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Exploration of fluorescence behavior of an imidazolium-based chemosensor in solution and in the solid state and its turn-on response to Al3+ in pure aqueous medium

Photochem. Photobiol. Sci., 2020, Advance Article
DOI: 10.1039/C9PP00477G, Paper
Vaishali Saini, Rangan Krishnan, Bharti Khungar
An imidazolium-based quinoline framework is constructed, and its fluorescence behaviour studies with fluorescence turn-on chemosensory response to the selective detection of Al3+ in aqueous medium are discussed in detail.
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Turn-on mode fluorescent diarylethenes: Effect of electron-donating and electron-withdrawing substituents on photoswitching performance

Photochem. Photobiol. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0PP00064G, Paper
Ryota Iwai, Masakazu Morimoto, Masahiro Irie
Diarylethene derivatives having benzothiophene S,S-dioxide groups undergo turn-on mode fluorescence photoswitching. For the practical application to super-resolution fluorescence microscopy, the photoswitchable fluorescent molecules are desired to be resistant against photodegradation....
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Deshaun Watson said before the 2017 draft that he talked to the Bears

Texans quarterback Deshaun Watson raised plenty of eyebrows on Friday when he tweeted, "The Bears NEVER ONCE talked to me" before the 2017 NFL draft. But that's not what Watson said at the time. Prior to the 2017 draft, Watson said in an interview with Rich Eisen that the Bears had talked to him. "I've [more]




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Can Jameis Winston be a productive QB despite the multitude of INTs?

Production vs. volatility: Can a quarterback outproduce a bad turnover-worthy throw rate?




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When Stephen Jones get the schedule, he first looks for a three-game road trip

As it turns out, America's Team prefer not to excessively travel the country for which they are named. When fans and media get their eyes on the schedule, they immediately look for certain specific things. During a Friday visit to the PFTPM podcast, Cowboys COO, executive V.P., and director of player personnel Stephen Jones addressed [more]




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Follow-up Testing Among Children With Elevated Screening Blood Lead Levels

Interview with Alex R. Kemper, MD, MPH, MS, author of Follow-up Testing Among Children With Elevated Screening Blood Lead Levels, published in the May 11 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. About half the children (six years and younger) with elevated blood lead levels did not receive follow up testing. 2. Nonwhite children, and those living in urban as well as high-risk lead settings, were less likely to receive follow up testing compared to their counterparts. 3. Follow-up testing for children with high blood lead levels is essential for managing lead poisoning and for maximizing cognitive development. 4. Interventions are needed to overcome disparities in care.




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Combined Tetanus, Diphtheria, and 5-Component Pertussis Vaccine for Use in Adolescents and Adults

Interview with Michael E. Pichichero, MD, author of Combined Tetanus, Diphtheria, and 5-Component Pertussis Vaccine for Use in Adolescents and Adults, published in the June 22/29 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Need: The combined tetanus-diphtheria 5-component pertussis vaccine is needed; There has been a 300% increase of pertussis among US adolescents in the last three years. 2. Safety: The combined tetanus-diphtheria 5-component pertussis vaccine is safe, as the reactions are the same as the tetanus vaccine. 3. Universal: On June 30, 2005, the American Academy of Pediatrics (ASAP), America Academy of Family Physicians (AFAR), and the Advisory Committee on Immunization Practices (ACID) all recommended the universal use of the combined tetanus-diphtheria 5-component pertussis vaccine or its competitor vaccine for adolescents.




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Symptom Experience After Discontinuing Use of Estrogen Plus Progestin

Interview with Judith K. Ockene, PhD, MEd, author of Symptom Experience After Discontinuing Use of Estrogen Plus Progestin, published in the July 13 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Of the women who stopped E plus P, 21.2% had menopausal symptoms (hot flashes or night sweats) after stopping study medication compared to 4.8% of women who were on placebo. 2. Of the women who had menopausal symptoms when they started the study (about 12%) and were in the active hormone group, over 50% had a recurrence of symptoms after they stopped MHT compared to 21% of placebo users who had a recurrence of symptoms. 3. Women in the E plus P group reported higher rates of pain or stiffness (36.8%) after they stopped study medication compared to women who had been on placebo (22.2%). 4. Women who had symptoms after they stopped study medication reported using a wide range of strategies to manage symptoms and a large proportion found the strategies to be helpful.




