Lab Chip, 2020, 20,1358-1389
DOI: 10.1039/C9LC01112A, Critical Review

Fumihiro Sassa, Gokul Chandra Biswas, Hiroaki Suzuki
Electrochemistry provides possibilities to realize smart microdevices of the next generation with high functionalities.
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Lab Chip, 2020, 20,1426-1440
DOI: 10.1039/C9LC01187K, Paper

M. Shane Woolf, Leah M. Dignan, Hannah M. Lewis, Christopher J. Tomley, Aeren Q. Nauman, James P. Landers
Microvalving is a pivotal component in many microfluidic lab-on-a-chip platforms and micro-total analysis systems (μTAS).
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Lab Chip, 2020, 20,1449-1460
DOI: 10.1039/C9LC01220F, Paper

Ronny Frank, Christoph Prönnecke, Ronny Azendorf, Heinz-Georg Jahnke, Annette G. Beck-Sickinger, Andrea A. Robitzki
We developed a novel 96-well microtiter plate based bioelectrochemical platform with a vertical divided cell three-electrode architecture and a 96-multipotentiostat to perform fully parallelised bioelectrocatalytic screenings on redox enzymes.
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Lab Chip, 2020, 20,1390-1397
DOI: 10.1039/D0LC00021C, Communication

Bo Wang, Ximiao Wen, Yan Cao, Shan Huang, Hoa A. Lam, Tingyi “Leo” Liu, Pei-Shan Chung, Harold G. Monbouquette, Pei-Yu Chiou, Nigel T. Maidment
PDMS thin-film transfer and enzyme microstamping enabled 3-in-1 Si/PDMS hybrid chemtrode for multi-analyte sensing and chemical delivery in vivo.
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Lab Chip, 2020, 20,1513-1520
DOI: 10.1039/C9LC01261C, Paper

Yuan Yuan, Julie Brouchon, J. Mauricio Calvo-Calle, Jing Xia, Li Sun, Xu Zhang, Kiera L. Clayton, Fangfu Ye, David A. Weitz, John A. Heyman
In-droplet cytokine capture assays combined with FACS to accurately identify and isolate activated immune cells.
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Lab Chip, 2020, 20,1461-1471
DOI: 10.1039/C9LC01097A, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Mario Rothbauer, Gregor Höll, Christoph Eilenberger, Sebastian R. A. Kratz, Bilal Farooq, Patrick Schuller, Isabel Olmos Calvo, Ruth A. Byrne, Brigitte Meyer, Birgit Niederreiter, Seta Küpcü, Florian Sevelda, Johannes Holinka, Oliver Hayden, Sandro F. Tedde, Hans P. Kiener, Peter Ertl
We demonstrate that the integration of complex human synovial organ cultures in a lab-on-a-chip provides reproducible and reliable information on how systemic stress factors affect synovial tissue architectures using light scatter biosensing.
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Lab Chip, 2020, 20,1398-1409
DOI: 10.1039/C9LC01103J, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Kartik Totlani, Jan-Willem Hurkmans, Walter M. van Gulik, Michiel T. Kreutzer, Volkert van Steijn
We developed a microfluidic droplet on-demand (DoD) generator that enables the production of droplets with a volume solely governed by the geometry of the generator for a range of operating conditions.
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Lab Chip, 2020, 20,1493-1502
DOI: 10.1039/C9LC01039D, Paper

Zachary Ballard, Sarah Bazargan, Diane Jung, Shyama Sathianathan, Ashley Clemens, Daniel Shir, Saba Al-Hashimi, Aydogan Ozcan
A rapid and cost-effective method for monitoring proteins in tear-fluid is reported, which enables biomarker monitoring using contact lenses toward personalized mobile-health applications.
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Lab Chip, 2020, 20,1472-1492
DOI: 10.1039/C9LC01047E, Paper

Open Access

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Mark Schurdak, Lawrence Vernetti, Luke Bergenthal, Quinn K. Wolter, Tong Ying Shun, Sandra Karcher, D. Lansing Taylor, Albert Gough
The Microphysiology Systems Database (MPS) is a critical tool for the design, management, analysis, and sharing of MPS study data.
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Lab Chip, 2020, 20,1318-1357
DOI: 10.1039/C9LC00775J, Critical Review

Open Access

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Masoud Madadelahi, Luis F. Acosta-Soto, Samira Hosseini, Sergio O. Martinez-Chapa, Marc J. Madou
This paper focuses on theory and computational modelling of lab-on-a-disc devices of relevance for novel applications discovery and optimal designs.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00051E, Paper

Jinxin Zhang, Jessica H. Hartman, Chuyi Chen, Shujie Yang, Qi Li, Zhenhua Tian, Po-Hsun Huang, Lin Wang, Joel N. Meyer, Tony Jun Huang
Acoustofluidic sorting of Caenorhabditis elegans in a high throughput manner.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01226E, Paper

