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A sociology of jurisprudence [electronic resource] / Richard Nobles and David Schiff

Nobles, Richard




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Soziologische Theorien kompakt [electronic resource] / von Martin Endreß

Endress, Martin, author




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Talking about Leaving Revisited [electronic resource] : Persistence, Relocation, and Loss in Undergraduate STEM Education / edited by Elaine Seymour, Anne-Barrie Hunter




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Rural Cinema Exhibition and Audiences in a Global Context [electronic resource]




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Variable protein expression in marine-derived filamentous fungus Penicillium chrysogenum in response to varying copper concentrations and salinity

Metallomics, 2020, Advance Article
DOI: 10.1039/C9MT00316A, Paper
Nikita Lotlikar, Samir Damare, Ram Murti Meena, Saranya Jayachandran
Copper is one of the essential trace dietary minerals for all living organisms, but is potentially toxic at higher concentrations, mainly due to the redox reactions in its transition state.
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en

Characterization of the Fe metalloproteome of a ubiquitous marine heterotroph, Pseudoalteromonas (BB2-AT2): multiple bacterioferritin copies enable significant Fe storage

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00034E, Paper
Open Access
Michael G. Mazzotta, Matthew R. McIlvin, Mak A. Saito
Despite the extreme scarcity of Fe in seawater, the marine heterotroph Pseudoalteromonas has expansive Fe storage capacity and utilization strategies.
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en

Hydrogen sulfide increases copper-dependent neurotoxicity via intracellular copper accumulation

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00015A, Paper
Norika Goto, Hirokazu Hara, Mao Kondo, Naomi Yasuda, Tetsuro Kamiya, Kensuke Okuda, Tetsuo Adachi
Copper (Cu) is an essential trace element and acts as a redox cofactor for many enzymes; however, excess Cu is toxic to cells.
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en

Proteomic analysis of the S. cerevisiae response to the anticancer ruthenium complex KP1019

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00008F, Paper
Open Access
Laura K. Stultz, Alexandra Hunsucker, Sydney Middleton, Evan Grovenstein, Jacob O’Leary, Eliot Blatt, Mary Miller, James Mobley, Pamela K. Hanson
Proteomic analysis reveals that the anticancer ruthenium KP1019 induces proteotoxic, genotoxic, and oxidative stress responses in Saccharomyces cerevisiae.
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en

The first copper(II) complex with 1,10-phenanthroline and salubrinal with interesting biochemical properties

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00006J, Paper
Sebastiano Masuri, Enzo Cadoni, Maria Grazia Cabiddu, Francesco Isaia, Maria Giovanna Demuru, Lukáš Moráň, David Buček, Petr Vaňhara, Josef Havel, Tiziana Pivetta
The novel complex Cu(phen)2(salubrinal)(ClO4)2 shows high free radical scavenging activity and good cytotoxic activity and induces cell death through ER-stress.
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en

Gold(III) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00064G, Paper
Diana Fontinha, Silvia Andreia Sousa, Tânia S. Morais, Miguel Prudêncio, Jorge Leitão, Yann Le Gal, Dominique Lorcy, Rafaela Silva, Mariana Velho, Dulce Belo, Manuel Almeida, Joana Guerreiro, Teresa Pinheiro, Fernanda M. Marques
The anticancer, antimicrobial and antiplasmodial activities of six gold(III) bis(dithiolene) complexes were studied. Complexes (1-6) showed relevant anticancer properties against A2780/A2780cisR ovarian cancer cells (IC50 values of 0.08-2 µM), also...
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en

Studies of the labile lead pool using a rhodamine-based fluorescent probe

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00056F, Communication
Jianping Zhu, Jia Hao Yeo, Amy A. Bowyer, Nicholas Proschogo, Elizabeth J. New
A rhodamine-based fluorescent lead probe reports on the labile lead pool within cells.
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en

Enantiomeric Copper Based Anticancer Agents Promoting Sequence-Selective Cleavage of G-Quadruplex Telomeric DNA and non-random cleavage of plasmid DNA

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00084A, Paper
Sabiha Parveen, J. A. Cowan, Zhen Yu, Farukh Arjmand
Copper-based binuclear enantiomeric complexes 1S and 1R were synthesized as anticancer chemotherapeutic agents to target G-quadruplex rich region of DNA and thoroughly characterized by various spectroscopic and single X-ray crystal...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,474-490
DOI: 10.1039/C9MT00271E, Paper
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qinguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
BEOV activates PPARγ to affect JAK2/STAT3/SOCS1 signaling and eventually prevents Aβ generation. Meanwhile, BEOV inactivates PTP1B to affect PI3K/Akt/GSK3β signaling and finally reduces tau hyperphosphorylation.
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en

