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La Union named most competitive province

La Union has been named as the most competitive province in Ilocos region and placed seventh in the nationwide 2024 Cities and Municipalities Competitiveness Index for two consecutive years.




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PNP seizes P40.3 billion drugs under Marcos Jr. government

The drug war under the administration of President Marcos has netted P40.32 billion worth of illegal drugs, the Philippine National Police reported yesterday.




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Transport minister on SiGMA traffic: ‘Events like this will result in congestion’

Minister Chris Bonett said he sympathises with those who were stuck in traffic on Tuesday evening but added that events of this kind will inevitably result in congestion




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Court lifts €20 million freezing order on DF Advocates in Vitals case

Court removes temporary freezing order on DF Advocates after decreeing that the law firm could not be found criminally guilty




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Inquiry expert tells court she could not find Malta Enterprise due diligence report for Vitals concession

Vitals inquiry expert Miroslava Milenović faces heated scrutiny over qualifications and methods for her role in uncovering complex financial links




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Italian Court fully acquits Palumbo Shipyards of waste dumping conviction

Antonio Palumbo, owner of Palumbo Shipyards, fully acquitted by Messina Court of Appeal, which ruled his actions in alleged illegal dumping did not constitute a crime




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MIA posts €39.5 million net profit in nine-month review

Malta International Airport generated €107.8 million in revenue for the first nine months of 2024, posting a net profit of €39.5 million




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Government to mark 50 years as a Republic with L-Istorja, Int’ celebrations in Valletta

'L-Istorja, Int' (History, You), will be the theme for the 50th anniversary celebrations for Malta's Republic Day




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CESAFI: CIT-U Junior Wildcats claw back USPF in come-from-behind win

CEBU CITY, Philippines —The Cebu Institute of Technology-University (CIT-U) Junior Wildcats mounted a dramatic second-half comeback to edge out the University of Southern Philippines Foundation (USPF) Baby Panthers, 53-50. The game was part of the Cebu Schools Athletic Foundation, Inc. (CESAFI) Season 24 High School Basketball Tournament, held on Wednesday, November 13, at the Cebu Coliseum. With the victory, the Junior Wildcats improved to a 6-4 record, securing the No. 6 spot in the standings, while USPF slipped to 4-5, dropping to No. 7. CIT-U forward Daniel Mapula was a key contributor throughout the game, dominating the paint with 10 […]...

Keep on reading: CESAFI: CIT-U Junior Wildcats claw back USPF in come-from-behind win




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BingoPlus’ newest Mega Jackpot winner bags ₱154 million

BingoPlus, the country’s comprehensive entertainment platform, announced its newest Bingo Mega Jackpot winner on November 13, 2024 with a grand total of 154,148,662 Pesos winning prize. The Bingo Mega Jackpot winner of 154 million Pesos is the highest prize ever won so far in the BingoPlus platform. With only 5 Pesos worth of cards, the BingoPlus user purchased 20 random green cards for only 100 Pesos, and amazingly, hit the biggest jackpot in BingoPlus history. BingoMega is among many games in BingoPlus that allows you to both enjoy and win prizes while playing. For just 5 Pesos, you can have […]...

Keep on reading: BingoPlus’ newest Mega Jackpot winner bags ₱154 million




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World Bank oks $750-M PH digital transformation program

The World Bank (WB) has approved a new $750-million development policy loan aimed at helping the Philippine government ramp up its digital transformation efforts, marking its second financial aid of this type to a country where the internet economy has seen rapid expansion. The multilateral lender said on Wednesday that its second digital transformation package […]...

Keep on reading: World Bank oks $750-M PH digital transformation program




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British police officer arrested on suspicion of Hamas support


The alleged support for Hamas related to online activity, Gloucestershire Police said.




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Israel visits Paris amid tight security for Nations League soccer clash


"I’m more concerned about France’s attack on the pitch than anything that might happen off it" Ben Shimon said, regarding possible threats to the upcoming game.




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Biden, Trump to meet at White House for transition talks after Harris defeat


Biden and Trump have sharply criticized each other for years, and their respective teams hold vastly different positions on policies from climate change to Russia to trade.




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'The Guardian' leaves X following Musk's new government nomination


“We think that the benefits of being on X are now outweighed by the negatives and that resources could be better used promoting our journalism elsewhere," The Guardian explained.




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Bill to weaken Israel Bar Association passes preliminary Knesset vote


The bill would give the Justice Minister the authority to set the amount of the annual membership fee instead of IBA's national council.




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Israel questions ICC judge's impartiality in Netanyahu arrest case


The request requires the approval of ICC judges, but their decision has been delayed, partly because of several rounds of legal filings by Israel that have challenged the court's jurisdiction.




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KKL-JNF leads commemoration efforts at Re’im Recreation Site


KKL-JNF allocates NIS 4m. to upgrade, create memorial at Re'im Recreation Site in Be'eri Forest, where 384 people were murdered at Nova music festival on October 7.




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Why Trump’s victory is a victory over antisemitism - opinion


Donald Trump winning the election is a game-changer not just for America, but for Jews worldwide.




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Israel rejects aid groups' Gaza report, says it 'relies on partial information'


The Israeli military "intends to continue its tireless efforts to improve the humanitarian situation in the Strip during the ongoing conflict," a statement said.




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Fingers pointing in all directions: Dutch politicians debate Amsterdam attacks, antisemitism


The members of the House debated the role of lack of integration, antisemitism within the Muslim population, and failure of authority in a discussion about the attacks.




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CIA official arrested in Cambodia for classified doc. leak on Israel retaliation on Iran - report


CIA official Asif W. Rahman held top-secret security clearance and had access to sensitive information, the New York Times reported.




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Grossi visits Iran, only after Trump's election in first visit since new Iranian president


Grossi highlighted that the Islamic Republic continues to increase its 20% and 60% enriched uranium stock as well as the number of cascades it has for enriching uranium in violation of the 2015 deal.




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SC releases cause list for cases to be heard by constitutional bench

The Supreme Court on Wednesday released the cause list of cases which will be heard by the recently established constitutional bench on November 14 and 15.