Jia Liu, Guoyun Sun, Shih-Chung Wei, Song Guo, Weikang Nicholas Lin, Chia-Hung Chen
Nanoplasmon-enhanced drop screen is developed to measure single-cell multiple miRNAs with high sensitivity of 0.1 nM, addressing cell nucleocytoplasmic profile in a throughput ∼100 cells per minute.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01028A, Paper

Open Access

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Yan Jiang, Theodore Feldman, Julia A. M. Bakx, Darren Yang, Wesley P. Wong
High-speed hydrodynamic trapping enables combined surface-free force spectroscopy and fluorescence imaging of single DNA molecules at extreme forces.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01209E, Paper

Open Access

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J. A. Crowe, A. El-Tamer, D. Nagel, A. V. Koroleva, J. Madrid-Wolff, O. E. Olarte, S. Sokolovsky, E. Estevez-Priego, A.-A. Ludl, J. Soriano, P. Loza-Alvarez, B. N. Chichkov, E. J. Hill, H. R. Parri, E. U. Rafailov
We identified photopolymers for 2-photon polymerisation with biocompatibility for human iPSC-derived neural network development. Generation of microscale scaffold topologies enabled neurite guidance, demonstrating use in reproducing aligned networks.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01192G, Paper

Roman Mikhaylov, Fangda Wu, Hanlin Wang, Aled Clayton, Chao Sun, Zhihua Xie, Dongfang Liang, Yinhua Dong, Fan Yuan, Despina Moschou, Zhenlin Wu, Ming Hong Shen, Jian Yang, Yongqing Fu, Zhiyong Yang, Christian Burton, Rachel J. Errington, Marie Wiltshire, Xin Yang
We demonstrate a novel SAW device fabrication technique by mechanically clamping interdigital electrodes (IDEs) on the printed circuit board (PCB) to a LiNbO₃ wafer. The novel PCB-SAW device is capable of performing all the functions of standard SAW devices.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00263A, Paper

Jaime L. Korner, Elanna B. Stephenson, Katherine S. Elvira
A new type of pharmacokinetic compartment model using artificial cell membranes that predicts intestinal absorption three times more accurately than the current state of the art.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00134A, Paper

Sayali Upasham, Shalini Prasad
SLOCK is a sweat based platform for monitoring circadian relevant biomarkers-cortisol and DHEA, using electrochemical detection modality.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00144A, Critical Review

Jia Li, Chang-Jin “CJ” Kim
Electrowetting on EWOD surface: a droplet beading or spreading (left) or translating (right) by electric signals. The EWOD technology made the once-obscure electrowetting phenomenon practical, leading to the host of commercial products today.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00001A, Paper

Kiing S. Wong, William T. H. Lim, Chien W. Ooi, Leslie Y. Yeo, Ming K. Tan
We demonstrate an efficient technique for in situ production and application of plasma-activated aerosols for surface disinfection.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01268K, Paper

Bohee Maeng, Hyung-kwan Chang, Jungyul Park
A powerless smart contact lens enabling to monitor intraocular pressure (IOP) by checking the visual color change in photonic crystal structure with a microhydraulic amplification system has been realized.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00079E, Paper

Kenji Akama, Hiroyuki Noji
Homogeneous digital immunoassay is a powerful analytical method for highly sensitive biomarker detection with a simple protocol. By using this method, we demonstrated the simultaneous multiple protein detection.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00248H, Paper

Matthias Hermann, Kyle Bachus, Graham T. T. Gibson, Richard D. Oleschuk
This paper reports a portable viscometer that requires less than 10 μL of sample for a measurement.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01064E, Paper

Seungbeom Noh, Hanseup Kim
This paper reports in-air monitoring of in vitro monolayer cells under air-exposure utilizing electrochemical impedance spectroscopy (EIS).
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00318B, Paper

Ren Shen, Yanwei Jia, Pui-In Mak, Rui P. Martins
A proposed DNA amplification enhancer with a “clip-to-release on amplification” mechanism reduces dye-mediated inhibition to amplification, increases fluorescence signal up to 10-fold, and eliminates false-negative results for on-chip PCR.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00175A, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Karl Olofsson, Björn Hammarström, Martin Wiklund
A novel, simple and robust route for binary separation of viable and dead cells using a density modified medium which takes advantage of the compromised cell membrane of dead cells.
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Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00133C, Paper

George Banis, Luke Beardslee, Justin Stine, Rajendra Mayavan Sathyam, Reza Ghodssi
Ingestible capsule systems continue evolving to overcome drawbacks associated with traditional gastrointestinal (GI) diagnostic and therapeutic processes, such as location restrictions or insufficient sensitivity measures when obtaining information on local...
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Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00250J, Paper

