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Israeli researchers develop software to allow processing in memory, bypassing CPU




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UDAN scheme helps improve passenger footfall at Mysore Airport: Airport Director




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Lithuania's Social Democratic Party signs coalition agreement




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South Korea's Covid handling a lesson for future pandemic response: Unitaid chief




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South Korean independence fighter's remains to return home after 105 years




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Banks in South Korea to adjust operating hours on college entrance exam day




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No longer one-sided beneficiary of alliance with US: South Korean National Security Advisor




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North Korea jams GPS signals for 5th straight day: South Korea




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South Korea: 7 out of 10 people say couples can live together without marriage




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Kerala to soon get brand new Vande Bharat racks




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Life insurance announced for Sabarimala devotees in new pilgrimage season




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Devotee wants SOP for preparation of appam and aravana prasadam at Sabarimala




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I’m So Old: Web Edition

Time can be a funny thing. I still remember discovering HTML, CSS, and JavaScript coding. I still remember my first college programming course. I still remember my first day at my first coding job, then my first day at my second coding job, and then my first day at Mozilla. I still remember my first […]

The post I’m So Old: Web Edition appeared first on David Walsh Blog.




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Get Started in AI and NFTs with the Limewire API (Sponsored)

AI media creation has expanded to incredible video art and a host of other important improvements, and LimeWire is leading the way in creating an awesome interface for the average user to become an AI artist. Limewire has just released its Developer API, a method for engineers like us to create dynamic AI art on […]

The post Get Started in AI and NFTs with the Limewire API (Sponsored) appeared first on David Walsh Blog.




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Soccer PICS: Juventus drop points; Musiala tricks

All the action from football matches played in Europe on Wednesday




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Israel rescues soccer fans attacked in Amsterdam

An eyewitness captured a video verified by Reuters showing a group of men running near Amsterdam central station, chasing and assaulting other men, as police sirens sounded.




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Can microbial communities regenerate? [electronic resource] : uniting ecology and evolutionary biology / S. Andrew Inkpen and W. Ford Doolittle.

Chicago, IL : The University of Chicago Press , 2022.




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In the herbarium [electronic resource] : the hidden world of collecting and preserving plants / Maura C. Flannery.

New Haven : Yale University Press , 2023.




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Journal of the Arnold Arboretum [electronic resource]. Supplementary series / Harvard University

[Cambridge, Massachusetts] : Harvard University, 1991




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Digital transformation solutions player UST named Workday services deployment partner 

UST will leverage its cross-platform SaaS expertise, Generative AI thought leadership, industry solutions, and automation tools to enable customers get the most from their Workday experience




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Sonata Software secures multi-year deal from Fortune 500 manufacturing company

The client is partnering with Sonata Software to modernise its operations and deliver a homogenous, unified user experience at scale




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Delta sues CrowdStrike over ‘catastrophic’ software glitch

Delta says the faulty update cost the airline at least $500 million in out-of-pocket losses — in addition to “severe harm to its reputation and goodwill,” according to the complaint, filed Friday in state court in Georgia




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CMS Info Systems reports 8% increase in consolidated net profit at ₹91 crore

The company said slower consumption, elections and intense rains in the first half (H1) of FY25, which impacted realisations




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Ericsson expects network densification to drive next phase of growth in India

Ericsson estimates that the data traffic in India will grow from 29 GB per smartphone user per month to 68 GB per smartphone user per month by 2029




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Bharti Airtel Q2 preview: Consolidated net profit expected to grow multifold

According to analysts, industry-leading ARPU and support from other businesses bode well for Airtel’s revenue growth during the quarter




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IT/ITEeS demand for hybrid work model continuation in SEZs beyond Dec 31 being considered: Govt sources

Some units want long-term flexibility but government only open to only periodic extension




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Tessolve to acquire German chip design company for up to ₹400 crore

It will expand Tessolve’s European operations by adding four delivery locations across Germany and the Netherlands, including a specialized ADAS and imaging centre-of-excellence lab




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RRP Semiconductor secures ₹440 crore order from Telecrown Infratech for solar project

The order includes Silicon Solar Cells, melted Silicon Crystals, and Polycrystalline materials, aimed at supporting the setup of 106 MW solar power PV modules in various locations across Maharashtra




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DENSO, T-Hub tie up to promote automotive start-ups

DENSO would support T-Hub in conducting hackathons and innovation challenges targeting automotive technologies




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India among fastest-growing markets for Microsoft Copilot

Microsoft’s refreshed Copilot, launched last month, gives users the ability to talk with Copilots real-time, moving human-computer interaction to a completely new paradigm




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With Trump win, DoT gears up to sort out issues related to Elon Musk’s Starlink

The department of telecommunications is looking into security aspects while considering the demands made by two American companies — Starlink and Amazon (project Kuiper), say sources