Earlier, the SC constituted a three-judge committee to fix cases, issue court rosters, form benches, and decide weekly caseload for its recently established constitutional bench.

SC on Tuesday announced that the constitutional bench will start hearing cases on November 14 and 15.

According to the cause list, available on the SC’s website, a six-member bench headed by Justice Aminud Din Khan will hear a total of 34 cases, including 18 cases on Nov 14 and 16 cases on November 15.

On Nov 5, the Judicial Commission of Pakistan (JCP), in its maiden session, had picked Justice Amin as head of the constitutional bench by a seven-to-five majority.

Chaired by Chief Jus­tice of Pakistan (CJP) Jus­tice Yahya Afridi, the reconstituted JCP for­m­ed a seven-member con­stitutional bench, inc­­luding Justices Ami­nud Din Khan, Jamal Khan Mandokhail, Muha­m­mad Ali Mazhar, Ayesha A Malik, Hassan Azhar Rizvi, Musarrat Hilali and Naeem Akhtar Afghan.

Cases related to environmental pollution from 1993, 2003, and 2018 have been scheduled for hearing.

The scheduled cases also include a revision petition against the dismissal of the petition regarding the appointment of Qazi Faez Isa as the chief jus­tice of the Balochistan High Court.

A request for rescheduling the 2024 general elections has also been fixed for hearing where the petition sought to shift the elections from Feb to the first week of March.

According to the cause list, cases related to harassment of women in offices have been fixed. The Ali Zafar and Meesha Shafi harassment case has also been fixed for hearing.

A suo motu notice case on private use of the Islamabad Convention Centre will also be heard by the bench. The convention centre suo motu was taken on the note of former judge Qazi Faiz Isa.

An application filed for the disqualification of the members of the assembly having business and assets abroad has also been scheduled.

Other scheduled cases include a petition for banning the marriage of government officials with foreign nationals, a petition to declare the legislation passed by the Pakistan Democratic Movement (PDM) government as null and void and a suo motu notice case on overseas bank accounts of Pakistanis.

A petition filed by Mohammad Ali Durrani to bring back laundered money from other countries will also be heard.

Moreover, cases related to the jurisdiction of Gilgit-Baltistan courts in Pakistan and various applications of Khawaja Asif regarding energy projects have also been scheduled.




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Heated debate on Amsterdam violence in Dutch parliament

Dutch parliamentarians clashed on Wednesday in a heated debate to discuss the attacks on Israeli fans after a football match last week, with some lawmakers pointing fingers and others urging unity.

The Netherlands is still dealing with the political fallout from last week’s violence in Amsterdam, when fans of Tel Aviv Maccabi were assaulted by men on scooters in several parts of the capital.

Five Macabi fans were briefly hospitalised after being beaten up following a match with the local Ajax team last Thursday, in what Dutch Prime Minister Dick Schoof termed an incident of “unadulterated anti-Semitism”.

After the match, groups of men on scooters engaged in “hit-and-run” attacks on Maccabi fans in areas of the city.

Police said the attackers were mobilised by calls on social media to target Jewish people.

Far-right MP Geert Wilders, leader of the biggest party in the coalition government, said the perpetrators of the violence against Maccabi Tel Aviv fans were “all Muslims” and “for the most part Moroccans”.

The anti-Islam Wilders called for the attackers to be prosecuted “for terrorism.”

“For the first time since the Second World War there was a hunt on Jews,” Wilders said, adding “I am sick of being criticised when I tell the truth.”

But the firebrand MP drew the ire of opposition parties, who accused him of “adding fuel to fire”.

‘Dividing the country’

While unanimously condemning the violence, left-wing parties have called for dialogue with the Muslim community instead of “dividing the country”.

“I share the condemnation of the violence in Amsterdam and yes, there was indeed anti-Semitic violence,” left-wing opposition leader Frans Timmermans said.

“You are simply stoking the fires while this country has a need for politicians to unite people and find solutions,” Timmermans told Wilders.

Amsterdam mayor Femke Halsema on Tuesday called the attacks a “poisonous cocktail” of anti-Semitism and hooliganism.

Events ahead of the match heightened tensions, including anti-Arab chants by Maccabi fans, who also set fire to a Palestinian flag on the city’s central square and vandalising a taxi.

After the match, which passed off peacefully, reports emerged of social media calls to attack Jews, Amsterdam police said.

The violence took place against the backdrop of an increasingly polarised Europe, with heightened tensions following a rise in antisemitic, anti-Israeli and Islamophobic attacks since the start of the Gaza conflict.

The Dutch PM indicated that the government would present concrete steps to tackle antisemitism on Friday.

Eight people remained in custody over the violence.




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Previous financial pledges on climate change yet to materialise, PM Shehbaz tells COP29 summit

Prime Minister Shehbaz Sharif highlighted on Wednesday that financial pledges made at the previous two United Nations’ annual climate summits — COP27 and COP28 — were yet to materialise.

He made the remarks during the 29th United Nations Climate Change Conference, also known as COP29, that is being held in Azerbaijan’s capital of Baku. The premier presented Pakistan’s case on the second and final day of the World Leaders Climate Action Summit.

Pakistan is ranked among the top 10 most climate-vulnerable countries, according to the Global Climate Risk Index. It has faced increasingly frequent and severe weather events, such as unprecedented floods, intense monsoon rains, devastating heat waves, rapid glacial melting and glacial lake outburst floods.

Addressing the summit, PM Shehbaz asserted that COP29 should “make this understanding loud and clear that we will have to fulfil those financial pledges” committed at COP27 and COP28.

“And yet, I think, those huge financial commitments have to be materialised.”

The prime minister said the event was aimed at understanding the “calamities which, unfortunately, some of the countries have already faced and some will if we do not act”.

At COP27 in 2022, which was also attended by PM Shehbaz, countries had adopted a hard-fought final agreement to set up a “loss and damage fund” to help poor countries battered by climate disasters.

At COP28 last year, then-caretaker premier Anwaarul Haq Kakar had called for immediately executing the $100 billion in commitments for climate finance.

