be A way out: On the government and doctor-led protests in West Bengal By www.thehindu.com Published On :: Wed, 18 Sep 2024 00:20:00 +0530 The West Bengal government must enable the changes doctors want to see Full Article Editorial
be Split decision: On the rivalry between the two NCP factions By www.thehindu.com Published On :: Fri, 04 Oct 2024 00:25:00 +0530 The ECI and the office of the Speaker have not played fair in cases of defection Full Article Editorial
be Regulation role: On the 2024 Medicine Nobel By www.thehindu.com Published On :: Tue, 08 Oct 2024 00:36:00 +0530 The discovery of microRNA changed the understanding of gene regulation Full Article Editorial
be Deep roots: On the 2024 Physics Nobel Prize By www.thehindu.com Published On :: Wed, 09 Oct 2024 00:10:00 +0530 Physics Nobel Prize acknowledges the diverse foundations of AI Full Article Editorial
be Biology transformed: On the Nobel Prize in chemistry By www.thehindu.com Published On :: Mon, 14 Oct 2024 00:28:00 +0530 Nobel for determining protein structure recognises a big advance Full Article Editorial
be A Korean win: On the 2024 Nobel Prize in Literature By www.thehindu.com Published On :: Tue, 15 Oct 2024 00:20:00 +0530 A Nobel raises Korean prose to success levels of its drama and music Full Article Editorial
be Sufferers, awarded: On the 2024 Nobel Peace Prize By www.thehindu.com Published On :: Wed, 16 Oct 2024 00:20:00 +0530 The Nobel Peace for the selfless Nihon Hidankyo should help stir debates on nuclear disarmament Full Article Editorial
be Fate of nations: On the 2024 Economics Nobel By www.thehindu.com Published On :: Sat, 19 Oct 2024 00:10:00 +0530 The 2024 Nobel recognises the need for ‘inclusive’ institutions Full Article Editorial
be Allow for deliberation: On the legitimate demands of Ladakh By www.thehindu.com Published On :: Tue, 22 Oct 2024 00:15:00 +0530 The lack of a legislature and regional autonomy in Ladakh has led to the current protests Full Article Editorial
be Beyond intoxication: On alcohol regulation, judicial verdict By www.thehindu.com Published On :: Mon, 28 Oct 2024 00:20:00 +0530 Batting for States, the Supreme Court of India holds federal balance on regulating alcohol Full Article Editorial
be Escalation ladder: On conflict between Israel and Iran By www.thehindu.com Published On :: Tue, 29 Oct 2024 00:15:00 +0530 Iran should show strategic restraint; and the world should rein in Israel Full Article Editorial
be Beautifully vague: On the Tamilaga Vettri Kazhagam’s inaugural conference By www.thehindu.com Published On :: Wed, 30 Oct 2024 00:10:00 +0530 Actor Vijay seems to be targeting both the BJP and the DMK Full Article Editorial
be Design, synthesis, inhibitory activity, and molecular simulations study for D-glucose-conjugated thioureas containing pyrimidine ring as multitarget inhibitors against α-amylase, α-glucosidase, DDP-4, and PTP1B in Type 2 diabetes mellitus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, 15,3395-3417DOI: 10.1039/D4MD00334A, Research ArticleVu Ngoc Toan, Do Son Hai, Hoang Thi Kim Van, Nguyen Minh Tri, Duong Ngoc Toan, Nguyen Thi Thanh Mai, Nguyen Dinh ThanhD-Glucose-conjugated thioureas from 2-aminopyrimidines had inhibitory activity against α-amylase, α-glucosidase, DPP-4, PTP1B. The cytotoxicity, inhibitory kinetics, and molecular simulations of the most potent inhibitors 8k, 8j, 8f, and 8h were studied.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
be Design, synthesis, and structure–activity relationship studies of 6H-benzo[b]indeno[1,2-d]thiophen-6-one derivatives as DYRK1A/CLK1/CLK4/haspin inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00537F, Research Article Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Abdelfattah Faouzi, Alexandre Arnaud, François Hallé, Jean Roussel, Mandy Aymard, Vincent Denavit, Cong Viet Do, Angélique Mularoni, Mohamed Salah, Ahmed ElHady, Thanh-Nhat Pham, Alexandre Bancet, Marc Le Borgne, Raphaël Terreux, Roland Barret, Matthias Engel, Thierry LombergetA series of sulfur-containing tetracycles was designed and evaluated for their ability to inhibit protein kinase DYRK1A, a target known to have several potential therapeutic applications including cancers, Down syndrome or Alzheimer's disease.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
