ot

P3MOT-decorated metal-porphyrin-based zirconium-MOF for the efficient electrochemical detection of 4-nitrobenzaldehyde

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2093-2100
DOI: 10.1039/D4AY00152D, Paper
Wen-yi Chen, Xin-yu Huang, Qian Sun, En-qing Gao
Developed a novel hybrid P3MOT@PCN-222(Fe) via in situ polymerization for 4-NBA detection. Showcased broad detection range, high sensitivity, selectivity and stability, laying groundwork for environmental monitoring.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Capillary action-driven surface-enhanced Raman spectroscopy (SERS) for the identification of phthalocyanine blue in modern paintings based on the BPG spot test

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2147-2151
DOI: 10.1039/D3AY01378B, Technical Note
Shao-Chun Hsueh, Ling-Hsuan Wang, Yung-Chen Liao, Hui-Yu Chiang, Cheng-Huang Lin
A method for the extraction and accumulation of Ag nanoparticles utilizing capillary action through a piece of triangular-shaped cotton paper is reported.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Construction of a three-mode sensor based on gold nanoparticles and carbon quantum dots as probes for the detection of thiosemicarbazone

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2127-2134
DOI: 10.1039/D4AY00256C, Paper
Zhili Liu, Xiaojun Wang, Jing Li, Wenfeng Zhou, Haixiang Gao, Runhua Lu
A three-mode sensor for thiocarbazone (TSC) was constructed based on gold nanoparticles and carbon quantum dots (CQDs). (A) Synthesis process of CQDs using ginkgo leaves. (B) Colorimetric and chrominance TSC detection. (C) Fluorescence detection of TSC.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Subtle adjustment of the cyclic potential on electro-activated glassy carbon electrodes for sensitive sensing of methyl parathion

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00079J, Paper
Yunyin Yang, Sian Chen, Changqiu Zhang, Yanqing Li, Xinrong Zong, Yitao Lv, Min Zhang
Upon experiencing a negligible change of 0.5 V which only takes 5 more seconds, the signal value of an e-GCE was efficiently enhanced from 2-fold to 30-fold compared with a bare GCE.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Simple and convenient preconcentration procedure for the isotopic analysis of uranium in seawater

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY01381B, Paper
Minami Abe, Noriaki Seko, Hiroyuki Hoshina, Shigeki Wada, Shinya Yamasaki, Keisuke Sueki, Aya Sakaguchi
Amidoxime adsorbent was synthesised by graft polymerisation. The adsorbent was efficient for collection of U in seawater for both the adsorption and desorption steps, thus affording a new strategy for measurement of U isotopes.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Near-infrared responsive gold nanorods for highly sensitive colorimetric and photothermal lateral flow immuno-detection of SARS-CoV-2

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00347K, Paper
Xiaohui Liu, Jingwen Li, Kun Wang, Xiang Li, Shenming Wang, Gengchen Guo, Qiaowen Zheng, Maosheng Zhang, Jingbin Zeng
We developed a colorimetric and photothermal dual-mode LFIA platform for sensitive and selective SARS-CoV-2 N protein detection based on gold nanorods.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Dual-signal detection of tannin acid in red wines based on peroxidase activity carbon dots

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00526K, Paper
Bin Liu, Yu Yin, qianwen Li, wanwan Li, Fubing Xiao, Jinquan Liu, Yan Tan, Shengyuan Yang
Herein, a novel sort of phosphorus and iron-doped carbon dots (P,Fe-CDs) with outstanding peroxidase activity and excellent fluorescence performance was hydrothermally synthesized to colorimetrically and fluorimetrically detect tannic acid (TA)....
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Field method for preservation of total mercury in waters, including those associated with artisanal scale gold mining

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02216A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
David C. P. King, Michael J. Watts, Elliott M. Hamilton, Robert J. G. Mortimer, Mike Coffey, Odipo Osano, Maureene Auma Ondayo, Marcello Di Bonito
A method was developed for sampling and preserving total Hg from water samples, recovering >75% Hg over 4 weeks of storage. The method was assessed using water samples at artisanal gold mining sites in Kenya.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Construction of a stable fluorescent sensor based on CsPbBr3/CdS core/shell quantum dots for selective and sensitive detection of tetracycline in ethanol

