1. Evening brief: BJP asks Delhi govt to close schools amid rising AQI; IMA condemns attack on doctor in Chennai; and more  Hindustan Times
2. Smog Blanket Over North India, Air Quality Drops To "Severe" Level  NDTV
3. BJP targets govt on pollution, AAP says don’t play politics  The Times of India
4. Delhi overtakes Lahore to become world's most polluted city  The Economic Times
5. City In Greyscale: Season’s First Fog, ‘Severe’ Air Day  The Times of India

Extracellular vesicles (EVs) released by various cells play crucial roles in intercellular communication within the respiratory system. This review explores the historical context and significance of research into extracellular vesicles. Categorised into exosomes (sized 30–150 nm), microvesicles (sized 50–1000 nm) and apoptotic bodies (sized 500–2000nm), based on their generation mechanisms, extracellular vesicles carry diverse cargoes of biomolecules, including proteins, lipids and nucleic acids. Respiratory ailments are the primary contributors to both mortality and morbidity across various populations globally, significantly impacting public health. Recent studies have underscored the pivotal role of extracellular vesicles, particularly their cargo content, in mediating intercellular communication between lung cells in respiratory diseases. This comprehensive review provides insights into extracellular vesicle mechanisms and emphasises their significance in major respiratory conditions, including acute lung injury, COPD, pulmonary hypertension, pulmonary fibrosis, asthma and lung cancer.

Publisher Chucklefish and developer Robust Games announced the point-and-click puzzle game, Loco Motive, will launch for the Nintendo Switch and PC via Steam and GOG n November 21 for $17.99 / £14.99 / €17.99.

"Were thrilled to get Loco Motive into the hands of players!” said Robust Games creative director and co-founder Adam Riches. "From the humble origins of a simple game jam to a fully fledged adventure in its own right, the last few years have been a whirlwind."

Robust Games technical director and co-founder Joseph Riches added, "My brother and I always wanted to create something together, and we’re very grateful to have had that opportunity. There was an unrelenting drive to make Loco Motive happen, and it’s our hope that players will see our passion and love for the genre reflected in this game."

View the release date trailer below:

Read details on the game below:

Welcome aboard the Reuss Express, a journey of a life-time derailed by an unexpected assassination.

On the eve of a landmark speech by the wealthy heiress Lady Unterwald, a straight-laced lawyer, a crime novelist-turned rookie detective, and an undercover spy find themselves embroiled in a murder, a mystery, and worst of all… an adventure! Now stuck onboard a luxurious steam train, within stabbing distance of a cold-blooded killer, the race is on to prove their innocence once and for all!

Play as Diana, Arthur and Herman to unwrap the mystery and put your point and click puzzle-solving skills to the test...

Features:

• A comedy adventure that hits like smooth jazz, set onboard a 1930s express train
• Take control of three playable characters, in an interlinking comedic adventure
• Uncover a deadly mystery, full of twists, turns and slapstick humour
• Meet a train-full of quirky and somewhat suspicious fellow passengers
• Stop at nothing to solve item-based puzzles, that won’t leave you head-scratching for hours
• Choose how you play - take direct interactive character control, or opt for a classic point and click experience
• Beautifully detailed pixel art animations
• Need a little nudge in the right direction? Telephone for assistance with an in-game hint call-line!
• With the slinky sounds of composer Paul Zimmermann (Wildfrost, Space Haven)
• Voice Acting!

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463050/loco-motive-releases-november-21-for-switch-and-pc/

Microsoft Gaming CEO Phil Spencer speaking with Bloomberg revealed Xbox is still open to acquiring more publishers and developers.

"We definitely want to be in the market, and when we can find teams and technology and capability that add to what we're trying to do in gaming at Microsoft, absolutely we will keep our heads up," said Spencer.

Spencer added no deals were "imminent" and any that might happen won't be on the scale of Activision Blizzard.

China is a potential area for acquisitions, according to Spencer. 

"It’s been a good area for us to learn from creative teams that have real unique capability," he said. "The real opportunity is to partner with creative teams in China for global."

Xbox in recent years has acquired Activision Blizzard, Bethesda parent company ZeniMax, and over a dozen other studios.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463054/xbox-is-still-open-to-acquiring-more-publishers-and-developers/

Microsoft Gaming CEO Phil Spencer speaking with Bloomberg confirmed Xbox is working on prototypes for a handheld Xbox, however, any device is at least a few years away from release.

Spencer wants the Xbox hardware team to analyze the handheld market, which includes the Nintendo Switch, the Steam Deck, and more. He wants the team to "develop its vision based on what it learns."

In the short term, Spencer wants Xbox to focus on making its app work better on current portable devices and to partner with hardware manufacturers to ensure Xbox products sync.

