Ye Olde Wardrobe Malfunction

Sit back and enjoy as Dillon floats through the forest.
( Photos: 4, Comments: 2 )

A new 20” hardtail, a redesigned 24” full suspension, and a 27.5” young adult full suspension bike.
( Photos: 8, Comments: 40 )

‘Where people have made genuine mistakes they shouldn’t be prosecuted’ says transport secretary Louise Haigh

Apple executives have defended the relocation of the power button to the bottom of its new M4 Mac mini, citing the computer's significantly reduced size as the driving factor behind the design change. In a Bilibili video interview, Apple's Greg Joswiak and John Ternus explained that the Mac mini's form factor, now half the size of its predecessor, necessitated finding a new position for the power button. The executives said that the bottom placement allows for convenient access despite initial user criticism.

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An anonymous reader shares a report: Officials inside the Secret Service clashed over whether they needed a warrant to use location data harvested from ordinary apps installed on smartphones, with some arguing that citizens have agreed to be tracked with such data by accepting app terms of service, despite those apps often not saying their data may end up with the authorities, according to hundreds of pages of internal Secret Service emails obtained by 404 Media. The emails provide deeper insight into the agency's use of Locate X, a powerful surveillance capability that allows law enforcement officials to follow a phone, and person's, precise movements over time at the click of a mouse. In 2023, a government oversight body found that the Secret Service, Customs and Border Protection, and Immigration and Customs Enforcement all used their access to such location data illegally. The Secret Service told 404 Media in an email last week it is no longer using the tool. "If USSS [U.S. Secret Service] is using Locate X, that is most concerning to us," one of the internal emails said. 404 Media obtained them and other documents through a Freedom of Information Act (FOIA) request with the Secret Service.

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The IOC needs to improve rules on transgender athletes to protect "female sport", says World Athletics president Lord Coe.

Justin Welby behaved like a politician and in some ways has faced the downfall of one, writes religion editor Aleem Maqbool.

Pistiwan Jameel described migrants as "pigeons" or "sticks" as he facilitated illegal crossings.

Homebase enters administration, but The Range buys up to 70 stores and the brand.

1. Year-long action plan to combat diabetes to be launched on World Diabetes Day  The Hindu
2. World Diabetes Day 2024  PIB
3. World Diabetes Day: Why diabetes is more than abnormal blood sugar level  The Times of India
4. World Diabetes Day 2024: 10 Foods That Are Secretly Increasing Your Risk Of Diabetes  NDTV
5. World Diabetes Day 2024: 5 ways to detect diabetes quickly  Health shots

1. After Sunita Williams, NASA now worried about her stranded mission partner's losing body mass  Hindustan Times
2. "My Body Has Changed, But....": Sunita Williams On Health Aboard Space Station  NDTV
3. Stranded Sunita Williams dismisses severe weight loss rumours, says she feels ‘healthier than ever’  The Times of India
4. Sunita Williams explains reason behind her changed appearance in space | 'They have routine checks, dedicated surgeons' | Inshorts  Inshorts
5. Inside Sunita Williams' extended mission: What she’s doing in space  India Today

1. John Krasinski reveals wife Emily Blunt's reaction to his Sexiest Man Alive title  Hindustan Times
2. Actor John Krasinski Named 'Sexiest Man Alive' Of 2024 By People Magazine  NDTV
3. Is Jim from The Office really the sexiest man in the world?  The Guardian
4. Not Shah Rukh Khan, Hrithik Roshan, Leonardo Dicaprio, Chris Evans, or Tom Cruise, THIS actor is the sexiest  India.com
5. John Krasinski Is PEOPLE's 2024 Sexiest Man Alive!  PEOPLE

Filed under: Asia, Thailand

Not only are tourists still coming, but they've been arriving in increasing numbers in recent years, according to government data.

Continue reading Demonstrations in Thailand? No Problem, Travelers Say.

Demonstrations in Thailand? No Problem, Travelers Say. originally appeared on Gadling on Mon, 02 Dec 2013 11:26:00 EST. Please see our terms for use of feeds.

