PURPOSE

We undertook a trial to test the efficacy of a technology-assisted health coaching intervention for weight management, called Goals for Eating and Moving (GEM), within primary care.

Advancements in immunotherapy in the perioperative setting have revolutionised the treatment of resectable nonsmall cell lung cancer (NSCLC). Here we present the methodology and results of the clinical trial CheckMate 816 demonstrating the benefit of neoadjuvant therapy with nivolumab plus chemotherapy compared with chemotherapy alone. Furthermore, this article discusses the implications for future practice in resectable NSCLC and the need for future research.

Central sleep apnoea (CSA) is characterised by recurrent episodes of airway cessation or reduction in the absence of respiratory effort. Although CSA is less common than obstructive sleep apnoea, it shares similar symptoms. CSA can be secondary to various medical conditions, high altitude and medication exposure. CSA can also emerge during obstructive sleep apnoea therapy. There are a range of treatment options and selecting the right therapy requires an understanding of the pathophysiology of CSA. This review explores the aetiology, pathophysiology and clinical management of non-hypercapnic CSA.

Writer-director partners Scott Beck and Bryan Woods dive into the biggest spoilers of their new Hugh Grant thriller.

Robert Eggers' re-imagining of the legendary vampire has his fangs out for prey in a very unusual manner.

Season six's latest episode introduced Laszlo's father—and chaos inevitably followed.

The current growth and consumption based economy is not sustainable. The world must move towards a circular economy and sustainability.

The post Degrowth, green energy, social equity, and circular economy appeared first on rabble.ca.

Danielle Smith says she is “100 per cent committed” to a leaked plan to replace Alberta Health Services with new health boards, agencies, bureaucracy, all directed out of her office.

The post UCP set to announce plan to bust up AHS appeared first on rabble.ca.

WASHINGTON — Secretary of State Rex Tillerson says diplomatic efforts aimed at resolving the North Korean crisis “will continue until the first bomb drops.”

That statement comes despite President Donald Trump’s tweets a couple of weeks ago that his chief envoy was “wasting his time” trying to negotiate with “Little Rocket Man,” a mocking nickname Trump has given the nuclear-armed nation’s leader, Kim Jong Un.

“I think he does want to be clear with Kim Jong Un and that regime in North Korea that he has military preparations ready to go and he has those military options on the table. And we have spent substantial time actually perfecting those,” Tillerson told CNN’s “State of the Union” on Sunday. “But be clear: The president has also made clear to me that he wants this solved diplomatically. He’s not seeking to go to war.”

Recent mixed messaging from the top of the U.S. government has raised concerns about the potential for miscalculation amid the increasingly bellicose exchange of words by Trump and the North Korean leader.

Trump told the U.N. General Assembly last month that if the U.S. is “forced to defend itself or its allies, we will have no choice but to totally destroy North Korea.” Trump also tweeted that Korea’s leadership “won’t be around much longer” if it continued its provocations, a declaration that led the North’s foreign minister to assert that Trump had “declared war on our country.”

Tillerson acknowledged during a recent trip to Beijing that the Trump administration was keeping open direct channels of communications with North Korea and probing the North’s willingness to talk. He provided no elaboration about those channels or the substance of any discussions.

Soon after, Trump took to Twitter, saying he had told “our wonderful Secretary of State, that he is wasting his time trying to negotiate with Little Rocket Man … Save your energy Rex, we’ll do what has to be done!” Trump offered no further explanation, but he said all military options are on the table for dealing with North Korea’s nuclear and missile programs.

Analysts have speculated about whether the president and his top diplomat were playing “good cop, bad cop” with North Korea, and how China might interpret the confusing signals from Washington. Beijing is the North’s main trading partner, and the U.S. is counting on China to enforce U.N. sanctions.

“Rest assured that the Chinese are not confused in any way what the American policy towards North Korea (is) or what our actions and efforts are directed at,” Tillerson said.

Asked if Trump’s tweets undermined Tillerson, the secretary said: “I think what the president is doing is he’s trying to motivate action on a number of people’s part, in particular the regime in North Korea. I think he does want to be clear with Kim Jong Un and that regime in North Korea that he has military preparations ready to go and he has those military options on the table and we have spent substantial time perfecting those.”

He added that Trump “has made it clear to me to continue my diplomatic efforts, which we are, and I’ve told others those diplomatic efforts will continue until the first bomb drops.”