"Longer term, I love us building devices," he said. "And I think our team could do some real innovative work, but we want to be informed by learning and what’s happening now."

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463056/spencer-xbox-working-on-prototype-handhelds-any-device-is-a-few-years-out/

SUCCESS Corporation announced the twin-stick roguelite shooter, HEAVEN SEEKER: The Savior of This Cruel World, will launch for the PlayStation 5, PlayStation 4, and Nintendo Switch on December 5.

Read details on the game below:

HEAVEN SEEKER: The Savior of This Cruel World is a twin-stick roguelite shooter where you take your own shot at the castle in the sky! A dungeon with a different structure each time you enter, a variety of magic bullets—and a formidable barrage of bullets—await you.

Story

In this world, Pentagaia, there were five countries that had been transferred from five different worlds.

Magi Province, the land of wizards, where magical technology flourished. A land of priestesses and samurai, a land of warriors and the four seasons. A land of elves, with the blessings of the World Tree. A land of mechanical ingenuity, where super-science rules the world. A land of wilderness and dust, ruled by demons.

The rulers of each nation sent explorers to the Castle of Heaven, where the secrets of Pentagaia were said to lie. They did so with the longing to return to the original world. These explorers were called Heaven Seekers.

Explore a Dungeon That Changes Each Time You Enter

In this title, you move with the left stick and aim with the right stick. This is a bullet hell shooting game where you freely control your character and explore random dungeons. When your HP reaches 0, you will lose all the items you have gained during this exploration. The player gains experience by exploring many times and learning the patterns of the rooms and the nature of the enemies.

Create Your Own Magic Shot!

The shot fired by the player character can be modified by freely combining over 20 customizable items to change its properties. Since items are randomly acquired during each quest, players will fight with a different personalized shot each time they dive into a dungeon.

Dot Art Style Game Visuals

All in-game elements in this title, including player characters, enemies, and dungeons, are rendered in high-quality dot art.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463057/heaven-seeker-the-savior-of-this-cruel-world-releases-december-5-for-ps5-ps4-and-switch/

Stay up to date on the latest AI technology advancements and learn about the challenges and opportunities AI presents now and for the future.

Further excavations may reveal how ancient human populations likely interacted with each other, researchers say

1. Don’t follow self-healing methods to control diabetes, says diabetologists  The Hindu
2. Study: 100mn Indians have diabetes  The Times of India
3. The Hindu webinar on diabetes management to be held on November 13  The Hindu
4. Combat diabetes with urgent lifestyle changes: Experts  The Times of India
5. Rice University’s ROGUE device implants a ‘living pharmacy’ to combat diabetes and obesity  Express Pharma

5 rare supernova images captured by NASA's Hubble Space Telescope  India.com

1. Sunita Williams breaks silence on weight loss rumours, says THIS has 'definitely changed' her body | Mint  Mint
2. "My Body Has Changed, But....": Sunita Williams On Health Aboard Space Station  NDTV
3. After Sunita Williams, NASA now worried about her stranded mission partner's losing body mass  Hindustan Times
4. Stranded Sunita Williams dismisses severe weight loss rumours, says she feels ‘healthier than ever’  The Times of India
5. Exclusive | NASA races to stabilize astronaut Sunita Williams' weight  New York Post

1. Tata Steel Chess India - Live!  Chess News | ChessBase
2. Magnus Carlsen interview: I probably will have the most fun playing Gukesh  Hindustan Times
3. Tata Steel Chess 2024: Abdusattorov, Goryachkina lead standings; Carlsen joint-second after third rapid round  Sportstar
4. Chess tournament, Guru Nanak Jayanti and more Kolkata news in pictures  Telegraph India
5. Tata Steel Chess India Rapid and Blitz: Magnus Carlsen held to draws by Praggnanandhaa and Nihal Sarin  The Indian Express

1. Your Google Pixel Phone's Newest Android 15 Beta Update Arrived  Droid Life
2. Google rolls out Android 15 QPR2 Beta 1 update  FoneArena
3. Google is preparing to bring back a beloved customization feature from Android 11  Android Authority
4. Android 15 QPR2: Do Not Disturb gets big upgrade with Modes  9to5Google
5. Android 15 QPR2 brings the Pixel 9's new Linux kernel to all Tensor-powered phones and tablets  Android Police

1. Zomato welcomes rival Swiggy on Dalal Street  The Economic Times
2. Swiggy's dollar millionaires: 70 employees to pocket over $1 million each as company delivers IPO  Moneycontrol
3. Swiggy shares surge 17% on debut, market capitalization exceeds Rs 1 lakh crore  The Times of India
4. Swiggy Share Price & IPO Listing Highlights: Swiggy shares surge 10% after listing at premium on NSE, BSE  BusinessLine
5. Swiggy's IPO debut sees strong gains, but competition challenges loom  Business Standard

