The former soldier has pleaded guilty to escaping from prison but still faces other charges.

Homebase enters administration, but The Range buys up to 70 stores and the brand.

1. After Sunita Williams, NASA now worried about her stranded mission partner's losing body mass  Hindustan Times
2. "My Body Has Changed, But....": Sunita Williams On Health Aboard Space Station  NDTV
3. Stranded Sunita Williams dismisses severe weight loss rumours, says she feels ‘healthier than ever’  The Times of India
4. Sunita Williams explains reason behind her changed appearance in space | 'They have routine checks, dedicated surgeons' | Inshorts  Inshorts
5. Inside Sunita Williams' extended mission: What she’s doing in space  India Today

1. Global carbon market gets green signal at COP29 under Paris Agreement's Article 6  The Hindu
2. Why India and China have pushed against climate change-related trade measures at COP29  The Indian Express
3. COP29: G77, China agree to use new NCQG draft text as basis for finance negotiations  The New Indian Express
4. Video | UN Scientists Warn Of 'Rising Emissions' Worldwide  NDTV
5. COP29 gets momentum with consensus on creation of carbon credits standards, India wants to conclude work  The Times of India

Encouraging pre-kindergarten children to write affords teachers the opportunity to provide scaffolds to improve spelling development. Teachers, however, tend to provide more support than necessary to guide children's early spelling, which may stifle children's opportunities to engage in important thinking that helps them to grow in their literacy knowledge.

Reading depends on spoken language. This is a simple statement with profound consequences for children whose spoken language differs from the language they are expected to read. For most children, the language skills they bring to school will support learning to read, which is mainly learning to understand their spoken language in a new form: print. However, some children’s language skills differ in important ways from the classroom language variety, and teachers rarely receive sound guidance on how to enhance their literacy instruction to meet these children’s needs.

Filed under: Food and Drink, North America, Canada, United States

Continue reading Will You Be a Horrible Restaurant Customer This Holiday Season?

Will You Be a Horrible Restaurant Customer This Holiday Season? originally appeared on Gadling on Wed, 27 Nov 2013 16:31:00 EST. Please see our terms for use of feeds.

Filed under: North America, United States

Continue reading Sorry Indianapolis, You're No Longer the Sole Location Offering TSA PreCheck Enrollment Background Checks

Sorry Indianapolis, You're No Longer the Sole Location Offering TSA PreCheck Enrollment Background Checks originally appeared on Gadling on Mon, 16 Dec 2013 15:07:00 EST. Please see our terms for use of feeds.

Filed under: Europe, North America, France, United Kingdom, United States

Continue reading London, Rome, Paris Top TripAdvisor's Most-Reviewed Cities List

London, Rome, Paris Top TripAdvisor's Most-Reviewed Cities List originally appeared on Gadling on Tue, 17 Dec 2013 14:11:00 EST. Please see our terms for use of feeds.

Donald Trump’s policies risk making the US dollar a source of global instability Expert comment LToremark 13 November 2024

Although Trump favours a weaker exchange rate, his policies are likely to have the opposite effect. The risk is that the US dollar could become too strong, which is bad news for the global economy.

President-elect Donald Trump has a dollar problem. In recent months he has shown a clear preference for a weaker exchange rate to support the competitiveness of US exports and help reduce the US trade deficit. And yet, as the market has sensed since the US election, the much more likely outcome is that his policies end up strengthening the greenback. The risk is that the US dollar – which is expensive already – becomes more obviously overvalued, and this could increase the risk of global financial instability. 

The dollar has been on a rollercoaster ride in the past few decades. From 2002 until 2011, for example, the dollar weakened by around 30 per cent in inflation-adjusted, trade-weighted terms, according to BIS data. Yet in the years since 2011, the dollar has strengthened and is now at a more appreciated level than at any time since 1985.

What shapes this rollercoaster, broadly speaking, is the global balance of economic vitality: when the US economy gains momentum relative to the rest of the world, the dollar tends to strengthen; and vice versa. 

After China joined the WTO in 2001, the balance of economic vitality shifted decisively away from the US, in favour of China and other emerging economies. This was the decade of the commodity boom: the longest, biggest peacetime increase in commodity prices in nearly 200 years during which a sustained surge in China’s economy supported GDP growth across the developing world. The dollar weakened as a result.

But after 2011, a combination of factors – including the eurozone crisis and its aftermath, together with the sagging of the Chinese economy – tipped the balance of economic vitality back in favour of the US. The dollar strengthened once again.

And since both the European and Chinese economies remain very fragile, the balance of economic vitality seems likely to keep favouring the US dollar.