North Korea has launched missiles that potentially can strike the U.S. mainland and recently conducted its largest ever underground nuclear explosion. It has threatened to explode another nuclear bomb above the Pacific.

The post Rex Tillerson says continue diplomacy with North Korea ‘until first bomb drops’ appeared first on PBS NewsHour.

TOKYO — U.S. and Japanese diplomats agreed Tuesday to maximize pressure on North Korea to resolve tensions over its nuclear program, while citing the need to be prepared for the worst if diplomacy fails.

U.S. Deputy Secretary of State John Sullivan, after meeting his Japanese counterpart, Shinsuke Sugiyama, told reporters that the focus at the State Department is still on diplomacy to solve the problem and eventually denuclearize the Korean Peninsula.

“We must, however, with our allies in Japan and South Korea and elsewhere, be prepared for the worst should diplomacy fail,” he said. The U.S. must be prepared to defend itself and its allies, he said.

Sugiyama, briefing reporters separately, reiterated Japan’s support for President Donald Trump’s policy of keeping all options open, but stressed the need for a diplomatic solution by bolstering cooperation among Japan, U.S. and South Korea, as well as via cooperation with China and Russia.

The two diplomats will join their South Korean counterpart in Seoul for further talks Wednesday on North Korea.

READ MORE: Rex Tillerson says continue diplomacy with North Korea ‘until first bomb drops’

The talks come as the U.S. and South Korea hold joint naval drills this week. They regularly conduct joint exercises, though North Korea condemns them as an invasion rehearsal.

North Korea’s deputy U.N. ambassador warned on Monday that the situation on the peninsula “has reached the touch-and-go point and a nuclear war may break out any moment.”

Kim In Ryong told the U.N. General Assembly’s disarmament committee that North Korea has been subjected to a direct nuclear threat from the United States and has the right to possess nuclear weapons in self-defense.

He pointed to military exercises and what he called a U.S. plan to stage a “secret operation aimed at the removal of our supreme leadership.”

Kim’s speech follows increasingly tough U.N. sanctions. Russian President Vladimir Putin said his country is curtailing economic, scientific and other ties with North Korea in line with U.N. sanctions, and the European Union announced new sanctions as well.

The post U.S., Japan agree to maximize diplomatic pressure on North Korea appeared first on PBS NewsHour.

Christian Lealiifano will draw inspiration from his newborn son in the second Test in Melbourne this Saturday.

PM Malcolm Turnbull says Australians should vote to keep a stable majority government in uncertain economic times, as the fallout from Brexit continues.

The Herald understands that former first minister Nicola Sturgeon has made no decisions on whether she will stand for election in 2026.

"Kate Forbes still has her own leadership ambitions, setting them aside this Spring in the interest of party unity to accept Mr Swinney's offer to become Deputy First Minister."

Sir Keir Starmer's beleaguered former chief of staff will no longer take up the position of “envoy to the nations and regions.”

AS the nights draw in, and we wake up and it’s still dark out, it just feels that little harder to get out of bed. For some, however, kicking off those warm, cosy covers is far harder than for others.

A new Nordic-style Open Kindergarten will be trialled in part of Scotland ahead of a potential roll-out across the country.

A "renowned" restructuring advisory business has been acquired by a major player.

The SNP's Westminster leader has announced he is to contest a seat at Holyrood – and will ‘double-job’ as an MP and MSP if he wins.

Sir Andy Murray will swap Centre Court for the stage next summer as he embarks on a tour discussing his illustrious tennis career.

It’s a slightly more potty mouthed cast than usual, as Alice joins Peter, Kelley, Anna Marie and Chris to discuss what the cast has been playing for the week. Anna Marie’s 5-hour rule resurfaces and we explore what crazy black holes Chris has been down this week, alongside the news and your feedback.

The post RPG Cast – Episode 543: “Go Find Gnome, Dumb***” appeared first on RPGamer.

Things are looking grim: we get thrown out cars, assassinated for our kingdoms, drowned underwater, and struck out. If you’re scratching your head, don’t worry! Everything will make sense once you listen to this week’s podcast.

The post RPG Cast – Episode 544: “You Will NOT Bucket Shame Me” appeared first on RPGamer.

New Game Plus Expo comprises the bulk of this week’s news, while the crew ponders their love and hate for Phantasy Star Online 2. Just what has Anna Marie been playing the last two weeks? You’ll have to listen to the episode to find out!