According to the UN, around $700 million have been pledged so far for the loss and damage fund, with France, Italy, Germany and the UAE being the biggest contributors.

At COP29 today, PM Shehbaz also spoke about the devastating monsoon floods of 2022, highlighting they had resulted in 1,700 deaths, massive displacement, destruction of houses and crops, and $30 billion loss to the country’s economy.

He called on the international community “to take measures which are so important at this point in time to have a conducive environment” to combat climate change.

The prime minister stressed that Pakistan was one of the countries that “hardly contribute” to global emissions, yet it was vulnerable to climate change and listed as one of the “10 countries which can, God forbid, face this kind of devastation again”.

“My memories are still fresh,” he said, recalling a meeting with flood affectees in Balochistan, including a boy named Ikramullah who had “lost everything”.

“His entire village was erased from the face of the earth, his home was completely demolished, and his school was also submerged. And we had arranged his education [in] another part of Pakistan,” he said.

PM Shehbaz stated he would not want “other countries to face the plight Pakistan faced back in 2022”.

Describing Pakistan as a “resilient, hard-working and responsible nation”, the premier affirmed his country was “fully committed to being part of the global climate solutions”.

Concluding his speech, the prime minister expressed the hope that under Azerbaijan’s leadership, COP29 can transform into a “finance COP by restoring confidence in the pledging process and scaling up climate finance”.

“I strongly feel that climate finance must be grant-based and not add to the debt burden of vulnerable developing countries,” he said, reiterating his remarks from yesterday on the sidelines of the summit.

“Two years ago, I warned, and I warned at the top of my voice, that the future would never forgive our inaction. Today, I echo the same warning with greater urgency,” PM Shehbaz asserted.

‘We shouldn’t brave impact of emissions by others’

Referring to the 2015 Paris Agreement, PM Shehbaz said: “Ten years ago in Paris, we had failed to stop the rise in emissions and catastrophic global warming, and those pledges in Paris 10 years ago, which were made have yet to see the light of the day.”

“As the minus-one emitters, we should not brave the impact of emissions realised by others without even the tools to finance resilience,” he emphasised.

“Without climate justice, there can be no real resilience,” the prime minister asserted.

The premier further said Pakistan would “go through a renewable energy revolution”, noting that the country last year presented a “comprehensive National Adaptation Plan”.

He continued: “This year, we have developed our National Carbon Market Framework. But we cannot do it alone. Pakistan needs international support to deliver on its climate ambitions.”

“My government has taken concrete actions to deliver on its commitment of producing 60 per cent of all energy from green sources and shifting 30pc of our vehicles to EVs (electric vehicles) by the end of this decade,” he told the summit.

PM Shehbaz stated that developing countries would need an estimated $6.2 trillion by 2030 to implement less than half of their current Nationally Determined Contributions (NDCs).

“The same goes for adaption and loss and damage,” he added, recalling the efforts at COP27 led by then-climate change minister Sherry Rehman.

Early warning systems for all

Addressing the COP29 summit, Deputy Prime Minister Ishaq Dar highlighted the utility of early warning systems for climate-induced disasters and extended his gratitude to UN Secretary-General Antonio Guterres for launching the ‘Early Warning for All’ initiative.

“Today, the threat is not limited to floods, we are facing rising temperatures, more intense and frequent heatwaves, and erratic rainfall patterns,” Dar said. “Early warning systems for various climate-induced hazards including floods, glacial lake outbursts, droughts and extreme heat are essential for resilience, not just for Pakistan but for all vulnerable nations worldwide,” he added.

The deputy PM thanked the UN Secretary-General for the early warning initiative, which “aims to protect every person on earth with an early warning system by 2027”.

Dar added that the threat of extreme heat emphasises the necessity of multi-hazard early warning systems, which he said were “critical to saving lives and supporting sustainable development in the face of climate adversity”.

“Despite our limited resources, Pakistan is committed to climate action and has set very ambitious goals,” the deputy PM said. “Our pledge to reduce projected greenhouse gas emissions by 50pc by 2030 comprises a 15pc reduction through national efforts and an additional 35pc contingent on international support.”

Dar named the Green Pakistan Project, an “electric vehicle policy”, a large-scale project to rehabilitate mangroves and implement Bus Rapid Transit (BRT) mass transit systems in Pakistan’s major cities.

“These efforts aim to fulfil our nationally determined contributions and to balance our global mitigation role with local adaptation needs,” Dar said. “However, we must acknowledge that national efforts alone are insufficient.”

The deputy PM highlighted that accessible climate finance is essential for Pakistan to meet these targets. “We urgently call on developed nations to honour their $100bn climate finance annual pledge and establish a new collective quantitative goal that reflects today’s needs with funding reaching the trillions,” he stated.

He added that this funding must be “accessible, grant-based and reflective of the historical responsibilities of industrialised nations”, adding that the burden “cannot rest solely on developing countries”.

“While Pakistan is ready to do its part, we look to the international community for support, particularly in accessing climate finance for early warning systems and climate resilience projects,” he said. “We need mechanisms that ensure easy, direct access to funds that can bolster national programmes rather than piloting isolated projects.”

Dar reiterated Pakistan’s commitment to “being part of the solution” to the shared climate crisis and stressed that through shared partnerships and support from global allies, “we can bridge the early warning gap, enhance resilience and build a safer, more sustainable future for generations to come”.

‘Debt cannot be new normal’

Speaking at a Pakistan-organised conference at COP29 yesterday, PM Shehbaz had said debt cannot become the “acceptable new normal” in climate financing.

He had explained that finan­c­ing in the form of loans pushes developing nations towards “mounting debt traps”, which he ref­erred to as “death traps”.

Speaking at Glaciers 2025: Actions for Glaciers, the prime minister had also linked humanity’s survival with the health of glaciers, saying Pakistan was ready to work with the world on the matter.

