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Preservation News: New Video -- Early Printing in Afghanistan

Elham Bakhtary, the 2016-2017 CLIR/Mellon Fellow at the Library of Congress Preservation Research and Testing Division, examines the first printing presses raised in Afghanistan during the reign of Amir Sher Ali Khan (1863-1866 and 1868-1878).

Click here for more information and to watch the video.




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Preservation News: 4/10 Lecture: Science Meets Music

Lecture Event

Science Meets Music: Technical Studies of Musical Instruments

Tuesday April 10, 3:00-5:00 pm

Whittall Pavilion (Jefferson Building, Ground Floor)

Library of Congress Jefferson Building

10 First St. SE

Washington, DC 20540

An afternoon of lectures featuring recent in-depth collaborative musical studies by curators, conservators, musicians, and cultural heritage scientists.

Click here for more information and to register for the webcast.




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Preservation News: Come tour Preservation!

On Monday, April 23, come on a behind-the-scenes tour of Preservation at the Library of Congress.

Tours start at 9:30 am and at 3:00 pm at the Information Desk at the front of the Library's James Madison Memorial Building (101 Independence Ave SE).

Limited space, registration required.

Click here to register and for more information about the rest of the day's program to celebrate Preservation Week.




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Preservation News: 4/23 Preservation Week Lecture and Collection Viewing

We're celebrating Preservation Week with a lecture and open collection display with conservators and archivists that showcase the value of preserving the first-person accounts of those we send to fight in wars.

Monday, April 23 from noon-2:00 pm in the Whittall Room (Jefferson Building, Ground floor)

Click here to register for the live webcast of the lecture and for more information about the Library's Preservation Week programming.




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Preservation News: New Video: Centuries of Cellulose

Watch Library of Congress preservation scientist Andrew Davis discuss Centuries of Cellulose: Lessons Learned from the Molecular Analysis of Cellulose in Aged Paper Collections.

Click here to watch the video and for more information.




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Preservation News: Today's Twitter Takeover

Starting at 3:00 pm EDT, you can interact with our preservation experts to discuss the challenges of space and storage, digitizing collections, born-digital collections, brittle collections, and more during the Twitter Conference organized in conjunction with the Society of American Archivists for Preservation Week. #PresTC

Click here to find the Library on Twitter.




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Preservation News: New Video: Mold Case Study

Watch veteran preservation expert Randy Silverman (Head of Preservation, University of Utah, Marriott Library) discuss A Mold Outbreak in Tbilisi, Georgia: Technical and Interpersonal Challenges

Click here to watch the video and for more information.




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Preservation News: 5/16 Lecture on Cartography and Code

Join us for the next Topics in Preservation Series lecture:

Cartography and Code: Incorporating Automation in the Comparison of Medieval Toponyms Across Maps

Wednesday, May 16, 2018
1:30 pm EDT

Library of Congress James Madison Memorial Building
Pickford Theater (third floor)

Register for the live webcast by Tuesday, May 15 at 5:00 pm. 

Click here for more information and to register for the live webcast.




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Preservation News: Preservation Week 2019 @ The Library of Congress

April 22-26, 2019, the Library of Congress celebrates Preservation Week with programming throughout the week, including behind-the-scenes tours of Preservation at the Library, a Preservation takeover of the Library’s main Twitter account, and tips presented by Library conservators in the Baseball Americana exhibit.

Click here to register for the tours and for more information about the programs to celebrate Preservation Week.




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Preservation News: Are you coming to ALA DC? Take a Tour of Library of Congress’ Preservation Services!

On Friday, June 21st, the Library’s preservation staff will be hosting two (2) behind the scenes tours of preservation labs and services in the James Madison Building. The tour is free, but registration is required and space is limited.

  • For the morning tour - Friday, June 21 at 10:00-11:30 am – register here.
  • For the afternoon tour - Friday, June 21 at 1:30-3:00 pm – register here.

Click here for more information about preservation programming throughout the week of ALA, including behind-the-scenes tours of Preservation at the Library, an information pavilion at the Exhibition Hall, and an open house in the Jefferson Building.




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Preservation News: Topics in Preservation Series (TOPS) Webinars for Preservation Week 2020, Starting April 27

The Library of Congress Preservation Directorate is excited to present a Topics in Preservation Series (TOPS) for Preservation Week 2020! From April 27-May 1, we are hosting webinars every day at 11am (EST). The five, hour-long webinars will feature preservation related projects conducted at the Library of Congress. Register now for any, or all, of the following webinars at http://LOCPreservation.eventbrite.com or at the links below. For more information and resources related to preservation at the Library of Congress, visit https://www.loc.gov/preservation/

Keeping it Cool – Designing the Library’s New Gutenberg Bible Display Case

Monday, April 27th, 11am – 12pm Register here

The Library of Congress’ Gutenberg Bible is on permanent display in the Thomas Jefferson Building. Even though its three volumes are displayed on a rotating basis, the concerns about the adverse effects of long-term display required the Library’s’ conservation staff to create a purpose designed display case that would mitigate these adverse effects. The speakers will talk about the design process, present various features of the new case, and share with the audience some lessons learned now that the case is fully functioning for a little over a year.

