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Reversible bonding in thermoplastic elastomer microfluidic platforms for harvestable 3D microvessel networks

Lab Chip, 2024, 24,4948-4961
DOI: 10.1039/D4LC00530A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Byeong-Ui Moon, Kebin Li, Lidija Malic, Keith Morton, Han Shao, Lauren Banh, Sowmya Viswanathan, Edmond W. K. Young, Teodor Veres
An openable, reversibly bonded microfluidic cell culture platform fabricated in thermoplastic elastomer and polystyrene for the generation, recovery, and extraction of engineered-microvessel networks.
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Artificial intelligence performance in testing microfluidics for point-of-care

Lab Chip, 2024, 24,4998-5008
DOI: 10.1039/D4LC00671B, Paper
Open Access
Mert Tunca Doganay, Purbali Chakraborty, Sri Moukthika Bommakanti, Soujanya Jammalamadaka, Dheerendranath Battalapalli, Anant Madabhushi, Mohamed S. Draz
AI is revolutionizing medicine by enhancing diagnostics and patient care. Our study showed ML and DL AI models excel in microchip testing, underscoring AI's potential to improve precision medicine and POC diagnostics.
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Dynamic sampling from ex vivo adipose tissue using droplet-based microfluidics supports separate mechanisms for glycerol and fatty acid secretion

Lab Chip, 2024, 24,5020-5031
DOI: 10.1039/D4LC00664J, Paper
Md Moniruzzaman, Andresa B. Bezerra, Md Mohibullah, Robert L. Judd, James G. Granneman, Christopher J. Easley
Droplet-based microfluidic sampling of adipose tissue reveals unique information on lipolytic dynamics.
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Inertial co-focusing of heterogeneous particles in hybrid microfluidic channels with constantly variable cross-sections

Lab Chip, 2024, 24,5032-5042
DOI: 10.1039/D4LC00479E, Paper
Tianwei Zhao, Peng Zeng, Yuanting Zhang, Jinxia Li, Hui Sun, Imrich Gablech, Honglong Chang, Xichen Yuan, Pavel Neužil, Jianguo Feng
Inertial focusing chips based on hybrid microfluidic channels were presented for high-efficiency heterogeneous particle co-focusing, offering significant applications in microfluidic flow cytometry and single-cell analysis.
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Microfluidic antisolvent crystallization for chiral symmetry breaking

Lab Chip, 2024, 24,5055-5064
DOI: 10.1039/D4LC00658E, Paper
Jiye Jang, Gerard Coquerel, Tae Seok Seo, Woo-Sik Kim, Bum Jun Park
Microfluidic antisolvent crystallization was used to study the effect of solution volume on chiral symmetry breaking (CSB) in NaClO3 crystals. 100% CSB occurs below a critical emulsion volume due to rapid molecule depletion and suppressed nucleation.
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Surface modification of paper-based microfluidic devices via initiated chemical vapor deposition

Lab Chip, 2024, 24,4940-4947
DOI: 10.1039/D4LC00414K, Tutorial Review
Stacey Bacheller, Malancha Gupta
Paper-based microfluidic devices offer a low-cost platform for biological and environmental detection. This tutorial review shows that initiated chemical vapor deposition can be used to modify these devices with functional polymers.
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Rapid low-cost assembly of modular microvessel-on-a-chip with benchtop xurography

Lab Chip, 2024, 24,5065-5076
DOI: 10.1039/D4LC00565A, Paper
Open Access
Shashwat S. Agarwal, Marcos Cortes-Medina, Jacob C. Holter, Alex Avendano, Joseph W. Tinapple, Joseph M. Barlage, Miles M. Menyhert, Lotanna M. Onua, Jonathan W. Song
Our study is a novel implementation of xurography for multi-layer microfluidic device fabrication. We demonstrate the versatility of this approach by presenting several modular 3D vessel-matrix arrangements.
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A microfluidic hanging droplet as a programmable platform for mammalian egg vitrification

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00428K, Paper
Open Access
Haidong Feng, Georgios Katsikis, India D. Napier, Gong Du, Josh Lim, Joseph O. Doyle, Scott R. Manalis, Linda G. Griffith
Programmable microfluidic hanging drop system for motorized, contactless cryoprotectant loading and egg vitrification.
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Zonal patterning of extracellular matrix and stromal cell populations along a perfusable cellular microchannel

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00579A, Paper
Open Access
Brea Chernokal, Bryan J. Ferrick, Jason P. Gleghorn
Developed a system to regionally pattern stromal cell populations and hydrogel properties along the length of a perfused epithelial tube. This enables the dissection of specific microenvironmental factors that govern developmental tissue patterning.
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Self-actuated microfluidic chiplet for two-stage multiplex nucleic acid amplification assay

