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A colorimetric tandem combination of CRISPR/Cas12a with dual functional hybridization chain reaction for ultra-sensitive detection of mycobacterium bovis

By pubs.rsc.org
Published On ::

Anal. Methods, 2024, Accepted Manuscript
DOI: 10.1039/D3AY02200E, Paper
Qiong Liu, Mei Yang, He Zhang, Wenjie Ma, Xin Fu, Huiqing Li, Sainan Gao
Tuberculosis caused by Mycobacterium bovis poses a global infectious threat to humans and animals. Therefore, there is an urgent need to develop a sensitive, precise, and easy-to-readout strategy. Here, a...
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Are These the Most Interesting Front-end Developer Tools for 2021?

By www.impressivewebs.com
Published On :: Tue, 05 Jan 2021 09:47:31 +0000

When I come to the end of any given year, it’s always interesting to look back through the click-through stats for my weekly newsletter Web Tools Weekly to see which tools got the most attention.

This year wasn’t all that different from previous years. I’ve learned that clicks happen for basically one of two reasons:

The post Are These the Most Interesting Front-end Developer Tools for 2021? appeared first on Impressive Webs.


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  • Roundups and Resources
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A better Twitter app for Android, at last

By www.thehindubusinessline.com
Published On :: Fri, 05 Apr 2013 14:05:30 +0530


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BSNL customer service changing for the better

By www.thehindubusinessline.com
Published On :: Thu, 09 Jan 2014 15:55:31 +0530


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 Milestones and U-turns: On the government in its third term

By www.thehindu.com
Published On :: Fri, 20 Sep 2024 00:20:00 +0530

The optics of the 100-day mark cannot conceal changed dynamics for the BJP


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Staunch the breach: On India, Pakistan and the Indus Waters Treaty

By www.thehindu.com
Published On :: Sat, 21 Sep 2024 00:20:00 +0530

India and Pakistan need to drop their hard line stances on the Indus Waters Treaty


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Politicising the laddu: On the Tirupati laddu and its ‘adulteration’

By www.thehindu.com
Published On :: Tue, 24 Sep 2024 00:30:00 +0530

The Tirupati laddu issue should be limited to one of quality control


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​Embattled CM: On Karnataka Chief Minister Siddaramaiah

By www.thehindu.com
Published On :: Fri, 27 Sep 2024 00:20:00 +0530

Anti-graft moves should not be overshadowed by political motive


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​Delay and bail: On former Tamil Nadu Minister V. Senthilbalaji’s case

By www.thehindu.com
Published On :: Sat, 28 Sep 2024 00:20:00 +0530

Senthilbalaji’s release on bail was overdue, but he should not be made a Minister


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A learning curve: On the PM Internship Scheme

By www.thehindu.com
Published On :: Mon, 07 Oct 2024 00:15:00 +0530

The outcomes of the PM Internship Scheme’s pilot project need monitoring


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Sweet and sour: On the laddu ‘adulteration’ case  

By www.thehindu.com
Published On :: Thu, 10 Oct 2024 00:10:00 +0530

The inquiry into laddu adulteration must not be communalised


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A Korean win: On the 2024 Nobel Prize in Literature

By www.thehindu.com
Published On :: Tue, 15 Oct 2024 00:20:00 +0530

A Nobel raises Korean prose to success levels of its drama and music 


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​West versus the rest: On western conduct and India

By www.thehindu.com
Published On :: Wed, 23 Oct 2024 00:10:00 +0530

The West must not tolerate terror threats in the name of free speech 


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Western front: On the parties and their prospects in the Maharashtra polls

By www.thehindu.com
Published On :: Tue, 29 Oct 2024 00:30:00 +0530

Granular factors can determine the outcome in Maharashtra 


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Alia-Ranbir's Daughter Raha Turns 2

By www.rediff.com
Published On ::

Alia Bhatt and Ranbir Kapoor's little girl Raha turned two on November 6, and we were treated to the most adorable pictures on social media.


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A comprehensive apoptotic assessment of niloticin in cervical cancer cells: a tirucallane-type triterpenoid from Aphanamixis polystachya (Wall.) Parker

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3444-3459
DOI: 10.1039/D4MD00318G, Research Article
Anuja Gracy Joseph, Mohanan Biji, Vishnu Priya Murali, Daisy R. Sherin, Alisha Valsan, Vimalkumar P. Sukumaran, Kokkuvayil Vasu Radhakrishnan, Kaustabh Kumar Maiti
Niloticin, a triterpenoid from Aphanamixis polystachya, induces apoptosis in HeLa cells which is primarily validated through in silico analysis and subsequently in vitro apoptotic evaluation by modulating the apoptotic proteins.
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Rational design and in vitro testing of new urease inhibitors to prevent urinary catheter blockage