Chiral Ru(II) complexes act as a potential non-viral gene carrier for directional transportation to the nucleus and cytoplasm

Metallomics, 2020, 12,504-513
DOI: 10.1039/C9MT00192A, Paper
Qiong Wu, Shuang-Yan Zhang, Si-Yan Liao, Jie-Qiong Cao, Wen-Jie Zheng, Li Li, Wen-Jie Mei
A novel approach has been proposed to develop a potent gene carrier system for enantioselectivity on the self-assembly of G-quadruplex DNA promoted by chiral Ru(II) complexes, and the different assembled nanostructures of cellular uptake to the nucleus and cytoplasm.
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en

Gene expression in mouse muscle over time after nickel pellet implantation

Metallomics, 2020, 12,528-538
DOI: 10.1039/C9MT00289H, Paper
Desmond I. Bannon, Wenjun Bao, Stephen D. Turner, Wilfred C. McCain, William Dennis, Russ Wolfinger, Ed Perkins, Roger Abounader
Implanted nickel becomes toxic when it exceeds homeostasis, initiating a range of global gene effects over time, including oxidative phosphorylation and immune responses, which are impacted in opposite directions.
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Distribution and chemical form of selenium in Neptunia amplexicaulis from Central Queensland, Australia

Metallomics, 2020, 12,514-527
DOI: 10.1039/C9MT00244H, Paper
Maggie-Anne Harvey, Peter D. Erskine, Hugh H. Harris, Gillian K. Brown, Elizabeth A. H. Pilon-Smits, Lachlan W. Casey, Guillaume Echevarria, Antony van der Ent
Elemental mapping of selenium in the hyperaccumulator Neptunia amplexicaulis determined whole plant and tissue level selenium distribution. The total concentrations and chemical forms of selenium are also reported for this species.
The content of this RSS Feed (c) The Royal Society of Chemistry




en

Heterobimetallic Ru(II)/Fe(II) complexes as potent anticancer agents against breast cancer cells, inducing apoptosis through multiple targets

Metallomics, 2020, 12,547-561
DOI: 10.1039/C9MT00272C, Paper
Adriana Pereira Mundim Guedes, Francyelli Mello-Andrade, Wanessa Carvalho Pires, Maria Alice Montes de Sousa, Paula Francinete Faustino da Silva, Mariana S. de Camargo, Hendryk Gemeiner, Menegário A. Amauri, Clever Gomes Cardoso, Paulo Roberto de Melo Reis, Elisângela de Paula Silveira-Lacerda, Alzir A. Batista
Antimetastatic activity, high selectivity and cytotoxicity for human tumor cell lines make ruthenium(II) complexes attractive for the development of new chemotherapeutic agents for cancer treatment.
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en

Copper accumulation and the effect of chelation treatment on cerebral amyloid angiopathy compared to parenchymal amyloid plaques

Metallomics, 2020, 12,539-546
DOI: 10.1039/C9MT00306A, Paper
Xiayoue Zhu, Tiffany W. Victor, Ashwin Ambi, Joseph K. Sullivan, Joshua Hatfield, Feng Xu, Lisa M. Miller, William E. Van Nostrand
Multimodal imaging studies show that Aβ amyloid in brain vessels of Tg2576 mice (green) preferentially binds copper (red) – a pathology that can be reduced with copper chelators.
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Selenium deficiency exacerbates LPS-induced necroptosis by regulating miR-16-5p targeting PI3K in chicken tracheal tissue

Metallomics, 2020, 12,562-571
DOI: 10.1039/C9MT00302A, Paper
Lanqiao Wang, Xu Shi, Shufang Zheng, Shiwen Xu
Se deficiency can induce necroptosis in tracheal tissue. LPS-induced necroptosis can be exacerbated by Se deficiency. The miR-16-5p-PI3K/AKT pathway participates in the occurrence of necroptosis.
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Comparative differential cuproproteomes of Rhodobacter capsulatus reveal novel copper homeostasis related proteins

Metallomics, 2020, 12,572-591
DOI: 10.1039/C9MT00314B, Paper
Nur Selamoglu, Özlem Önder, Yavuz Öztürk, Bahia Khalfaoui-Hassani, Crysten E. Blaby-Haas, Benjamin A. Garcia, Hans-Georg Koch, Fevzi Daldal
Cuproproteome of model bacterium Rhodobacter capsulatus reveals 75 Cu-responsive proteins that are strongly influenced (2–300 fold) by Cu availability.
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The role of necroptosis and apoptosis through the oxidative stress pathway in the liver of selenium-deficient swine