The post RPG Cast – Episode 548: “Do Not Karen on Me” appeared first on RPGamer.

It's just the core trio this week, as Chris tosses a coin to his hunting horn partner Kelley, and Anna Marie rolls her eyes as Chris cracks terrible jokes about what the Vita really means. We all consider MiHoYo's bottom line, as well as whether we're classified as normies.

The post RPG Cast – Episode 580: “Marshmallow Is Canon” appeared first on RPGamer.

Josh wishes on a monkey paw and gets a new Shining Force game. Chris's body isn't ready for Death's Door. And no expects the shadow drop of Boyfriend Dungeon.

The post RPG Cast – Episode 596: “I’m Not Into Tails Unless I’m Shooting Them Out of a Cannon” appeared first on RPGamer.

The podcast trio is not at all ready for the flood of September releases. Anna Marie is kind of sick of the trigger, Chris insists Eclipse is owed an apology, and Kelley wants to know what is this garbage and how she can get more of it.

The post RPG Cast – Episode 599: “Serious Health Issues? No, Just a Cat” appeared first on RPGamer.

Chris embraces our cyberpunk subscription overlords. Josh kills the innkeeper (accidentally). Meanwhile Robert plunges down the .Hack hole.

The post RPG Cast – Episode 610: “No One Should Learn Japanese from Super Robot Wars” appeared first on RPGamer.

This week on RPG Cast, Kelley falls asleep for four years and misses the announcement of Kingdom Hearts 4. Chris is a five year old with beefy fists. Sam tells us how her video game marriage life works. And we all agree that Bidoof is our buddy.

The post RPG Cast – Episode 627: “Maybe His Feet Are Nobodies” appeared first on RPGamer.

Kelley dodge rolls into graves in Elden Ring, Chris is tempted by the Diablo FOMO, and Anna Marie is spreading fake news? Yep, it's the weekly RPG Cast.

The post RPG Cast – Episode 635: “TMNT Is an RPG Now” appeared first on RPGamer.

Chris is not an automated phone system. Josh has been delayed until 2023. And Kelley gets cases for her Star Wars cases.

The post RPG Cast – Episode 642: “We Are Not Bringing Up Your Cat Fountain” appeared first on RPGamer.

Chris suffers from "The Curse of the Steam Deck." Kelley can't pickpocket, so she mugs people at night. And Ryan likes practical grave robbers. Curl up in your clothmap quilt and enjoy our cozy '60s demon world.

The post RPG Cast – Episode 681: “Ganon Is Afraid of Homemade Apple Pie” appeared first on RPGamer.

Kelley tries to capture a goat. Robert is trapped in a corner by the nightmares. Josh upgrades his tank and hopes to get a good ending this time. Will Chris beat FFXVI this week?

The post RPG Cast – Episode 685: “You Erased My Save, Now You Have to Beat It” appeared first on RPGamer.

Chris sets out to get justice for Hana. Kelley complains about vegan technology. Robert tells us all about the vacuum cleaner machine gun. And Ryan wonders why the "silent" princess won't shut up.

The post RPG Cast – Episode 694: “There’s No D in Journey” appeared first on RPGamer.

Sam wants two things, coke and nuggs. Robert hails the hypnobooty. Ryan has to go recruit more Ryans. And Chris commissions a new Sesame Street horror adventure. Guard your eyes.

The post RPG Cast – Episode 695: “Jason Statham Is the Best Dinosaur” appeared first on RPGamer.

Chris builds a house with a tiger in it. Ryan remembers that bush. And Robert has to fend off the fan boys trying to take his Nikke girls. One week till Extra Life, please help us heal kids and identify bicycles.

The post RPG Cast – Episode 697: “Paper Marliano” appeared first on RPGamer.

Kelley got WHAM'd and ran out of a hair salon. Chris can afford boat loads of ramen for his Path of Exile sessions now. Tam gives birth to a baby space ship. Oh, hi Mark.

The post RPG Cast – Episode 704: “She’s Lying, I Did Not Hit the Ornaments” appeared first on RPGamer.

Robert finds out what Godzilla sushi tastes like. Josh pimps his Segway. Phil has a pictomancer at home. The awards all Chris's fault, because he didn't vote. Also, PoE is to Chris, as CoH is to Phil.

The post RPG Cast – Episode 710: “Xenoblade Chronicles X Doesn’t Love You Back” appeared first on RPGamer.