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, 15,3597-3608
DOI: 10.1039/D4MD00378K, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Rachel A. Heylen, Nicola Cusick, Tom White, Emily J. Owen, Bethany L. Patenall, Martin Alm, Peter Thomsen, Maisem Laabei, A. Toby A. Jenkins
In silico identification of urease inhibitors based on thiourea, tested to determine IC50 and tested on a catheterised in vitro bladder model, showing efficacy in reducing catheter blockage.
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Inhibition of monoamine oxidases by heterocyclic derived conjugated dienones: synthesis and in vitro and in silico investigations

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00608A, Research Article
Sunil Kumar, Bishnu Prasad Pandey, Mohamed A. Abdelgawad, Mohammed M. Ghoneim, Rania B. Bakr, Hoon Kim, Bijo Mathew
A total of 18 heterocyclic derived conjugated dienones (CD1–CD18) were evaluated for their potential monoamine oxidase (MAO)-A/-B inhibitory activity.
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Synthesis and biological evaluation of novel D-ring fused steroidal N(2)-substituted-1,2,3-triazoles

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00297K, Research Article
Branislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač, Andrea Nikolić
In this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.
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Design and Synthesis of coumarin-based amphoteric antimicrobials with the biofilm interference and immunoregulation effects

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00721B, Research Article
Qun Tang, Haiyang Zhang, Kasemsiri Chandarajoti, Zirui Jiao, Lianhua Nie, Sai Lv, Jiakun Zuo, Wen Zhou, Xiangan Han
Bacterial infections pose a threat to the health of animals and human being, and the biofilm formation exacerbates the microbial threat. New antimicrobial agents to address this challenge are much...
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Modulating polybasic character of galactose-based glycosylated antitumor ether lipids for enhanced cytotoxic response

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00662C, Research Article
Rajat Arora, Ayan Mukherjee, Gilbert Arthur, Mark W. Nachtigal, Frank Schweizer
We describe the multi-step synthesis of different dibasic and tribasic galactosamine-based glycosylated antitumor ether lipids (GAELs) and their cytotoxic response in comparison to doxorubicin and cisplatin.
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Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00645C, Research Article
Geetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra Borah
Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.
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Human microbiome derived synthetic antimicrobial peptides with activity against Gram-negative, Gram-positive, and antibiotic resistant bacteria

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00383G, Research Article
Open Access
Walaa K. Mousa, Ashif Y. Shaikh, Rose Ghemrawi, Mohammed Aldulaimi, Aya Al Ali, Nour Sammani, Mostafa Khair, Mohamed I. Helal, Farah Al-Marzooq, Emilia Oueis
An AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect and a membrane-targeting mode of action.
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Azo derivatives of monoterpenes as anti-Helicobacter pylori agents: from synthesis to structure-based target investigation

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00511B, Research Article
Open Access
Francesco Melfi, Marialuigia Fantacuzzi, Simone Carradori, Ilaria D'Agostino, Alessandra Ammazzalorso, Noemi Mencarelli, Marialucia Gallorini, Mattia Spano, Paolo Guglielmi, Mariangela Agamennone, Sazan Haji Ali, Ali Al-Samydai, Francesca Sisto
Monoterpene-derived azo benzenes showed selective antibacterial activity against Helicobacter pylori with a safe profile. An in silico investigation highlighted the inosine 5'-monophosphate dehydrogenase enzyme as the putative target.
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Recent advances from computer-aided drug design to artificial intelligence drug design

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00522H, Review Article
Keran Wang, Yanwen Huang, Yan Wang, Qidong You, Lei Wang
CADD and AIDD contribute to the drug discovery.
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A decade of pyridine-containing heterocycles in US FDA approved drugs: a medicinal chemistry-based analysis

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00632A, Review Article
Ashish Ranjan Dwivedi, Shivani Jaiswal, Deepak Kukkar, Roshan Kumar, Thakur Gurjeet Singh, Mahendra Pratap Singh, Abhay M. Gaidhane, Sorabh Lakhanpal, K. Nagendra Prasad, Bhupinder Kumar
The present review is a concerted effort to cover drugs bearing pyridine rings approved in the last decade, and it provides thorough discussion and commentary on their pharmacokinetics and pharmacodynamics together with in-depth structural analysis.
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Advances in antibacterial agents for Mycobacterium fortuitum

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00508B, Review Article
Carlos Roberto Tavolari Jortieke, Angélica Rocha Joaquim, Fernando Fumagalli
This review presents the recent findings on antibacterial agents against Mycobacterium fortuitum and reveals the most promising and effective chemical frameworks to inspire the development of new drugs.
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Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00623B, Research Article
Ojaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi Yaddanapudi
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.
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Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00670D, Research Article
Yuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen Zhou
In the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...
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Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Accepted Manuscript
DOI: 10.1039/D4MD00373J, Research Article
YongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian Zhang
The mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....
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Metal-free synthesis of N-fused quinazolino-quinazoline-diones as a MALAT1 RNA triple helix intercalator