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00752B, Paper
Open Access
Felix Ansah, Marziyeh Hajialyani, Fatemeh Ahmadi, Yuming Gu, Ergün Alperay Tarım, Michael G. Mauk, Gordon A. Awandare, Haim H. Bau
Self-actuated chiplet for Penn-RAMP assay.
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5-axis CNC micro-milling machine for three-dimensional microfluidics

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00496E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Mitchell Modarelli, Devin Kot-Thompson, Kazunori Hoshino
The gold standard of microfluidic fabrication techniques, SU-8 patterning, requires photolithography equipment and facilities and is not suitable for 3D microfluidics. A 3D printer is more convenient and may achieve...
The content of this RSS Feed (c) The Royal Society of Chemistry




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3D-printed microfluidic–microwave device for droplet network formation and characterisation

Lab Chip, 2024, 24,5101-5112
DOI: 10.1039/D4LC00387J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kai Silver, Jin Li, Adrian Porch, William David Jamieson, Oliver Castell, Pantelitsa Dimitriou, Colin Kallnik, David Barrow
A 3D-printed microwave–microfluidic device using a liquid metal resonator for droplet network formation and characterisation.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Real-time monitoring of a 3D blood–brain barrier model maturation and integrity with a sensorized microfluidic device

Lab Chip, 2024, 24,5085-5100
DOI: 10.1039/D4LC00633J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Maria Cristina Ceccarelli, Marie Celine Lefevre, Attilio Marino, Francesca Pignatelli, Katarzyna Krukiewicz, Matteo Battaglini, Gianni Ciofani
A new in vitro sensorized model of the blood–brain barrier has been developed and characterized.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Impact of microchannel width on axons for brain-on-chip applications

Lab Chip, 2024, 24,5155-5166
DOI: 10.1039/D4LC00440J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Katarina Vulić, Giulia Amos, Tobias Ruff, Revan Kasm, Stephan J. Ihle, Joël Küchler, János Vörös, Sean Weaver
Axon growth is influenced by the width and number of microchannels, with growth cone adaptability reaching its limit for constraints smaller than 350 nm. Tradeoffs between axon growth and control need to be made for neurofluidic devices.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Optical tweezer-assisted cell pairing and fusion for somatic cell nuclear transfer within an open microchannel

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00561A, Paper
Yidi Zhang, Han Zhao, Zhenlin Chen, Zhen Liu, Hanjin Huang, Yun Qu, Yaowei Liu, Mingzhu Sun, Dong Sun, Xin Zhao
We developed a somatic cell nuclear transfer-electrofusion system for pairing and fusing oocytes and somatic cells with a thousand-fold volume difference. The system showed a 90.56% pairing efficiency, potentially boosting batch cloning efficiency.
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Dual-drive acoustic micromixer for rapid nucleation and ultrafast growth of perovskite nanoparticles

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00721B, Paper
Zhifang Liu, Yuwen Lu, Wei Tan, Guorui Zhu
An acoustic micromixer driven by bubbles and sharp edges, controlling the nucleation and growth of perovskite nanoparticles.
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Discretised microfluidics for noninvasive health monitoring using sweat sensing

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00763H, Paper
Open Access
Emma J. M. Moonen, Walther Verberne, Eduard Pelssers, Jason Heikenfeld, Jaap M. J. den Toonder
We present the first wearable device with integrated electrowetting, which collects and transports sweat from single glands and measures sweat rate for extremely low sweat rate. This enables non-invasive biomarker monitoring of hospitalized patients.
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An imaging scheme to study the flow dynamics of co-flow regimes in microfluidics: implications for nanoprecipitation

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00652F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Wali Inam, Anton Vladyka, Joanna W. Pylvänäinen, Junel Solis, Dado Tokic, Pasi Kankaanpää, Hongbo Zhang
Herein, by presenting a novel imaging-based scheme for analyzing fluid interactions in co-flow regimes, we identify oscillatory and chaotic flow behaviors to optimize nanoprecipitation through controlled fluid manipulation.
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Microstring-engineered tension tissues: a novel platform for replicating tissue mechanics and advancing mechanobiology

Lab Chip, 2024, Advance Article
DOI: 10.1039/D4LC00753K, Paper
Zixing Zhou, Tingting Li, Wei Cai, Xiaobin Zhu, Zuoqi Zhang, Guoyou Huang
A simple, cost-effective approach for fabricating soft microstring chips that enables precise engineering of tension tissues (METTs), advancing research in mechanobiology and biomedical applications.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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SERS-based pump-free microfluidic chip sensor for highly sensitive competitive immunoassay of cortisol in human sweat