Filed under: Skiing, North America, United States

• 16 Easy Ski Vacation Ideas from U.S. Cities
• 50 Ways to Ski in 50 States

Where to Ski In Every State and 16 Ski Vacations Near Big U.S. Cities originally appeared on Gadling on Thu, 05 Dec 2013 11:29:00 EST. Please see our terms for use of feeds.

Filed under: Internet Tools, News

Continue reading Facebook, Instagram Release Top Checked-in Locations of 2013

Facebook, Instagram Release Top Checked-in Locations of 2013 originally appeared on Gadling on Fri, 13 Dec 2013 14:23:00 EST. Please see our terms for use of feeds.

Filed under: North America, United States

Continue reading Sorry Indianapolis, You're No Longer the Sole Location Offering TSA PreCheck Enrollment Background Checks

Sorry Indianapolis, You're No Longer the Sole Location Offering TSA PreCheck Enrollment Background Checks originally appeared on Gadling on Mon, 16 Dec 2013 15:07:00 EST. Please see our terms for use of feeds.

Filed under: North America, United States

Continue reading MapQuest Unveils 10 Top Destinations of 2013

MapQuest Unveils 10 Top Destinations of 2013 originally appeared on Gadling on Mon, 23 Dec 2013 10:29:00 EST. Please see our terms for use of feeds.

Filed under: Business, Europe, North America, Denmark, Iceland, Belize, United States

Continue reading Top 5 Family Travel Destinations for 2014 (and Possibly Beyond)

Top 5 Family Travel Destinations for 2014 (and Possibly Beyond) originally appeared on Gadling on Thu, 09 Jan 2014 13:09:00 EST. Please see our terms for use of feeds.

Filed under: Panama, Airports, News, Central America

Continue reading $7.2 Million Cash Found in Suitcases at Panama City Airport

$7.2 Million Cash Found in Suitcases at Panama City Airport originally appeared on Gadling on Fri, 17 Jan 2014 17:04:00 EST. Please see our terms for use of feeds.

Implications of the new US presidency: what awaits Ukraine? 19 November 2024 — 2:00PM TO 3:30PM Anonymous (not verified) 13 November 2024 Online

After 1000 days of Kyiv’s resistance, experts discuss how to secure Ukraine’s and Europe’s future.   

The 19 November marks 1,000 days since Russia’s full-scale invasion of Ukraine. The country faces an ever-more ferocious fight for its future existence.

The 19^th November marks 1,000 days since Russia’s full-scale invasion of Ukraine. The country faces an ever-more ferocious fight for its future existence.

Having been given time to adapt, largely due to the slow release of Western military aid, the Russian army is pressing home its advantage. Along the entire eastern frontline, the Russians are simultaneously bombarding Ukraine’s energy infrastructure and cities. With the election of Donald Trump in the US, it seems to many that the tide has turned definitively in Putin’s favour at the political, as well as the military, level.

Trump’s declared ambition to resolve the war in 24 hours implies a Russian-American deal, cutting Kyiv out of negotiations. Such an ‘agreement’ would endanger the country’s future and expose the rest of Europe.

This webinar will cover:

• Ukraine’s strategy of resistance in the context of Trump’s White House.
• The immediate risks during the transition period.
• How Kyiv sees Europe’s role in the new geopolitical environment. Will Kyiv completely give up on the US?
• The extent to which Germany, Ukraine’s second largest donor, can step in.  

Fans and analysts spend the entire offseason speculating where the top free agents could go, but sometimes an under-the-radar pickup can end up making a world of difference. As positional competitions begin to heat up at Spring Training camps this month, MLB.com's beat writers were asked to identify one potentially overlooked acquisition for each of the 30 clubs. Here's who they came up with.

Having two pitchers of notable accomplishment and one of immense promise is a luxury for the Rockies. But it creates a decision nonetheless for manager Bud Black.

Rockies third baseman Nolan Arenado said Thursday he won't make Opening Day a hard deadline for negotiations on a possible multiyear contract.

Raimel Tapia has renewed opportunity with the Rockies in 2019, along with a need to deliver.