Yuexiao Song, Feng Xin, Yongsheng Xu
This work develops a reliable method to achieve stratified flow in squared cross-section microchannels by endowing the four channel walls with very different wettabilities. The gas–liquid flows are studied experimentally...
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Lab Chip, 2020, 20,1628-1638
DOI: 10.1039/C9LC01165J, Paper

Jose A. Wippold, Han Wang, Joseph Tingling, Julian L. Leibowitz, Paul de Figueiredo, Arum Han
Identifying antibodies (Abs) that neutralize infectious agents is the first step for developing therapeutics, vaccines, and diagnostic tools for these infectious agents.
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Lab Chip, 2020, 20,1601-1611
DOI: 10.1039/D0LC00115E, Paper

Veasna Soum, Sooyong Park, Albertus Ivan Brilian, Jae-Youl Choi, Yongwoo Lee, Wonjung Kim, Oh-Sun Kwon, Kwanwoo Shin
A precise, simple, and inexpensive method for controlling fluid flow in a photo-paper-based microfluidic device was reported.
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Lab Chip, 2020, 20,1687-1693
DOI: 10.1039/C9LC01021A, Paper

Zongdai Liu, Dan Luo, Kun-Lin Yang
The concentration of toluene vapor is obtained based on polymer-stabilized liquid crystals by viewing a colourful gamut under a polarized optical microscope.
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Lab Chip, 2020, 20,1612-1620
DOI: 10.1039/D0LC00089B, Paper

Baris R. Mutlu, Taronish Dubash, Claudius Dietsche, Avanish Mishra, Arzu Ozbey, Kevin Keim, Jon F. Edd, Daniel A. Haber, Shyamala Maheswaran, Mehmet Toner
Cell–cell adhesion strength of freely suspended cell clusters can be measured using an oscillatory inertial microfluidic system.
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Lab Chip, 2020, 20,1676-1686
DOI: 10.1039/D0LC00244E, Paper

Open Access

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Andreas Kleiber, Anuradha Ramoji, Günter Mayer, Ute Neugebauer, Jürgen Popp, Thomas Henkel
The control of the focus plane allows multi-directional imaging flow cytometry.
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Lab Chip, 2020, 20,1586-1600
DOI: 10.1039/D0LC00099J, Paper

Karina M. Lugo-Cintrón, José M. Ayuso, Bridget R. White, Paul M. Harari, Suzanne M. Ponik, David J. Beebe, Max M. Gong, María Virumbrales-Muñoz
Lymphatic organotypic in vitro model allows the examination of components of the tumor microenvironment (e.g., ECM density, cancer cells) in lymphatic vessel biology in the context of cancer, providing insights into potential therapeutic targets.
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Lab Chip, 2020, 20,1554-1561
DOI: 10.1039/D0LC00063A, Communication

Nianzuo Yu, Yongshun Liu, Bai Ji, Shuli Wang, Yunyun Chen, Tianmeng Sun, Junhu Zhang, Bai Yang
Blood pressure sensors are proposed to measure the value of central venous pressure, and diagnose the severity of hypertension, hypotension and arterial thrombosis.
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Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00112K, Paper

Yuncheng Man, Erdem Kucukal, Ran An, Quentin Watson, Jürgen Bosch, Peter A. Zimmerman, Jane A Little, Umut A. Gurkan
Abnormal red blood cells (RBC) deformability contributes to hemolysis, thrombophilia, inflammation, and microvascular occlusion in various circulatory diseases. A quantitative and objective assessment of microvascular occlusion mediated by RBCs with...
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00354A, Paper

Naotomo Tottori, Takasi Nisisako
We propose sheath-free microfluidic deterministic lateral displacement devices with inertially focused single straight input.
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Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00153H, Paper

Zhening Su, Jinxu He, Peipei Zhou, Lu Huang, Jianhua Zhou
Crystallization of active pharmaceutical ingredients (APIs) is a crucial process in the pharmaceutical industry due to its great impact in drug efficacy. However, conventional approaches for screening the optimal crystallization...
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00142B, Paper

Sharif M. Rahman, Joshua M. Campbell, Rachael N. Coates, Katie M. Render, C. Ethan Byrne, Elizabeth C. Martin, Adam T. Melvin
Breast cancer cells co-cultured with adipose-derived stem cells (ASCs) in a microfluidic device exhibited enhanced growth, a more aggressive morphology and polarization towards the ASCs, and increased drug resistance.
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Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00300J, Paper

Asmaa Khater, Osama Abdelrehim, Mehdi Mohammadi, Milad Azarmanesh, Mohsen Jonmaleki, Razieh Salahandish, AbdulMajeed Mohamad, Amir Sanati Nezhad
Droplet microfluidics has provided lab-on-a-chip platforms with the capability of bacteria encapsulation in biomaterials, controlled culture environment, and live monitoring of growth and proliferation. The droplets are mainly generated from...
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