A surgical stapling device particularly suited for endoscopic procedures is described. The device includes a handle assembly and an elongated body extending distally from the handle assembly. The distal end of the elongated body is adapted to engage a disposable loading unit. A control rod having a proximal end operatively connected to the handle assembly includes a distal end extending through the elongated body. A control rod locking member is provided to prevent movement of the control rod until the disposable loading unit is fully secured to the elongated body of the stapling device.

A surgical device including a handle assembly, an elongated body extending from the handle assembly, and an articulation mechanism connected to the handle assembly and configured to selectively articulate and lock an articulable tool assembly in one or more positions is provided. The articulation mechanism includes a main shaft member mounted for rotation and connected to an articulation linkage, a locking member configured to be received about the shaft portion of the main shaft member, the locking member defining a plurality of notches, an articulation handle fixedly secured to shaft portion of the main shaft member and configured for rotation relative to the locking member, and a lug member operatively mounted on the articulation handle and including a locking tab configured to be selectively received within a notch of the plurality of notches formed in the locking member.

Devices for attaching a sheet-like implant to a target tissue include a sheath and a staple push rod. The sheath has a distal end configured to be pressed against the target tissue. The staple push rod is disposed within at least a portion of the sheath and is slidable relative thereto. The staple push rod includes a pair of stakes. Each stake is dimensioned to abut a surface of a staple to apply pushing forces thereto. The stakes are biased to assume a bow-like shape such that an intermediate portion of a staple extends tautly between the first stake and the second stake when the stakes are extending beyond the distal end of the tubular member. Methods for attaching a sheet-like implant to a target tissue are also disclosed.

A device for attaching a sheet-like implant to a target tissue. The device includes a fastener push rod including a first portion, a second portion and a force limiting mechanism operably coupled between the first portion and the second portion. A fastener is carried by the second portion of the fastener push rod. The force limiting mechanism transmits longitudinal movement of the first portion to the second portion while the forces applied to the fastener by the fastener push rod are less than a predetermined value such that longitudinal movement of the first portion of the fastener push rod causes substantially equivalent longitudinal movement of the second portion. The force limiting mechanism allows relative longitudinal motion between the first and second portions while the forces applied to the fastener are equal to or greater than the predetermined value such that the application of undue forces to the fastener is prevented.

A surgical instrument including a handle portion, a body portion, a movable handle, a tool assembly, a drive beam and a closure apparatus is disclosed. At least one of the closure apparatus and a contact surface of the tool assembly include a plastic surface. The body portion extends distally from the handle portion. The movable handle is located on the handle portion and is in mechanical cooperation with a drive member. The tool assembly includes an anvil, a cartridge assembly and a contact surface. The drive beam includes a proximal engagement portion and is configured to engage a portion of the drive member. The closure apparatus is configured to engage the contact surface of the tool assembly. At least a partial actuation of the movable handle moves the closure apparatus distally into engagement with the contact surface to approximate the anvil and the cartridge assembly.

A surgical stapling instrument can comprise, one, a handle comprising an actuator and, two, an end effector comprising a proximal end, a distal end, and a longitudinal axis extending between the proximal end and the distal end. The end effector can further comprise a first jaw configured to support staples comprising staple legs and, in addition, a second jaw supporting a matrix element opposite the staples, wherein one of the jaws is movable toward the other in order to engage the matrix element with the staple legs. The stapling instrument can further comprise a cam operably coupled with the actuator, wherein the cam is movable along the longitudinal axis to deform the staple legs.

Circular stapling instruments and anvil assemblies. The anvil assemblies may have collapsible anvil support members that may be inserted through an opening in a patient and then expanded to be attached to an anvil plate assembly that has a staple-forming surface thereon. The anvil support member is attachable to the anvil plate assembly in such a way that when the anvil assembly is coupled to the stapling head of a circular stapler, the staple-forming surface is in substantial registry with the staples supported in the stapling head. A variety of different anvil support members and anvil plate assemblies are disclosed. Various embodiments have a tissue-piercing feature.

An exemplary surgical apparatus may include a shaft defining a lumen therein; articulation bands extending through and slidable generally longitudinally within the lumen of the shaft; an end effector affixed to the articulation bands; and generally annular segments positioned about the articulation bands along at least a portion of the length of the articulation bands to define an articulated region, where the segments laterally constrain the articulation bands.