Metallomics, 2020, 12,607-616
DOI: 10.1039/C9MT00295B, Paper
Yuan Zhang, Dahai Yu, Jiuli Zhang, Jun Bao, Chaohua Tang, Ziwei Zhang
Necroptosis is regarded as a new paradigm of cell death that plays a key role in the liver damage observed with selenium (Se) deficiency.
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en

Multi-genomic analysis of the cation diffusion facilitator transporters from algae

Metallomics, 2020, 12,617-630
DOI: 10.1039/D0MT00009D, Paper
Aniefon Ibuot, Andrew P. Dean, Jon K. Pittman
Cation diffusion facilitator metal transporters are widespread throughout algae and include a novel algal-specific clade. Functional analysis of Chlamydomonas reinhardtii isoforms partly validated phylogenetic prediction of substrate specificity.
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en

Correction: Bis(ethylmaltolato)oxidovanadium(IV) inhibited the pathogenesis of Alzheimer's disease in triple transgenic model mice

Metallomics, 2020, 12,631-631
DOI: 10.1039/D0MT90008G, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhijun He, Shuangxue Han, Chong Wu, Lina Liu, Huazhang Zhu, Ang Liu, Qiying Lu, Jingqiang Huang, Xiubo Du, Nan Li, Qingguo Xie, Lu Wan, Jiazuan Ni, Lingling Chen, Xiaogai Yang, Qiong Liu
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Ruthenium(III) complexes containing thiazole-based ligands that modulate amyloid-β aggregation

Metallomics, 2020, 12,491-503
DOI: 10.1039/D0MT00054J, Paper
Samantha E. Huffman, Gideon K. Yawson, Samuel S. Fisher, Paige J. Bothwell, David C. Platt, Marjorie A. Jones, Christopher G. Hamaker, Michael I. Webb
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder where one of the commonly observed pathological hallmarks is extracellular deposits of the peptide amyloid-β (Aβ).
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en

Peptide bond cleavage in the presence of Ni-containing particles

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00070A, Communication
Nina Ewa Wezynfeld, Tomasz Frączyk, Arkadiusz Bonna, Wojciech Bal
NiO nanoparticles and non-stoichiometric black NiO were shown to be effective sources of Ni2+ ions causing sequence-selective peptide bond hydrolysis. NiO nanoparticles were as effective in this reaction as their...
The content of this RSS Feed (c) The Royal Society of Chemistry




en

Correction: Identification and determination of selenocysteine, selenosugar, and other selenometabolites in turkey liver

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT90015J, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katarzyna Bierla, Rachel M. Taylor, Joanna Szpunar, Ryszard Lobinski, Roger A. Sunde
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en

Diphenyl Diselenide Protects Caenorhabditis elegans Model for Huntington's Disease by Activation of Antioxidant Pathway and Decrease in Protein Aggregation

Metallomics, 2020, Accepted Manuscript
DOI: 10.1039/D0MT00074D, Paper
Fabiane Bicca Obetine Baptista, Marina Lopes Machado, Aline da Silva Franzen, Larissa Marafiga Cordeiro, Tassia da Silveira, Leticia Arantes, Félix A. A. Soares
Huntington’s disease (HD) is an autosomal dominant, progressive neurodegenerative disease with a distinct phenotype. It occurs due to a mutation in huntingtin (or IT19) gene with abnormal CAG repeat, leading...
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The study of levels from redox-active elements in cerebrospinal fluid of amyotrophic lateral sclerosis patients carrying disease-related gene mutations shows potential copper dyshomeostasis

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00051E, Paper
Federica Violi, Nikolay Solovyev, Marco Vinceti, Jessica Mandrioli, Marianna Lucio, Bernhard Michalke
Gene-environment interaction is as a possible key factor in the development of ALS. The levels of redox species of Cu, Fe, and Mn were assessed in cerebrospinal fluid, showing a possible positive association between Cu and genetic ALS.
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en

Linc-ROR promotes arsenite-transformed keratinocyte proliferation by inhibiting P53 activity

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00076K, Paper
Xinyang Li, Chao Zuo, Mei Wu, Zunzhen Zhang
Linc-ROR modulates the cell proliferation in arsenite-transformed keratinocytes via inhibiting P53 activity through the PI3K/AKT pathway.
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Evidence that levels of nine essential metals in post-mortem human-Alzheimer's-brain and ex vivo rat-brain tissues are unaffected by differences in post-mortem delay, age, disease staging, and brain bank location

