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Toddlers and Tiaras...

Toddlers and Tiaras... Gets more competitive every season.




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My Barkeep calls this drink a "Hurricane Sandy" But it tastes like a watered-down Manhattan




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Transition Releases New Youth MTB Lineup



A new 20” hardtail, a redesigned 24” full suspension, and a 27.5” young adult full suspension bike.
( Photos: 8, Comments: 40 )




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Is it safe to travel to Spain and should I cancel my holiday after flooding disaster?

Extreme weather in Spain is back over Malaga as flights and train travel are disrupted due to wind and rain




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Canada Passes New Right To Repair Rules With the Same Old Problem

An anonymous reader quotes a report from The Register: Royal assent was granted to two right to repair bills last week that amend Canada's Copyright Act to allow the circumvention of technological protection measures (TPMs) if this is done for the purposes of "maintaining or repairing a product, including any related diagnosing," and "to make the program or a device in which it is embedded interoperable with any other computer program, device or component." The pair of bills allow device owners to not only repair their own stuff regardless of how a program is written to prevent such non-OEM measures, but said owners can also make their devices work with third-party components without needing to go through the manufacturer to do so. Bills C-244 (repairability) and C-294 (interoperability) go a long way toward advancing the right to repair in Canada and, as iFixit pointed out, are the first federal laws anywhere that address how TPMs restrict the right to repair -- but they're hardly final. TPMs can take a number of forms, from simple administrative passwords to encryption, registration keys, or even the need for a physical object like a USB dongle to unlock access to copyrighted components of a device's software. Most commercially manufactured devices with proprietary embedded software include some form of TPM, and neither C-244 nor C-294 place any restrictions on the use of such measures by manufacturers. As iFixit points out, neither Copyright Act amendments do anything to expand access to the tools needed to circumvent TPMs. That puts Canadians in a similar position to US repair advocates, who in 2021 saw the US Copyright Office loosen DMCA restrictions to allow limited repairs of some devices despite TPMs, but without allowing access to the tools needed to do so. [...] Canadian Repair Coalition co-founder Anthony Rosborough said last week that the new repairability and interoperability rules represent considerable progress, but like similar changes in the US, don't actually amount to much without the right to distribute tools. "New regulations are needed that require manufacturers and vendors to ensure that products and devices are designed with accessibility of repairs in mind," Rosborough wrote in an op-ed last week. "Businesses need to be able to carry out their work without the fear of infringing various intellectual property rights."

Read more of this story at Slashdot.




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Connor McGregor tells court sex with rape accuser was consensual

Irish mixed martial artist Conor McGregor claimed to have had consensual sex with a woman who is accusing him of rape, a court has heard.




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The masked headliners freshening up Download festival

Mysterious metal group Sleep Token are one of three headliners announced for Download festival.




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Gary Lineker steps down as Sports Personality host

The news comes a day after confirmation that he will leave the BBC's Match of the Day.




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Daniel Khalife denies asking Iran for help after prison escape

The former soldier has pleaded guilty to escaping from prison but still faces other charges.




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Assisted dying law would hit other NHS care, says Streeting

The health secretary has ordered officials to review the costs for the NHS of implementing changes in the law.




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Homebase collapses into administration with 2,000 jobs at risk

Homebase enters administration, but The Range buys up to 70 stores and the brand.







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Discover Something New at Home this Holiday Season

Filed under: , ,

Traveling "home" this holiday season? Don't fall into your old routine. Your high school hangout may be an easy go-to, but if you don't live there anymore there's a good chance you're missing out on some great new local spots. (Plus, be honest: you already know what all your classmates are up to from Facebook.)

We turned to local writers to help you rediscover your hometown over Thanksgiving and the winter holidays. Each city guide features a great new restaurant to try while you're in town, a cool neighborhood that wasn't on the radar last year or a store where you can pick up a keepsake to bring your old home back to your new home. We'll also catch you up to speed on the hot topics of conversation in each city, so you'll come back savvy enough to join the local sports banter or eat your holiday weight in Cronuts.