be Design, synthesis, and evaluation of benzhydrylpiperazine-based novel dual COX-2/5-LOX inhibitors with anti-inflammatory and anti-cancer activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00471J, Research ArticlePoorvi Saraf, Bhagwati Bhardwaj, Akash Verma, Mohammad Aquib Siddiqui, Himanshu Verma, Pradeep Kumar, Samridhi Srivastava, Sairam Krishnamurthy, Saripella Srikrishna, Sushant Kumar ShrivastavaScreening piperazine derivatives via ChEMBL database led to the design and synthesis of novel dual COX-2/5-LOX inhibitors with strong anti-inflammatory, analgesic, and anti-cancer activity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
be Development, biological evaluation, and molecular modelling of some benzene-sulfonamide derivatives as protein tyrosine phosphatase-1B inhibitors for managing diabetes mellitus and associated metabolic disorders By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00594E, Research ArticleNagat Ghareb, Khaled M. Darwish, Mohamed S. Nafie, Ranwa Elrayess, Noha M. Abourobe, Shaimaa A. Fattah, Reem M. Hazem, Eman T. Mehanna, Ranza ElrayessOne benzene-sulfonamide derivative exhibited potent protein tyrosine phosphatase-1B inhibition for managing diabetes mellitus and associated metabolic disorders.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
be Breaking boundaries in diabetic nephropathy treatment: design and synthesis of novel steroidal SGLT2 inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00645C, Research ArticleGeetmani Singh Nongthombam, Semim Akhtar Ahmed, Kangkon Saikia, Sanjib Gogoi, Jagat Chandra BorahVirtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment of diabetic nephropathy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
be Novel benzenesulfonamides containing a dual triazole moiety with selective carbonic anhydrase inhibition and anticancer activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00617H, Research ArticleAida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha, Şükrü BeydemirIn this research, a series of sulfonamides incorporating a 1,2,3-triazolyloxime substituted 1,2,3-triazolyl moiety was conceptualized, synthesized, and investigated as carbonic anhydrase inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
be Synthesis and anti-tumor activity of new benzofuran-based chalcone derivatives as potent VEGFR-2 inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00621F, Research ArticleChunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei MaoA series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
be S-MGBs bearing amidine tail groups are potent, selective antiplasmodial agents By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00619D, Research Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Marina Perieteanu, Tayner Rodriguez Garzon, Leah M. C. McGee, Abedawn I. Khalaf, Colin J. Suckling, Rebecca Beveridge, Vicky M. Avery, Fraser J. Scott25 S-MGBs, including those bearing an amidine tail group, were investigated for their antiplasmodial, in vitro activity against 3D7 and Dd2 strains of P. falciparum. Several potent, and selective, hit compounds were identified.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
be Design and synthesis of (E)-3-benzylideneindolin-2-one derivatives as potential allosteric inhibitors of Aurora A kinase By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00373J, Research ArticleYongLai Jiao, Jie Zhong, Jin-Fang Xu, Shaobo Ning, Taigang Liang, Mingzhu Zhao, Jian ZhangThe mitotic kinase Aurora A, a pivotal regulator of cell cycle, is overexpressed in various cancers and has emerged as one of the most promising targets for anticancer drug discovery....The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
be Discovery of N-substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00553H, Research ArticleStefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Carminia Maria Della Corte, Emma Baglini, Giorgio Amendola, Anna Messere, Salvatore Di Maro, Elisabetta Barresi, Federico Da Settimo, Maria Letizia Trincavelli, Fortunato Ciardiello, Sabrina Taliani, Floriana Morgillo, Sandro CosconatiNon-small cell lung cancer (NSCLC), the leading cause of cancer-related mortality worldwide, poses a formidable challenge due to its heterogeneity and the emergence of resistance to targeted therapies.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