One example of a surgical apparatus may include a feeder belt, a plurality of staples frangibly connected to the feeder belt, and at least one pull tab extending laterally from the feeder belt. An example of a surgical method of treating tissue within the body of a patient may include providing at least one feeder belt and staples frangibly connected thereto, and at least one wedge movable relative to the feeder belt; moving at least one wedge in a first direction to contact and thereby form and shear at least one staple from at least one feeder belt; and moving at least one wedge in a second direction to engage and advance the feeder belt.

A circular stapling instrument including a stapling forming assembly that is actuated independently from actuation of the cutting assembly is provided. The instrument includes a handle assembly, an elongate body extending from the handle assembly, a cartridge assembly mounted on a distal end of the elongate body. The cartridge assembly includes a pusher and a knife assembly. The knife assembly is selectively fixed relative to the pusher.

Devices and methods are provided for forming and securing a tissue plication. More particularly, the devices and methods of the present invention can be used to create multiple tissue folds on an anterior and posterior wall of a stomach cavity to reduce the volume thereof. In one aspect, a method of acquiring and fixating tissue is disclosed that includes inserting a surgical device having first and second jaws and a tissue acquisition member into a body lumen, positioning the device in a first position in which the jaws extend substantially parallel to a tissue surface, drawing tissue through the jaws by moving the tissue acquisition member away from the jaws, and driving at least one fastener through the tissue disposed between the jaws.

The present invention relates to a tin-containing organolithium compound which can be used as anionic polymerization initiators, represented by the following formula (1): R4−xSn(Ya—Zm—Yb—Li)x (1)Wherein R, Z and Y are defined as in the specification; x represents a value of 1 or 2; m represents a value of 0 or 1; a represents a value of 0 to 6, b represents a value of 0 to 6, a+b is from 0 to 6, provided that m=1 when x=1. The tin-containing organolithium compounds according to the present invention can be used as initiators to initiate the polymerization of conjugated dienes and/or monovinyl aromatic hydrocarbons, thereby synthesizing various linear, star or telechelic polymers. The present invention also relates to a method for preparing the tin-containing organolithium compounds according to the present invention.

Disclosed herein is a colorless or pale-colored liquid composition comprising a cationic substance, wherein the liquid composition contains in combination a cationic substance and a nonionic polymeric substance.

A process for the purification of organometallic compounds or heteroatomic organic compounds from oxygen, water and from the compounds deriving from the reaction of water and oxygen with the organometallic or heteroatomic compounds whose purification is sought, comprising the operation of contacting the organometallic or heteroatomic compound to be purified in the liquid state or in form of vapor, pure or in a carrier gas, with a hydrogenated getter alloy, and optionally also with one or more gas sorber materials selected among palladium on porous supports and a mixture of iron and manganese supported on zeolites.

The present invention is concerned with a novel process for the preparation of 1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-one (CAS 30071-93-3). This compound is useful as an intermediate in the synthesis of therapeutic agents.

The subject invention pertains to matrix metalloproteinase (MMP) inhibitors that exhibit an IC50 of below 10−4M against MMP and have substantially no activity against non-MMP metalloproteinase-related events. The MMP inhibitors of the invention have reduced side-effects, especially with respect to joint pain.

Fiber-reinforced ceramic composites contain bundles, tows or hanks of long fibers, wherein the long fiber bundles, tows or hanks are completely surrounded by a short fiber-reinforced matrix, with the long and short fibers having, independently of one another, a mean diameter of from 4 to 12 μm and the long fibers having a mean length of at least 50 mm and the short fibers having a mean length of not more than 40 mm, a process for producing them and their use for producing clutch disks or brake disks.

A chemical plant for performing a chemical reaction between particles of a material such as lithium metal, and a reagent such as butyl chloride in solution in hexane, in which one reaction product is a solid material, includes a reaction vessel (12). Several ultrasonic transducers (16) are attached to a wall of the vessel (12) so as to irradiate ultrasonic waves into the vessel, the vessel being large enough that each transducer irradiates into fluid at least 0.1 m thick, each transducer irradiating no more than 3 W/cm2, and the transducers being sufficiently close to each other and the number of transducers being sufficiently high that the power dissipation within the vessel is at least 10 W/liter but no more than 200 W/liter. The high intensity of ultrasound ensures that lithium chloride is cleaned off the surface of lithium metal particles throughout the vessel (12).