1. IndiGo, Air India cancel flights to and from Bali after volcanic eruption: ‘Ash clouds may impact air travel’ | Today News  Mint
2. Deadly volcano still erupting near Indonesian holiday island: IndiGo, Air India cancel Bali flights  Moneycontrol
3. Bali volcano eruption: Tourists stranded after ash clouds from Mount Lewotobi Laki-laki force flight canc  The Times of India
4. Indonesia's volcanic eruption grounds flights on tourist island of Bali  Business Standard
5. International airlines cancel Bali flights amid ongoing volcanic eruptions in Indonesia  The Financial Express

1. John Thune elected Senate majority leader, Florida Sen. Rick Scott’s bid comes up short  Florida’s Voice
2. John Thune elected Senate Majority Leader  CNBC
3. Republican John Thune, who once sparred with Trump, elected as next Senate majority leader  Hindustan Times
4. Latest News Today Live Updates November 13, 2024: Big GOP leadership change: John Thune named next Senate Republican leader  Mint
5. US Senate Republicans pick insider John Thune as their next leader  Reuters

1. HIGHLIGHTS | Jharkhand Assembly elections |Phase 1 sees voter turnout of 64.86 per cent  The New Indian Express
2. Jharkhand Phase-I Assembly poll records over 65% turnout; Wayanad bypoll 64.72%  The Hindu
3. Despite Maoist threats, Jharkhand records 64.86 per cent voter turnout during first phase of polling  The New Indian Express
4. Craze to capture video of MS Dhoni and wife Sakshi casting vote in Ranchi reaches new heights  Hindustan Times
5. Jharkhand elections: MS Dhoni casts his vote in Ranchi  India Today

The upcoming season, created by Sam Levinson, will consist of eight episodes and is expected to include a time jump that catches up with the characters in new stages of their turbulent lives

Seven years after transitioning from Malayalam playback to the world of ghazals, Gayatri Asokan is set to release yet another track, ‘Kitne Aish Se Rahte Honge’, inspired by the poetry of Jaun Elia

The unscripted Telugu Original eight-episode series will feature a host of guests, including Dulquer Salmaan, Naga Chaitanya Akkineni, Siddhu Jonnalagadda, Sree Leela, Nani, S.S. Rajamouli and Ram Gopal Varma

Directed by Haneef Adeni, ‘Marco’ is a spin-off of Unni’s character in the director’s 2019 film, ‘Mikhael’

The second film in the ‘Black Panther’ series grossed over USD 850 million globally, marking a major milestone for the franchise in the wake of the tragic death of Chadwick Boseman

‘Aitraaz’ starred Akshay Kumar, Priyanka Chopra Jonas and Kareena Kapoor Khan

The feverish Cannes-winning spectacle dazzles with audacity but stumbles under the weight of its own ambition

Justices G. Jayachandran and C.V. Karthikeyan clear the decks after the producer deposits ₹6.41 crore on Wednesday

Actor said he won’t be ‘rushing’ to watch it after hearing about scene

Season 33 welcomed a new cast of celebrity contestants all competing for the coveted Mirrorball trophy

Artificial intelligence is rapidly transforming industries and is now accessible to small and medium-sized businesses (SMBs). According to Forbes, 91% of SMBs that have implemented AI report improved business success. The benefits of AI extend beyond enhanced customer experiences to include significant cost savings, revenue growth and a competitive edge. However, the journey to effective AI implementation can be challenging for many businesses. Avoiding AI roadblocks For SMBs with limited resources,…

The body of a 52-year-old man was discovered in his Toa Payoh flat last Sunday (Nov 10), several days after his death. The police told AsiaOne they were alerted to the case at 11.15am on Sunday, where they pronounced the man dead at the scene. It is not known when he died.  The man, Bai Zongren (transliteration), had been living alone in his unit at Block 157 Toa Payoh Lorong 1 for several years after divorcing his wife, according to a neighbour who spoke to Shin Min Daily News. He also had a daughter, who moved out with his ex-wife after they split.  The neighbour, who did not want to be named, added that Bai would occasionally get visits from relatives. "His mother used to live on the fifth floor, but she died a few years ago."  The neighbour told Shin Min that she was unaware of Bai's death when she passed by his unit several days ago. As Bai's door was locked, she assumed the flat was empty.  When she passed by his unit again on Saturday, she detected a foul smell but thought that it was from wastewater. She said she only found out about his death when she saw the police at his door.