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2267-2277
DOI: 10.1039/D4AY00032C, Paper
Yang He, Yangjie Li, Han Wang, Site Luo, Haihu Yu
Construction of a stable fluorescent sensor based on CsPbBr3/CdS core/shell quantum dots for selective and sensitive detection of tetracycline in ethanol via a mechanism integrating photoinduced electron transfer.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Characterizing a visual lateral flow device for rapid SARS-CoV-2 virus protein detection: pre-clinical and system assessment

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D3AY02075D, Paper
Natpapas Wiriyachaiporn, Jetnapang Kongrueng, Kannika Sukkuea, Rattana Tanrattanawong, Jarunee Vanichtanankul, Thanaya Saeyang, Tararat Jantra, Deanpen Japrung, Weerakanya Maneeprakorn, Suwussa Bamrungsap, Pareena Janchompoo, Ekawat Pasomsub
Analytical and pre-clinical evaluation of a visual screening lateral flow device for SARS-CoV-2 virus protein detection and its system characterization.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Fe3+-induced luminescence quenching in carbon dots – mechanism unveiled

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, 16,2349-2358
DOI: 10.1039/D3AY02202A, Paper
Varsha Raveendran P.T., Anjali C., Renuka Neeroli Kizhakayil
Luminescence quenching in carbon dots with an increase in Fe3+ concentration and the quantitative variation in luminescence intensity with added ferric ions.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Online quantification of nicotine in e-cigarette aerosols by vacuum ultraviolet photoionization mass spectrometry

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00279B, Paper
Shaoxin Ye, Zuoying Wen, Kai Xie, Xuejun Gu, Jian Wang, Xiaofeng Tang, Weijun Zhang
A new method for quantifying nicotine in e-cigarette aerosols within a few seconds using a homemade VUV-AMS.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

A highly sensitive and selective fluorescent biosensor for breast cancer derived exosomes using click reaction of azide–CD63 aptamer and alkyne-polymer dots

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00146J, Paper
Dumei Ma, Yiting Luo, Xiaoya Zhang, Zehu Xie, Yinghua Yan, Chuan-Fan Ding
A fluorescence method based on Cu-triggered click reaction of azide modified CD63 aptamer and alkyne capped Pdots was developed for breast cancer derived exosome detection.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Quantifying platinum binding on protein-functionalized magnetic microparticles using single particle-ICP-TOF-MS

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00268G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Veronica C. Bradley, Benjamin T. Manard, Lyndsey Hendriks, Daniel R. Dunlap, Amber N. Bible, Ada Sedova, Patricia Saint-Vincent, Brian C. Sanders, Hunter B. Andrews
This work describes an analytical procedure, single particle-inductively coupled plasma-time-of-flight-mass spectrometry (SP-ICP-TOF-MS), that was developed to determine the platinum binding efficiency of protein-coated magnetic microparticles.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Polymeric membrane potentiometric sensors based on template-removal-free imprinted receptors for determination of antibiotics

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D4AY00263F, Paper
Xinyao Wang, Guohua Cui, Rongning Liang, Wei Qin
Currently, Nernstian-response-based polymeric membrane potentiometric sensors using the molecularly imprinted polymers (MIPs) as the receptors have been successfully developed for determination of organic ionic species. However, the preparation of these...
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Three-dimensional hotspot structures constructed from nanoporous gold with a V-cavity and gold nanoparticles for surface-enhanced Raman scattering

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Advance Article
DOI: 10.1039/D4AY00348A, Paper
Yang Xu, Yan Wu, Jianjun Wei, Yuanyu Zhao, Peili Xue
A nanoporous gold V-shaped resonant cavity (NPGVRC) structure constructed with plasmonic resonance coupling effect. The NPGVRC has excellent SERS performance and 3D hotspot properties.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

The not-so-smart use of mobiles

By www.thehindubusinessline.com
Published On :: Wed, 07 Aug 2013 17:27:58 +0530


Full Article

ot

Good, but not enough: On the extended coverage of the Ayushman Bharat scheme

By www.thehindu.com
Published On :: Fri, 13 Sep 2024 00:20:00 +0530

Extension of free health coverage to all over 70 years is good, but more needs to be done  