Compositions and methods for inhibiting and controlling the growth of microbes are disclosed. The composition comprises at least one chemically-modified peptide with antimicrobial activity and at least one carrier. The method comprises of administering an amount, effective for the prevention, inhibition and termination of microbial growth for industrial, pharmaceutical, household and personal care use.

Methyllithium is prepared by reacting chloromethane with a dispersion lithium metal in an aromatic organic solvent with methyltetrahydrofuran.

The invention relates to a process for preparing Grignard compounds of the formula I. The invention additionally relates to compounds of the formula I and to polymer-bound compounds of the formula Ia. The invention further relates to the use of the process for preparing substance libraries and to the use of the compounds of the formulae I and Ia in chemical synthesis.

The present invention relates to shaped bodies made of fiber-reinforced ceramic composites and comprising a core zone and at least one covering layer which has a coefficient of thermal expansion which is higher than that of the core zone. The covering layer is an SiC-rich covering layer and is divided into segments which are separated from the adjacent segments by gaps or bridging zones of a material which is different from the material of the segments. The invention also relates to a process for producing such shaped bodies by infiltration of an intermediate body with molten silicon and their use for friction disks, in vehicle construction or as protective plates.

A method is provided for producing a fiber-reinforced material which is composed, at least in a region of a surface layer, of a ceramic composite and has carbon-containing fibers reaction-bonded to a matrix containing the elements Si and C. In particular a method of producing fiber-reinforced silicon carbide is provided in which a structure of a matrix contains cracks and/or pores, at least at ambient temperature, because of a high thermal expansion coefficient compared with that of the fibers. Metals are selectively electrodeposited in the open pores and cracks of the matrix and, in particular, in a region of the electrically conductive reinforcing fibers. As a result, the open pores and cracks are filled and, in addition, metallic top layers are optionally formed that are firmly keyed to the ceramic composite and that may serve as an interlayer for glass top layers or ceramic top layers. A fiber-reinforced composite material, as well as moldings, in particular brake discs, brake linings or clutch plates, composed of such a composite material, are also provided.

Process for a fiber-reinforced ceramic material whose reinforcing fibers are present in the form of at least one of woven fabrics, short fibers and long fibers, wherein the mass ratio of the fibers in the form of woven fabrics, short fibers and long fibers is 0-35:25-80:0-45 and at least a part of the reinforcing fibers has at least one protective layer of carbon produced by pyrolysis of resins or pitches, boron compounds or phosphorus compounds or combinations thereof which have been deposited thereon, a process for producing it and its use as material for brake linings

A fullerene derivative, with a solubility in n-hexane of not lower that 0.1 mg/ml at 25° C., includes a fullerene skeleton and three or more organic groups attached to the fullerene skeleton, where each of the organic groups is represented by the general formula (III): —CH2—X (R2)(R3)(R4) (III) where X represents an element belonging to the group 14 in the periodic table; and R2, R3 and R4 may be the same or different and each represents a hydrogen atom, hydrocarbon group, alkoxy group or amino group.

Volatile liquid precursors are provided for use in the formation of alkali metal-containing materials. The compound includes an alkali metal and an amide ligand and is a liquid at a temperature of less than about 70° C.

A process for preparing alkyllithium compounds by reacting a sodium-lithium alloy with alkyl halides at temperatures of about 50 to 125° C.

A functionally graded friction material 18 having improved wear resistance and thermal conductivity with fibers 10 and heat conducting elements 12 disposed in an arrangement that conducts heat away from a first surface 20 to a second surface 22. Preferably, the heat conducting elements 12 are copper, copper alloy, filaments, threads, or wire situated substantially perpendicular to the engaging surface and extending to the non-engaging surface 22.

Disclosed is a method for producing Alkyllithium compounds by reacting metallic lithium with an Alkyl halide in a solvent. The reaction is performed at a reduced pressure at the boiling point of the solvent.

