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Video: Mille Johnset - 2024 DH World Cup Highlights Video



We're already counting down the days until the 2025 DH season kicks off.




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Transition Releases New Youth MTB Lineup



A new 20” hardtail, a redesigned 24” full suspension, and a 27.5” young adult full suspension bike.
( Photos: 8, Comments: 40 )




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Review: Silt's $400 Enduro Alloy Wheelset



The Silt Enduro Wheels offer a lot of what riders want - value, service features, and reliability.
( Photos: 5, Comments: 26 )




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Pinkbike's 2024 Community Survey: What Parts do Pinkbike Users Use?



And how have they changed over the past few years?
( Photos: 2, Comments: 72 )




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Review into rail fare-dodging enforcement after ‘egregious’ prosecutions

‘Where people have made genuine mistakes they shouldn’t be prosecuted’ says transport secretary Louise Haigh




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New CrossCountry train service will directly connect Wales, England and Scotland for the first time

The service will run between Edinburgh and Cardiff passing through Birmingham New Street




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New Study On Moons of Uranus Raises Chance of Life

A new analysis of data from NASA's Voyager 2 mission reveals that the planet Uranus and its five largest moons might harbor subsurface oceans and potential conditions for life. The BBC reports: Much of what we know about them was gathered by Nasa's Voyager 2 spacecraft which visited nearly 40 years ago. But a new analysis shows that Voyager's visit coincided with a powerful solar storm, which led to a misleading idea of what the Uranian system is really like. [...] So, for 40 years we have had an incorrect view of what Uranus and its five largest moons are normally like, according to Dr William Dunn of University College London. "These results suggest that the Uranian system could be much more exciting than previously thought. There could be moons there that could have the conditions that are necessary for life, they might have oceans below the surface that could be teeming with fish!". It has been nearly 40 years since Voyager 2 last flew past the icy world and its moons. Nasa has plans to launch a new mission, the Uranus Orbiter and Probe, to go back for a closer look in 10 years' time. According to Nasa's Dr Jamie Jasinski, whose idea it was to re-examine the Voyager 2 data, the mission will need to take his results into account when designing its instruments and planning the scientific survey. "Some of the instruments for the future spacecraft are very much being designed with ideas from what we learned from Voyager 2 when it flew past the system when it was experiencing an abnormal event. So we need to rethink how exactly we are going to design the instruments on the new mission so that we can best capture the science we need to make discoveries." Nasa's Uranus probe is expected to arrive by 2045, which is when scientists hope to find out whether these far-flung icy moons, once thought of as being dead worlds, might have the possibility of being home to life. The findings have been published in the journal Nature Astronomy.

Read more of this story at Slashdot.




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Canada Passes New Right To Repair Rules With the Same Old Problem

An anonymous reader quotes a report from The Register: Royal assent was granted to two right to repair bills last week that amend Canada's Copyright Act to allow the circumvention of technological protection measures (TPMs) if this is done for the purposes of "maintaining or repairing a product, including any related diagnosing," and "to make the program or a device in which it is embedded interoperable with any other computer program, device or component." The pair of bills allow device owners to not only repair their own stuff regardless of how a program is written to prevent such non-OEM measures, but said owners can also make their devices work with third-party components without needing to go through the manufacturer to do so. Bills C-244 (repairability) and C-294 (interoperability) go a long way toward advancing the right to repair in Canada and, as iFixit pointed out, are the first federal laws anywhere that address how TPMs restrict the right to repair -- but they're hardly final. TPMs can take a number of forms, from simple administrative passwords to encryption, registration keys, or even the need for a physical object like a USB dongle to unlock access to copyrighted components of a device's software. Most commercially manufactured devices with proprietary embedded software include some form of TPM, and neither C-244 nor C-294 place any restrictions on the use of such measures by manufacturers. As iFixit points out, neither Copyright Act amendments do anything to expand access to the tools needed to circumvent TPMs. That puts Canadians in a similar position to US repair advocates, who in 2021 saw the US Copyright Office loosen DMCA restrictions to allow limited repairs of some devices despite TPMs, but without allowing access to the tools needed to do so. [...] Canadian Repair Coalition co-founder Anthony Rosborough said last week that the new repairability and interoperability rules represent considerable progress, but like similar changes in the US, don't actually amount to much without the right to distribute tools. "New regulations are needed that require manufacturers and vendors to ensure that products and devices are designed with accessibility of repairs in mind," Rosborough wrote in an op-ed last week. "Businesses need to be able to carry out their work without the fear of infringing various intellectual property rights."