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Clinical Decision Support and Appropriateness of Antimicrobial Prescribing: A Randomized Trial

Interview with Matthew H. Samore, MD, author of Clinical Decision Support and Appropriateness of Antimicrobial Prescribing: A Randomized Trial, published in the November 9 issue of JAMA, the Journal of the American Medical Association. Summary points: 1. Repetitive use of a diagnostic and treatment algorithm to ingrain new prescribing habits was a valuable part of this practice change intervention. 2. Clinical decision support systems (CDSS) are feasibly implemented in practice settings that lack electronic medical records, including rural communities. 3. CDSS needs to be integrated with tools that save clinicians' time to be sustainable.




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Progress in Multiple Sclerosis Research: An Example of Bedside to Bench

This Viewpoint attributes improved understanding of the role of autoantibodies and B-cell activity in MS pathogenesis and the development of effective therapies to the ability of physician-scientists to bring clinical insights to laboratory research and it emphasizes the importance of supporting and encouraging these investigators to reinvigorate science at the bedside.




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The Equitable Distribution of COVID-19 Therapeutics and Vaccines

This Viewpoint proposes a framework for international cooperation among governments and organizations to replace competition and hoarding with equitable global distribution of COVID-19 therapeutics and vaccines as they are developed.




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Surgery in a Time of Uncertainty—The Need for Universal Respiratory Precautions in the Operating Room

This Viewpoint proposes that universal respiratory precautions in the operating room—use of respirators with face masks and eye protection—could protect staff from possible coronavirus disease 2019 (COVID-19) infection and facilitate resumption of elective surgeries canceled during the first wave of the pandemic.




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Trends in SARS-CoV-2 PCR Test Positivity Among Outpatients in Seattle and Washington State

This population epidemiology study characterizes trends in polymerase chain reaction (PCR) test positivity for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Washington State and the Seattle area between March 1 and April 16, 2020, before and after statewide physical distancing guidelines and stay-at-home orders.




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When Should Physicians Act on Non–Statistically Significant Results From Clinical Trials?

This Viewpoint discusses considerations that might lead physicians to change their practice based on RCTs reporting non–statistically significant differences in primary outcomes, including trial methodology, totality of evidence, cost, invasiveness, and labor-intensiveness of the interventions being compared.




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Doppelgänger—Parallel Struggles to Lose Weight

In this narrative medicine essay, a primary care physician describes his patient’s struggle with obesity, sees himself in his patient, and wonders if his own struggles with weight loss impede his patient’s efforts to lose weight.




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Miles Together—A Patient-Physician Journey

In this narrative medicine essay, a family physician shares the beginning and ending of a near 12-year journey with a patient, helping him reach sobriety that led to a full though short life and feeling humbled to have been so entrusted to travel with him.




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John Lennon’s Elbow: The Long, Winding Road of the EMR Progress Note

In this narrative medicine essay, an attending physician shares his observations of how the changing nature of electronic medical record (EMR) hospital progress notes—often entered out of sequence and becoming ever longer and more unreadable—can hamper interacting with patients and providing patient care.




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Crossing Boundaries—Violation or Obligation?

In this narrative medicine essay, a physician reflects on the rise of professional boundaries; on the ways in which such boundaries can in some instances foster uncaring patient-physician relationships; and on ways physicians might balance providing objective medical care and addressing social and economic injustices in the lives of their patients.




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Pimping Socrates

In this narrative medicine essay, a medical student reflects on individualized teaching practices in medicine, such as “the Socratic method,” in the context of her intervening course work related to a PhD in ancient history.




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The Greatest Generation

In this narrative medicine essay, the author discusses the inaccuracies of generational stereotypes and unfounded criticisms about trainees, and the problems that faculty members who voice these criticisms can cause among physicians.




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Questioning a Taboo

This narrative medicine essay summarizes ways in which physicians can use polite and scripted interruption to help patients effectively communicate their medical concerns, encourage further details, improve accuracy of the diagnosis, and set the agenda for the medical visit.




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Moral Choices for Today’s Physician

In this essay, Don Berwick considers moral choices physicians face personally, organizationally, and globally and exhorts them to understand that the health of humanity depends on their speaking out against the social injustice of overpricing drugs and services, mass incarceration, and the lack of environmental responsibility.