Fans and analysts spend the entire offseason speculating where the top free agents could go, but sometimes an under-the-radar pickup can end up making a world of difference. As positional competitions begin to heat up at Spring Training camps this month, MLB.com's beat writers were asked to identify one potentially overlooked acquisition for each of the 30 clubs. Here's who they came up with.

As MLB.com continues its annual Around the Horn series, it's time to take a closer look at the Blue Jays' starting rotation. It looks different now than it did a few months ago and it probably won't be long before the same thing will be said again because these changes are far from over.

Charlie Montoyo is about to embark on the first spring of his managerial career, and based on the number of decisions he has to make, it's going to be a challenging six weeks.

The Blue Jays were barely one hour into the official start of Spring Training when general manager Ross Atkins threw the first curveball of the year. The news wasn't so much who made the list, but rather who did not. Despite an impressive 2018 rookie season, lefty Ryan Borucki apparently hasn't been guaranteed anything quite yet.

Donald Trump did not win the 2020 election, but asserting that he did became a prerequisite for Republicans standing for nomination to Congress or the Senate to win their primaries. An entire party became a vehicle for disinformation.1 Trump did win the 2024 presidential election, and key to that victory was building on the success of that lie. If you control enough of the information ecosystem, truth no longer matters.Another telling example: Haitian migrants in Springfield, Ohio, are not eating cats and dogs. US vice president elect, JD Vance, the source of that claim, admitted as much even as he justified it. “If I have to create stories so that the American media actually pays attention to the suffering of the American people, then that’s what I'm going to do,” he said.2Disinformation in politics is nothing new. History is replete with claims that were fabricated to advance political aims. Although...

Terminally ill adults in England and Wales who are expected to die within six months would be able to get help to end their lives if their applications were approved by two doctors and a High Court judge, under proposed new legislation.1Labour MP Kim Leadbeater, who proposed the bill, said it provided the “strictest safeguards anywhere in the world.” The law would apply only to people who have full mental capacity and are terminally ill. Mental illness and disability are both excluded as eligibility criteria, and a person would need to declare twice in writing that they wanted to be helped to die.A person who wished to end their life would have to administer the medication themselves. It will remain illegal for a doctor or anybody else to end a person’s life. No doctor will be obliged to participate in any part of the process.The bill would also make it...

At one of my first meetings as an elected council member of the Royal College of Surgeons of England, we approved a report called Access All Ages. It encouraged less ageist thinking and bias among healthcare staff that might lead to them denying older people surgery.1 But sometimes an operation isn’t the best option. Among patients who have surgery, 14% express regret and 15% experience complications, which are at least four times as likely if they’re frail or physically inactive.2 The Centre for Perioperative Care has published information on the importance of exercise before surgery,3 but that alone may not be enough.We need shared decision making,4 including asking patients what matters to them. The public should be primed to ask about BRAN—the benefits, risks, and alternatives to surgery and the likely result from doing nothing.4 A slew of data supports this approach, especially from the POPS initiative (Perioperative Care of...

The current system for delivering NHS cardiovascular disease (CVD) health checks is not working effectively and must be reviewed to ensure that it reaches people with the highest risk, the National Audit Office has said.1In a review of the commissioning, delivery, and performance of CVD health checks the watchdog found that just over one in 12 people (8.8%) who were eligible attended a health check in 2023-24—which, if maintained, would equate to a five year coverage of 44%.Health checks were first introduced in 2009, with the aim of reducing ill health from CVD by offering everyone aged 40-74 without a pre-existing heart condition a check-up every five years. However, problems have arisen since the responsibility for commissioning these checks was transferred to local authorities in 2013, said the National Audit Office.The move led to the Department of Health and Social Care (DHSC) losing its ability to influence local authority performance,...