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00048E, Paper
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Sarah Kassab, Natalie J. Gardiner, Federico Roncaroli, Nigel M. Hooper, Richard D. Unwin, Garth J. S. Cooper
Metal findings in human Alzheimer brains are consistent despite differences in sample post-mortem delay, age, Braak stage and biobank location.
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In vitro selenium supplementation suppresses key mediators involved in myometrial activation and rupture of fetal membranes

Metallomics, 2020, Advance Article
DOI: 10.1039/D0MT00063A, Paper
Dineli Matheesha Kalansuriya, Ratana Lim, Martha Lappas
Selenium suppresses key mediators involved in preterm birth in human fetal membranes and myometrium.
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en

A Companion to the Harlem Renaissance


 

A Companion to the Harlem Renaissance presents a comprehensive collection of original essays that address the literature and culture of the Harlem Renaissance from the end of World War I to the middle of the 1930s.



Read More...




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Quarantine centres for two ACs set up

Quarantine centres for two ACs set up




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Bodies merged, new guidelines implemented

Bodies merged, new guidelines implemented




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TSE proprietor extends helping hand to widows, differently abled persons

TSE proprietor extends helping hand to widows, differently abled persons




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Disqualification case of 7 MLAs : Tribunal reserves judgement

Disqualification case of 7 MLAs : Tribunal reserves judgement




en

Kangpokpi asks passenger vehicles not to stop midway

Kangpokpi asks passenger vehicles not to stop midway




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Speaker inspects quarantine centre

Speaker inspects quarantine centre




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1200 to board special train from Chennai today

1200 to board special train from Chennai today




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[ASAP] In Vitro Identification of the Hamiltonian Cycle Using a Circular Structure Assisted DNA Computer

ACS Combinatorial Science
DOI: 10.1021/acscombsci.9b00150




en

[ASAP] Development of Mischmetal–Fe–Co–B Permanent Magnet Alloys via High-Throughput Methods

ACS Combinatorial Science
DOI: 10.1021/acscombsci.9b00190




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[ASAP] Ce(OTf)<sub>3</sub>-Catalyzed Multicomponent Reaction of Alkynyl Carboxylic Acids, <italic toggle="yes">tert</italic>-Butyl Isocyanide, and Azides for the Assembly of Triazole–Oxazole Derivatives

ACS Combinatorial Science
DOI: 10.1021/acscombsci.0c00012




en

[ASAP] Optimized Multimetal Sensitized Phosphor for Enhanced Red Up-Conversion Luminescence by Machine Learning

ACS Combinatorial Science
DOI: 10.1021/acscombsci.0c00035




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[ASAP] Magnetic Bead-Immobilized Mammalian Cells Are Effective Targets to Enrich Ligand-Displaying Yeast

ACS Combinatorial Science
DOI: 10.1021/acscombsci.0c00036




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[ASAP] Experimental and Theoretical Investigation on Phase Formation and Mechanical Properties in Cr–Co–Ni Alloys Processed Using a Novel Thin-Film Quenching Technique

ACS Combinatorial Science
DOI: 10.1021/acscombsci.9b00170




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Annual Report to the Nation: Overall cancer mortality continues to decline; Special section on adults ages 20 to 49 shows higher cancer incidence and mortality for women than men

The 2019 Annual Report to the Nation on the Status of Cancer finds overall cancer death rates continue to decline and cancer incidence dropped in men and remained stable in women. A special section reports on recent cancer trends in younger adults.




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NCI study finds long-term increased risk of cancer death following common treatment for hyperthyroidism

Findings from a new NCI study of patients who received radioactive iodine (RAI) treatment for hyperthyroidism show an association between the dose of treatment and long-term risk of death from solid cancers, including breast cancer.




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Immunotherapy drug improves outcomes for some children with relapsed leukemia

For children and young adults with certain relapsed B-cell acute lymphoblastic leukemia (B-ALL), the immunotherapy drug blinatumomab is superior to standard chemotherapy, an NCI-sponsored Children’s Oncology Group trial shows.




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In NIH trial, selumetinib shrinks tumors, provides clinical benefit for children with NF1

An NCI clinical trial finds the drug selumetinib improves outcomes for children with neurofibromatosis type 1 (NF1), shrinking inoperable tumors called plexiform neurofibromas, reducing pain, and improving function and overall quality of life.




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NCI study provides genetic insights into osteosarcoma in children

A new study offers insight into genetic alterations associated with osteosarcoma, the most common bone tumor of children and adolescents, and the findings have implications for genetic testing of children with osteosarcoma and their families.