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Physician-Parents Whose Children Have Rare Diseases

In this essay, a critical care pediatric hospitalist finds herself on the other side of the office table advocating for the specific medical care needed to address her son’s rare skeletal dysplasia and her search for a pediatric specialist with whom to travel on this quest.




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A Medical Student Shares Her Struggle With Depression

In this essay, a young medical student describes her struggle with depression and how the experience of vulnerability has bred a deep compassion for her patients and peers.




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A dual-targeted CeO2–DNA nanosensor for real-time imaging of H2O2 to assess atherosclerotic plaque vulnerability

J. Mater. Chem. B, 2020, 8,3502-3505
DOI: 10.1039/C9TB02459J, Communication
Zhenhua Liu, Yujie Cao, Xiaona Zhang, Huazhen Yang, Yujie Zhao, Wen Gao, Bo Tang
A novel dual-targeted CeO2–DNA nanosensor by modifying with folic acid (FA) and CD36 antibody was designed.
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Highly efficient electrochemiluminescence of ruthenium complex-functionalized CdS quantum dots and their analytical application

J. Mater. Chem. B, 2020, 8,3598-3605
DOI: 10.1039/C9TB02463H, Paper
Xiaofei Wang, Huiwen Liu, Honglan Qi, Qiang Gao, Chengxiao Zhang
Highly efficient electrochemiluminescence of ruthenium complex-functionalized CdS quantum dots via ECL resonance energy transfer (ECL-RET) and their analytical application.
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Electrodeposition of nickel nanostructures using silica nanochannels as confinement for low-fouling enzyme-free glucose detection

J. Mater. Chem. B, 2020, 8,3616-3622
DOI: 10.1039/C9TB02472G, Paper
Jialian Ding, Xinru Li, Lin Zhou, Rongjie Yang, Fei Yan, Bin Su
This work reports an enzyme-free glucose sensor based on nickel nanostructures electrodeposited on a fluorine-doped tin oxide (FTO) electrode modified with a silica nanochannel membrane (SNM).
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Recent advances of tissue-interfaced chemical biosensors

J. Mater. Chem. B, 2020, 8,3371-3381
DOI: 10.1039/C9TB02476J, Review Article
Chuanrui Chen, Yue Guo, Peining Chen, Huisheng Peng
This review discusses recent advances of tissue interfaced chemical biosensors, highlights current challenges and gives an outlook on future possibilities.
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Glutamate detection at the cellular level by means of polymer/enzyme multilayer modified carbon nanoelectrodes

J. Mater. Chem. B, 2020, 8,3631-3639
DOI: 10.1039/C9TB02461A, Paper
Miriam Marquitan, Melanie D. Mark, Andrzej Ernst, Anna Muhs, Stefan Herlitze, Adrian Ruff, Wolfgang Schuhmann
Carbon nanoelectrodes in the sub-micron range were modified with an enzyme cascade immobilized in a spatially separated polymer double layer system for the detection of glutamate at the cellular level.
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Nucleoside-based fluorescent carbon dots for discrimination of metal ions

J. Mater. Chem. B, 2020, 8,3640-3646
DOI: 10.1039/C9TB02758K, Paper
Tieli Zhou, Jinyi Zhang, Biwu Liu, Shihong Wu, Peng Wu, Juewen Liu
Using nucleosides and citrate as starting materials, a series of fluorescent carbon dots were synthesized showing different quenching properties by metal ions for their detection by a sensor array.
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Advances in functional nucleic acid based paper sensors

J. Mater. Chem. B, 2020, 8,3213-3230
DOI: 10.1039/C9TB02584G, Review Article
Rudi Liu, Erin M. McConnell, Jiuxing Li, Yingfu Li
This article provides an extensive review of paper-based sensors that utilize functional nucleic acids, particularly DNA aptamers and DNAzymes, as recognition elements.
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Boosting biomolecular interactions through DNA origami nano-tailored biosensing interfaces

J. Mater. Chem. B, 2020, 8,3606-3615
DOI: 10.1039/C9TB02439E, Paper
Iene Rutten, Devin Daems, Jeroen Lammertyn
Nano-tailored DNA origami designs nanostructure the bioreceptor layer of encoded microparticles in an innovative microfluidic platform, hereby boosting biomolecular interactions.
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From design to applications of stimuli-responsive hydrogel strain sensors