Presented by Elmer Eusman, Chief, Conservation Division and Nancy Lev-Alexander, Head, Collection Stabilization Section

Acquiring and Developing an Offsite High Density Collections Storage Facility

Tuesday, April 28th, 11am – 12pm Register here

In addition to operating state-of-the art preservation quality storage facilities at Ft. Meade, the Library operates a rental property which meets its needs for interim storage.  This webinar discusses the Library’s experience in acquiring and developing this facility.  Cabin Branch (located in Landover, MD) shows a way to control costs without compromising on collections care.  The webinar will explain how the Library of Congress designed an interim storage warehouse with collections safety foremost in mind, while keeping cost under control by working with the developer to focus on the features most critical to safeguarding our collections.

Presented by Steve Herman, Chief, Collections Management Division; Rohn Roache, Assistant Chief, Collections Management Division; Nancy Lev-Alexander, Head, Collection Stabilization Section

Assessing the Condition of the United States National Collection

Wednesday, April 29th, 11am – 12pm Register here

A national research initiative funded by the Mellon Foundation “Assessing the Physical Condition of the National Collection” is undertaking the task to objectively assess the condition of books held in collecting institutions of the United States by performing an in-depth scientific analysis on a representative sample.

The research focuses on analyzing the same 500 volumes from five different research libraries in five different climatic zones through the time period 1840-1940. Research to date has shown some extremely interesting trends. This presentation will focus on the analytical techniques used in the program and show what this means to the preservation of print collections throughout the United States.

Presented by Fenella France, Chief, Preservation Research and Testing Division

Environment, Housing & Building Materials Testing to Protect our Collections

Thursday, April 30th, 11am – 12pm Register here

Challenges to preserving the national collection come from both inherent risks in the collections themselves and from materials in the immediate environment. The Library’s quality assurance program is focused on analyzing all materials that come into contact with collections or are part of the surrounding environment. The quality assurance (QA) program involves testing of materials used for housing, storage, and in conservation treatments, as well as evaluation, definition, and dissemination of standards for the use of these materials.

 This presentation will give specific examples of QA testing, new developments in quantification and identification of volatile organic compounds, fast and accurate test methodologies, examples of collection inherent material challenges, and assessment of off-gassing from potential building and housing materials to determine safety for special collections.

Presented by Dr. Eric Monroe, Supervisory Physical Scientist

Would You Like to Save Your Game?

Friday, May 1st, 11am – 12pm Register here

Libraries, archives and museums are facing an ever increasing amount of interactive media in their collections, including software applications, time based artworks and video games. These materials provide unique challenges in regards to acquisition, description and preservation, and many institutions are working to develop new approaches to ensuring the long term preservation of and access to born digital cultural artifacts. The Library’s National Audio-Visual Conservation Center (NAVCC) holds over 5,000 videogames amassed through copyright deposit and private donation. This collection contains not only a wide array of formats from 5.25” floppy disks to modern console cartridges, but also packaging, documentation, and adjacent materials such as magazines. The Preservation Reformatting Division and NAVCC work together to describe, reformat, and preserve these complex digital objects and preserve this important part of culture. This webinar will highlight different aspects of the preservation workflow.

Presented by Amanda May, Digital Conservation Specialist; David Gibson, Processing Technician; Laura Davis, Project Specialist

Click here for more information about the webinars.




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[ASAP] Cell Type-Dependent Specificity and Anti-Inflammatory Effects of Charge-Reversible MSNs-COS-CMC for Targeted Drug Delivery in Cervical Carcinoma

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00004




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[ASAP] Microparticles-in-Thermoresponsive/Bioadhesive Hydrogels as a Novel Integrated Platform for Effective Intra-articular Delivery of Triamcinolone Acetonide

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00126




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[ASAP] What We Need to Know about Solid-State Isothermal Crystallization of Organic Molecules from the Amorphous State below the Glass Transition Temperature

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00181




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[ASAP] NMR and Thermal Studies for the Characterization of Mass Transport and Phase Separation in Paracetamol/Copovidone Hot-Melt Extrusion Formulations

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00188




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[ASAP] Melt Crystallization of Indomethacin Polymorphs in the Presence of Poly(ethylene oxide): Selective Enrichment of the Polymer at the Crystal–Liquid Interface

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00220




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[ASAP] Targeted Delivery of Anti-inflammatory and Imaging Agents to Microglial Cells with Polymeric Nanoparticles

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.9b00489




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[ASAP] Intelligent Escape System for the Oral Delivery of Liraglutide: A Perfect Match for Gastrointestinal Barriers

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.9b01307




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[ASAP] Lyoprotectant Optimization for the Freeze-Drying of Receptor-Targeted Trojan Horse Liposomes for Plasmid DNA Delivery

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00310




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[ASAP] Comparison of Absolute Protein Abundances of Transporters and Receptors among Blood–Brain Barriers at Different Cerebral Regions and the Blood–Spinal Cord Barrier in Humans and Rats