Participating world leaders and delegates pose for a group photo during the United Nations Climate Change Conference (COP29) in Baku on Nov 12, 2024. — AFP

PM Shehbaz also met with various world leaders on the sidelines of the summit, including UAE President Sheikh Moha­m­med bin Zayed Al Nahyan, UK PM Sir Keir Starmer and Turkish President Recep Tayyip Erdogan, as well as those from South and Central Asia.

Dozens of world leaders convened in Azerbaijan for COP29 but many big names skipped the UN climate talks where the impact of Donald Trump’s election victory was keenly felt.

US President Joe Biden, China’s President Xi Jinping, India’s PM Narendra Modi and France’s President Emmanuel Macron were among the G20 leaders missing the event.

Pakistan witnessed devastating floods during the 2022 monsoon season, induced by climate change, resulting in the loss of at least 1,700 lives.

With 33m people affected and swathes of agricultural land washed away, the damage incurred losses worth $30bn, according to government estimates.

In June 2024, a heat wave brought record-high temperatures, severely impacting public health and agriculture.




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4 terrorists, including high value target, killed in Kech operation: ISPR

Security forces killed four terrorists, including a “high-value target”, during an exchange of fire in Balochistan’s Kech district, the military’s media wing said on Wednesday.

According to a statement by Inter-Services Public Relations (ISPR), security forces conducted an intelligence-based operation in the general Balgatar area of Kech District on the “reported presence of terrorists”.

“During [the] conduct of the operation, after an intense fire exchange between own troops and the terrorists, four terrorists including a high-value target, terrorist ring leader Sana [alias] Baru were killed,” the statement said.

It added that the killed terrorist was a focal recruitment agent, “especially suicide bombers, for the so-called Majeed Brigade in District Kech and was highly wanted by the law enforcement agencies.”

A sanitisation operation is being conducted to eliminate any other terrorists found in the area.

Pakistan’s security forces “remain determined to thwart attempts of sabotaging peace, stability and progress of Balochistan,” the statement said.

The country has lately witnessed a sharp uptick in the number of attacks targeting security forces, other law enforcement agencies, and security checkpoints, particularly in Balochistan and KP.

Attacks escalated after the TTP broke a fragile ceasefire agreement with the government in 2022 and vowed to target security forces.

Last Sunday, security forces killed 10 terrorists and injured eight others during three different engagements in North Waziristan.

On Nov 7, security forces killed five terrorists during an exchange of fire in South Waziristan, while four soldiers were martyred in the operation.

In another incident on Nov 4, security forces killed seven terrorists in separate operations, with one terrorist killed in Balochistan and the other six killed during two operations in KP.

Likewise, on November 2, four terrorists were killed during an intelligence-based operation in KP’s South Waziristan region.




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PTA introduces new registration portal for VPN users

The Pakistan Telecommunication Authority (PTA) on Tuesday hosted a consultation session on its virtual private networks (VPNs) registration framework, which aimed to foster a “secure environment for the IT and e-commerce sectors in Pakistan”, a press statement said.

VPNs are widely used around the world to access content that may be inaccessible or blocked for internet users in their home country. In the case of Pakistanis, VPNs are used to access X, among other restricted websites.

The move comes days after multiple internet users from across the country reported they were experiencing “restricted access” to VPNs, alongside poor internet connectivity.

Digital rights activists termed the disruption the government’s attempt to “enforce strict censorship and surveillance over citizens”. The PTA, however, dismissed users’ claim that it was “throttling” VPNs and said the disruptions were caused by a “technical glitch”. It also urged users to register their VPNs.

According to the statement, today’s meeting was attended by representatives from the Ministry of IT & Telecommunication (MoIT&T), the Pakistan Software Export Board (PSEB), and the Pakistan Software Houses Association (P@SHA).

“The PTA introduced a streamlined VPN registration process, allowing legitimate users to register their VPNs through a new online portal at ipregistration.pta.gov.pk,” the statement said.

The authority claimed that this simplified framework “supports uninterrupted access for IT companies, freelancers, and other stakeholders, reinforcing PTA’s commitment to Pakistan’s expanding digital economy”.

Participants also addressed concerns about the potential use of VPNs for “illegal activities.”

“As a proactive measure, companies and freelancers will be encouraged to register their VPNs to ensure smooth operations and mitigate disruptions,” it added.

“This consultation process underscores PTA’s dedication to creating a safe, accessible, and compliant digital landscape, empowering the country’s IT sector while safeguarding national security,” the statement concluded.

In August, the Pakistan Telecommunication Authority (PTA) was clamping down on VPN usage, aiming to prevent access to the already banned social media platform X.

Information Minister Attaullah Tarar said in September that X had been banned due to national security issues, not to curb freedom of expression. He added that “separatists and terrorists” were using the platform against Pakistan, which could not be allowed.

In the same month, the PTA dispelled rumours and clarified that VPNs in the country were not being blocked.





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'Toxic media platform': Why 'The Guardian' quit X after US election results - The Times of India

  1. 'Toxic media platform': Why 'The Guardian' quit X after US election results  The Times of India
  2. Why the Guardian is no longer posting on X  The Guardian
  3. ‘Toxic’: Leading UK media house decides to stop posting on Elon Musk-led X  Hindustan Times
  4. A 200-year-old British media giant stops posting on X. Here's why  India Today
  5. UK's 'The Guardian' Quits X Citing "Disturbing Content" On Platform  NDTV




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Officers Carrying Out Illegal Demolitions Liable To Restore Properties At Personal Cost & Pay Damages:... - Live Law - Indian Legal News

  1. Officers Carrying Out Illegal Demolitions Liable To Restore Properties At Personal Cost & Pay Damages:...  Live Law - Indian Legal News
  2. How the Supreme Court clamped down on ‘bulldozer’ demolition drives | Explained  The Hindu
  3. Akhilsh Yadav`s `Parked In Garage` Jab At Yogi Govt After SC`s Bulldozer Verdict  Zee News
  4. SC parked bulldozer in garage forever: Akhilesh Yadav  Hindustan Times
  5. What's the message from Supreme Court's order on bulldozer action? Experts debate  India Today




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Particulate matter-induced epigenetic modifications and lung complications