J. Mater. Chem. B, 2020, 8,3171-3191
DOI: 10.1039/C9TB02692D, Review Article
Dong Zhang, Baiping Ren, Yanxian Zhang, Lijian Xu, Qinyuan Huang, Yi He, Xuefeng Li, Jiang Wu, Jintao Yang, Qiang Chen, Yung Chang, Jie Zheng
Stimuli-responsive hydrogel strain sensors that synergize the advantages of both hydrogel and smart functional materials have attracted increasing interest from material design to emerging applications in health monitors and human–machine interfaces.
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Wearable biochemical sensors for human health monitoring: sensing materials and manufacturing technologies

J. Mater. Chem. B, 2020, 8,3423-3436
DOI: 10.1039/C9TB02474C, Review Article
Guanglei Li, Dan Wen
Recent achievements and challenges in materials and manufacturing technologies of sensing electrodes in wearable biosensors have been highlighted.
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Silver nanoprism-based plasmonic ELISA for sensitive detection of fluoroquinolones

J. Mater. Chem. B, 2020, 8,3667-3675
DOI: 10.1039/C9TB02776A, Paper
Meifang Yuan, Qirong Xiong, Ganggang Zhang, Zhijuan Xiong, Daofeng Liu, Hongwei Duan, Weihua Lai
Silver nanoprism-based plasmonic ELISA for qualitative and quantitative detection of fluoroquinolones.
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Aptamer-based nanostructured interfaces for the detection and release of circulating tumor cells

J. Mater. Chem. B, 2020, 8,3408-3422
DOI: 10.1039/C9TB02457C, Review Article
Pi Ding, Zhili Wang, Zeen Wu, Weipei Zhu, Lifen Liu, Na Sun, Renjun Pei
This paper summarizes various aptamer-functionalized nanostructured interfaces for the detection and release of circulating tumor cells.
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Novel perylene probe-encapsulated metal–organic framework nanocomposites for ratiometric fluorescence detection of ATP

J. Mater. Chem. B, 2020, 8,3661-3666
DOI: 10.1039/C9TB02319D, Paper
Xiaomeng Zhou, Juanmin Li, Li-Li Tan, Qiang Li, Li Shang
Schematic illustration of PDI@ZIF-8 nanocomposite synthesis and ratiometric fluorescence assay for ATP sensing. 2-MIm: 2-methylimidazole.
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Stretchable and tough conductive hydrogels for flexible pressure and strain sensors

J. Mater. Chem. B, 2020, 8,3437-3459
DOI: 10.1039/C9TB02570G, Review Article
Zhenwu Wang, Yang Cong, Jun Fu
This review summarises recent advances in stretchable and tough conductive hydrogel sensors for wearable and implantable devices.
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Enhanced biosensing strategies using electrogenerated chemiluminescence: recent progress and future prospects

J. Mater. Chem. B, 2020, 8,3192-3212
DOI: 10.1039/C9TB02578B, Review Article
Rashaad A. Husain, Snigdha Roy Barman, Subhodeep Chatterjee, Imran Khan, Zong-Hong Lin
An overview of enhancement strategies for highly sensitive ECL-based sensing of bioanalytes enabling early detection of cancer.
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A perylenetetracarboxylic dianhydride and aniline-assembled supramolecular nanomaterial with multi-color electrochemiluminescence for a highly sensitive label-free immunoassay

J. Mater. Chem. B, 2020, 8,3676-3682
DOI: 10.1039/C9TB02368B, Paper
Wei Zhang, Yue Song, Yunyun Wang, Shuijian He, Lei Shang, Rongna Ma, Liping Jia, Huaisheng Wang
A novel multi-color ECL nanomaterial assembled from 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA) and aniline (An) was used for highly sensitive label-free CEA detection.
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Assessing the range of enzymatic and oxidative tunability for biosensor design

J. Mater. Chem. B, 2020, 8,3460-3487
DOI: 10.1039/C9TB02666E, Review Article
Hattie C. Schunk, Derek S. Hernandez, Mariah J. Austin, Kabir S. Dhada, Adrianne M. Rosales, Laura J. Suggs
This review aims to inspire novel biosensor design by addressing materials chemistries through the lense of enzymatic and oxidative susceptibility in the spectra of inflammatory disease biomarkers.
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A general strategy for designing NIR-II emissive silk for the in vivo monitoring of an implanted stent model beyond 1500 nm