Read more of this story at Slashdot.




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Secret Service Says You Agreed To Be Tracked With Location Data

An anonymous reader shares a report: Officials inside the Secret Service clashed over whether they needed a warrant to use location data harvested from ordinary apps installed on smartphones, with some arguing that citizens have agreed to be tracked with such data by accepting app terms of service, despite those apps often not saying their data may end up with the authorities, according to hundreds of pages of internal Secret Service emails obtained by 404 Media. The emails provide deeper insight into the agency's use of Locate X, a powerful surveillance capability that allows law enforcement officials to follow a phone, and person's, precise movements over time at the click of a mouse. In 2023, a government oversight body found that the Secret Service, Customs and Border Protection, and Immigration and Customs Enforcement all used their access to such location data illegally. The Secret Service told 404 Media in an email last week it is no longer using the tool. "If USSS [U.S. Secret Service] is using Locate X, that is most concerning to us," one of the internal emails said. 404 Media obtained them and other documents through a Freedom of Information Act (FOIA) request with the Secret Service.

Read more of this story at Slashdot.




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Connor McGregor tells court sex with rape accuser was consensual

Irish mixed martial artist Conor McGregor claimed to have had consensual sex with a woman who is accusing him of rape, a court has heard.




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Homebase collapses into administration with 2,000 jobs at risk

Homebase enters administration, but The Range buys up to 70 stores and the brand.




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Tata Steel Chess India Day 1: Abdussatorov Leads Carlsen, So, Narayanan - Chess.com

  1. Tata Steel Chess India Day 1: Abdussatorov Leads Carlsen, So, Narayanan  Chess.com
  2. Magnus Carlsen interview: I probably will have the most fun playing Gukesh  Hindustan Times
  3. Tata Steel Chess India - Live!  Chess News | ChessBase
  4. Abdusattorov Nodirbek leads, Magnus Carlsen close behind in India Open chess  The Times of India
  5. Indian chess has come a long way, courtesy Anand: Carlsen  The Hindu





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K2 Plugin for sh404SEF


A plugin for supporting K2 in sh404SEF.

Use the plugin to configure K2 URLs when using sh404SEF in a multitude of options.

Unlike the previous built-in implementation for sh404SEF, this new plugin provides new URL manipulation options and it has dual compatibility with K2 versions 2.7.0+ as well as the upcoming K2 version 3.

The plugin has been successfully tested with sh404SEF versions 4.6.x in Joomla 2.5 and 3.x.

Requirements

  • K2 v2.7.0 or newer
  • sh404SEF v4.6.x or newer
  • Joomla 2.5 or 3.x

Installation

  • Make sure you meet the requirements above and that K2 and sh404SEF are already present on your Joomla installation.
  • Upload the latest version of the plugin on your Joomla site.
  • Locate the plugin under the "sh404SEF ext plugins" group in the Joomla Plugin Manager.
  • Click the plugin name to edit its settings - most options are pretty self explanatory.
  • Make sure the plugin is enabled and hit "Save & Close" after you adjust settings as you see fit.
  • Clean your sh404SEF URLs cache.
  • Clean Joomla's cache if it's enabled.
  • K2 URLs should now be optimized by sh404SEF.

 

Screenshots

 




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Discover Something New at Home this Holiday Season

Filed under: , ,

Traveling "home" this holiday season? Don't fall into your old routine. Your high school hangout may be an easy go-to, but if you don't live there anymore there's a good chance you're missing out on some great new local spots. (Plus, be honest: you already know what all your classmates are up to from Facebook.)

We turned to local writers to help you rediscover your hometown over Thanksgiving and the winter holidays. Each city guide features a great new restaurant to try while you're in town, a cool neighborhood that wasn't on the radar last year or a store where you can pick up a keepsake to bring your old home back to your new home. We'll also catch you up to speed on the hot topics of conversation in each city, so you'll come back savvy enough to join the local sports banter or eat your holiday weight in Cronuts.

Click your city below to learn what's new since the last time you went home:

Continue reading Discover Something New at Home this Holiday Season

Discover Something New at Home this Holiday Season originally appeared on Gadling on Mon, 25 Nov 2013 12:15:00 EST. Please see our terms for use of feeds.

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Will You Be a Horrible Restaurant Customer This Holiday Season?

