el Climate hypocrites are all tell, no show By www.washingtonexaminer.com Published On :: Tue, 23 Aug 2022 11:14:57 GMT Many celebrities are full of sermons about how you need to save the planet. Often, they are the very same ones maximizing their own carbon footprints by flying on private jets. This has long been known, but the internet has now made it significantly easier to quantify their hypocrisy. Full Article
el CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients By scienceblogs.com Published On :: Thu, 06 Feb 2020 19:52:53 +0000 CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients In the first-ever (sanctioned) investigational use of multiple edits to the human genome, a study found that cells edited in three specific ways and then removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion. This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients' immune cells. The ongoing study is a cooperative between Tmunity Therapeutics, the Parker Institute for Cancer Immunotherapy, and the University of Pennsylvania. Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, co-lead author on the study. The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient's T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell's natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job. Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months. Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors. The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events. CRISPR technology has not previously been tested in humans in the U.S. so the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health's Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn's institutional review board and institutional biosafety committee. The entire process required more than two years. Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn. sb admin Thu, 02/06/2020 - 14:52 Categories Life Sciences Full Article
el John Fetterman says social media was an 'accelerant' that made depression worse By www.washingtonexaminer.com Published On :: Sun, 31 Dec 2023 20:59:43 GMT Sen. John Fetterman (D-PA) said Sunday that social media served as "an accelerant" for his clinical depression, to the point that doctors advised him to stay off of it. Full Article
el Economists call arena relocation threats ‘extortion’ By www.washingtonexaminer.com Published On :: Mon, 07 Aug 2023 12:21:49 GMT (Center Square) — Monumental Sports and Entertainment have been in talks this summer of a future move to northern Virginia for some of Washington, D.C.’s professional sports teams if the city doesn’t chip in more for improvements to their sports arena, the Washington Post has reported. Full Article
el DC Mayor Muriel Bowser forgets which Metro lines service arena stop while defending keeping teams downtown By www.washingtonexaminer.com Published On :: Wed, 13 Dec 2023 20:58:49 GMT Washington, D.C., Mayor Muriel Bowser forgot which lines on the D.C. Metro service Capital One Arena while trying to argue against the NBA's Washington Wizards and the NHL's Washington Capitals moving to a new arena in Virginia. Full Article
el Majority of Virginians are against electric vehicle mandate: Poll By www.washingtonexaminer.com Published On :: Thu, 04 Jan 2024 16:48:42 GMT While some Virginians weren't previously aware of their state's mandate to only sell electric vehicles after 2035, most are against it. Full Article
el Washington's streak of 718 days without snow unlikely to be broken despite East Coast bracing for storm By www.washingtonexaminer.com Published On :: Fri, 05 Jan 2024 22:20:38 GMT Washington, D.C.'s streak of 718 days without heavy snow will not likely be broken anytime soon, even as the rest of the East Coast prepares for a winter storm this weekend. Full Article
el How the Homelessness Problem in Virginia Compares to Other States By www.washingtonexaminer.com Published On :: Sun, 07 Jan 2024 15:41:19 GMT On a single night in 2022, 582,462 people experienced homelessness in the United States, and numbers are on the rise. Since 2017, there has been a 6% increase in homelessness. Full Article
el Hospitals that pursue patients for unpaid bills will have to tell L.A. County By www.latimes.com Published On :: Wed, 7 Aug 2024 00:40:26 GMT Hospitals must promptly report to the Los Angeles County public health department each time they try to collect medical debt from patients, under an ordinance backed Tuesday by county supervisors. Full Article
el Summer break is ending. Here are 10 ways parents can help their kids get back into school mode By www.latimes.com Published On :: Fri, 9 Aug 2024 10:00:54 GMT With summer break ending, The Times spoke with psychologists about how parents can help their students embrace a back-to-school mindset. Here's their advice. Full Article
el Power-hungry AI data centers are raising electric bills and blackout risk By www.latimes.com Published On :: Mon, 12 Aug 2024 10:00:28 GMT Experts warn that a frenzy of data center construction could delay California's transition away from fossil fuels, raise electric bills and increase risk of blackouts Full Article