Air pollution is one of the leading causes of early deaths worldwide, with particulate matter (PM) as an emerging factor contributing to this trend. PM is classified based on its physical size, which ranges from PM10 (diameter ≤10 μm) to PM2.5 (≤2.5 μm) and PM0.5 (≤0.5 μm). Smaller-sized PM can move freely through the air and readily infiltrate deep into the lungs, intensifying existing health issues and exacerbating complications. Lung complications are the most common issues arising from PM exposure due to the primary site of deposition in the respiratory system. Conditions such as asthma, COPD, idiopathic pulmonary fibrosis, lung cancer and various lung infections are all susceptible to worsening due to PM exposure. PM can epigenetically modify specific target sites, further complicating its impact on these conditions. Understanding these epigenetic mechanisms holds promise for addressing these complications in cases of PM exposure. This involves studying the effect of PM on different gene expressions and regulation through epigenetic modifications, including DNA methylation, histone modifications and microRNAs. Targeting and manipulating these epigenetic modifications and their mechanisms could be promising strategies for future treatments of lung complications. This review mainly focuses on different epigenetic modifications due to PM2.5 exposure in the various lung complications mentioned above.




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Predicting paediatric asthma exacerbations with machine learning: a systematic review with meta-analysis

Background

Asthma exacerbations in children pose a significant burden on healthcare systems and families. While traditional risk assessment tools exist, artificial intelligence (AI) offers the potential for enhanced prediction models.

Objective

This study aims to systematically evaluate and quantify the performance of machine learning (ML) algorithms in predicting the risk of hospitalisation and emergency department (ED) admission for acute asthma exacerbations in children.

Methods

We performed a systematic review with meta-analysis, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The risk of bias and applicability for eligible studies was assessed according to the prediction model study risk of bias assessment tool (PROBAST). The protocol of our systematic review was registered in the International Prospective Register of Systematic Reviews.

Results

Our meta-analysis included seven articles encompassing a total of 17 ML-based prediction models. We found a pooled area under the curve (AUC) of 0.67 (95% CI 0.61–0.73; I2=99%; p<0.0001 for heterogeneity) for models predicting ED admission, indicating moderate accuracy. Notably, models predicting child hospitalisation demonstrated a higher pooled AUC of 0.79 (95% CI 0.76–0.82; I2=95%; p<0.0001 for heterogeneity), suggesting good discriminatory power.

Conclusion

This study provides the most comprehensive assessment of AI-based algorithms in predicting paediatric asthma exacerbations to date. While these models show promise and ML-based hospitalisation prediction models, in particular, demonstrate good accuracy, further external validation is needed before these models can be reliably implemented in real-life clinical practice.




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Association between second-hand smoke exposure and lung cancer risk in never-smokers: a systematic review and meta-analysis

Background

Lung cancer ranks as the leading cause of cancer-related deaths worldwide. There is evidence that second-hand smoke (SHS) exposure is a risk factor for the development of lung cancer in never-smokers. This systematic review and meta-analysis aims to provide the most accurate quantification of the association between SHS exposure and lung cancer risk in never-smokers.

Materials and methods

Through the use of an innovative method to identify original publications, we conducted a systematic review of the literature, with corresponding meta-analysis, of all epidemiological studies evaluating the association between SHS exposure and lung cancer risk among never-smokers, published up to May 2023. Pooled relative risks were obtained using random-effects models. Dose–response relationships were derived using log-linear functions or cubic splines.

Results

Out of 126 identified eligible studies, 97 original articles were included in the meta-analysis. The pooled relative risk for lung cancer for overall exposure to SHS was 1.24 (95% CI 1.16–1.32, number of articles, n=82). Setting-specific relative risks were 1.20 (95% CI 1.12–1.28, n=67) for SHS exposure at home, 1.38 (95% CI 1.28–1.62, n=30) at a workplace, 1.37 (95% CI 1.22–1.53, n=28) at home or a workplace and 1.27 (95% CI 1.11–1.44, n=24) in nonspecified settings. The risk of lung cancer significantly increased with the duration, intensity and pack-years of SHS exposure.

Conclusions

This meta-analysis shows that exposure to SHS increases by more than 20% the risk of lung cancer among never-smokers, providing definitive evidence of the association between SHS exposure and lung cancer risk.




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Harmonising cellular conversations: decoding the vital roles of extracellular vesicles in respiratory system intercellular communications

Extracellular vesicles (EVs) released by various cells play crucial roles in intercellular communication within the respiratory system. This review explores the historical context and significance of research into extracellular vesicles. Categorised into exosomes (sized 30–150 nm), microvesicles (sized 50–1000 nm) and apoptotic bodies (sized 500–2000nm), based on their generation mechanisms, extracellular vesicles carry diverse cargoes of biomolecules, including proteins, lipids and nucleic acids. Respiratory ailments are the primary contributors to both mortality and morbidity across various populations globally, significantly impacting public health. Recent studies have underscored the pivotal role of extracellular vesicles, particularly their cargo content, in mediating intercellular communication between lung cells in respiratory diseases. This comprehensive review provides insights into extracellular vesicle mechanisms and emphasises their significance in major respiratory conditions, including acute lung injury, COPD, pulmonary hypertension, pulmonary fibrosis, asthma and lung cancer.




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Irem Collection Volume 2 (NS)

It's time for more Irem. Approximately one year after the launch of the first volume, publisher ININ and developers Tozai Games & Ratalaika Games have produced Irem Collection Volume 2, the second installment of a five-part anthology. Like the last one, this collection includes three Irem arcade games from yesteryear. In this instance, the games are the vertically-scrolling shoot-'em-up Air Duel, the side-scrolling run-and-gun game GunForce, and its direct sequel GunForce II. And just like the coin-op games from the first volume, these titles arrive with a few bells and whistles, although fewer than you'd like.