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Getty Images

So you've finished your Thanksgiving dinner and you're finally sick of turkey leftovers. It's time to get out there and hit the great new restaurant that just opened in your hometown or wherever you're spending the holidays. (FYI: Aol Travel knows the hot restaurants in cities around the U.S.)

Wherever you go, remember that there are appropriate ways to behave. And there are horrible ways to behave, as highlighted in this Montreal Gazette story by two Montreal-area restaurant servers. Among other things, they urge:

Continue reading Will You Be a Horrible Restaurant Customer This Holiday Season?

Will You Be a Horrible Restaurant Customer This Holiday Season? originally appeared on Gadling on Wed, 27 Nov 2013 16:31:00 EST. Please see our terms for use of feeds.

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Because There Aren't Enough Reasons to Visit San Diego in Winter, Now You Can Ice Skate

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Hotel Solamar
Top reasons to visit San Diego right now:

Continue reading Because There Aren't Enough Reasons to Visit San Diego in Winter, Now You Can Ice Skate

Because There Aren't Enough Reasons to Visit San Diego in Winter, Now You Can Ice Skate originally appeared on Gadling on Tue, 10 Dec 2013 15:32:00 EST. Please see our terms for use of feeds.

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Facebook, Instagram Release Top Checked-in Locations of 2013

Filed under: ,

Alamy
Photo-sharing app Instagram and Facebook, a website your parents visit, released lists of their users most checked-in locations for 2013 earlier this week.

Congratulations to Disneyland for being the top U.S. spot for Facebook check-ins and the third most photographed location on Instagram. And props to all of Canada: its most checked-in location was a hockey arena.

Here are both lists.

Continue reading Facebook, Instagram Release Top Checked-in Locations of 2013

Facebook, Instagram Release Top Checked-in Locations of 2013 originally appeared on Gadling on Fri, 13 Dec 2013 14:23:00 EST. Please see our terms for use of feeds.

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Discover Something New at Home this Holiday Season

Filed under: , ,

Traveling "home" this holiday season? Don't fall into your old routine. Your high school hangout may be an easy go-to, but if you don't live there anymore there's a good chance you're missing out on some great new local spots. (Plus, be honest: you already know what all your classmates are up to from Facebook.)

AOL Travel turned to local writers to help you rediscover your hometown over the winter holidays. Each city guide features a great new restaurant to try while you're in town, a cool neighborhood that wasn't on the radar last year or a store where you can pick up a keepsake to bring your old home back to your new home. AOL Travel also will catch you up to speed on the hot topics of conversation in each city, so you'll come back savvy enough to join the local sports banter or eat your holiday weight in Cronuts.

Click your city below to learn what's new since the last time you went home:

Continue reading Discover Something New at Home this Holiday Season

Discover Something New at Home this Holiday Season originally appeared on Gadling on Wed, 18 Dec 2013 11:04:00 EST. Please see our terms for use of feeds.

Permalink | Email this | Comments




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Off-Broadway Comedy 'Craving for Travel' Showcases Travel Agents Trying to do the Impossible

Filed under: , ,

Facebook/Craving for Travel

Joanne and Gary, rival travel agents compete for their industry's top honor, the Globel Prize, while trying to address their clients' impossible demands in an Off-Broadway comedy that debuts this week, "Craving for Travel."

The 85-minute, two-actor, 30-character comedy was commissioned and produced by Jim Strong, president of the Dallas-based Strong Travel Services travel agency.

"Travel agents are always asked to do the impossible, and this play shows how that is done, from finding the impossible rooms to making dreams come true," Strong told the "Dallas Morning News." "I decided to bring it to life on stage as a comedy in New York."

From "Craving for Travel's" press release:

With their reputations on the line, travel agents Joanne and Gary will tackle any request, no matter how impossible, and any client, no matter how unreasonable. Full of overzealous travelers, overbooked flights, and hoteliers who are just over it, Craving for Travel reminds us why we travel-and everything that can happen when we do.

"Craving for Travel" opens Thursday at the Peter J. Sharp Theater, where it'll run through Feb. 9. Tickets are $32.50 and $49. They can be purchased at CravingForTravel.com, 212-279-4200 or the Ticket Central Box Office (416 W. 42nd St., 12-8 p.m. daily). More than half of the shows are already sold out.

Continue reading Off-Broadway Comedy 'Craving for Travel' Showcases Travel Agents Trying to do the Impossible

Off-Broadway Comedy 'Craving for Travel' Showcases Travel Agents Trying to do the Impossible originally appeared on Gadling on Tue, 07 Jan 2014 10:19:00 EST. Please see our terms for use of feeds.