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Sonata Software optimistic about revenue growth in H2FY25; eyes $1.5 billion revenue by FY27

The company’s international services revenue in the September-ended quarter stood at ₹707.9 crore




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Zuckerberg not personally liable in lawsuits over social media harm to children

A US District Judge rejected accusations that Zuckerberg directed Meta's efforts to conceal from children the serious mental health risks of using Facebook and Instagram




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Exploring the self-assembly dynamics of novel steroid–coumarin conjugates: a comprehensive spectroscopic and solid-state investigation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00192C, Paper
Open Access
Claudia M. Ramírez-Lozano, Ma. Eugenia Ochoa, Pablo Labra-Vázquez, Arturo Jiménez-Sánchez, Norberto Farfán, Rosa Santillan
The design, synthesis, and characterization of seven novel steroid–coumarin conjugates with diverse steroidal nuclei as lipophilic fluorescent materials for bioimaging applications are presented.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Synthesis of 3,5-disubstituted isoxazoles by domino reductive Nef reaction/cyclization of β-nitroenones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00232F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Muhammad Ehtisham Ibraheem Khan, Tomas Lighuen Cassini, Marino Petrini, Alessandro Palmieri
β-Nitroenones were converted into 3,5-disubstituted isoxazoles via a domino reaction promoted by tin(II) dichloride. The protocol efficiently works under both microwave and flow conditions.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00190G, Paper
Kai-Cheng Yang, Shi-Lu Zheng, Zhong Wen, Yu-Shan Zhang, Hai-Liang Ni, Long Chen
A HOTf or Fe(OTf)3-catalyzed dehydrative alkynylation of 3-hydroxyisoindolinones with terminal alkynes was developed, which represents a brand-new procedure for the synthesis of 3-alkynylated 3,3-disubstituted isoindolinones.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Diastereoselective synthesis of functionalized spiroindolines via intramolecular ipso-iodocyclization/nucleophile addition cascade reactions of indole-tethered ynones

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00112E, Paper
Debojyoti Bag, Sanghapal D. Sawant
Herein, we describe a highly diastereoselective approach for synthesizing polyfunctionalized spiroindolines from indolyl-ynones involving an ipso-iodocyclization/nucleophile addition cascade.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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Kinetic resolution of 1,1'-binaphthyl-2,2'-diamine derivatives by chiral calcium phosphate-catalyzed acylation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00355A, Paper
Tatsuhiro Uchikura, Yuki Kanno, Yukino Fukuda, Mikoto Sato, Takahiko Akiyama
Chiral calcium phosphate-catalyzed kinetic resolution of BINAM derivatives.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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An efficient synthesis of mono-, di-, and tri-substituted 1,3-thiazoles employing functionalized thioamides as thiocarbonyl precursors

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00229F, Paper
Kalleshappa Sheela, Chikkappaiahnayaka Santhosh, Krishna Ravi Singh, Kalleshappa Sharath, Maralinganadoddi P. Sadashiva
Herein, we report an efficient strategy to synthesize functionalized 1,3-thiazoles using alkyl 2-amino-2-thioxoacetates.
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The content of this RSS Feed (c) The Royal Society of Chemistry




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A copper-catalyzed asymmetric Friedel–Crafts hydroxyalkylation of pyrazole-4,5-diones with 5-aminoisoxazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00322E, Communication
Siyu Gao, Xiang Sun, Sijie Peng, Zhenggen Zha, Qi Sun, Zhiyong Wang
An asymmetric Friede-Crafts hydroxyalkylation reaction was developed under the catalysis of chiral copper complexes. A variety of pyrazolone derivatives were obtained with excellent yields and enantioselectivities.
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DMSO promoted catalyst-free oxidative C–N/C–O couplings towards synthesis of imidazoles and oxazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00383G, Paper
Debasish Bera, Rajib Sarkar, Tiyasa Dhar, Pinaki Saha, Prasanta Ghosh, Chhanda Mukhopadhyay
Dimethyl sulfoxide (DMSO)-promoted catalyst-free oxidative C–N coupling and C–O coupling under oxidant-free conditions are outlined.
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Structural flexibility of favipiravir and its structural analogues in solutions: experimental and computational insight

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00404C, Paper
Tatiana P. Gerasimova, Almaz A. Zagidullin, Anastasiia N. Nikolaeva, Robert R. Fayzullin, Aliya M. Saitova, Vasili A. Miluykov, Stefan Grimme, Sergey A. Katsyuba
Keto-enol transformations of 6-R-3-hydroxy-2-pyrazinecarboxamides in solutions are accompanied by deprotonation of enol tautomers and the formation of corresponding anionic species. The key factors determining these processes have been identified.
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Catalyst- and base-free visible light-enabled radical relay trihalomethylation/functional group-migration/carbonylation with CX3SO2Cl