Two more considerations also point to a stronger US dollar under a second Trump administration.

The first is the exchange rate implications of Donald Trump’s proposed tariffs on imports. When the US imposes tariffs on a trading partner, the foreign exchange market tends to sell that trading partner’s currency, forcing it to weaken to offset the dollar-price increase induced by the tariff. This helps explain why the Chinese renminbi depreciated by some 10 per cent in 2018 after Trump began imposing trade restrictions on China in January of that year. 

More widespread tariffs on a whole range of US trading partners should therefore strengthen the dollar more broadly.

A stronger dollar should also result from the macroeconomic framework Trump seems likely to deliver. He will certainly want to extend his 2017 tax cuts beyond 2025 when they are currently due to expire, so a more sustained loosening of US fiscal policy seems likely. Since boosting the US economy will create inflationary pressure, the market will expect interest rates to end up higher than they might otherwise be. The resulting combination of looser fiscal and tighter monetary policy tends to be a stronger currency.

The dollar probably has a fair amount of room to keep going up, since it is not obviously overvalued just yet. The US current account deficit – the broadest measure of a country’s trade deficit, and a rough but useful measure of financial vulnerability – was a little over 3 per cent of GDP last year. 

This is around half the level it reached in 2006, just before the 2008 global financial crisis, meaning the risks arising from an overvalued dollar may be for the latter part of Trump’s second presidency.

A strengthening dollar is also not great news for the rest of the world economy. A strong dollar tends to depress global trade growth, restrict developing countries’ access to international capital markets, and make it more difficult for countries whose currencies will be weakening to keep inflation under control.

If and when the dollar becomes unsustainably expensive, a further problem will present itself: how to deal with an overvalued currency without risking a lot of financial dislocation.

This problem last occurred in early 1985, when the dollar was universally reckoned to be dangerously dear. At that time the US was able to call on trading partners who depended on the US security umbrella – the UK, Germany, France and Japan – to negotiate the ‘Plaza Accord’, which coordinated a series of interventions in the foreign exchange market that allowed the dollar to decline in a measured way.  

It is virtually unimaginable that something similar could be negotiated today, not least because Chinese policymakers believe that the post-Plaza strengthening of the yen in the late 1980s led to an economic disaster for Japan. Beijing will not play ball.

Without much scope for a negotiated decline in the dollar, more chaotic alternatives seem likely. 

One is that the market decides suddenly that it no longer has an appetite for expensive dollar-denominated assets, and this might lead to a messy adjustment in the foreign exchange market. 

Here is what you need to know about Rockies Spring Training, set to begin soon at Salt River Fields at Talking Stick, in Scottsdale, Ariz.

Infielder Brendan Rodgers, the Rockies' top-ranked prospect, headlined the 19 players announced as non-roster invitees to Major League Spring Training on Wednesday.

Left-handed reliever Mike Dunn's recovery from season-ending left shoulder surgery has gone well enough that the Rockies are cautiously optimistic he will be ready to open the season -- the final one in his three-year, $19 million contract.

With new faces on the team, Spring Training is a time for excitement, but the Rockies had October in mind with their one big offseason signing: Daniel Murphy for two years and $24 million.

Familiar sounds of encouragement and needling filled a practice field at Salt River Fields at Talking Stick on Monday as Nolan Arenado, Trevor Story and the infielders took grounders and Charlie Blackmon and the outfielders gathered their bats and spikes. Only a few faces that always seemed to be around are missing as Spring Training begins.

The 2019 MLB season feels so close now. Spring Training has begun. Players are taking the field. So it's time to rank the best of the best.

Having two pitchers of notable accomplishment and one of immense promise is a luxury for the Rockies. But it creates a decision nonetheless for manager Bud Black.

At an age that is generally considered to be past an athlete's prime, Ian Desmond will try to rely more on his speed as the Rockies move him to center field.

The next five weeks will see lots of shuffling on Major League rosters. Here are the most intriguing positional battles on each of the 30 MLB clubs.

Rockies top prospect Brendan Rodgers realizes he has to keep his spirits light even though his assignment is heavy.

Rockies manager Bud Black said the team prefers that longtime center fielder Charlie Blackmon move to right field, rather than left.

The Blue Jays are less than one week away from the start of Spring Training. Here's a brief rundown of everything fans need to know before the Grapefruit League season officially begins.

No matter what happens this spring, the player everyone is going to be talking about on a daily basis is Vladimir Guerrero Jr.

Vladimir Guerrero Jr. hasn't even reported for duty yet and already he has become the main talking point at Blue Jays Spring Training. General manager Ross Atkins was bombarded with questions about MLB Pipeline's top prospect during his first media availability of the spring on Thursday.