Click your city below to learn what's new since the last time you went home:

Continue reading Discover Something New at Home this Holiday Season

Discover Something New at Home this Holiday Season originally appeared on Gadling on Mon, 25 Nov 2013 12:15:00 EST. Please see our terms for use of feeds.

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Will You Be a Horrible Restaurant Customer This Holiday Season?

Filed under: , , ,

Getty Images

So you've finished your Thanksgiving dinner and you're finally sick of turkey leftovers. It's time to get out there and hit the great new restaurant that just opened in your hometown or wherever you're spending the holidays. (FYI: Aol Travel knows the hot restaurants in cities around the U.S.)

Wherever you go, remember that there are appropriate ways to behave. And there are horrible ways to behave, as highlighted in this Montreal Gazette story by two Montreal-area restaurant servers. Among other things, they urge:

Continue reading Will You Be a Horrible Restaurant Customer This Holiday Season?

Will You Be a Horrible Restaurant Customer This Holiday Season? originally appeared on Gadling on Wed, 27 Nov 2013 16:31:00 EST. Please see our terms for use of feeds.

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Because There Aren't Enough Reasons to Visit San Diego in Winter, Now You Can Ice Skate

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Hotel Solamar
Top reasons to visit San Diego right now:

Continue reading Because There Aren't Enough Reasons to Visit San Diego in Winter, Now You Can Ice Skate

Because There Aren't Enough Reasons to Visit San Diego in Winter, Now You Can Ice Skate originally appeared on Gadling on Tue, 10 Dec 2013 15:32:00 EST. Please see our terms for use of feeds.

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Facebook, Instagram Release Top Checked-in Locations of 2013

Filed under: ,

Alamy
Photo-sharing app Instagram and Facebook, a website your parents visit, released lists of their users most checked-in locations for 2013 earlier this week.

Congratulations to Disneyland for being the top U.S. spot for Facebook check-ins and the third most photographed location on Instagram. And props to all of Canada: its most checked-in location was a hockey arena.

Here are both lists.

Continue reading Facebook, Instagram Release Top Checked-in Locations of 2013

Facebook, Instagram Release Top Checked-in Locations of 2013 originally appeared on Gadling on Fri, 13 Dec 2013 14:23:00 EST. Please see our terms for use of feeds.

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Discover Something New at Home this Holiday Season

Filed under: , ,

Traveling "home" this holiday season? Don't fall into your old routine. Your high school hangout may be an easy go-to, but if you don't live there anymore there's a good chance you're missing out on some great new local spots. (Plus, be honest: you already know what all your classmates are up to from Facebook.)

AOL Travel turned to local writers to help you rediscover your hometown over the winter holidays. Each city guide features a great new restaurant to try while you're in town, a cool neighborhood that wasn't on the radar last year or a store where you can pick up a keepsake to bring your old home back to your new home. AOL Travel also will catch you up to speed on the hot topics of conversation in each city, so you'll come back savvy enough to join the local sports banter or eat your holiday weight in Cronuts.

Click your city below to learn what's new since the last time you went home:

Continue reading Discover Something New at Home this Holiday Season

Discover Something New at Home this Holiday Season originally appeared on Gadling on Wed, 18 Dec 2013 11:04:00 EST. Please see our terms for use of feeds.

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Off-Broadway Comedy 'Craving for Travel' Showcases Travel Agents Trying to do the Impossible

Filed under: , ,

Facebook/Craving for Travel

Joanne and Gary, rival travel agents compete for their industry's top honor, the Globel Prize, while trying to address their clients' impossible demands in an Off-Broadway comedy that debuts this week, "Craving for Travel."

The 85-minute, two-actor, 30-character comedy was commissioned and produced by Jim Strong, president of the Dallas-based Strong Travel Services travel agency.

"Travel agents are always asked to do the impossible, and this play shows how that is done, from finding the impossible rooms to making dreams come true," Strong told the "Dallas Morning News." "I decided to bring it to life on stage as a comedy in New York."