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00292J, Paper
Jinkai Hu, Chenglei Yang, Xiaotao Qin, Hui Liu, Tongtong Ma, Ao-tong Shi, Qing-Long Lv, Xingman Liu, Jinhui Yang, Dianjun Li
A visible light-enabled photocatalyst-free radical trihalomethylation/cyano (or benzo[d]thiazol-2-yl) 1,4-migration/carbonylation reaction of 2-hydroxy-2-hex-5-enenitrile (or (benzo[d]thiazol-2-yl)-pent-4-enol) with CX3SO2Cl (X = F, Cl) is reported.
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Hydrosilylation of nitriles and tertiary amides using a zinc precursor

Org. Biomol. Chem., 2024, 22,3053-3058
DOI: 10.1039/D4OB00161C, Paper
Ravi Kumar, Rohan Kumar Meher, Himadri Karmakar, Tarun K. Panda
A competent and selective hydrosilylation of nitriles and tertiary amides catalyzed by zinc bis(hexamethyldisilazide) [Zn(HMDS)2] under solvent-free and mild conditions are reported, as a sustainable and desirable alternative to existing methods.
The content of this RSS Feed (c) The Royal Society of Chemistry




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3-Halo-5,6-dihydro-4H-1,2-oxazine N-oxides as synthetic equivalents of unsaturated nitrile oxides in the [3 + 2]-cycloaddition with arynes: synthesis of substituted 3-vinyl-1,2-benzisoxazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00391H, Communication
Alexander A. Lukoyanov, Svetlana A. Aksenova, Andrey A. Tabolin, Alexey Yu. Sukhorukov
3-Halo-1,2-oxazine N-oxide derivatives act as surrogates of vinyl nitrile oxides in tandem [3 + 2]-cycloaddition/[3 + 2]-cyclofragmentation with arynes leading to benzisoxazoles.
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Cu(OTf)2/HFIP catalyzed regioselective cycloisomerization of indole-C3-functionalized alkynols to carbazoles

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00421C, Communication
Srinivasarao Yaragorla, Tabassum Khan, Sayonika Chakroborty
We report here a simple and atom economic cycloisomerization reaction of indole-tethered alkynols for constructing diverse carbazoles via 1,2-alkly migration using Cu(OTf)2/HFIP as the excellent promoter system.
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Electro-oxidative three-component cascade coupling of isocyanides with elemental sulfur and amines for the synthesis of 2-aminobenzothiazoles

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00432A, Paper
Peng-Fei Huang, Jia-Le Fu, Ying Peng, Jian-Hong Fan, Long-Jin Zhong, Kewen Tang, Yu Liu
2-Aminobenzothiazoles are commonly encountered in various functional compounds. Herein, we disclose an electro-oxidative three-component reaction for the effective synthesis of 2-aminobenzothiazoles under mild conditions, utilizing non-toxic and abundant elemental sulfur...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Revisiting Biginelli-like Reactions: Solvent Effects, Mechanisms, Biological Applications and Correction of Several Literature Reports

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00272E, Paper
Brenno A. D. Neto, Pedro Beck, Arthur Leitão, Yasmin Santana, Jose R. Correa, Carime Vitória da Silva Rodrigues, Daniel Machado, Guilherme Matos, Luciana Machado Ramos, Claudia Cristina Gatto, Carlos Kleber Z. Andrade, Sarah Caldas
This study critically reevaluates reported Biginelli-like reactions using a Kamlet-Abboud-Taft-based solvent effect model. Surprisingly, structural misassignments were discovered in certain multicomponent reactions, leading to the identification of pseudo three-component derivatives...
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Isothiocyanates: Happy-Go-Lucky Reagents in Organic Synthesis

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00281D, Review Article
Bubul Das, Anjali Dahiya, Bhisma K Patel
: Owing to their unique structural features, isothiocyanates (ITCs) are a class of highly useful and inimitable reagents as the N=C=S group serves both as electrophile and nucleophile in organic...
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Synthesis of Deuteriodifluoromethylthiolated Isocoumarins-1- imines and Isocoumarins Enabled by Multi-Component Reagents System (MCRS)

Org. Biomol. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4OB00328D, Communication
Xuemin Li, Haofeng Shi, Jiaxin He, Jialiang Wu, Fengxia Sun, Yunfei Du
The combining use of BnSCF2D, mCPBA and Tf2O serves as an efficient multi-component reagents system (MCRS) for the synthesis of deuteriodifluoromethylthiolated isocoumarins-1-imines/isocoumarins via intramolecular cyclization/ deuteriodifluoromethylthiolation of 2-alkynylbenzamide/2-alkynylbenzoates. The approach...
The content of this RSS Feed (c) The Royal Society of Chemistry