The novel metallocenes of the formula I in which, preferably, M1 is Zr or Hf, R1 and R2 are alkyl or halogen, R3 and R4 are hydrogen, R5 and R6 are alkyl or haloalkyl, —(CR8R9)m—R7—(CR8R9)n— is a single- or multi-membered chain in which R7 may also be a (substituted) hetero atom, m+n is zero or 1, and R10 is hydrogen, form, together with aluminoxanes as cocatalysts, a very effective catalyst system for the preparation of polyolefins of high stereospecificity and high melting point.

In the process of synthesizing alkylborazine compound represented by the chemical formula 2, by a reaction of a halogenated borazine compound represented by the chemical formula 1 with a Grignard reagent, thus synthesized alkylborazine compound is washed with water, or subjected to sublimation purification or distillation purification at least three times, and/or subjected to distillation purification at least twice. In the formulas, R1 independently represents alkyl group; R2 independently represents alkyl group; and X represents halogen atom.

A mask for forming polysilicon has a first slit region where a plurality of horizontal slit patterns are arranged in the vertical direction while bearing the same width, a second slit region where a plurality of horizontal slit patterns are arranged in the vertical direction while bearing the same width, a third slit region where a plurality of horizontal slit patterns are arranged in the vertical direction while bearing the same width, and a fourth slit region where a plurality of horizontal slit patterns are arranged in the vertical direction while bearing the same width. The slit patterns arranged at the first to fourth slit regions are sequentially enlarged in width in the horizontal direction in multiple proportion to the width d of the slit pattern at the first slit region. The centers of the slit patterns arranged at the first to fourth slit regions in the horizontal direction are placed at the same line. The slit patterns arranged at the respective slit regions in the vertical direction are spaced from each other with a distance of 8*d. Alternatively, the first to fourth slit regions may be arranged in reverse order, or in the vertical direction.

Sliding element for seals includes 25 to 75 weight % carbonaceous impalpable powdery aggregate of non-graphitizing carbon and/or graphitizing carbon and 20 to 50 weight % synthetic resin as binder. The sliding element is blended with the range of 5 to 25 weight % carbonaceous carbon fibers without surface treatment and inside the carbon matrix, the carbon fibers are randomly scattered.

An improved method of producing a friction material for use in the production of brake pads. A first mixing step blends binder, fiber, and filler materials together in a mixer to create a pre-mix, with one of the materials doubling as a wetting agent promoting the homogeneity of the mixture. A second non-asbestos material is added to the pre-mix in the same mixer, and the two are mixed together to produce the final friction material.

A two-stage process is provided for purifying off-gases from a high-pressure melamine plant. In the first stage, the off-gases are contacted with a recirculated urea melt containing melamine precursors and NH3. In the second stage, the off-gases are contacted with a fresh urea melt.

A method for the production of alkyl lithium compounds is disclosed, in which metallic lithium is reacted with an alkyl halide in a solvent, whereby the metallic lithium is introduced in the form of lithium particles, generated by spraying molten lithium into an inert atmosphere or into a vacuum.

The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.

The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts—LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.

A process for preparing a functionalized polymerization initiator, the process comprising combining a functionalized styryl compound and an organolithium compound.

A method of forming a polycrystalline silicon active layer for use in a thin film transistor is provided. The method includes forming a buffer layer over a substrate, forming an amorphous silicon layer over the buffer layer, applying a catalytic metal to a surface of the amorphous silicon layer, crystallizing the amorphous silicon layer having the catalytic metal thereon into a polycrystalline silicon layer, annealing the polycrystalline silicon layer in an N2 gas atmosphere to stabilize the polycrystalline silicon layer, etching a surface of the polycrystalline silicon layer using an etchant, and patterning the polycrystalline silicon layer to form an island-shaped active layer.

The invention relates to a method for producing Grignard compounds, according to which magnesium is reacted in a suitable fluid reaction medium in a protective atmosphere with hologen-substituted organic compounds by means of microwave radiation.

A method by which a halogen atom of a halogen compound can be efficiently replaced with an electrophilic group. Also provided are: a reagent for converting a functional group through a halogen-metal exchange reaction, characterized by comprising either a mixture of a magnesium compound represented by the formula R1—Mg—X (I) (wherein R1 represents a halogen atom or an optionally substituted hydrocarbon residue; and X1 represents a halogen atom) and an organolithium compound represented by the formula R2—Li (II)(wherein R2 represents an optionally substituted hydrocarbon residue) or a product of the reaction of the magnesium compound with the organolithium compound; and a process for producing with the reagent a compound in which a halogen atom of a halogen compound has been replaced with an electrophilic group.