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00178




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[ASAP] Nerve Growth Factor Gene Delivery across the Blood–Brain Barrier to Reduce Beta Amyloid Accumulation in AD Mice

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00218




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[ASAP] Enhancing Safety and Efficacy by Altering the Toxic Aggregated State of Amphotericin B in Lipidic Nanoformulations

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00313




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[ASAP] Preclinical Evaluation of a High-Affinity Sarcophagine-Containing PSMA Ligand for <sup>64</sup>Cu/<sup>67</sup>Cu-Based Theranostics in Prostate Cancer

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00060




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[ASAP] Dissipative Particle Dynamics Aided Design of Drug Delivery Systems: A Review

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00175




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[ASAP] Correction to “Biomimetic Solid Lipid Nanoparticles for Oral Bioavailability Enhancement of Low Molecular Weight Heparin and Its Lipid Conjugates: <italic toggle="yes">In Vitro</italic> and <italic toggle="yes">

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00426




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[ASAP] Preparation, Characterization, and Formulation Optimization of Ionic-Liquid-in-Water Nanoemulsions toward Systemic Delivery of Amphotericin B

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.9b00809




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[ASAP] <italic toggle="yes">In Vitro</italic> Blood–Brain Barrier Permeability and Cytotoxicity of an Atorvastatin-Loaded Nanoformulation Against Glioblastoma in 2D and 3D Models

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.9b01117




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[ASAP] Combined Application of Albumin-Binding [<sup>177</sup>Lu]Lu-PSMA-ALB-56 and Fast-Cleared PSMA Inhibitors: Optimization of the Pharmacokinetics

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00199




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[ASAP] Correction to “The Roles of Fatty-Acid Modification in the Activity of the Anticancer Peptide R-Lycosin-I”

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00258




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[ASAP] OATP1A2 and OATP2B1 Are Interacting with Dopamine-Receptor Agonists and Antagonists

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00159




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[ASAP] Surfactin Ameliorated the Internalization and Inhibitory Performances of Bleomycin Family Compounds in Tumor Cells

Molecular Pharmaceutics
DOI: 10.1021/acs.molpharmaceut.0c00281




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[ASAP] Toxoplasmosis and Psychiatric and Neurological Disorders: A Step toward Understanding Parasite Pathogenesis

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.9b00245




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[ASAP] DARK Classics in Chemical Neuroscience: Gamma-Hydroxybutyrate (GHB)

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.9b00336




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[ASAP] Oleic Acid Coated Silver Nanoparticles Showed Better <italic toggle="yes">in Vitro</italic> Amoebicidal Effects against <italic toggle="yes">Naegleria fowleri</italic> than Amphotericin B

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.9b00289




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[ASAP] Protective Effects of a Neurohypophyseal Hormone Analogue on Prion Aggregation, Cellular Internalization, and Toxicity

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.9b00299




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[ASAP] Nanotechnology-Based Diagnostics and Therapy for Pathogen-Related Infections in the CNS

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.9b00470




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[ASAP] Targeting CNS Related Protist Pathogens: Calcium Ion Dependency in the Brain-Eating Amoebae

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.9b00635




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[ASAP] DARK Classics in Chemical Neuroscience: Kratom

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.9b00535




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[ASAP] Aryl Quinazolinone Derivatives as Novel Therapeutic Agents against Brain-Eating Amoebae

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.9b00596




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[ASAP] Are Pathogens Completely Harmful or Useless?

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.0c00035




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[ASAP] Discovery and Optimization of Triazine Nitrile Inhibitors of <italic toggle="yes">Toxoplasma gondii</italic> Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.9b00674




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[ASAP] Repurposing of Drugs Is a Viable Approach to Develop Therapeutic Strategies against Central Nervous System Related Pathogenic Amoebae

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.9b00613




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[ASAP] Mesenchymal Stem Cells Could Be Considered as a Candidate for Further Studies in Cell-Based Therapy of Alzheimer’s Disease via Targeting the Signaling Pathways

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.0c00052




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[ASAP] Manipulating Adult Neural Stem and Progenitor Cells with G-Quadruplex Ligands

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.0c00194




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[ASAP] Is the Collapse of the Respiratory Center in the Brain Responsible for Respiratory Breakdown in COVID-19 Patients?

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.0c00217




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[ASAP] Positive Allosteric Modulation of the 5-HT<sub>1A</sub> Receptor by Indole-Based Synthetic Cannabinoids Abused by Humans

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.0c00034




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[ASAP] Discovery and SAR Studies of Orally Active Somatostatin Receptor Subtype-2 (SSTR2) Agonists for the Treatment of Acromegaly

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.0c00124




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[ASAP] A Master Regulator of a-Synuclein Aggregation

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.0c00216




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[ASAP] Astragalin Exerted Antidepressant-like Action through SIRT1 Signaling Modulated NLRP3 Inflammasome Deactivation

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.0c00156




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[ASAP] Dissecting the Structural Organization of Multiprotein Amyloid Aggregates Using a Bottom-Up Approach

ACS Chemical Neuroscience
DOI: 10.1021/acschemneuro.0c00110