el What Elmo — and his human friends — learned by asking Americans about their mental health By www.latimes.com Published On :: Thu, 15 Aug 2024 10:00:49 GMT Mental and emotional health is on a par with physical health and financial security when it comes to negative impacts on overall well-being, researchers say. Full Article
el Kratom regulations shelved in California amid battle between advocacy groups By www.latimes.com Published On :: Thu, 15 Aug 2024 23:32:56 GMT A California bill that would have imposed regulations on kratom products has been shelved. Kratom is a substance derived from a tree native to Southeast Asia that is sold in the U.S. in powder, capsule and extract form. Full Article
el How a dire shortage of video game consoles helped prove that gaming boosts mental health By www.latimes.com Published On :: Mon, 19 Aug 2024 15:00:10 GMT A run on consoles during the pandemic allowed researchers to test whether gaming causes changes in the mental well-being of players. Full Article
el COVID and bird flu are rising. Here's how to keep yourself safe By www.latimes.com Published On :: Tue, 20 Aug 2024 10:00:43 GMT Doctors urge people who are experiencing respiratory problems to see a medical professional who can check their symptoms and test to determine what their illness is. Full Article
el Desperate parents turn to magnetic therapy to help kids with autism. They have little evidence to go on By www.latimes.com Published On :: Thu, 5 Sep 2024 10:00:44 GMT MERT is being marketed to families of children with autism. Providers suggest the treatment has been thoroughly studied, but there is little evidence to date of its efficacy. Full Article
el How to rediscover hope during election season By www.latimes.com Published On :: Thu, 12 Sep 2024 10:00:42 GMT In his new book 'Hope for Cynics,' Stanford psychology professor Jamil Zaki explains how cynicism became an American epidemic — and how to cure it. Full Article
el Why AI is better than humans at talking people out of their conspiracy theory beliefs By www.latimes.com Published On :: Thu, 12 Sep 2024 18:00:29 GMT An AI chatbot was able to persuade people to reconsider their beliefs in conspiracy theories about the JFK assassination, the moon landing and election fraud. Full Article
el Wildfires can release more energy than an atomic bomb. No wonder they look apocalyptic By www.latimes.com Published On :: Sun, 22 Sep 2024 10:00:07 GMT Uncontrolled wildfires can be powerful enough to generate their own weather. Full Article
el Brett Favre, testifying at welfare fraud hearing, reveals he has Parkinson's By www.latimes.com Published On :: Tue, 24 Sep 2024 17:38:19 GMT Brett Favre, 54, says he has Parkinson's disease while testifying before a House committee about welfare fraud in which he was allegedly involved in Mississippi. Full Article
el The Tijuana River smells so bad, the CDC is coming to investigate By www.latimes.com Published On :: Fri, 4 Oct 2024 15:46:18 GMT The CDC plans to knock on the doors of randomly selected homes in the Tijuana River Valley later this month to ask them about how the sewage crisis has affected their wellbeing. Full Article
el Former Caltech and Google scientists win physics Nobel for pioneering artificial intelligence By www.latimes.com Published On :: Tue, 8 Oct 2024 12:24:33 GMT John Hopfield dreamed up the modern neural network while at Caltech. Geoffrey Hinton built on it, creating an AI firm that Google bought for $44 million. Full Article
el Opinion: Menopausal women have a lot at stake in this election By www.latimes.com Published On :: Thu, 17 Oct 2024 10:00:47 GMT The politics of reproductive health aren't just about abortion and aren't limited to younger women. Full Article
el As Musk seeks to launch tens of thousands of Starlink satellites, space researchers urge caution By www.latimes.com Published On :: Tue, 29 Oct 2024 14:54:53 GMT Starlink satellites burn up in Earth's atmosphere after five years. Some researchers worry this injection of metals in the upper atmosphere could be damaging. Full Article
el A concerning development: H5N1 bird flu has infected a pig in Oregon, officials say By www.latimes.com Published On :: Wed, 30 Oct 2024 21:23:42 GMT H5N1 bird flu has been discovered in a pig in Oregon, a development that has sparked new concerns among infectious disease experts. Full Article
el Berkeley startup wins government award to develop radiation and lead poisoning treatment By www.latimes.com Published On :: Thu, 31 Oct 2024 10:00:34 GMT Few drugs are available to treat heavy metals that enter the body, either from lead poisoning or nuclear fallout. A UC Berkeley startup hopes to change that. Full Article
el Bird flu virus found in Los Angeles County wastewater By www.latimes.com Published On :: Sat, 2 Nov 2024 00:51:56 GMT Public health officials maintain the risk of H5N1 bird flu infection remains low. They are searching for the source. Full Article