Goal-directed visual attention is a fundamental cognitive process that enables animals to selectively focus on specific regions of the visual field while filtering out irrelevant information. However, given the domain specificity of social behaviors, it remains unclear whether attention to faces versus nonfaces recruits different neurocognitive processes. In this study, we simultaneously recorded activity from temporal and frontal nodes of the attention network while macaques performed a goal-directed visual search task. V4 and inferotemporal (IT) visual category-selective units, selected during cue presentation, discriminated fixations on targets and distractors during the search but were differentially engaged by face and house targets. V4 and IT category-selective units also encoded fixation transitions and search dynamics. Compared with distractors, fixations on targets reduced spike–LFP coherence within the temporal cortex. Importantly, target-induced desynchronization between the temporal and prefrontal cortices was only evident for face targets, suggesting that attention to faces differentially engaged the prefrontal cortex. We further revealed bidirectional theta influence between the temporal and prefrontal cortices using Granger causality, which was again disproportionate for faces. Finally, we showed that the search became more efficient with increasing target-induced desynchronization. Together, our results suggest domain specificity for attending to faces and an intricate interplay between visual attention and social processing neural networks.

Endogenous reprogramming of glia into neurogenic progenitors holds great promise for neuron restoration therapies. Using lessons from regenerative species, we have developed strategies to stimulate mammalian Müller glia to regenerate neurons in vivo in the adult retina. We have demonstrated that the transcription factor Ascl1 can stimulate Müller glia neurogenesis. However, Ascl1 is only able to reprogram a subset of Müller glia into neurons. We have reported that neuroinflammation from microglia inhibits neurogenesis from Müller glia. Here we found that the peripheral immune response is a barrier to CNS regeneration. We show that monocytes from the peripheral immune system infiltrate the injured retina and negatively influence neurogenesis from Müller glia. Using CCR2 knock-out mice of both sexes, we found that preventing monocyte infiltration improves the neurogenic and proliferative capacity of Müller glia stimulated by Ascl1. Using scRNA-seq analysis, we identified a signaling axis wherein Osteopontin, a cytokine highly expressed by infiltrating immune cells is sufficient to suppress mammalian neurogenesis. This work implicates the response of the peripheral immune system as a barrier to regenerative strategies of the retina.

The activation of autonomic and hypothalamo-pituitary-adrenal (HPA) systems occurs interdependently with behavioral adjustments under varying environmental demands. Nevertheless, laboratory rodent studies examining the neural bases of stress responses have generally attributed increments in these systems to be monolithic, regardless of whether an active or passive coping strategy is employed. Using the shock probe defensive burying test (SPDB) to measure stress-coping features naturalistically in male and female rats, we identify a neural pathway whereby activity changes may promote distinctive response patterns of hemodynamic and HPA indices typifying active and passive coping phenotypes. Optogenetic excitation of the rostral medial prefrontal cortex (mPFC) input to the ventrolateral periaqueductal gray (vlPAG) decreased passive behavior (immobility), attenuated the glucocorticoid hormone response, but did not prevent arterial pressure and heart rate increases associated with rats’ active behavioral (defensive burying) engagement during the SPDB. In contrast, inhibition of the same pathway increased behavioral immobility and attenuated hemodynamic output but did not affect glucocorticoid increases. Further analyses confirmed that hemodynamic increments occurred preferentially during active behaviors and decrements during immobility epochs, whereas pathway manipulations, regardless of the directionality of effect, weakened these correlational relationships. Finally, neuroanatomical evidence indicated that the influence of the rostral mPFC->vlPAG pathway on coping response patterns is mediated predominantly through GABAergic neurons within vlPAG. These data highlight the importance of this prefrontal->midbrain connection in organizing stress-coping responses and in coordinating bodily systems with behavioral output for adaptation to aversive experiences.

The sudden appearance of a visual distractor shortly before saccade initiation can capture spatial attention and modulate the saccade trajectory in spite of the ongoing execution of the initial plan to shift gaze straight to the saccade target. To elucidate the neural correlates underlying these curved saccades, we recorded from single neurons in the frontal eye field of two male rhesus monkeys shifting gaze to a target while a distractor with the same eccentricity appeared either left or right of the target at various delays after target presentation. We found that the population level of presaccadic activity of neurons representing the distractor location encoded the direction of the saccade trajectory. Stronger activity occurred when saccades curved toward the distractor, and weaker when saccades curved away. This relationship held whether the distractor was ipsilateral or contralateral to the recorded neurons. Meanwhile, visually responsive neurons showed asymmetrical patterns of excitatory responses that varied with the location of the distractor and the duration of distractor processing relating to attentional capture and distractor inhibition. During earlier distractor processing, neurons encoded curvature toward the distractor. During later distractor processing, neurons encoded curvature away from the distractor. This was observed when saccades curved away from distractors contralateral to the recording site and when saccades curved toward distractors ipsilateral to the recording site. These findings indicate that saccadic motor planning involves dynamic push–pull hemispheric interactions producing attraction or repulsion for potential but unselected saccade targets.