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$7.2 Million Cash Found in Suitcases at Panama City Airport

Filed under: , , ,

Newsy
Travel tip: If you're trying to smuggle cash into Panama, start using the train.

Three Honduran men were arrested at Panama City's international airport after police found $7.2 million, mostly in $100 bills, in secret compartments in eight pieces of luggage. According to this video from Newsy (Newsy? Really? Really.), officials in Panama believe the money was connected to a drug cartel. Thirty-two officers and airport security staffers have been suspended as a result of the find.

Continue reading $7.2 Million Cash Found in Suitcases at Panama City Airport

$7.2 Million Cash Found in Suitcases at Panama City Airport originally appeared on Gadling on Fri, 17 Jan 2014 17:04:00 EST. Please see our terms for use of feeds.

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Rockies' youth could fill offseason departures

This time of year you read a lot about championship windows -- a way of thinking that seems to be standard operating procedure, whether clubs are in small or big markets. Well, the Rockies don't believe in that concept.




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Inbox: How will Rox use McMahon this year?

How do you see the Rockies utilizing Ryan McMahon this season? Beat reporter Thomas Harding answers this question and more from fans in the latest Rockies Inbox.




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Freeland looking to expand arsenal

Rockies left-hander Kyle Freeland plans to expand his arsenal and attack hitters in every quadrant of the strike zone this season.




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Uniform patch to mark 150 years of pro baseball

All 30 Major League teams will wear special "MLB 150" patches on their uniforms for the entire 2019 season in honor of the 150th anniversary of the 1869 Cincinnati Red Stockings, the first openly all-salaried professional baseball team.




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Rox's catchers looking to step up offense

Somewhere within any conversation, Rockies catchers will note the team's strong starting pitching and 91 wins last season. But they understand that more offense from their position can facilitate more winning.




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Arenado won't set hard deadline on negotiations

Rockies third baseman Nolan Arenado said Thursday he won't make Opening Day a hard deadline for negotiations on a possible multiyear contract.




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Arenado: Manny deal 'really good for baseball'

The baseball field is Rockies third baseman Nolan Arenado's refuge from contract talks. But Tuesday's breaking news -- Manny Machado's 10-year, $300 million contract with the Padres -- made its way onto the field.




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Call for a review of services for people with neurological disorders




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A real opportunity to improve neurology services in England




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Assessment and management of facial nerve palsy




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US drug makers have imposed big price rises for top selling drugs, study finds




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Australian neuroscientist given two year suspended sentence for falsifying Parkinson's research




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Seven days in medicine: 8-14 June 2016




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Disease modifying therapies for relapsing multiple sclerosis




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Potential role for BCG in treatment of autoimmune diseases




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Projecting Vlad Jr.'s first 10 seasons

If Vladimir Guerrero Jr. can handle the hot corner -- at least for a while -- that would be gravy. The real attraction is the bat, and if these projections are any indication, it may be a special one.




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Jansen among biggest prospect bargains

Considering the players that get the big bucks often get most of the attention when they are signed and drafted, let's take some time to look at the other end of the spectrum. Here are the biggest steals on the Top 100 Prospects list.




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Uniform patch to mark 150 years of pro baseball

All 30 Major League teams will wear special "MLB 150" patches on their uniforms for the entire 2019 season in honor of the 150th anniversary of the 1869 Cincinnati Red Stockings, the first openly all-salaried professional baseball team.




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Sanchez impresses in first spring bullpen

Blue Jays manager Charlie Montoyo was so impressed with Aaron Sanchez's first bullpen session of the spring that it would have been almost impossible to wipe the smile off his face afterwards.




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Vlad Jr. draws praise upon spring arrival

The Blue Jays' biggest star arrived Saturday morning when top prospect Vladimir Guerrero Jr. officially reported to Spring Training. Guerrero took part in a few rounds of batting practice and hit at least one ball out of the park. The Dominican native is expected to speak to the media Monday for the first time this spring as he sets out to begin his first full Major League Spring Training.