NEW DELHI — A toxic haze enveloped India's national capital on the morning of Nov 13 as temperatures dropped and pollution surged, reducing visibility in some parts and prompting a warning from airport authorities that flights may be affected. Delhi overtook Pakistan's Lahore as the world's most polluted city in Swiss group IQAir's live rankings, with an air quality index (AQI) score of more than 1,000, considered "hazardous", but India's pollution authority said the AQI was around 350. Officials were not immediately available to explain the variation. Vehicles drive on a highway on a polluted smoggy morning in New Delhi, India, Nov 7, 2024. PHOTO: Reuters file The India Meteorological Department (IMD) said the pollution had reduced visibility to 100 metres in some places by around 8am local time.

DENPASAR, Indonesia — Several international airlines cancelled flights to and from Indonesia's resort island of Bali on Wednesday (Nov 13), after further eruptions of a volcano that has spewed ash clouds as high as 10km and forced thousands to evacuate. Jetstar and Qantas said they had stopped flights to Bali on Wednesday for safety reasons because of volcanic ash, while plane tracking website Flightradar24 showed flights to the island by AirAsia and Virgin were also cancelled. Bali is Indonesia's top tourist hotspot and is a popular destination for Australian visitors. The first eruption of the Mount Lewotobi Laki-laki on Nov 3 in the East Nusa Tenggara province, about 800 km from Bali, killed at least nine people. It has since erupted repeatedly, including multiple times on Tuesday. From Nov 4 to Nov 12, 80 flights in Bali were cancelled, including from Singapore, Hong Kong, and several Australian cities, said Ahmad Syaugi Shahab, general manager of Bali's Ngurah Rai airport. Indonesia has close to 130 active volcanoes and sits on the Pacific "Ring of Fire", an area of high seismic activity atop various tectonic plates.

Immigrant rights lawyers are preparing to fight back against Donald Trump’s plans to carry out the largest mass deportation in U.S. history once he takes office again in January. The president-elect has already named some leading anti-immigration figures for his incoming administration who will lead the plan, including former ICE head Tom Homan and his longtime aide Stephen Miller. Trump’s picks were central in family separations, the Muslim ban, attacks on Deferred Action for Childhood Arrivals, or DACA, and other anti-immigrant policies during the first Trump administration. Trump is also reportedly planning to greatly expand immigrant detention in private for-profit prisons, and during the campaign he spoke of invoking the Alien Enemies Act of 1798 to speed up deportations. “We have been preparing nearly a year for this,” says attorney Lee Gelernt, deputy director of the ACLU Immigrants’ Rights Project, who argued some of the most high-profile immigration cases during the first Trump administration. He stresses that while groups like the ACLU will challenge the Trump administration in the courts, “it needs to be a national effort” to prevent abuses. “We are not opposed to basic immigration reform, but this cannot be a situation where we’re just going after immigrants left and right.”

Environmental defenders are raising alarm over Donald Trump’s pick to lead the Environmental Protection Agency, former New York Congressmember Lee Zeldin, who has a history of opposing critical environmental protections and clean energy job investments. Zeldin’s nomination comes as Trump is reportedly discussing moving the EPA headquarters outside of Washington, D.C., which could lead to an exodus of staff and expertise from the agency. “I really don’t think this is about government efficiency. I think this is about terrorizing the career staff,” says Judith Enck, who served as a regional administrator of the EPA in the Obama administration.

Respected Members I have a genuine question regarding Equity Shares in the Secondary Markets in India .Mr. A and his wife Mrs A have DEMAT account since 2007 and both of them have invested in BSE and NSE listed companies' equity shares over the years since 2007 .

Hello everyone,I've recently transitioned into freelancing in IT (software development & support) after a decade in a salaried role. I've learned that I may need to register for GST and apply for an LUT. Could anyone guide me on the key steps I should take? I currently have one US-ba

agar hum jis party se 50000 se upar ke goods purchase kar rahe hai aur usi party se delivery bhi karwa rahe hai to is case hum party se bolte hai ki customer ko bill na de hum apna bill de rahe hai to kya hume bhi e-way bill banana zaruri hai kyunki jo party goods delivery kar raha hai usne bhi e-way bill generate kiya hoga same address par jis par hum apna bill de rahe h?

FiveThirtyEight founder and editor-in-chief Nate Silver said in a blog post

Indian-American women politicians are making a mark in this year's general elections in the US with Democrat Kamala Harris all set to be elected as the first Senator from the community.

Democratic presidential nominee Hillary Clinton leads her Republican rival Donald Trump by 4% points, a latest national opinion poll said on Sunday, two days ahead of the crucial US general elections.

An unprecedented 'desi' wave hit the US general elections as a record number of five Indian- Americans were all set to be elected to the US Congress today.

Indian-American Democrat Raja Krishnamoorthi today won the Congressional election from Illinois, defeating Republican former Elmhurst Mayor Peter DiCianni.

With four Indian-Americans, including two women, elected to the US Congress, euphoric community members said that the unprecedented victory shows they have become part of the mainstream political landscape.