The first game on offer is Air Duel, a middle-of-the-pack shoot-'em-up from 1990. For the most part the game is hopelessly generic, but it does benefit from a couple of interesting ideas. The first is that it allows players to change their aircraft at the start of each level; you can choose between a forward-firing jet fighter or a helicopter that turns and fires at an angle. The second is the bomb, which extends outward in several horizontal blasts that can actually be directed left, right, and center by the player. Even with these wrinkles, though, the game fails to leave a strong impression. The scoring system is rudimentary, the backgrounds are mostly boring, and the action is rather basic.

Things improve with GunForce, also known by the amazingly bonkers subtitle Battle Fire Engulfed Terror Island. A precursor of sorts to Metal Slug, GunForce is a bit rough around the edges but undeniably fun to play. The action is fast-moving, there are many different weapon types to collect, and, best of all, almost every stage has an assortment of vehicles and turrets to occupy. At various points, you can jump inside a cable car, a raft, a helicopter, a jeep, a mech, you name it. In the fourth stage, you actually start inside a tank. The game suffers from a couple of nagging problems, including a floaty jump and not enough enemy diversity, but overall it's a competent shooter.

Its sequel, GunForce II, is much more than competent. In fact, it's downright great. Developed by the team that would eventually leave Irem and form Nazca, the studio responsible for Metal Slug, it's a high-octane run-and-gun game with explosive action, spectacular boss fights, and lots of exciting vehicle sections. Everything from the premier GunForce has been dialed up to 11. The graphics are more vibrant and detailed; the explosions more fiery; the bosses far more unusual, dynamic, and dangerous; and the set-pieces more inspired. At one point, you'll scream down train tracks on a motorcycle while a mechanical centipede gives chase; at another point, in the beginning of the final stage, you'll pilot a hovercraft above the clouds and shoot down enemy missiles. The only downside: significant slowdown at times, when there are simply too many bullets, explosions, and bad guys on screen.

In addition to the three main games, all of which support two player local co-op, Irem Collection Volume 2 includes the SNES and Super Famicom ports of GunForce. While it's always nice to have extra games, the home console versions in this instance are inferior, due to frame rate issues and downgraded graphics & animations.

Unfortunately, the developers didn't go the extra mile to remove the slowdown, either from GunForce II or from the SNES/Super Famicom version of GunForce. Nor did they include any instruction manuals or bonus materials, although that was to be expected based on Volume 1.

This volume would have benefited particularly from some bonus content on Nazca, which seems to be the common denominator connecting all three games. Although it's difficult to tell due to the use of pseudonyms at the time, it's generally accepted that the team that would one day develop Metal Slug started its career within Irem with Air Duel and finished with GunForce II. Profiles of the developers and/or interviews with the people involved would certainly enhance this collection and help explain the theme.

While there's no bonus content to speak of, there are multiple quality-of-life features, including rewind, cheats, save states, control mapping, and auto-fire, plus plenty of display, shader, and wallpaper options. There are also online leaderboards for each game, as long as you play in "classic" mode.

Irem Collection Volume 2 is very much like the first volume — an uneven collection of old-school coin-op shooters ideal for collectors and arcade enthusiasts. The games here are arguably better overall than those in Volume 1, mostly due to the greatness of GunForce II, but they've received fewer upgrades. Hopefully future installments will include more refinements, more bonus content, and more ways to appreciate and celebrate each game. 

Full Article - https://www.vgchartz.com/article/463017/irem-collection-volume-2-ns/




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Monster Hunter Outlanders Announced for iOS and Android

Capcom and TiMi Studio Group have announced free-to-play open-world survival game, Monster Hunter Outlanders, for iOS and Android.

"It’s time for mobile players to fully enjoy what makes Monster Hunter one of the most beloved franchises in gaming," said TiMi Studio Group producer Dong Huang. "Monster Hunter Outlanders not only offers players an authentic hunting experience, but it does it in a massive open world featuring the community and social systems players are looking for today."

View the announcement trailer below:

Read details on the game below:

Vast Open World and Crafting

Explore seamlessly connected fields—including forests, swamps, and deserts—and enjoy hunting anytime and anywhere on your smartphone.

Not only can you utilize the environment’s creatures and field mechanics to gain the upper hand, elements useful for exploring the game’s vast open-world like crafting individualized gear and tools are also being prepared.

Traditional Monster Hunter Weapons

While maintaining the core gameplay experience of the Monster Hunter series, Monster Hunter Outlanders has optimized its battle system to maximize enjoyment. Face off against monsters while wielding the series’ traditional weapons.

Switchable Characters

As you progress through the story, you will encounter various unique characters. Not only can they become your allies, but you will also be able to control them yourself.

Reliable Companions

In addition to the Monster Hunter series’ familiar Felyne companions, Monster Hunter Outlanders will introduce other companions who will join you on quests and assist with item gathering and monster hunting.

Solo or Multiplayer

Partake in the traditional hunting experience where you can play solo, or join a hunting party of up to four.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463053/monster-hunter-outlanders-announced-for-ios-and-android/




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Phil Spencer: Xbox Won't Rule Out Any Games for PlayStation or Nintendo

Microsoft Gaming CEO Phil Spencer speaking with Bloomberg said Xbox won't rule out releasing any game on other platforms like PlayStation and Nintendo.

"I do not see sort of red lines in our portfolio that say 'thou must not,'" said Spencer. He added it is too early to make a decision on the next version of Halo.

Spencer did say he was pleased with the sales of the first wave of Xbox games that released on other platforms.

Xbox announced in February it would be releasing four its game on other platforms like the PlayStation 5 and Nintendo Switch. The four games were PentimentHi-Fi RushGrounded, and Sea of Thieves. Pentiment and Grounded released for the PS5, PS4, and Switch, while Hi-Fi Rush and Sea of Thieves released for the PS5.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463055/phil-spencer-xbox-wont-rule-out-any-games-for-playstation-or-nintendo/




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HEAVEN SEEKER: The Savior of This Cruel World Releases December 5 for PS5, PS4, and Switch

SUCCESS Corporation announced the twin-stick roguelite shooter, HEAVEN SEEKER: The Savior of This Cruel World, will launch for the PlayStation 5, PlayStation 4, and Nintendo Switch on December 5.