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Correspondence on 'Dispute arises over World Professional Association for Transgender Health’s involvement in WHO’s trans health guideline' by Jennifer Block




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Disinformation enabled Donald Trump’s second term and is a crisis for democracies everywhere

Donald Trump did not win the 2020 election, but asserting that he did became a prerequisite for Republicans standing for nomination to Congress or the Senate to win their primaries. An entire party became a vehicle for disinformation.1 Trump did win the 2024 presidential election, and key to that victory was building on the success of that lie. If you control enough of the information ecosystem, truth no longer matters.Another telling example: Haitian migrants in Springfield, Ohio, are not eating cats and dogs. US vice president elect, JD Vance, the source of that claim, admitted as much even as he justified it. “If I have to create stories so that the American media actually pays attention to the suffering of the American people, then that’s what I'm going to do,” he said.2Disinformation in politics is nothing new. History is replete with claims that were fabricated to advance political aims. Although...




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Cardiovascular disease: Just one in 12 eligible people had health check last year, watchdog finds

The current system for delivering NHS cardiovascular disease (CVD) health checks is not working effectively and must be reviewed to ensure that it reaches people with the highest risk, the National Audit Office has said.1In a review of the commissioning, delivery, and performance of CVD health checks the watchdog found that just over one in 12 people (8.8%) who were eligible attended a health check in 2023-24—which, if maintained, would equate to a five year coverage of 44%.Health checks were first introduced in 2009, with the aim of reducing ill health from CVD by offering everyone aged 40-74 without a pre-existing heart condition a check-up every five years. However, problems have arisen since the responsibility for commissioning these checks was transferred to local authorities in 2013, said the National Audit Office.The move led to the Department of Health and Social Care (DHSC) losing its ability to influence local authority performance,...




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Behavioral and Neural Mechanisms of Face-Specific Attention during Goal-Directed Visual Search

Goal-directed visual attention is a fundamental cognitive process that enables animals to selectively focus on specific regions of the visual field while filtering out irrelevant information. However, given the domain specificity of social behaviors, it remains unclear whether attention to faces versus nonfaces recruits different neurocognitive processes. In this study, we simultaneously recorded activity from temporal and frontal nodes of the attention network while macaques performed a goal-directed visual search task. V4 and inferotemporal (IT) visual category-selective units, selected during cue presentation, discriminated fixations on targets and distractors during the search but were differentially engaged by face and house targets. V4 and IT category-selective units also encoded fixation transitions and search dynamics. Compared with distractors, fixations on targets reduced spike–LFP coherence within the temporal cortex. Importantly, target-induced desynchronization between the temporal and prefrontal cortices was only evident for face targets, suggesting that attention to faces differentially engaged the prefrontal cortex. We further revealed bidirectional theta influence between the temporal and prefrontal cortices using Granger causality, which was again disproportionate for faces. Finally, we showed that the search became more efficient with increasing target-induced desynchronization. Together, our results suggest domain specificity for attending to faces and an intricate interplay between visual attention and social processing neural networks.




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A Prefrontal->Periaqueductal Gray Pathway Differentially Engages Autonomic, Hormonal, and Behavioral Features of the Stress-Coping Response

The activation of autonomic and hypothalamo-pituitary-adrenal (HPA) systems occurs interdependently with behavioral adjustments under varying environmental demands. Nevertheless, laboratory rodent studies examining the neural bases of stress responses have generally attributed increments in these systems to be monolithic, regardless of whether an active or passive coping strategy is employed. Using the shock probe defensive burying test (SPDB) to measure stress-coping features naturalistically in male and female rats, we identify a neural pathway whereby activity changes may promote distinctive response patterns of hemodynamic and HPA indices typifying active and passive coping phenotypes. Optogenetic excitation of the rostral medial prefrontal cortex (mPFC) input to the ventrolateral periaqueductal gray (vlPAG) decreased passive behavior (immobility), attenuated the glucocorticoid hormone response, but did not prevent arterial pressure and heart rate increases associated with rats’ active behavioral (defensive burying) engagement during the SPDB. In contrast, inhibition of the same pathway increased behavioral immobility and attenuated hemodynamic output but did not affect glucocorticoid increases. Further analyses confirmed that hemodynamic increments occurred preferentially during active behaviors and decrements during immobility epochs, whereas pathway manipulations, regardless of the directionality of effect, weakened these correlational relationships. Finally, neuroanatomical evidence indicated that the influence of the rostral mPFC->vlPAG pathway on coping response patterns is mediated predominantly through GABAergic neurons within vlPAG. These data highlight the importance of this prefrontal->midbrain connection in organizing stress-coping responses and in coordinating bodily systems with behavioral output for adaptation to aversive experiences.