Lab Chip, 2024, Accepted Manuscript
DOI: 10.1039/D4LC00858H, Paper
Siyue Xiong, Chushu Zhu, Chengxuan Wang, Peitao Dong, Xuezhong Wu
Cortisol, known as the "stress hormone," is secreted by the adrenal cortex. Measuring cortisol levels in body fluids is essential for evaluating stress levels, adrenal function, hormone imbalances, and psychological...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Amicus curiae suggests restricting elephant parades to religious festivals

Parading of elephants should be strictly restricted to registered temples, churches, mosques, and rituals which are associated with these institutions. Any introduction of new rituals or reviving of dormant rituals should not be permitted.




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Two youngsters from Kochi determined to smash their disabilities on the badminton court

Atul Krishna and Jyothish Kumar defy physical limitations to excel in badminton, inspiring with their determination and talent.




mi

Biomining of legacy waste at Kalamassery likely to begin soon




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Kerala High Court quashes criminal case against filmmaker Sreekumar Menon




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Union Minister Suresh Gopi inaugurates ‘Confluence-24’ in Kochi




mi

Hema Committee report: Preliminary inquiry in cases to be completed by December-end, Kerala govt tells HC

Submission made in a progress report filed by Kerala govt in response to public interest litigation in High Court filed in connection with Hema Committee report




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Boxing competition disrupted by man claiming to be YouTuber in Kerala




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Drones to emerge as game changer in fisheries sector, says Union Minister

George Kurian says Centre will develop 100 climate-resilient coastal villages to protect fishers’ livelihood




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Kerala, Tamil Nadu united to ensure that India belongs to everyone, says Kanimozhi

DMK MP Kanimozhi was addressing an event held at the Ernakulam Town Hall to felicitate Sr. Vinitha, director of St. Teresa’s College, for her contributions to higher education, social welfare, and culture.




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Coastal States must register all fishing vessels, says Union Minister George Kurian

George Kurian emphasises the need for a framed regulation and policy to improve the livelihood of the fishing community and increase the number of vessels to optimally exploit the country’s marine fisheries resources




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PDP declares support to LDF in forthcoming byelections

Decision assumes significance in the wake of a controversy over a reference in CPI(M) leader P. Jayarajan’s book that PDP supremo Abdul Nasir Maudany had a role in radicalising the Muslim youth in the State




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Union Minister inaugurates Milma’s fully solar-powered dairy

Milma Federation Chairman K.S. Mani handed over the keys of the Central Quality Control Lab to National Dairy Development Board Chairman Meenesh Shah.




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HC allows medical termination of pregnancy of minor rape survivor

Division Bench passed the order while allowing an appeal filed against a single judge’s order declining permission. Medical board said that termination of pregnancy was most appropriate




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Seaplane demo flight in Kochi draws mixed response




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1,000 consumer clubs to be formed on campuses, says Kerala Minister




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Illegally mined sand, vehicles seized in Ernakulam




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Kerala School Sports & Games: Govt. determined to reclaim Kerala’s lost glory in sports, says CM Pinarayi Vijayan

‘Kerala could attract investments worth ₹5,050 crore to the sports sector by becoming the first State to hold a sports summit’




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No separate categories of schools in adjudging winners, clarifies Minister




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Kerala HC quashes criminal case against former postal officials for taking possession of Waqf property

The post office was functioning from 1999, even before the insertion of section 52A in Waqf Act, which makes purchase or possession of Waqf property without Waqf Board nod punishable




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Migrant's progress



  • R K Nair

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Cashing in on calamity

Fleecing the pilgrims is big business in this country.



  • R K Nair

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Primitive blame game

The latest controversy gives rise to a nagging suspicion: Were the utterances of the Kerala Chief Minister and his Cabinet colleague aimed at deflecting attention from the raging solar scam?



  • R K Nair

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Grizzly should repeat in the Chief Minister’s Trophy




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Chief Minister’s Trophy declared null and void due to false start




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King’s Battalion, Still I Rise, Charukala and Admiral Shaw please




mi

Seeking The Stars, Pink Jasmine, Still I Rise and Multiflora catch the eye




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Madison, Trigger and Little Minister impress




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Thalassa and Misty catch the eye 




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Field Of Dreams, Irish Gold and Champagne Smile catch the eye




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Knotty Legend claims the General Rajendrasinhji Million