Read details on the game below:

HEAVEN SEEKER: The Savior of This Cruel World is a twin-stick roguelite shooter where you take your own shot at the castle in the sky! A dungeon with a different structure each time you enter, a variety of magic bullets—and a formidable barrage of bullets—await you.

Story

In this world, Pentagaia, there were five countries that had been transferred from five different worlds.

Magi Province, the land of wizards, where magical technology flourished. A land of priestesses and samurai, a land of warriors and the four seasons. A land of elves, with the blessings of the World Tree. A land of mechanical ingenuity, where super-science rules the world. A land of wilderness and dust, ruled by demons.

The rulers of each nation sent explorers to the Castle of Heaven, where the secrets of Pentagaia were said to lie. They did so with the longing to return to the original world. These explorers were called Heaven Seekers.

Explore a Dungeon That Changes Each Time You Enter

In this title, you move with the left stick and aim with the right stick. This is a bullet hell shooting game where you freely control your character and explore random dungeons. When your HP reaches 0, you will lose all the items you have gained during this exploration. The player gains experience by exploring many times and learning the patterns of the rooms and the nature of the enemies.

Create Your Own Magic Shot!

The shot fired by the player character can be modified by freely combining over 20 customizable items to change its properties. Since items are randomly acquired during each quest, players will fight with a different personalized shot each time they dive into a dungeon.

Dot Art Style Game Visuals

All in-game elements in this title, including player characters, enemies, and dungeons, are rendered in high-quality dot art.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463057/heaven-seeker-the-savior-of-this-cruel-world-releases-december-5-for-ps5-ps4-and-switch/




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PlayStation Plus Game Catalog and Classics for November 2024 Announced

Sony Interactive Entertainment on the PlayStation Blog has revealed the PlayStation Plus Game Catalog games for November 2024.

The PlayStation Plus Extra and Premium Game Catalog and Classics will be available from Tuesday, November 19.

The PlayStation Plus monthly games for November 2024 are currently available and includes Hot Wheels Unleashed 2 – Turbocharged for the PS5 and PS4, Ghostwire: Tokyo for the PS5, and Death Note Killer Within for the PS5 and PS4.

Check out the latest information below:

PlayStation Plus Extra and Premium | Game Catalog

Grand Theft Auto V* | PS4, PS5

When a young street hustler, a retired bank robber and a terrifying psychopath find themselves entangled with some of the most frightening and deranged elements of the criminal underworld, the U.S. government and the entertainment industry, they must pull off a series of dangerous heists to survive in a ruthless city in which they can trust nobody, least of all each other. Experience the interwoven stories of Franklin, Michael and Trevor in the sprawling open world of Los Santos and Blaine County.

*PlayStation Plus re-release.

Dying Light 2: Stay Human | PS4, PS5

In Dying Light 2, survival meets action adventure as you attempt to endure a hostile, post-apocalyptic world. Rival factions across The City aren’t the only enemy – a virus has turned a vast majority of the human population into monsters. Take on the role of Aiden Caldwell, a wanderer with the power to change the fate of The City, but your exceptional abilities come at a price. Haunted by memories you cannot decipher, you set out to learn the truth – and find yourself in a combat zone. Hone your skills to defeat your enemies and make allies. Unravel the dark secrets behind those that wield power, choose sides and decide your destiny. But wherever your actions take you, there’s one thing you must do – stay human.

Like a Dragon: Ishin | PS4, PS5

1860’s Kyo is plagued by widespread inequality, and one samurai will change the course of history in his search for justice. Take up the sword as Sakamoto Ryoma and venture to Kyoto to find your father’s killer, clear yourself of a framed murder, and restore your honor. In doing so, you will bring an end to the samurai era and forever change the future of Japan. Draw your blade, load your revolver, and join the revolution in this heated historical adventure that only the creators of Yakuza: Like a Dragon could produce.

MotoGP 24 | PS4, PS5

As a new season dawns, the winds of change are sweeping through the pit crews. Embark on your quest to become a MotoGP legend and shape your own epic saga. Challenge your abilities and immerse yourself in the exhilarating journey of the 2024 campaign. From humble beginnings to triumphant heights, the path is yours to forge. Engage in thrilling rivalries, build your reputation, and leave your mark on the history of your beloved team.

The Sims 4 Island Living* (Add-on only) | PS4

Welcome to Sulani, where the sun shines bright and the nights are totally chill. Escape the ordinary and enjoy a laid-back lifestyle surrounded by beaches in The Sims 4 Island Living. Explore a breezy world drenched in sun, sand, and endless fun as your Sims make their own paradise. Set sail on the glistening water in your island canoe, swim to your heart’s content, and explore the scenery on a watercraft. Everything is chill (except for the occasional sunburn) when it’s Island Living.

*Requires the original game The Sims 4. 

Digimon Survive | PS4

After getting lost on a school trip, Takuma Momozuka finds himself transported to a world inhabited by ferocious foes and new allies. Join Takuma and his friends as they fight their way back home. Digimon Survive is a hybrid visual novel and tactical RPG set in a mysterious world filled with dangerous monsters and deadly battles that will test your ability to survive. Persuade your opponents to join your team and evolve them to fight alongside you in thrilling turn-based battles. Unfold a dark tale about friendship and survival that is jam-packed with exciting drama, a unique cast of characters, and potentially grim choices.

Overcooked! All You Can Eat | PS4, PS5

Hold onto your chef hats and prepare your appetite for an XXL portion of Overcooked magic. Overcooked!, Overcooked! 2 and all additional content are blended together and remastered in this delicious definitive edition! Enjoy hundreds of levels of cooperative cooking chaos across increasingly perilous and obscure kitchens. 

Stick Fight: The Game | PS4

Stick Fight is a physics-based couch/online fighting game where you battle it out as the iconic stick figures from the golden age of the internet. Fight it out against your friends or find random sticks from around the world!

