b Donor-derived DNA variability in fingernails of acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation detected by direct PCR By feeds.nature.com Published On :: 2020-05-09 Full Article
b NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma By feeds.nature.com Published On :: 2020-05-07 Full Article
b Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells By feeds.nature.com Published On :: 2020-05-07 Full Article
b The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors By feeds.nature.com Published On :: 2020-05-07 Full Article
b QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism By feeds.nature.com Published On :: 2020-05-07 Full Article
b WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2 By feeds.nature.com Published On :: 2020-05-07 Full Article
b LncRNA <i>SNORD3A</i> specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression By feeds.nature.com Published On :: 2020-05-07 Full Article
b NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas By feeds.nature.com Published On :: 2020-05-07 Full Article
b MicroRNA let-7c (MIRLET7C; let-7c), miR-99a and miR-125b as prognostic markers of luminal breast cancer By feeds.nature.com Published On :: 2014-12-18 Studies in patient samples and cell culture suggest let-7c, miR-99a and miR-125b could serve as prognostic markers in patients with estrogen receptor–positive luminal breast cancers. Full Article
b Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE) By feeds.nature.com Published On :: 2014-12-18 Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE. Full Article
b RNAi against therapeutic targets with short interfering ribonucleic neutrals (siRNNs) By feeds.nature.com Published On :: 2014-12-18 siRNNs could enable RNAi knockdown of therapeutic targets in a broader range of cells and tissue types than siRNA. Full Article
b Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent binding to neonatal Fc receptor By feeds.nature.com Published On :: 2014-12-18 Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives. Full Article
b Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3) By feeds.nature.com Published On :: 2014-12-18 Mouse studies suggest inhibiting PGF could help treat hypertension. Full Article
b Topoisomerase II binding protein 1 (TOPBP1) By feeds.nature.com Published On :: 2014-12-18 Mouse and cell culture studies suggest inhibiting TOPBP1 could help treat cancer. Full Article
b Globohexaosylceramide (globo-H); stage-specific embryonic antigen-3 (SSEA-3); SSEA-4 By feeds.nature.com Published On :: 2014-12-18 Mouse studies suggest chemically modified carbohydrate conjugates could be useful as antigens for the development of cancer vaccines. Full Article
b Epidermal growth factor receptor 1 (EGFR1; ErbB1; HER1); HER2 (EGFR2; ErbB2; neu); HER3 (EGFR3; ErbB3); VEGF By feeds.nature.com Published On :: 2014-12-18 Tumor cell and mouse studies suggest tetravalent antibodies that target four different antigens could help treat cancers resistant to HER-targeted therapies. Full Article
b Cyclin dependent kinase 7 (CDK7); v-myc myelocytomatosis viral related oncogene neuroblastoma derived (MYCN; NMYC) By feeds.nature.com Published On :: 2014-12-18 In vitro and mouse studies suggest THZ1, a covalent CDK7 inhibitor, could help treat neuroblastoma and other cancers driven by MYCN and other c-MYC (MYC)-family oncoproteins. Full Article
b Resurrecting a magic bullet By feeds.nature.com Published On :: 2014-12-18 Heidelberg Pharma has resuscitated a long-dead ADC toxin with updated conjugation techniques, and its partner Roche has thrown the company a lifeline that could help validate the platform. Full Article
b Translational tidbits By feeds.nature.com Published On :: 2014-12-18 Yabao and MRC Technology partner in PD; charities form Neuro-MAP to insource pharma's abandoned compounds; Singapore creates a diagnostic hub; a roundup of public-private partnerships. Full Article
b Translational balance By feeds.nature.com Published On :: 2014-12-18 Moving discoveries from academia to industry requires a delicate balance of risk, reward, skill sets and personalities, according to a translational panel held at BIO-Europe's partnering conference. Full Article
b Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity By feeds.nature.com Published On :: 2020-04-27 Full Article
b In vitro capture and characterization of embryonic rosette-stage pluripotency between naive and primed states By feeds.nature.com Published On :: 2020-05-04 Full Article
b Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis By feeds.nature.com Published On :: 2020-05-04 Full Article
b FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome By feeds.nature.com Published On :: 2020-05-04 Full Article
b MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis By feeds.nature.com Published On :: 2020-03-23 Full Article
b In vivo antitumor activity by dual stromal and tumor-targeted oncolytic measles viruses By feeds.nature.com Published On :: 2020-03-31 Full Article
b Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice By feeds.nature.com Published On :: 2020-04-20 Full Article
b TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials By feeds.nature.com Published On :: 2020-04-28 Full Article
b Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40 By feeds.nature.com Published On :: 2020-05-01 Full Article
b UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53 By feeds.nature.com Published On :: 2020-05-06 Full Article
b High-purity orbital angular momentum states from a visible metasurface laser By feeds.nature.com Published On :: 2020-04-27 Full Article
b Engineering nanomedicines through boosting immunogenic cell death for improved cancer immunotherapy By feeds.nature.com Published On :: 2020-04-21 Full Article
b Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization By feeds.nature.com Published On :: 2020-04-23 Full Article
b Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation By feeds.nature.com Published On :: 2020-04-27 Full Article
b An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9 By feeds.nature.com Published On :: 2020-04-27 Full Article
b Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy By feeds.nature.com Published On :: 2020-04-27 Full Article
b Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy By feeds.nature.com Published On :: 2020-04-30 Full Article
b Head-to-head trials in inflammatory bowel disease: past, present and future By feeds.nature.com Published On :: 2020-04-17 Full Article
b Microbiota and colorectal cancer: colibactin makes its mark By feeds.nature.com Published On :: 2020-04-21 Full Article
b Colons or semi-colons: punctuating the regional variation of intestinal microbial–immune interactions By feeds.nature.com Published On :: 2020-04-22 Full Article
b Universal screening for hepatitis C virus infection should be linked to universal treatment access By feeds.nature.com Published On :: 2020-04-29 Full Article
b Author Correction: Management of IBD during the COVID-19 outbreak: resetting clinical priorities By feeds.nature.com Published On :: 2020-05-06 Full Article
b A novel multidimensional reinforcement task in mice elucidates sex-specific behavioral strategies By feeds.nature.com Published On :: 2020-05-06 Full Article
b Cannabinoid CB<sub>2</sub> receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear By feeds.nature.com Published On :: 2020-05-06 Full Article
b A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology By feeds.nature.com Published On :: 2020-05-06 Full Article
