The prefrontal cortex is critical for decision-making across species, with its activity linked to choosing between options. Drift diffusion models (DDMs) are commonly employed to understand the neural computations underlying this behavior. Studies exploring the specific roles of regions of the rodent prefrontal cortex in controlling the decision process are limited. This study explored the role of the prelimbic cortex (PLC) in decision-making using a two-alternative forced-choice task. Rats first learned to report the location of a lateralized visual stimulus. The brightness of the stimulus indicated its reward value. Then, the rats learned to make choices between pairs of stimuli. Sex differences in learning were observed, with females responding faster and more selectively to high-value stimuli than males. DDM analysis found that males had decreased decision thresholds during initial learning, whereas females maintained a consistently higher drift rate. Pharmacological manipulations revealed that PLC inactivation reduced the decision threshold for all rats, indicating that less information was needed to make a choice in the absence of normal PLC processing. μ-Opioid receptor stimulation of the PLC had the opposite effect, raising the decision threshold and reducing bias in the decision process toward high-value stimuli. These effects were observed without any impact on the rats’ choice preferences. Our findings suggest that PLC has an inhibitory role in the decision process and regulates the amount of evidence that is required to make a choice. That is, PLC activity controls "when," but not "how," to act.

Engage, OM South Africa’s bi-annual conference, provides a challenge and a channel for joining missions with OM.

Participants of a poverty simulation activity hosted by AIDSLink International discover that it’s very different to minister to the poor than to be the poor.

Unite Nations in Cape Town (UNIC) works alongside two local universities, building friendships with the international students for God’s kingdom.

OM SportsLink ministers to young boys in Mamelodi, the largest township of Pretoria, South Africa, every Friday.

Jabulani, a youth from South Africa affected by HIV, receives help and care from the OM team ministering in his community.

Missions Discipleship Training in South Africa is not a wasted six months--it's a springboard into your calling, preparing and equipping you for the real deal.

OM has trained thousands of young people into a stronger relationship with Christ and prepared them for the mission field.

Russian OMer Alexandra Bykova begins a Quilting Club to bring women closer to each other and to faith in Christ.

OM Russia’s Student Christian Centre, in partnership with the local Evangelical Church, reaches universities in Novosibirsk. The project leader shares about plans for this year.

After watching others be baptised, an Uzbek lady who had recently repented in the church expressed her desire to follow the others’ example.

How OM Founder George Verwer's visit to Siberia impacted local churches.

A young couple who met on the Internet answers God’s call to missions to help others find Christ using their IT and web design skills.

OM Russia leader Colin Cleaver discusses why he values the involvement of families in OM Russia’s ministry and encourages other families to consider missions.

The story of Yury, who came to Christ in prison.

OM Russia celebrated the 10th anniversary of the discipleship ministry.

OM Russia had a great kick-off to the STM summer season by serving in a camp for children with disabilities to hear about Christ.

A group of Russians participates in an OM Moldova summer outreach for children.

OM Philippines will host three training sessions this month in an effort to see sustainable, transformational and developmental ministries grow in Cebu City.

A team of three from OM Philippines travel to Leyte Island to assess the situation and connect with local churches.

After taking inventory of the relief effort, OM Philippines workers, in partnership with churches, distribute relief necessities to some of the least-reached disaster sites.

OM Philippines Field Leader Sally Ababa is concerned about the damage residents of Leyte Island face as clean-up efforts move forward.

Students from OM Philippines-Cebu's Alternative Learning System bring children joy through a Christmas party, following the trauma caused by Bohol earthquake and Typhoon Haiyan.

On 24 December, OM Philippines-Cebu witnessed the overflowing joy of about 135 families during Christmas parties they hosted in two typhoon-affected areas.

From Leyte Island to Northern Cebu to Bohol Island, the Christmas season brought overwhelming joy to many who received provision and care from OM Philippines.

OM Philippines’ Alternative Learning System teachers visit the homes of students in an effort to connect with their parents and encourage further education.

An Out of the Comfort Zone team experiences island life as they bring Christ’s love to children and families on Gilutungan and Kinatarcan Island.

OM Philippines celebrates 25 years of transforming lives and communities.

OM Philippines receives a short-term mission team from Hong Kong.

A teenage girl's courage and boldness opens door for family´s salvation (Philippines).

A shepherd from a Muslim background comes to Jesus thanks to a goat ministry started by OM Mozambique.

"...if they don’t believe you, you have to keep on talking and talking and talking until it gets stuck in their head," said Lansipe.

God uses a Scripture verse sent by text message to change a man’s life.

God opens doors for an international team to minister in Urfa, Turkey, an ancient city with no Christian church and only a handful of believers.

Newly married couple temporarily in Turkey uses spare time and unexpected opportunities to reach out to refugees.

No known believers from a Muslim background existed in Turkey when the first two OMers arrived in 1961. Now, nearly half of the 7,000 believers there can trace their journey through the Bible Correspondence Course.

Through the ups and downs of starting a new team, millennial workers see fruit when they start asking the right question.

A persuasive atheist changes his mind when Jesus meets him in a dream.

After experiencing answered prayer, a Syrian woman finds faith through gifts of the "Jesus Film" and a Bible.

An OM team in Coventry, UK, meets an 80-year-old woman who becomes an acquaintance, then a friend and then a sister in Christ.

A small Black Country, UK, church were blessed by the efforts of five young missionaries from different parts of the world.

“If you could have one wish from God today, what would you wish for?” Evangelism coach, Richard Sharp, taught his outreach method called ‘One Wish’.

When Rev Graham Clay, Pastor of Stratford-Upon-Avon Baptist Church, decided to have an OM ministry team work with his church, he didn’t hesitate to take action.

Dominic Notegen, a 27-year-old English Language Community Outreach student at OM Lifehope, feels called to spread the Gospel.

OM Lifehope coordinates ELCO—English Language and Community Outreach—to equip those considering serving God in missions.

At Manna House, in the Greater London Area, guests from all over the world come for accommodation and a place to rest.

The Kid's 'n' Things team visited two churches to run five-day long holiday clubs, with the theme of “Lionheart and the Great Wild West Adventure”.

In Tongwa village husbands and wives don't know how to love each other. A young couple is working to change that.

One young Zambian man’s life is transformed when he encounters Christ through an OM football team and a coach’s patient effort.