Blue Jays manager Charlie Montoyo was so impressed with Aaron Sanchez's first bullpen session of the spring that it would have been almost impossible to wipe the smile off his face afterwards.

MLB.com's beat reporters have you covered with the action from every team's training camp. Keep track of the latest highlights of Spring Training right here.

The Blue Jays' biggest star arrived Saturday morning when top prospect Vladimir Guerrero Jr. officially reported to Spring Training. Guerrero took part in a few rounds of batting practice and hit at least one ball out of the park. The Dominican native is expected to speak to the media Monday for the first time this spring as he sets out to begin his first full Major League Spring Training.

The next five weeks will see lots of shuffling on Major League rosters. Here are the most intriguing positional battles on each of the 30 MLB clubs.

Donald Trump did not win the 2020 election, but asserting that he did became a prerequisite for Republicans standing for nomination to Congress or the Senate to win their primaries. An entire party became a vehicle for disinformation.1 Trump did win the 2024 presidential election, and key to that victory was building on the success of that lie. If you control enough of the information ecosystem, truth no longer matters.Another telling example: Haitian migrants in Springfield, Ohio, are not eating cats and dogs. US vice president elect, JD Vance, the source of that claim, admitted as much even as he justified it. “If I have to create stories so that the American media actually pays attention to the suffering of the American people, then that’s what I'm going to do,” he said.2Disinformation in politics is nothing new. History is replete with claims that were fabricated to advance political aims. Although...

bmj;387/nov12_10/q2481/FAF1faJulia and Malcolm Donaldsondonaldson20241111.f1Malcolm Donaldson was a distinguished paediatric endocrinologist with a string of research publications to his name—but he was also happy to play second fiddle (almost literally) to his wife Julia, the celebrated author of much loved children’s books, including The Gruffalo and Room on the Broom.Malcolm, a talented musician and performer, accompanied his wife as she toured festivals, schools, and libraries in the UK and around the world. Together they performed the stories, with Malcolm acting characters ranging from an accident prone dragon to a comic cattle thief. His star role, in the words of Julia’s literary agent, was “a particularly suave fox” in The Gruffalo.Malcolm met Julia Shields when they were students at the University of Bristol and they married in 1972. Donaldson went on to work in Brighton, London, and Lyon, France, before moving back to Bristol to be a senior registrar in paediatrics. Six...

At one of my first meetings as an elected council member of the Royal College of Surgeons of England, we approved a report called Access All Ages. It encouraged less ageist thinking and bias among healthcare staff that might lead to them denying older people surgery.1 But sometimes an operation isn’t the best option. Among patients who have surgery, 14% express regret and 15% experience complications, which are at least four times as likely if they’re frail or physically inactive.2 The Centre for Perioperative Care has published information on the importance of exercise before surgery,3 but that alone may not be enough.We need shared decision making,4 including asking patients what matters to them. The public should be primed to ask about BRAN—the benefits, risks, and alternatives to surgery and the likely result from doing nothing.4 A slew of data supports this approach, especially from the POPS initiative (Perioperative Care of...

Goal-directed visual attention is a fundamental cognitive process that enables animals to selectively focus on specific regions of the visual field while filtering out irrelevant information. However, given the domain specificity of social behaviors, it remains unclear whether attention to faces versus nonfaces recruits different neurocognitive processes. In this study, we simultaneously recorded activity from temporal and frontal nodes of the attention network while macaques performed a goal-directed visual search task. V4 and inferotemporal (IT) visual category-selective units, selected during cue presentation, discriminated fixations on targets and distractors during the search but were differentially engaged by face and house targets. V4 and IT category-selective units also encoded fixation transitions and search dynamics. Compared with distractors, fixations on targets reduced spike–LFP coherence within the temporal cortex. Importantly, target-induced desynchronization between the temporal and prefrontal cortices was only evident for face targets, suggesting that attention to faces differentially engaged the prefrontal cortex. We further revealed bidirectional theta influence between the temporal and prefrontal cortices using Granger causality, which was again disproportionate for faces. Finally, we showed that the search became more efficient with increasing target-induced desynchronization. Together, our results suggest domain specificity for attending to faces and an intricate interplay between visual attention and social processing neural networks.