Peripheral taste neurons exhibit functional, genetic, and morphological diversity, yet understanding how or if these attributes combine into taste neuron types remains unclear. In this study, we used male and female mice to relate taste bud innervation patterns to the function of a subset of proenkephalin-expressing (Penk+) taste neurons. We found that taste arbors (the portion of the axon within the taste bud) stemming from Penk+ neurons displayed diverse branching patterns and lacked stereotypical endings. The range in complexity observed for individual taste arbors from Penk+ neurons mirrored the entire population, suggesting that taste arbor morphologies are not primarily regulated by the neuron type. Notably, the distinguishing feature of arbors from Penk+ neurons was their propensity to come within 110 nm (in apposition with) different types of taste-transducing cells within the taste bud. This finding is contrary to the expectation of genetically defined taste neuron types that functionally represent a single stimulus. Consistently, further investigation of Penk+ neuron function revealed that they are more likely to respond to innately aversive stimuli—sour, bitter, and high salt concentrations—as compared with the full taste population. Penk+ neurons are less likely to respond to nonaversive stimuli—sucrose, umami, and low salt—compared with the full population. Our data support the presence of a genetically defined neuron type in the geniculate ganglion that is responsive to innately aversive stimuli. This implies that genetic expression might categorize peripheral taste neurons into hedonic groups, rather than simply identifying neurons that respond to a single stimulus.

The prefrontal cortex is critical for decision-making across species, with its activity linked to choosing between options. Drift diffusion models (DDMs) are commonly employed to understand the neural computations underlying this behavior. Studies exploring the specific roles of regions of the rodent prefrontal cortex in controlling the decision process are limited. This study explored the role of the prelimbic cortex (PLC) in decision-making using a two-alternative forced-choice task. Rats first learned to report the location of a lateralized visual stimulus. The brightness of the stimulus indicated its reward value. Then, the rats learned to make choices between pairs of stimuli. Sex differences in learning were observed, with females responding faster and more selectively to high-value stimuli than males. DDM analysis found that males had decreased decision thresholds during initial learning, whereas females maintained a consistently higher drift rate. Pharmacological manipulations revealed that PLC inactivation reduced the decision threshold for all rats, indicating that less information was needed to make a choice in the absence of normal PLC processing. μ-Opioid receptor stimulation of the PLC had the opposite effect, raising the decision threshold and reducing bias in the decision process toward high-value stimuli. These effects were observed without any impact on the rats’ choice preferences. Our findings suggest that PLC has an inhibitory role in the decision process and regulates the amount of evidence that is required to make a choice. That is, PLC activity controls "when," but not "how," to act.

The extent to which neural representations of fear experience depend on or generalize across the situational context has remained unclear. We systematically manipulated variation within and across three distinct fear-evocative situations including fear of heights, spiders, and social threats. Participants (n = 21; 10 females and 11 males) viewed ~20 s clips depicting spiders, heights, or social encounters and rated fear after each video. Searchlight multivoxel pattern analysis was used to identify whether and which brain regions carry information that predicts fear experience and the degree to which the fear-predictive neural codes in these areas depend on or generalize across the situations. The overwhelming majority of brain regions carrying information about fear did so in a situation-dependent manner. These findings suggest that local neural representations of fear experience are unlikely to involve a singular pattern but rather a collection of multiple heterogeneous brain states.

OM teaches East London youth about the persecuted Christians in the world, as well as trains them in street ministry.

Engage, OM South Africa’s bi-annual conference, provides a challenge and a channel for joining missions with OM.

Participants of a poverty simulation activity hosted by AIDSLink International discover that it’s very different to minister to the poor than to be the poor.