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00614C, Research Article
Vijay Babu Pathi, Pranotosh Das, Abhyuday Guin, Manish Debnath, Biswadip Banerji
The development of chemical scaffolds that target highly conserved MALAT1 RNA received attention due to its significance in splicing, nuclear organization, and gene expression in disease progression pathways.
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Enhancing the antimycobacterial efficacy of pyridine-4-carbohydrazide: linkage to additional antimicrobial agents via oxocarboxylic acids

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00663A, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Václav Pflégr, Klára Konečná, Jiřina Stolaříková, Jan Ősterreicher, Ondřej Janďourek, Martin Krátký
Linking pyridine-4-carbohydrazide to other antimicrobial agents via oxocarboxylic acids significantly enhances efficacy against mycobacteria with promising selectivity and safety profiles.
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Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00626G, Research Article
Aleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan Veerappan
Lipidation modulates the Gram-selective antibacterial activity of QPyNATh.
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A practical guide for the assay-dependent characterisation of irreversible inhibitors

By pubs.rsc.org
Published On ::

RSC Med. Chem., 2024, Advance Article
DOI: 10.1039/D4MD00707G, Review Article
Lavleen K. Mader, Jessica E. Borean, Jeffrey W. Keillor
Kinetic evaluations for assay dependent characterization of irreversible inhibitors.
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Water level in Mettur Dam stands at 107.04 feet

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 16:35:38 +0530


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50 new primary health centres to be opened in State soon: Minister

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 19:37:18 +0530


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Heavy weed growth at Kasi Viswanathar Temple tank prevents replenishing of underground water table, say Tiruchi residents

By www.thehindu.com
Published On :: Tue, 05 Nov 2024 21:04:51 +0530


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Water level in Mettur dam stands at 106.89 feet

By www.thehindu.com
Published On :: Wed, 06 Nov 2024 18:06:24 +0530


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Bids invited for setting up International Dugong Conservation Centre at Manora

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 19:03:19 +0530

The proposed centre, to be set up at an estimate of ₹41 crore, is being established to conserve endangered Dugong species and its habitat in the Palk Bay


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Tiruchi Corporation embarks on special drive at night to capture and sterilise street dogs

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 19:10:58 +0530

About 125 stray dogs have been caught and sterilised at Tiruchi animal birth control centres in the last 10 days after the Corporation launched the special drive


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Railways using treated water from its STP for maintaining green spaces

By www.thehindu.com
Published On :: Thu, 07 Nov 2024 20:46:00 +0530

The treated water is stored in an overhead tank and used in gardens at the two railway rest houses meant for officers at Kallukuzhi near Tiruchi Railway Junction


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High-level committee formed to facilitate clearances for companies that signed MoU, says Minister

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 18:56:40 +0530

Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa


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EPS’s dream of AIADMK staging a comeback in 2026 election will not materialise: Law Minister Regupathy

By www.thehindu.com
Published On :: Fri, 08 Nov 2024 20:25:59 +0530


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Man attempts to end life, kills his wife and daughter

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 18:03:18 +0530


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Art and literary contests lined up for District Central Library’s National Library Week

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 18:07:57 +0530


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Water level in Mettur Dam stands at 106.58 feet

By www.thehindu.com
Published On :: Sat, 09 Nov 2024 18:10:37 +0530


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543: Zach Leatherman on Eleventy, Mastodon, Twitter, and is-land

By shoptalkshow.com
Published On :: Tue, 29 Nov 2022 16:30:32 +0000

Zach Leatherman talks with us about what's new with Eleventy, setting up on Mastodon, what's happened with Twitter, and is-land.


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551: PlanetScale with Iheanyi Ekechukwu and Mike Coutermarsh

By shoptalkshow.com
Published On :: Mon, 06 Feb 2023 19:44:27 +0000

Iheanyi Ekechukwu and Mike Coutermarsh talk about PlanetScale, what Vitess is, if PlanetScale is for both side and big projects, what read only regions are, what schema changes are, and how PlanetScale compares to other projects.


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558: Esoteric Weird Content Editable Problems with Kristin Valentine

By shoptalkshow.com
Published On :: Mon, 27 Mar 2023 07:34:54 +0000

Kristin Valentine from Vox joins the show to talk about text editor CMS fun across multiple sites, Vox's Chorus, The Verge redesign, sharing Design Systems, theming articles, and a fun new game called "Can Your Text Editor Do This??"


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589: CSS Functions, Read It Later, Making Money in Business, and More

By shoptalkshow.com
Published On :: Mon, 30 Oct 2023 07:28:10 +0000

A quick bit of union news follow up, CSS function round up, Read It Later inside Feedbin, fun uses for a Stream Deck+, how to turn up the money dial in your own business, and having the audacity to call yourself a publisher.


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