be 50 new primary health centres to be opened in State soon: Minister By www.thehindu.com Published On :: Tue, 05 Nov 2024 19:37:18 +0530 Full Article Tiruchirapalli
be Tiruchi Today (November 7, 2024) By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:16:44 +0530 Full Article Tiruchirapalli
be Pumping stations to be set up in eight low-lying areas in Tiruchi to prevent inundation By www.thehindu.com Published On :: Wed, 06 Nov 2024 19:30:58 +0530 Full Article Tiruchirapalli
be Power shutdown in parts of Tiruchi on November 9 By www.thehindu.com Published On :: Fri, 08 Nov 2024 17:45:18 +0530 Full Article Tiruchirapalli
be Consultant to be appointed soon to design Kalaignar grand library in Tiruchi By www.thehindu.com Published On :: Fri, 08 Nov 2024 18:41:18 +0530 The centre will offer translation, services for persons with disabilities and children, training and mentorship programmes, besides hosting monthly literary events Full Article Tiruchirapalli
be 549: Ben Ubois of Feedbin By shoptalkshow.com Published On :: Mon, 23 Jan 2023 08:43:45 +0000 Ben Ubois is the founder of Feedbin, the RSS reader of choice for Dave and Chris. What influenced the creation of Feedbin, the state of RSS in 2023, curating your RSS feed, and subscribing to newsletters in Feedbin. Full Article All Episodes json newsletters reading rss
be 555: React Documentary, Front of the Front End, Fast Fallacy, and Best Practices By shoptalkshow.com Published On :: Mon, 06 Mar 2023 09:39:37 +0000 Reacting to the React.js documentary, is there still jobs for front of the front end anymore? The fast fallacy in frameworks, best practices, dealing with too much or too little isolation, and AI test generation. Full Article All Episodes applying for a job React Tests
be 567: Full Stack Dev, Load Bearing Developer, and Being Zod Curious By shoptalkshow.com Published On :: Mon, 29 May 2023 09:00:16 +0000 What do you do if your computer dies? Chris applies to work at Luro, Dave applies at CodePen, Dave's Zod curious, TypeScript, sorting out a 10MB blog post, and how much do you miss jQuery? Full Article All Episodes full stack Jquery Zod
be 593: Beep & Texts, Tumblr, JavaScript & Web Components, & Cool Blog Post Ideas By shoptalkshow.com Published On :: Mon, 27 Nov 2023 09:00:10 +0000 Thoughts on smashing all communication messaging apps together, what's happened to Tumblr under Automattic, what the situation is with native web components and JavaScript, and looking at a list of types of blog posts. Full Article All Episodes communication Web Components
be 596: The Year of AI, Arc, and Being Mad About the Right Thing By shoptalkshow.com Published On :: Mon, 18 Dec 2023 09:03:32 +0000 Looking back at the year of AI, using Arc on macOS and now Windows, dreaming of subscriptions, and knowing how to be mad about the right thing. Full Article All Episodes arc OpenAI web3
be 600: Where Will The Web Be 12 Years from Now? By shoptalkshow.com Published On :: Mon, 29 Jan 2024 09:21:23 +0000 We've got your feedback as well as our thoughts on where we all think the web will be in 2036 - as we celebrate 12 years of ShopTalk Show history, we're looking forward to what's to come with ideas around cookie banners, undo, no more passwords, React, Deno, Node, and Mozilla's future, ChatGPT's thoughts, accessibility, blockchain, VR / AR, hoverboards, P3 color space, indie web, JS bundle sizes, and more! Full Article All Episodes future predictions recap show
be 617: Economic & AI Vibes with Jason Grigsby By shoptalkshow.com Published On :: Mon, 27 May 2024 07:14:06 +0000 We're chatting with Jason Grigsby about what a white-collar recession means, how the sources and methods of consuming news shape our perspectives, whether the current economic conditions represent a market correction and if a rebound is imminent. We explore the critical decision of whether to embrace AI advancements or risk being left behind. We also talk about AI-generated voices, large language models and ethics, and the impact of social media signals in an AI world. Full Article All Episodes AI economics ethics