el A Trump win could spell major changes for California's drinking water, RFK Jr. says By www.latimes.com Published On :: Tue, 5 Nov 2024 11:00:04 GMT Robert F. Kennedy Jr. described fluoride, which occurs naturally in all fresh water supplies, as an 'industrial waste' associated with various health risks. Full Article
el Are famous people more likely to die at 27, or does dying at 27 make them more famous? By www.latimes.com Published On :: Tue, 5 Nov 2024 11:00:33 GMT The deaths of people such as Kurt Cobain, Amy Winehouse and Jim Morrison fuel the myth that musicians face an increased risk of death at age 27. Full Article
el Jim Williams: Two days of coverage for the Preakness, Baltimore's jewel By www.washingtonexaminer.com Published On :: Thu, 16 May 2013 04:00:00 GMT NBC and the NBC Sports Network have taken over Pimlico Race Course in Baltimore for extensive coverage of the 138th running of the Preakness Stakes, the middle jewel of the Triple Crown. There will be no shortage of coverage of the Kentucky Derby winner Orb, who many think is a legitimate Triple Crown threat. Full Article
el Jim Williams: Tennis legend Chris Evert believes Serena Williams will take home French Open trophy By www.washingtonexaminer.com Published On :: Mon, 27 May 2013 04:00:00 GMT In the long storied history of the French Open, few men or women has been more successful on the red clay of Roland Garros than Chris Evert. She holds a record nine French Open titles: seven singles championships and two in doubles. Evert's 94-15 record at the French Open is the best winning percentage in the history of the event. Full Article
el Jim Williams: John McEnroe breaks down challenges of French Open, looks at who can beat Rafael Nadal on clay By www.washingtonexaminer.com Published On :: Tue, 28 May 2013 04:00:00 GMT As a player, John McEnroe was not a fan of the French Open. He has few fond memories of the dark red clay on the courts of Roland Garros. As brilliant a career as McEnroe had, he was never able to win a French Open title. He spoke with me by phone from Paris, where he is preparing for his job as a television analyst for the Tennis Channel. We talked about the 2013 French Open and the red clay at Roland Garros. Full Article
el Pelosi to throw out first pitch at Washington Nationals Night OUT game By www.washingtonexaminer.com Published On :: Tue, 06 Jun 2023 14:25:12 GMT Former House Speaker Nancy Pelosi (D-CA) is set to throw out the ceremonial first pitch Tuesday at the Washington Nationals' Night OUT game. Full Article
el Wild DC weather shuts down nation's capital early, causing traffic and travel nightmares By www.washingtonexaminer.com Published On :: Tue, 08 Aug 2023 01:19:57 GMT The federal Office of Personnel Management ordered federal employees to leave the office early on Monday amid Washington, D.C., area storm warnings. The severe storms covered most of the area with a tornado watch through 9 p.m., causing many places in the Beltway area to close early or adjust hours. Full Article
el Trump has ‘preliminary plans’ to visit Capitol Hill ahead of Biden meeting By www.washingtonexaminer.com Published On :: Tue, 12 Nov 2024 16:16:03 +0000 President-elect Donald Trump is expected to make a visit with House Republican leadership on Capitol Hill before meeting with President Joe Biden at the White House on Wednesday morning, Speaker Mike Johnson (R-LA) told reporters on Tuesday. Although the details have not been finalized, Johnson said they have “preliminary plans” to meet with the president-elect […] Full Article House News Congress Donald Trump Mike Johnson Trump Transition Washington D.C.
el US lowers El Salvador travel advisory to Level 2 after caucus protest By www.washingtonexaminer.com Published On :: Tue, 12 Nov 2024 22:31:41 +0000 The United States lowered El Salvador’s travel advisory to Level 2 after protests from the Congressional El Salvador Caucus. The United States had previously refused to lower the country’s travel designation from Level 3, “Reconsider Travel,” the second-highest rating possible, despite the transformation of the country’s crime situation. Over the past decade, the country had […] Full Article World Central America Congress El Salvador Nayib Bukele Travel
el Freedom Caucus chairman says Speaker Johnson should be challenged to avoid ‘Soviet-style’ election By www.washingtonexaminer.com Published On :: Wed, 13 Nov 2024 02:24:57 +0000 Freedom Caucus Chairman Andy Harris (R-MD) believes there should be more than one person in the race for House speaker to avoid a “Soviet-style” election following reports that hardline conservatives are hoping to find a challenger for Speaker Mike Johnson (R-LA). So far, Johnson is the only person seeking the speaker’s gavel after alerting his […] Full Article House Congress Freedom Caucus House Republicans Mike Johnson Speaker of the House Washington D.C.