Full Article

ot

A way out: On the government and doctor-led protests in West Bengal

By www.thehindu.com
Published On :: Wed, 18 Sep 2024 00:20:00 +0530

The West Bengal government must enable the changes doctors want to see


Full Article

ot

Wrong notion: On simultaneous elections

By www.thehindu.com
Published On :: Fri, 20 Sep 2024 00:10:00 +0530

The idea of simultaneous elections is inherently anti-federal


Full Article

ot

Pivot to watch: On the U.S. Fed’s rate reduction, its impact

By www.thehindu.com
Published On :: Sat, 21 Sep 2024 00:10:00 +0530


Full Article

ot

​Healthy sign: On the voting in the 2024 J&K Assembly elections

By www.thehindu.com
Published On :: Thu, 03 Oct 2024 00:10:00 +0530

Turnout numbers in the Assembly elections show distinct patterns in south Kashmir


Full Article

ot

The other monsoon: On the northeast monsoon

By www.thehindu.com
Published On :: Sat, 05 Oct 2024 00:08:24 +0530

Better modelling of the impact of northeast monsoon is essential


Full Article

ot

Deep roots: On the 2024 Physics Nobel Prize 

By www.thehindu.com
Published On :: Wed, 09 Oct 2024 00:10:00 +0530

Physics Nobel Prize acknowledges the diverse foundations of AI


Full Article

ot

Watch: When Jimmy Sheirgill Got Violent

By www.rediff.com
Published On ::

'As a storyteller, one always looks to create something for the audience which is thrilling, engaging and entertaining and that is exactly what we have endeavoured with Sikandar Ka Muqaddar.'


Full Article

ot

The Raj & DK Line-Up You Cannot Miss

By www.rediff.com
Published On ::

Sukanya Verma looks at their eclectic career of over two decades as their latest offering Citadel: Honey Bunny, the Indian leg of the Russo Brothers globetrotting spy universe series, drops on Amazon Prime Video on November 7.


Full Article

ot

Lead optimisation of OXS007417: in vivo PK profile and hERG liability modulation to optimise a small molecule differentiation agent for the potential treatment of acute myeloid leukaemia

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3495-3506
DOI: 10.1039/D4MD00275J, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Thomas J. Cogswell, Laia Josa-Culleré, David Zimmer, Sébastien R. G. Galan, Morgan Jay-Smith, Kate S. Harris, Carole J. R. Bataille, Thomas R. Jackson, Douzi Zhang, Stephen G. Davies, Paresh Vyas, Thomas A. Milne, Graham M. Wynne, Angela J. Russell
The optimisation of a class of AML differentiation agents is described to show improved potency, solubility and stability, reduced off target toxicity, and tumour regression in a murine model in vivo.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

The synthesis and bioactivities of ROCK2 inhibitors with 1,2-dithiolan-3-yl motif

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3576-3596
DOI: 10.1039/D4MD00438H, Research Article
Ruolin Cao, Fangyu Du, Zhiqiang Liu, Pengcheng Cai, Minggang Qi, Wei Xiao, Xuefei Bao, Guoliang Chen
Rho-associated coiled-coil containing kinase (ROCK) plays an important role in inflammation.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Discovery of highly potent SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3469-3476
DOI: 10.1039/D4MD00422A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Hugo Kocek, Dominika Chalupská, Milan Dejmek, Alexandra Dvořáková, Michala Zgarbová, Michal Šála, Karel Chalupský, Petra Krafčíková, Tomáš Otava, Matúš Drexler, Eliška Procházková, Blanka Klepetářová, Milan Štefek, Ján Kozic, Helena Mertlíková-Kaiserová, Evzen Boura, Jan Weber, Radim Nencka
SARS-CoV-2 nsp14 methyltransferase inhibitors based on adenosine 5'-carboxamides.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Synthesis and cytotoxic activity of madecassic acid–silybin conjugate compounds in liver cancer cells

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3418-3432
DOI: 10.1039/D4MD00170B, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Chien Van Tran, Thao Thi Phuong Tran, Anh The Nguyen, Loc Van Tran, Ninh Thi Pham, Luu Thi Nguyen, Dung Thi Nguyen, Michelle D. Garrett, Nga Thi Nguyen, Thao Thi Do, Christopher J. Serpell, Sung Van Tran
Madecassic acid and silybin have been conjoined to produce hybrid compounds with improved and different activity against liver cancer cells.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3444-3459
DOI: 10.1039/D4MD00318G, Research Article
Anuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Niloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Exploring apoptotic induction of malabaricone A in triple-negative breast cancer cells: an acylphenol phyto-entity isolated from the fruit rind of Myristica malabarica Lam.