From "Craving for Travel's" press release:

With their reputations on the line, travel agents Joanne and Gary will tackle any request, no matter how impossible, and any client, no matter how unreasonable. Full of overzealous travelers, overbooked flights, and hoteliers who are just over it, Craving for Travel reminds us why we travel-and everything that can happen when we do.

"Craving for Travel" opens Thursday at the Peter J. Sharp Theater, where it'll run through Feb. 9. Tickets are $32.50 and $49. They can be purchased at CravingForTravel.com, 212-279-4200 or the Ticket Central Box Office (416 W. 42nd St., 12-8 p.m. daily). More than half of the shows are already sold out.

Continue reading Off-Broadway Comedy 'Craving for Travel' Showcases Travel Agents Trying to do the Impossible

Off-Broadway Comedy 'Craving for Travel' Showcases Travel Agents Trying to do the Impossible originally appeared on Gadling on Tue, 07 Jan 2014 10:19:00 EST. Please see our terms for use of feeds.

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Another Boeing 787 Dreamliner Has a Battery Problem

Filed under: , , ,

Getty Images
Japan Airlines grounded a Boeing 787 Dreamliner aircraft today "after detecting smoke or gases that may have come from faults with the main battery," according to the BBC.

Last year, all 787s were grounded for three months, CBS reports, after a "fire in a lithium ion battery aboard a Japan Airlines 787 parked at Boston's Logan International Airport. That was followed nine days later by another battery incident that forced an emergency landing in Japan by an All Nippon Airways 787.

Continue reading Another Boeing 787 Dreamliner Has a Battery Problem

Another Boeing 787 Dreamliner Has a Battery Problem originally appeared on Gadling on Tue, 14 Jan 2014 14:57:00 EST. Please see our terms for use of feeds.

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$7.2 Million Cash Found in Suitcases at Panama City Airport

Filed under: , , ,

Newsy
Travel tip: If you're trying to smuggle cash into Panama, start using the train.

Three Honduran men were arrested at Panama City's international airport after police found $7.2 million, mostly in $100 bills, in secret compartments in eight pieces of luggage. According to this video from Newsy (Newsy? Really? Really.), officials in Panama believe the money was connected to a drug cartel. Thirty-two officers and airport security staffers have been suspended as a result of the find.

Continue reading $7.2 Million Cash Found in Suitcases at Panama City Airport

$7.2 Million Cash Found in Suitcases at Panama City Airport originally appeared on Gadling on Fri, 17 Jan 2014 17:04:00 EST. Please see our terms for use of feeds.

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Rockies' youth could fill offseason departures

This time of year you read a lot about championship windows -- a way of thinking that seems to be standard operating procedure, whether clubs are in small or big markets. Well, the Rockies don't believe in that concept.




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Uniform patch to mark 150 years of pro baseball

All 30 Major League teams will wear special "MLB 150" patches on their uniforms for the entire 2019 season in honor of the 150th anniversary of the 1869 Cincinnati Red Stockings, the first openly all-salaried professional baseball team.




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Reasons for optimism for each MLB club

On this opening week of Spring Training, all 30 Major League teams have one thing in common: optimism. Here's an optimism cheat sheet for each of them.




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Arenado: Manny deal 'really good for baseball'

The baseball field is Rockies third baseman Nolan Arenado's refuge from contract talks. But Tuesday's breaking news -- Manny Machado's 10-year, $300 million contract with the Padres -- made its way onto the field.




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Assessment and management of facial nerve palsy




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US drug costs are rising faster than overall health spending, officials report




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Disease modifying therapies for relapsing multiple sclerosis




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Potential role for BCG in treatment of autoimmune diseases




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Projecting Vlad Jr.'s first 10 seasons

If Vladimir Guerrero Jr. can handle the hot corner -- at least for a while -- that would be gravy. The real attraction is the bat, and if these projections are any indication, it may be a special one.