Ryan slip 'n slides his health away. Robert lives on the side of danger and poor choices in video games. Meanwhile, Chris makes his own bathtub Geralt.

The post RPG Cast – Episode 725: “Not Every Idea in the Factory Is a Good One” appeared first on RPGamer.

Kelley starts a Reddit fight. Robert learns about purrkour gaming. Pascal makes plans to be a booth babe. Chris eats the mic like it's meat flavored cereal. Mung beans.

The post RPG Cast – Episode 732: “Excited PoE Noises” appeared first on RPGamer.

Paul Cousins presents a multi-channel installation in which the listener becomes the performer.

The post Patch Notes: Atomised Listening appeared first on Fact Magazine.

MCDONALD’S revenues have slumped and there’s one key reason: Millennials aren’t Maccas fans, choosing fresher, healthier food instead.

Take-Two CEO Strauss Zelnick in the company's latest earnings report said he isn't worried about Rockstar getting Grand Theft Auto VI to run on the Xbox Series S.

"Look, we support the platforms where the consumers are for as long as they’re there, and we find a way to support platforms despite different levels of tech," said Zelnick (via VideoGamesChronicle) when asked about the Xbox Series S.

Zelnick added, "Our labels are really good at that. I’m not really worried. I’ve never worried about where hardware was going. And I’ve said this many times over the years because, first of all, I don’t worry about things over which I have zero control.

"Secondly, I believe in the audience. The audience is going to show up if you have great properties, and so we just have to make sure to be on an array of platforms."

Zelnick added PC is an important platform to release games on, despite the fact Grand Theft Auto VI has not been announced for PC.

"If one platform diminishes in value, there’s always another one," he said. "So we’re seeing great growth in PC right now, for example. And I have been able to view that open formats would continue to grow. PC is an open format.

"I do think PC will continue to be a more and more important part of the console business going forward, and that isn’t complicated for us to support at all. So the bottom line is we are selective about which platforms we support. We make the tech work when we can make it work as long as the audience is big enough to make that worthwhile."

Grand Theft Auto VI will launch for the PlayStation 5 and Xbox Series X|S in Fall 2025.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463023/take-two-ceo-is-not-worried-about-grand-theft-auto-vi-performance-on-xbox-series-s/

tinyBuild has announced Hello Neighbor 3 for PC via Steam.

View a developer log below:

Read details on the game below:

Arriving in Raven Brooks as a stranger with no ties to this place, you find yourself in a forgotten, half-abandoned town where every citizen has relations, desires, and goals. Your actions will ripple through the town, changing the course of events…

• Simulated town - Raven Brooks as a sandbox simulated in real-time. Residents act based on their personalities and circumstances.
• Every decision is the right one - The system-based nature of the game allows for complex ways of achieving your goals.
• Cozy yet eerie adventure - A fading half-abandoned town in early spring, tangled with overgrowth and memories.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463030/hello-neighbor-3-announced-for-pc/

Nintendo announced it will host a Super Nintendo World Direct livestream on Monday, November 11 at 2:00 pm PT / 5:00 pm ET. You will be able to watch it on YouTube.

The Direct will be roughly 10 minutes and feature the Donkey Kong Country area of Super Nintendo World at Universal Studios Japan.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463031/super-nintendo-world-direct-set-for-november-11/

Following a tease, Microsoft and Activision Blizzard have announced Spyro Reignited Trilogy will release for Xbox Game Pass tomorrow, November 12.

VGChartz staff gave Spyro Reignited Trilogy an 8 out of 10 and stated, "it was wise to steer away from marketing the collection as a remaster because that label undercuts the developers’ level of dedication and investment in revitalizing these games."

Read details on the trilogy below:

Remade from the ground up, the Spyro Reignited Trilogy features all three of the original games that started it all – Spyro the Dragon, Spyro 2: Ripto’s Rage, and Spyro: Year of the Dragon, amazing for the original fans and new players alike.

Spyro the Dragon

Our new favorite little purple dragon starts on a quest to rescue his dragon friends who have been turned into crystal by the villain Gnasty Gnorc (what an unfortunate and yet apt name!). Spyro explores vibrant Dragon Realms, collects gems, and flambés his enemies, all while learning to how breathe fire and glide.

Spyro 2: Ripto’s Rage!

Spyro finds himself in the magical land of Avalar where he is trying to save the realm from the evil sorcerer Ripto and his minions. Along the way, he befriends new entirely new allies, overcomes challenges, complete tasks, and unlocks even more powers to take down Ripto and restore peace.