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3558-3575
DOI: 10.1039/D4MD00391H, Research Article
Pothiyil S. Vimalkumar, Neethu Sivadas, Vishnu Priya Murali, Daisy R. Sherin, Madhukrishnan Murali, Anuja Gracy Joseph, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Malabaricone A isolated from Myristica malabarica induces apoptosis in triple-negative breast cancer cells through intrinsic and extrinsic pathways, which is validated through in vitro and in silico studies and resembles a potent phyto-entity.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Exploring 7β-amino-6-nitrocholestens as COVID-19 antivirals: in silico, synthesis, evaluation, and integration of artificial intelligence (AI) in drug design: assessing the cytotoxicity and antioxidant activity of 3β-acetoxynitrocholestane

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00257A, Research Article
Shahabuddin, Uzma, Mohammad Azam, Mehtab Parveen, Nurul Huda Abd Kadir, Kim Min, Mahboob Alam
In light of the ongoing pandemic caused by SARS-CoV-2, effective and clinically translatable treatments are desperately needed for COVID-19 and its emerging variants.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Design and Synthesis of coumarin-based amphoteric antimicrobials with the biofilm interference and immunoregulation effects

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00721B, Research Article
Qun Tang, Haiyang Zhang, Kasemsiri Chandarajoti, Zirui Jiao, Lianhua Nie, Sai Lv, Jiakun Zuo, Wen Zhou, Xiangan Han
Bacterial infections pose a threat to the health of animals and human being, and the biofilm formation exacerbates the microbial threat. New antimicrobial agents to address this challenge are much...
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Modulating polybasic character of galactose-based glycosylated antitumor ether lipids for enhanced cytotoxic response

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00662C, Research Article
Rajat Arora, Ayan Mukherjee, Gilbert Arthur, Mark W. Nachtigal, Frank Schweizer
We describe the multi-step synthesis of different dibasic and tribasic galactosamine-based glycosylated antitumor ether lipids (GAELs) and their cytotoxic response in comparison to doxorubicin and cisplatin.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00594E, Research Article
Nagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza Elrayess
One benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Design, synthesis and mechanistic insights into triclosan derived dimers as potential anti-plasmodials

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00494A, Research Article
Shekhar, Shefali Chowdhary, Joel Mosnier, Isabelle Fonta, Bruno Pradines, Vipan Kumar
In pursuit of novel anti-plasmodial agents, a library of triclosan-based dimers both with and without a 1H-1,2,3 triazole core were designed, synthesized and evaluated in order to achieve a multitargeted approach.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Correction: Anti-schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD90044H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki Fujii
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Human microbiome derived synthetic antimicrobial peptides with activity against Gram-negative, Gram-positive, and antibiotic resistant bacteria

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00383G, Research Article
Open Access
Walaa K. Mousa, Ashif Y. Shaikh, Rose Ghemrawi, Mohammed Aldulaimi, Aya Al Ali, Nour Sammani, Mostafa Khair, Mohamed I. Helal, Farah Al-Marzooq, Emilia Oueis
An AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect and a membrane-targeting mode of action.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Amides of moronic acid and morolic acid with the tripeptides MAG and GAM targeting antimicrobial, antiviral and cytotoxic effects

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00742E, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Uladzimir Bildziukevich, Lucie Cerna, Jana Trylčová, Marie Kvasnicova, Lucie Rárová, David Šaman, Petra Lovecká, Jan Weber, Zdenek Wimmer
A series of amides of the selected plant triterpenoids, moronic acid and morolic acid, with the tripeptides MAG and GAM was designed and synthesized. Two required tripeptides 5 and 10...
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00562G, Research Article
Open Access
Andreas Simoens, Andreas Dejaegere, Marthe Vandevelde, Christian V. Stevens
Flow chemistry allows for the rapid and clean synthesis of therapeutically relevant tryptamines in good yields, including the large scale drug rizatriptan.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Azo derivatives of monoterpenes as anti-Helicobacter pylori agents: from synthesis to structure-based target investigation