el McConnell successor shrouded in uncertainty ahead of monumental Senate vote By www.washingtonexaminer.com Published On :: Wed, 13 Nov 2024 05:34:46 +0000 Republican senators emerged Tuesday night from a candidate forum largely tight-lipped on which of their colleagues they would support to replace Senate GOP Leader Mitch McConnell (R-KY) on the eve of a secret ballot vote and President-elect Donald Trump’s visit to Washington. Two hours of huddling behind closed doors with the trio of contenders fielding […] Full Article News Senate Congress John Cornyn John Thune Mitch McConnell Rick Scott
el Raskin says there is antisemitism in the GOP: ‘Where does Elise Stefanik get off?’ By www.washingtonexaminer.com Published On :: Mon, 11 Dec 2023 03:38:15 GMT Rep. Jamie Raskin (D-MD) railed against the GOP Sunday regarding the recent national response to antisemitism on college campuses. He took specific aim at Rep. Elise Stefanik (R-NY) and former President Donald Trump on the topic. Full Article
el Washington official fined $500 for voting in 2020 election twice By www.washingtonexaminer.com Published On :: Tue, 19 Dec 2023 20:17:25 GMT An elected Washington, D.C., official was among six people who were fined by the city this week after voting in the 2020 elections twice. Full Article
el US Open: Inside the exclusive Los Angeles Country Club drawing the sporting world's attention this weekend By www.washingtonexaminer.com Published On :: Thu, 15 Jun 2023 19:00:25 GMT The U.S. Open is being hosted at the exclusive Los Angeles Country Club for the first time in the club's history, with the world getting an up-close look at one of the most mysterious golf courses in the country. Full Article
el Trump says he believes LIV-PGA merger will go through: 'Very good for golf' By www.washingtonexaminer.com Published On :: Sun, 02 Jul 2023 20:45:52 GMT Former President Donald Trump spoke favorably of the controversial merger between LIV Golf and PGA Tour. Full Article
el Randy Travis releases new music with the help of AI after a stroke By www.latimes.com Published On :: Tue, 7 May 2024 17:16:20 GMT Randy Travis has released a new song, "Where That Came From," with the help of artificial intelligence. It's his first single since he had a stroke. Full Article
el Pro-Palestinian activists protest at Google developer conference amid Israel-Hamas war By www.latimes.com Published On :: Tue, 14 May 2024 20:05:49 GMT A group of protesters blocked the entrance of Google's developer conference in Mountain View, Calif. The demonstrators have condemned the tech giant's cloud computing contract with Israel's government. Full Article
el How YouTube became must-see TV: Shorts, sports and Coachella livestreams By www.latimes.com Published On :: Thu, 16 May 2024 10:00:34 GMT YouTube said more people are watching live events like Coachella and short form videos on TV sets. Sports, including the NFL, are also boosting viewership. Full Article
el Opinion: Why the push to legalize gambling on U.S. elections is so dangerous By www.latimes.com Published On :: Tue, 28 May 2024 10:30:56 GMT The Commodity Futures Trading Commission denied financial services firm Kalshi's bid to allow betting on control of Congress. Now the company is suing to overturn the decision. Full Article
el Trump plans to raise money in California in the aftermath of felony conviction By www.latimes.com Published On :: Fri, 31 May 2024 16:51:37 GMT Former President Trump is scheduled to headline fundraisers in San Francisco, Beverly Hills and Newport Beach next week after his felony convictions. Full Article
el Elon Musk blasts Apple's OpenAI deal over alleged privacy issues. Does he have a point? By www.latimes.com Published On :: Wed, 12 Jun 2024 20:37:19 GMT The Tesla and SpaceX leader's beef with OpenAI flared up again after Apple unveiled its plans to use ChatGPT to support some of its AI features. Apple said privacy is a key component of its entry into the space. Full Article
el Foundation honoring 'Star Trek' creator offers million-dollar prize to develop AI that's 'used for good' By www.latimes.com Published On :: Thu, 20 Jun 2024 12:00:35 GMT The Gene Roddenberry foundation will award $1 million to an early-stage venture focused on harnessing artificial intelligence in service of humanity. Full Article
el California lawmakers advance tax on Big Tech to help fund news industry By www.latimes.com Published On :: Fri, 28 Jun 2024 00:43:46 GMT The bill would tax Amazon, Meta and Google for the data they take from users and pump the money into news organizations in the form of tax credits. Full Article