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Uniform patch to mark 150 years of pro baseball

All 30 Major League teams will wear special "MLB 150" patches on their uniforms for the entire 2019 season in honor of the 150th anniversary of the 1869 Cincinnati Red Stockings, the first openly all-salaried professional baseball team.




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Roster in transition as Blue Jays open camp

Charlie Montoyo is about to embark on the first spring of his managerial career, and based on the number of decisions he has to make, it's going to be a challenging six weeks.




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Reasons for optimism for each MLB club

On this opening week of Spring Training, all 30 Major League teams have one thing in common: optimism. Here's an optimism cheat sheet for each of them.




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Re: Assisted dying bill: Two doctors would need to approve action




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Correspondence on 'Dispute arises over World Professional Association for Transgender Health’s involvement in WHO’s trans health guideline' by Jennifer Block




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Assisted dying bill: Two doctors would need to approve action

Terminally ill adults in England and Wales who are expected to die within six months would be able to get help to end their lives if their applications were approved by two doctors and a High Court judge, under proposed new legislation.1Labour MP Kim Leadbeater, who proposed the bill, said it provided the “strictest safeguards anywhere in the world.” The law would apply only to people who have full mental capacity and are terminally ill. Mental illness and disability are both excluded as eligibility criteria, and a person would need to declare twice in writing that they wanted to be helped to die.A person who wished to end their life would have to administer the medication themselves. It will remain illegal for a doctor or anybody else to end a person’s life. No doctor will be obliged to participate in any part of the process.The bill would also make it...




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Cardiovascular disease: Just one in 12 eligible people had health check last year, watchdog finds

The current system for delivering NHS cardiovascular disease (CVD) health checks is not working effectively and must be reviewed to ensure that it reaches people with the highest risk, the National Audit Office has said.1In a review of the commissioning, delivery, and performance of CVD health checks the watchdog found that just over one in 12 people (8.8%) who were eligible attended a health check in 2023-24—which, if maintained, would equate to a five year coverage of 44%.Health checks were first introduced in 2009, with the aim of reducing ill health from CVD by offering everyone aged 40-74 without a pre-existing heart condition a check-up every five years. However, problems have arisen since the responsibility for commissioning these checks was transferred to local authorities in 2013, said the National Audit Office.The move led to the Department of Health and Social Care (DHSC) losing its ability to influence local authority performance,...




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Monocyte Invasion into the Retina Restricts the Regeneration of Neurons from Müller Glia

Endogenous reprogramming of glia into neurogenic progenitors holds great promise for neuron restoration therapies. Using lessons from regenerative species, we have developed strategies to stimulate mammalian Müller glia to regenerate neurons in vivo in the adult retina. We have demonstrated that the transcription factor Ascl1 can stimulate Müller glia neurogenesis. However, Ascl1 is only able to reprogram a subset of Müller glia into neurons. We have reported that neuroinflammation from microglia inhibits neurogenesis from Müller glia. Here we found that the peripheral immune response is a barrier to CNS regeneration. We show that monocytes from the peripheral immune system infiltrate the injured retina and negatively influence neurogenesis from Müller glia. Using CCR2 knock-out mice of both sexes, we found that preventing monocyte infiltration improves the neurogenic and proliferative capacity of Müller glia stimulated by Ascl1. Using scRNA-seq analysis, we identified a signaling axis wherein Osteopontin, a cytokine highly expressed by infiltrating immune cells is sufficient to suppress mammalian neurogenesis. This work implicates the response of the peripheral immune system as a barrier to regenerative strategies of the retina.