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00511B, Research Article
Open Access
Francesco Melfi, Marialuigia Fantacuzzi, Simone Carradori, Ilaria D'Agostino, Alessandra Ammazzalorso, Noemi Mencarelli, Marialucia Gallorini, Mattia Spano, Paolo Guglielmi, Mariangela Agamennone, Sazan Haji Ali, Ali Al-Samydai, Francesca Sisto
Monoterpene-derived azo benzenes showed selective antibacterial activity against Helicobacter pylori with a safe profile. An in silico investigation highlighted the inosine 5'-monophosphate dehydrogenase enzyme as the putative target.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Ligand-centred phenotype-driven development of potent kinase inhibitors against oesophageal cancer

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00579A, Research Article
Open Access
Cecilia C. Ayala-Aguilera, Yang Ge, Álvaro Lorente-Macías, Benjamin N. Jones, Catherine Adam, Neil O. Carragher, Asier Unciti-Broceta
A ligand-centred strategy combined with phenotypic screening was used to develop novel antiproliferative inhibitors against oesophageal cancer and identified a lead compound that induces potent anticancer activity and inhibits Aurora kinase A.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Synthesis and anti-tumor activity of new benzofuran-based chalcone derivatives as potent VEGFR-2 inhibitors

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00621F, Research Article
Chunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei Mao
A series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

S-MGBs bearing amidine tail groups are potent, selective antiplasmodial agents

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00619D, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Marina Perieteanu, Tayner Rodriguez Garzon, Leah M. C. McGee, Abedawn I. Khalaf, Colin J. Suckling, Rebecca Beveridge, Vicky M. Avery, Fraser J. Scott
25 S-MGBs, including those bearing an amidine tail group, were investigated for their antiplasmodial, in vitro activity against 3D7 and Dd2 strains of P. falciparum. Several potent, and selective, hit compounds were identified.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00373J, Research Article
YongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian Zhang
The mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00495G, Research Article
Yakup Berkay Yilmaz, Tuğba Güngör, Serhat Dönmez, Hazal Nazlıcan Atalay, Pınar Siyah, Serdar Durdağı, Mehmet Ay, Tugba Boyunegmez Tumer
New isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

meso-Substituted AB3-type phenothiazinyl porphyrins and their indium and zinc complexes photosensitising properties, cytotoxicity and phototoxicity on ovarian cancer cells

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00601A, Research Article
Open Access
Brém Balázs, Bianca Stoean (Vasile), Éva Molnár, Eva Fischer-Fodor, Ovidiu Bălăcescu, Raluca Borlan, Monica Focsan, Adriana Grozav, Patriciu Achimaş-Cadariu, Emese Gál, Luiza Gaina
New meso-substituted AB3-type phenothiazinyl porphyrins and ferrocenylvinyl phenothiazinyl porphyrin were synthesised by Suzuki–Miyaura and Mizoroki–Heck cross-coupling reactions, respectively.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Light enhanced cytotoxicity and antitumoral effect of a ruthenium-based photosensitizer inspired from natural alkaloids

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00600C, Research Article
Open Access
Gennaro Sanità, Maria Laura Alfieri, Barbara Carrese, Serena Damian, Vincenza Mele, Gaetano Calì, Brigida Silvestri, Sebastiano Marra, Susan Mohammadi, Giuseppina Luciani, Paola Manini, Annalisa Lamberti
Biological assays carried out on melanoma and breast cancer cells highlighted the role of light in boosting the cytotoxic effect of a ruthenium complex featuring a dihydroisoquinoline ligand suggesting applications in photodynamic therapy.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article

ot

Property-based optimisation of PROTACs

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00769G, Opinion
James Scott, Iacovos Michaelides, Markus Schade
PROTACs are an emerging therapeutic approach towards targeted protein degradation. This article examines the leading examples of this modality that are in clinical development through the prism of their physicochemical...
The content of this RSS Feed (c) The Royal Society of Chemistry


Full Article