be 627: Getting Comfortable with the Struggle and Vibe Driven Development By shoptalkshow.com Published On :: Mon, 05 Aug 2024 08:52:17 +0000 Chris brings some blog posts to talk about including being comfortable with the struggle of developer life, Cloudflare Workers + monorepos, vibe driven development, and questions about database migrations, and whether we think AI free blogs are going to be a rarity in the future? Full Article All Episodes cloudflare workers database struggle
be Let’s be water sensitive By www.thehindu.com Published On :: Fri, 05 Dec 2014 15:31:36 +0530 For too long have we ignored water bodies in a city’s life. Their role is utilitarian as well as aesthetic. Full Article Property Plus
be It’s good ‘office times’ for Bengaluru By www.thehindu.com Published On :: Fri, 30 Jan 2015 20:21:59 +0530 The buoyant office market of Bangalore quite makes up for the lukewarm residential segment, according to findings. Full Article Property Plus
be Beware of excess cement By www.thehindu.com Published On :: Fri, 27 Mar 2015 19:26:05 +0530 Cement deteriorates with age, and has an inherent weakness of cracking. Full Article Property Plus
be Beyond planting a tree By www.thehindu.com Published On :: Fri, 24 Apr 2015 16:51:28 +0530 What is the significance of Earth Day and why does one have to celebrate it? Chandrashekar Hariharan of BCIL, an active associate of IGBC, shares a few points with Ranjani Govind Full Article Property Plus
be Design to beat the heat By www.thehindu.com Published On :: Sun, 03 May 2015 20:42:58 +0530 Keeping the air conditioner on for long will only create heat islands, says Sathya Prakash Varanashi Full Article Design
be Becoming nature-friendly, voluntarily By www.thehindu.com Published On :: Fri, 29 Apr 2016 15:28:30 +0530 We should not wait for rules and regulations to save the earth from depradation. By Sathya Prakash Varanashi Full Article Property Plus
be Could Maini be India's next F1 driver? By www.rediff.com Published On :: India could finally have a driver on the F1 grid after 13 long years. Full Article
be Balrampur Chini hopes success of polylactic acid plant will be sweet By www.thehindubusinessline.com Published On :: Sun, 29 Sep 2024 20:46:00 +0530 In conversation with Avantika Saraogi, ED, and Stefan Barot, President, Chemicals Division, Balrampur Chini Mills Full Article Corporate File
be October decisions on ‘assisted dying’ for terminally ill By www.thehindubusinessline.com Published On :: Sun, 06 Oct 2024 21:38:00 +0530 India, UK to legislate on allowing patients this choice Full Article Pulse
be Flat organisation believers: Can you imagine a world without managers? By www.thehindubusinessline.com Published On :: Sun, 13 Oct 2024 20:24:36 +0530 What does a manager do that we keep hiring new ones or keep promoting more of them? Which managerial layer is the most important? Full Article Corporate File
be The secret sauce behind ITC’s enduring restaurant brands By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 10:45:54 +0530 The promise of an unchanged, consistent menu and supreme culinary artistry has drawn food lovers to ITC’s tables for decades Full Article Marketing
be Galathea Bay: New major port can be game changer By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 19:56:00 +0530 Transshipment port at Galathea Bay is strategically located on the East-West international trade and shipping route Full Article Logistics
be Diamonds are a UV photodetector’s best friend By www.thehindubusinessline.com Published On :: Sun, 20 Oct 2024 21:34:55 +0530 How lab-grown rocks from Surat are set to power the development of high-performance electronics Full Article Science and Technology
be ‘Our goal is beauty for each,’ says L’Oréal India chief By www.thehindubusinessline.com Published On :: Sat, 26 Oct 2024 13:11:01 +0530 Aseem Kaushik, who leads the global beauty giant in India, says tech is playing a big part in its personalisation journey Full Article Corporate File
be Bengaluru startup develops new tech for battery recycling, begins production By www.thehindubusinessline.com Published On :: Sun, 27 Oct 2024 18:13:56 +0530 Li-ion battery recycler Metastable Materials launches commercial ops Full Article Clean Tech