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/C9TB02685A, Paper
Zhiming Deng, Junqing Huang, Zhenluan Xue, Mingyang Jiang, Youbin Li, Songjun Zeng
The NIR-II emissive silk is explored by a general feeding strategy for NIR-II imaging guided in situ monitoring of the implanted biological stent model made from silk.
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Development of CeO2 nanodot encrusted TiO2 nanoparticles with reduced photocatalytic activity and increased biocompatibility towards a human keratinocyte cell line

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00629G, Paper
Alexander Morlando, Marcela Chaki Borrás, Yaser Rehman, Shahnaz Bakand, Philip Barker, Ronald Sluyter, Konstantin Konstantinov
Low photocatalytic CeO2/TiO2 nanocomposite particles with high UV attenuation and reduced ROS generation for application in sunscreen products.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Recent progress of SERS optical nanosensors for miRNA analysis

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00280A, Review Article
Yudie Sun, lin shi, Lan Mi, Ruiyan Guo, Tao Li
This review focus on emerging applications of surface-enhanced Raman spectroscopy (SERS) optical nanosensors for miRNA analysis, in which the key enhancement factors of SERS signal, i.e. SERS-active substrates, SERS nanoprobes...
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Stable Anchoring of Bacteria-based Protein Nanoparticles for Surface Enhanced Cell Guidance

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00702A, Paper
Open Access
Imma Ratera, Marc Martínez-Miguel, Adriana Kyvik, Lena Montaña, Albert Martínez-Moreno, Olivia Cano-Garrido, Elena Garcia-Fruitos, Esther Vazquez, Nora Ventosa, Judith Guasch, Jaume Veciana, Antonio Villaverde
In tissue engineering, biological, physical, and chemical inputs have to be combined to properly mimic cellular environments and successfully build artificial tissues, which can be designed to fulfil different biomedical...
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Mechanically robust enzymatic degradable shape memory polyurethane urea with rapid recovery response induced by NIR

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00798F, Paper
Xin Li, Wenkai Liu, Yaomin Li, Wanling Lan, Daiguo Zhao, Hecheng Wu, Yuan Feng, Xueling He, Zhen Li, Jiehua Li, Feng Luo, Hong Tan
Biodegradable shape memory polymers have great potential using in minimally invasive surgical procedures. Herein, a series of shape memory polyurethanes (SMPUs) containing chymotrypsin-inspired chain extenders with adjustable mechanical properties and...
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Design principles and fundamental understanding of biosensors for amyloid-β detection

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00344A, Review Article
Yanxian Zhang, Baiping Ren, Dong Zhang, Yonglan Liu, Mingzhen Zhang, Chao Zhao, Jie Zheng
Aβ as biomarker in Alzheimer’s disease (AD) drives the significant research efforts for developing different biosensors with different sensing strategies, materials, and mechanisms for Aβ detection.
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Development of mucoadhesive cationic polypeptide micelles for sustained cabozantinib release and inhibition of corneal neovascularization

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00874E, Paper
Haijie Han, Qichuan Yin, Xiajing Tang, Xiaoning Yu, Qiang Gao, Yelei Tang, Andrzej Grzybowski, Ke Yao, Jian Ji, Xingchao Shentu
Corneal neovascularization (CNV) is one of the leading risk factors for vision loss. Anti-angiogenic drugs can theoretically be extended to the treatment of CNV. However, the application of these drugs...
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The rise of bio-inspired polymer compartments responding to pathology related signals

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00475H, Perspective
Open Access
Luisa Zartner, Moritz Sylvester Muthwill, Ionel Adrian Dinu, Cora-Ann Schoenenberger, Cornelia G. Palivan
Self-organized nano- and microscale polymer compartments (polymersomes, GUVs, PICsomes and LbL capsules) have increasing potential in many sensing applications. In this review, we highlight the key role they play in...
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Multi-Stimuli Responsive Polymeric Prodrug Micelles for Combined Chemotherapy and Photodynamic Therapy

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00539H, Paper
Cheng Hu, Weihua Zhuang, Tao Yu, Liang Chen, Zhen Liang, Gaocan Li, Yunbing Wang
Nowadays, cancer therapy faces severe challenges on boosting therapeutic efficiency and reducing the side effects of drugs. To overcome these challenges, herein multifunctional polymeric prodrug micelles with combining chemotherapy and...
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