Spyro: Year of the Dragon

In Spyro: Year of the Dragon, Spyro finds out that the Dragon Eggs have been stolen by the devious Sorceress, sending him on a new mission to recover the eggs and save the dragon population. Our favorite purple dragon meets new friends, learns new abilities, all while exploring more vibrant realms with challenges (and treasures!).

Xbox players have been able to explore the Dragon Realms with Spyro since 2018 with the release of the Reignited Trilogy, and now we’re excited to invite our community to jump into these incredible adventures once again and relive the fun and nostalgia that only Spyro can bring.

Available on Game Pass Standard, Game Pass Ultimate, and PC Game Pass, for cloud, console and PC, it’s sure to ignite some serious fun. Let’s go save the Dragon Realms!

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463034/spyro-reignited-trilogy-headed-to-xbox-game-pass-tomorrow-november-12/

Valve has announced Steam Deck OLED: Limited Edition White.

The handheld is a limited edition white version of the Steam Deck OLED that will be available in limited quantities for $679.

Pre-orders will open up on Steam on November 18 at 3:00 pm PT / 6:00 pm ET / 11:00 pm UK.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463040/valve-announces-steam-deck-oled-limited-edition-white/

Tencent Games subsidiary LightSpeed Studios has announced Hideaki Itsuno, who recently left Capcom after 30 years working for the company, will be leading a new video game studio called LightSpeed Japan Studio.

LightSpeed Japan Studio will have two locations in Tokyo and Osaka and is focused on developing original AAA games.

"Joining LightSpeed Studios is an exciting new chapter for me," said Hideaki Itsuno. "With LightSpeed’s strong development capability and global network, I look forward to creating original AAA action game titles together with the amazing team and building aesthetic and innovative experiences for the global player community. We welcome all talented and passionate game creators from the world over to join our vision."

LightSpeed Studios president Jerry Chen added, "It is our great honor to have Hideaki Itsuno join LightSpeed Studios. The establishment of LightSpeed Japan Studio is a significant step in LightSpeed Studios’ expansion and demonstrates our commitment to bringing the best possible games to our players."

Itsuno directed entries in the Rival Schools, Power Stone, Capcom VS. SNK, Devil May Cry, and Dragon’s Dogma franchises.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463041/hideaki-itsuno-to-lead-new-aaa-developer-lightspeed-japan-studio/

Publisher Whitethorn Games and developer Balloon Studios announced Botany Manor will launch for the PlayStation 5 and PlayStation 4 on December 17.

The game first released for the Xbox Series X|S, Xbox One, Nintendo Switch, PC via Steam, and Xbox Game Pass in April of this year.

Our own Lee Mehr gave the game an eight out of 10 in his review and stated, "The lynchpin to Botany Manor's success is it being like an orderly garden: a well-attended array of various flowers with nary a dastardly weed in sight.  It may not capture the next mind-blowing concept within the genre, nor overwhelm you with a wild barrage of challenges, but there's an understated value in being among the most succinct within its field."

View the PS5 and PS4 release date trailer below:

Read details on the game below:

Botany Manor is a botanical puzzle game set in a historical English homestead brimming with a lifetime of memorabilia and research to explore, where players will uncover long-forgotten seeds and piece together clues as they solve puzzles to help each rare plant grow.

The enduring estate of Botany Manor is home to retired botanist Arabella Greene. After a long career, she has amassed a collection of rare, long-forgotten plants that require some research to help them live again. Play as Arabella and explore the stunning historic manor and its grounds to look for clues in her notes, books, posters, and items scattered around the residence to determine the correct set of circumstances to help the flora flourish. Unlock new seeds and plant them. Interactable items around the property that can be turned and flipped will provide information to help you solve each gardening puzzle, grow the plants, and discover their mysterious qualities.

Features:

• Explore the peaceful grounds and many calming rooms of the beautifully rendered, historically accurate 19th century manor.
• Pick up, flip, turn, and rotate the many items found around the estate to piece together the clues to solve each plant-based puzzle.
• Learn about Arabella’s life, career, and the challenges she faced as a woman scientist during the 19th century as you explore.
• Fall in love with the calming soundtrack that perfectly compliments the environment and flowers you bring to full bloom.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463043/botany-manor-headed-to-ps5-and-ps4-on-december-17/