Clash: Artifacts of Chaos | PS4, PS5

Drawing upon both surreal and punk fantasy influences, the world and civilisations of Zenozoik are brimming with fascinating characters, creatures and landscapes. You play as Pseudo, a master of martial arts who lives as a recluse in the strange land of Zenozoik. When you cross paths with the Boy, a small creature whose mysterious powers have attracted the attention of Gemini, the Mistress of the Artifacts, you decide to protect him, unaware that much greater forces are involved. Roam this intriguing land and discover its paths, inhabitants and ancient secrets.

Killer Frequency | PS4, PS5

The year is 1987, and as the clock strikes midnight in small-town Gallows Creek, USA, former big city radio DJ Forrest Nash is live on air in what will turn out to be the graveyard shift of a lifetime… In this horror comedy, you must solve puzzles to save callers from being hunted down by a mysterious killer. Where every call is life and death, can you save the inhabitants of Gallows Creek? Step into the shoes of a late-night radio talk-show host – new in town and fallen from grace. The Sheriff is dead, so the townsfolk turn to you for help. You, Forrest Nash, are the only person in town who can run a phone line.

Hungry Shark World | PS4

Become a shark and spread terror on the beach! Fight man, machine and beast as you explore tropical islands, sunken temples, vast cities and frozen icebergs. Enjoy discovering expansive levels with their own distinctive enemies, hidden treasures and unique missions. Take on everything the sea throws at you, from gruesome goblin sharks and the adorable porbeagle, to prehistoric monsters and giant submarines. With rebalanced enemies and pacing, there’s a challenge around every corner!

Chivalry 2 | PS4, PS5

Return to the ultimate medieval battlefield. Chivalry 2 is a multiplayer first person slasher inspired by epic medieval movie battles. Players are thrust into the action of every iconic moment of the era – from clashing swords, to storms of flaming arrows, to sprawling castle sieges and more. Charge headfirst into stunning 64-Player cinematic battles inspired by epic medieval action films. Pick your playstyle with 4 classes and 12 subclasses, each with their own unique weapons and abilities.

PlayStation Plus Premium

Synapse | PS VR2

Dual-wield brutal firepower and surging telekinesis in the ultimate mind-breaking VR action shooter. Unleash your inner anti-hero and invade the twisted subconscious of a notorious enemy of the state. Become a mind-breaking operative and wreak havoc on the enemy’s mind with deadly weaponry in one hand and expressive telekinetic abilities in the other. Combine your powers to overcome formidable defences and delve deeper into a hostile mindscape.

Blood Omen: Legacy of Kain | PS4, PS5

Ready yourself for next month’s launch of Soul Reaver 1 & 2 Remastered by discovering the origins of this dark gothic fantasy franchise with the original PlayStation title Blood Omen: Legacy of Kain. In this top-down action adventure, embark on an epic quest through a vampire kingdom fraught with murder, magic and vengeance. Journey through an expansive world containing more than 100 hours of intense, blood-sucking, spell-casting gameplay, and enjoy cinema-quality voice-overs, dynamic lighting effects and more than 25 minutes of full-motion-video footage. 

Blood Omen 2 | PS4, PS5

Fierce attacks and brutal combos await in this action adventure, originally released on PS2 in 2002, after Soul Reaver 2’s launch the year previous. Blood Omen 2 will take you back to an alternate timeline set between the events of the first Blood Omen and Soul Reaver. Cast down from power by a mysterious warlord centuries ago, Kain reawakens in a world he barely recognizes. His armies slain, his vampire brethren nearly extinct, Kain is one of the last of his kind. With an agenda of vengeance, Kain shall unleash a wicked wrath to uncover the plot that threatens the land he seeks to conquer.

Resistance: Fall of Man

Epic military action and unnerving tension blend together in PS3’s 2006 first-person shooter Resistance: Fall of Man. Humanity faces annihilation as a relentless alien force known as the Chimera ravages Europe. Amidst the chaos, Nathan Hale emerges an unlikely hero, confronting unimaginable horrors while uncovering secrets that could change the course of the war. 

Resistance 2

Initially released in 2008 on PS3, Resistance 2 is the continuation of Insomniac Games’ science-fiction FPS saga. Now on American soil, the alien Chimera threatens Hale’s humanity in a gripping race against time to put a stop to the invasion. Once again at the forefront of humanity’s fight for survival, Nathan Hale must lead his squad through desperate missions, as new weapons and giant boss encounters increase the scale of the conflict to new heights.

A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012 and taking over the hardware estimates in 2017. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel. You can contact the author on Twitter @TrunksWD.

Full Article - https://www.vgchartz.com/article/463059/playstation-plus-game-catalog-and-classics-for-november-2024-announced/




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Archaeologists discover ancient ‘migration route’ likely followed by several human species

Further excavations may reveal how ancient human populations likely interacted with each other, researchers say




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Canada’s first human bird flu case: Teen in critical condition; dangers of H5N1 in kids and young - The Times of India

  1. Canada’s first human bird flu case: Teen in critical condition; dangers of H5N1 in kids and young  The Times of India
  2. Teenager in critical condition with Canada’s first human case of bird flu  The Guardian
  3. B.C. teen in critical condition in hospital with Canada’s 1st presumptive human case of bird flu  Global News Toronto
  4. Bird flu alert in Canada as teen tests positive; officials launch investigation  Business Insider India
  5. All you need to know about H5N1 avian influenza  CTV News





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'Congratulations Donald Trump': Gautam Adani says his group will invest $10 billion in US energy, infra p - The Times of India

  1. 'Congratulations Donald Trump': Gautam Adani says his group will invest $10 billion in US energy, infra p  The Times of India
  2. Adani Group commits $10 bn in US energy, infrastructure projects  The Economic Times
  3. Adani commits $10 billion in U.S. energy, infra projects  The Hindu
  4. Gautam Adani pledges USD 10 billion investment in US energy, infrastructure projects  India TV News
  5. Video | Gautam Adani Commits $10 Billion To Energy, Resilient Infra Projects In US  NDTV









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Actor Rupali Ganguly files ₹50 crore defamation suit against stepdaughter Esha Verma

Rupali Ganguly, known for the Hindi serial ‘Anupamaa’, has filed Rs 50 crore defamation suit against stepdaughter Esha Verma for “false and damaging statements”