsa Munda statue in Delhi on November 15




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Delhi’s air quality remains ‘very poor’, layer of smog over city for ninth day post-Diwali

Delhi’s air quality reaches severe levels, blamed on stubble-burning, Diwali fireworks, and low wind speed