Endogenous reprogramming of glia into neurogenic progenitors holds great promise for neuron restoration therapies. Using lessons from regenerative species, we have developed strategies to stimulate mammalian Müller glia to regenerate neurons in vivo in the adult retina. We have demonstrated that the transcription factor Ascl1 can stimulate Müller glia neurogenesis. However, Ascl1 is only able to reprogram a subset of Müller glia into neurons. We have reported that neuroinflammation from microglia inhibits neurogenesis from Müller glia. Here we found that the peripheral immune response is a barrier to CNS regeneration. We show that monocytes from the peripheral immune system infiltrate the injured retina and negatively influence neurogenesis from Müller glia. Using CCR2 knock-out mice of both sexes, we found that preventing monocyte infiltration improves the neurogenic and proliferative capacity of Müller glia stimulated by Ascl1. Using scRNA-seq analysis, we identified a signaling axis wherein Osteopontin, a cytokine highly expressed by infiltrating immune cells is sufficient to suppress mammalian neurogenesis. This work implicates the response of the peripheral immune system as a barrier to regenerative strategies of the retina.

The activation of autonomic and hypothalamo-pituitary-adrenal (HPA) systems occurs interdependently with behavioral adjustments under varying environmental demands. Nevertheless, laboratory rodent studies examining the neural bases of stress responses have generally attributed increments in these systems to be monolithic, regardless of whether an active or passive coping strategy is employed. Using the shock probe defensive burying test (SPDB) to measure stress-coping features naturalistically in male and female rats, we identify a neural pathway whereby activity changes may promote distinctive response patterns of hemodynamic and HPA indices typifying active and passive coping phenotypes. Optogenetic excitation of the rostral medial prefrontal cortex (mPFC) input to the ventrolateral periaqueductal gray (vlPAG) decreased passive behavior (immobility), attenuated the glucocorticoid hormone response, but did not prevent arterial pressure and heart rate increases associated with rats’ active behavioral (defensive burying) engagement during the SPDB. In contrast, inhibition of the same pathway increased behavioral immobility and attenuated hemodynamic output but did not affect glucocorticoid increases. Further analyses confirmed that hemodynamic increments occurred preferentially during active behaviors and decrements during immobility epochs, whereas pathway manipulations, regardless of the directionality of effect, weakened these correlational relationships. Finally, neuroanatomical evidence indicated that the influence of the rostral mPFC->vlPAG pathway on coping response patterns is mediated predominantly through GABAergic neurons within vlPAG. These data highlight the importance of this prefrontal->midbrain connection in organizing stress-coping responses and in coordinating bodily systems with behavioral output for adaptation to aversive experiences.

Peripheral taste neurons exhibit functional, genetic, and morphological diversity, yet understanding how or if these attributes combine into taste neuron types remains unclear. In this study, we used male and female mice to relate taste bud innervation patterns to the function of a subset of proenkephalin-expressing (Penk+) taste neurons. We found that taste arbors (the portion of the axon within the taste bud) stemming from Penk+ neurons displayed diverse branching patterns and lacked stereotypical endings. The range in complexity observed for individual taste arbors from Penk+ neurons mirrored the entire population, suggesting that taste arbor morphologies are not primarily regulated by the neuron type. Notably, the distinguishing feature of arbors from Penk+ neurons was their propensity to come within 110 nm (in apposition with) different types of taste-transducing cells within the taste bud. This finding is contrary to the expectation of genetically defined taste neuron types that functionally represent a single stimulus. Consistently, further investigation of Penk+ neuron function revealed that they are more likely to respond to innately aversive stimuli—sour, bitter, and high salt concentrations—as compared with the full taste population. Penk+ neurons are less likely to respond to nonaversive stimuli—sucrose, umami, and low salt—compared with the full population. Our data support the presence of a genetically defined neuron type in the geniculate ganglion that is responsive to innately aversive stimuli. This implies that genetic expression might categorize peripheral taste neurons into hedonic groups, rather than simply identifying neurons that respond to a single stimulus.

OM teaches East London youth about the persecuted Christians in the world, as well as trains them in street ministry.

HIV and AIDS can be prevented. It just takes you.

Engage, OM South Africa’s bi-annual conference, provides a challenge and a channel for joining missions with OM.

Five OM entities based in South Africa previously working in three separate offices throughout Pretoria have recently united under one roof.

Participants of a poverty simulation activity hosted by AIDSLink International discover that it’s very different to minister to the poor than to be the poor.

On 23 January 2015, OM South Africa celebrated Pranesh Anandlal’s leadership as director since 2008 and welcomed his successor, Andrè van der Bergh.

Logos Hope crew members share the Gospel in a hair salon with someone who has never before heard about Jesus.

OMer Jan Willem Otten uses basketball as a way to keep kids off the streets and put them in touch with the gospel

Missions Discipleship Training in South Africa is not a wasted six months--it's a springboard into your calling, preparing and equipping you for the real deal.