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Deciphering Peripheral Taste Neuron Diversity: Using Genetic Identity to Bridge Taste Bud Innervation Patterns and Functional Responses

Peripheral taste neurons exhibit functional, genetic, and morphological diversity, yet understanding how or if these attributes combine into taste neuron types remains unclear. In this study, we used male and female mice to relate taste bud innervation patterns to the function of a subset of proenkephalin-expressing (Penk+) taste neurons. We found that taste arbors (the portion of the axon within the taste bud) stemming from Penk+ neurons displayed diverse branching patterns and lacked stereotypical endings. The range in complexity observed for individual taste arbors from Penk+ neurons mirrored the entire population, suggesting that taste arbor morphologies are not primarily regulated by the neuron type. Notably, the distinguishing feature of arbors from Penk+ neurons was their propensity to come within 110 nm (in apposition with) different types of taste-transducing cells within the taste bud. This finding is contrary to the expectation of genetically defined taste neuron types that functionally represent a single stimulus. Consistently, further investigation of Penk+ neuron function revealed that they are more likely to respond to innately aversive stimuli—sour, bitter, and high salt concentrations—as compared with the full taste population. Penk+ neurons are less likely to respond to nonaversive stimuli—sucrose, umami, and low salt—compared with the full population. Our data support the presence of a genetically defined neuron type in the geniculate ganglion that is responsive to innately aversive stimuli. This implies that genetic expression might categorize peripheral taste neurons into hedonic groups, rather than simply identifying neurons that respond to a single stimulus.




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Orbitofrontal Cortex Mediates Sustained Basolateral Amygdala Encoding of Cued Reward-Seeking States

Basolateral amygdala (BLA) neurons are engaged by emotionally salient stimuli. An area of increasing interest is how BLA dynamics relate to evolving reward-seeking behavior, especially under situations of uncertainty or ambiguity. Here, we recorded the activity of individual BLA neurons in male rats across the acquisition and extinction of conditioned reward seeking. We assessed ongoing neural dynamics in a task where long reward cue presentations preceded an unpredictable, variably time reward delivery. We found that, with training, BLA neurons discriminated the CS+ and CS– cues with sustained cue-evoked activity that correlated with behavior and terminated only after reward receipt. BLA neurons were bidirectionally modulated, with a majority showing prolonged inhibition during cued reward seeking. Strikingly, population-level analyses revealed that neurons showing cue-evoked inhibitions and those showing excitations similarly represented the CS+ and behavioral state. This sustained population code rapidly extinguished in parallel with conditioned behavior. We next assessed the contribution of the orbitofrontal cortex (OFC), a major reciprocal partner to the BLA. Inactivation of the OFC while simultaneously recording in the BLA revealed a blunting of sustained cue-evoked activity in the BLA that accompanied reduced reward seeking. Optogenetic disruption of BLA activity and OFC terminals in the BLA also reduced reward seeking. Our data indicate that the BLA represents reward-seeking states via sustained, bidirectional cue-driven neural encoding. This code is regulated by cortical input and is important for the maintenance of vigilant reward-seeking behavior.




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Introducing basketball to Mamelodi

Basketball is not played much in South Africa, but OM SportsLink successfully introduces the game to students in Mamelodi, a township outside of Pretoria.




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Midwifery in the Middle East

A South African OMer plans to use her nursing skills to build relationships with Muslim women in the Arabian Peninsula.




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Passing on the baton

After leading AIDS Hope for the past 11 years, Nico and Alma hand over the leadership of Meetse a Bophelo centre in Mamelodi.




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Holiday Bible class becomes community event

The OM Philippines-Cebu team, in partnership with the local church, touches the lives of young and old through a five-day Bible class.




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Christmas cheer for poor children in Tacloban

Students from OM Philippines-Cebu's Alternative Learning System bring children joy through a Christmas party, following the trauma caused by Bohol earthquake and Typhoon Haiyan.




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Christmas parties and food packages

On 24 December, OM Philippines-Cebu witnessed the overflowing joy of about 135 families during Christmas parties they hosted in two typhoon-affected areas.




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Not forgotten this Christmas

From Leyte Island to Northern Cebu to Bohol Island, the Christmas season brought overwhelming joy to many who received provision and care from OM Philippines.




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Into the last frontier

From 8-26 April, OM Philippines will host their annual short-term missions conference GO EXTRA MILE in Palawan for the first time ever.




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Livelihood training for the destitute and devastated

OM Philippines hosts micro-business workshops that offer a future with hope.