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Deciphering Peripheral Taste Neuron Diversity: Using Genetic Identity to Bridge Taste Bud Innervation Patterns and Functional Responses

Peripheral taste neurons exhibit functional, genetic, and morphological diversity, yet understanding how or if these attributes combine into taste neuron types remains unclear. In this study, we used male and female mice to relate taste bud innervation patterns to the function of a subset of proenkephalin-expressing (Penk+) taste neurons. We found that taste arbors (the portion of the axon within the taste bud) stemming from Penk+ neurons displayed diverse branching patterns and lacked stereotypical endings. The range in complexity observed for individual taste arbors from Penk+ neurons mirrored the entire population, suggesting that taste arbor morphologies are not primarily regulated by the neuron type. Notably, the distinguishing feature of arbors from Penk+ neurons was their propensity to come within 110 nm (in apposition with) different types of taste-transducing cells within the taste bud. This finding is contrary to the expectation of genetically defined taste neuron types that functionally represent a single stimulus. Consistently, further investigation of Penk+ neuron function revealed that they are more likely to respond to innately aversive stimuli—sour, bitter, and high salt concentrations—as compared with the full taste population. Penk+ neurons are less likely to respond to nonaversive stimuli—sucrose, umami, and low salt—compared with the full population. Our data support the presence of a genetically defined neuron type in the geniculate ganglion that is responsive to innately aversive stimuli. This implies that genetic expression might categorize peripheral taste neurons into hedonic groups, rather than simply identifying neurons that respond to a single stimulus.




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The Role of the Rat Prefrontal Cortex and Sex Differences in Decision-Making

The prefrontal cortex is critical for decision-making across species, with its activity linked to choosing between options. Drift diffusion models (DDMs) are commonly employed to understand the neural computations underlying this behavior. Studies exploring the specific roles of regions of the rodent prefrontal cortex in controlling the decision process are limited. This study explored the role of the prelimbic cortex (PLC) in decision-making using a two-alternative forced-choice task. Rats first learned to report the location of a lateralized visual stimulus. The brightness of the stimulus indicated its reward value. Then, the rats learned to make choices between pairs of stimuli. Sex differences in learning were observed, with females responding faster and more selectively to high-value stimuli than males. DDM analysis found that males had decreased decision thresholds during initial learning, whereas females maintained a consistently higher drift rate. Pharmacological manipulations revealed that PLC inactivation reduced the decision threshold for all rats, indicating that less information was needed to make a choice in the absence of normal PLC processing. μ-Opioid receptor stimulation of the PLC had the opposite effect, raising the decision threshold and reducing bias in the decision process toward high-value stimuli. These effects were observed without any impact on the rats’ choice preferences. Our findings suggest that PLC has an inhibitory role in the decision process and regulates the amount of evidence that is required to make a choice. That is, PLC activity controls "when," but not "how," to act.




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Orbitofrontal Cortex Mediates Sustained Basolateral Amygdala Encoding of Cued Reward-Seeking States

Basolateral amygdala (BLA) neurons are engaged by emotionally salient stimuli. An area of increasing interest is how BLA dynamics relate to evolving reward-seeking behavior, especially under situations of uncertainty or ambiguity. Here, we recorded the activity of individual BLA neurons in male rats across the acquisition and extinction of conditioned reward seeking. We assessed ongoing neural dynamics in a task where long reward cue presentations preceded an unpredictable, variably time reward delivery. We found that, with training, BLA neurons discriminated the CS+ and CS– cues with sustained cue-evoked activity that correlated with behavior and terminated only after reward receipt. BLA neurons were bidirectionally modulated, with a majority showing prolonged inhibition during cued reward seeking. Strikingly, population-level analyses revealed that neurons showing cue-evoked inhibitions and those showing excitations similarly represented the CS+ and behavioral state. This sustained population code rapidly extinguished in parallel with conditioned behavior. We next assessed the contribution of the orbitofrontal cortex (OFC), a major reciprocal partner to the BLA. Inactivation of the OFC while simultaneously recording in the BLA revealed a blunting of sustained cue-evoked activity in the BLA that accompanied reduced reward seeking. Optogenetic disruption of BLA activity and OFC terminals in the BLA also reduced reward seeking. Our data indicate that the BLA represents reward-seeking states via sustained, bidirectional cue-driven neural encoding. This code is regulated by cortical input and is important for the maintenance of vigilant reward-seeking behavior.




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Youth experience persecution

OM teaches East London youth about the persecuted Christians in the world, as well as trains them in street ministry.