1-Fluoro-2-substituted-3-chlorobenzenes are selectively deprotonated and functionalized in the position adjacent to the fluoro substituent.

The present invention provides a raw material for forming a strontium-containing thin film of a cyclopentadienyl-based strontium compound, which is in the liquid state at room temperature to 50° C., can be purified by distillation, present as a monomer, has high vapor pressure, and suitable for mass production, and a process for preparing the same. Sr[C5(CH3)4(C3H7)]2 is prepared by reacting Na[C5(CH3)4(C3H7)]2 or K[C5(CH3)4(C3H7)]2 with SrI2 in THF to produce a THF adduct of Sr[C5(CH3)4(C3H7)]2; evaporating THF and extracting the residue with toluene to give a toluene solution; evaporating toluene and drying the residue under reduced pressure; and heating to 100 to 160° C. in vacuo to dissociate and remove THF and distilling.

Barium, strontium, tantalum and lanthanum precursor compositions useful for atomic layer deposition (ALD) and chemical vapor deposition (CVD) of titanate thin films. The precursors have the formula M(Cp)2, wherein M is strontium, barium, tantalum or lanthanum, and Cp is cyclopentadienyl, of the formula (I), wherein each of R1-R5 is the same as or different from one another, with each being independently selected from among hydrogen, C1-C12 alkyl, C1-C12 amino, C6-C10 aryl, C1-C12 alkoxy, C3-C6 alkylsilyl, C2-C12 alkenyl, R1R2R3NNR3, wherein R1, R2 and R3 may be the same as or different from one another and each is independently selected from hydrogen and C1-C6 alkyl, and pendant ligands including functional group(s) providing further coordination to the metal center M. The precursors of the above formula are useful to achieve uniform coating of high dielectric constant materials in the manufacture of flash memory and other microelectronic devices.

Pulverulent solid which consists essentially of at least one metal alkyl compound bound chemically and/or physically to a finely divided, porous, mechanically stable and chemically inert support, has a proportion by weight of metal alkyl compound of at least 5% by weight, based on the support, and has an angle of repose, determined in accordance with ISO 4324, of up to 48°. The solid allows trouble-free metering as active component into a reactor.

The present invention provides a novel dicarbanionic initiator of formula (I). The present process further provides a process for the preparation of dicarbanionic initiator of formula (I) comprising reacting 1-bromo-4-(4'-bromophenoxy)-2-pentadecyl benzene of formula (II) with alkyllithium compound for an effecting halogen-lithium exchange reaction of 1-bromo-4-(4'-bromophenoxy)-2-pentadecyl benzene with sec-butyllithium in the presence of a non polar solvent, at a temperature in the range of 0 to 25° C. and its use as an initiator for the synthesis of telechelic polydienes and polystyrenes and SBS or SIS triblock copolymers.

A diorganomagnesium-containing synthesis means, a method for its preparation and its use.

A process is described for preparing aryllithium compounds by reaction of metallic lithium in an ether-containing solvent with an aryl halide, wherein prior to or at the beginning of the reaction a catalyst is added, the catalyst containing a halogen-free, polynuclear aromatic (aryl catalyst) or consisting of such a compound.

This invention provides a process for reducing the amount of soluble halide in a solution comprising a liquid organic medium, at least one viscosity reducing agent, at least one dihydrocarbylmagnesium compound, and an initial amount of soluble halide. The process comprises mixing at least one alkali metal with the solution at a mole ratio of alkali metal to magnesium of less than about 1:2.5, thereby forming precipitated soluble halides. Also provided by this invention is a process for reducing the amount of soluble halide in a slurry comprising a liquid organic medium, at least one viscosity reducing agent, at least one dihydrocarbylmagnesium compound, solids from the formation of said dihydrocarbylmagnesium compound, and an initial amount of soluble halide. This process comprises mixing at least one alkali metal with the slurry at a mole ratio of alkali metal to magnesium of less than about 1:1.25, thereby forming precipitated soluble halides.