Caroline Fenton & Jason Fitz react to the second edition of the 2024 College Football Playoff Rankings, discuss Heisman pretenders vs. contenders and preview the biggest matchups of Week 12.

The Mississippi education department will be the first to operate a teacher residency program, which aims to increase retention and diversity in the profession.

Voters in three southern states will head to the polls for governors races that have shined a spotlight on educator activism, school funding, and teacher pay.

Governors' races in Kentucky and Mississippi took center stage, testing the political muscle of teacher activists and yielding possible policy implications for everything from public employee pensions to teacher pay.

This year's November elections—a preview to next year's nationwide showdowns—cast their own spotlight on education, a dynamic that played out most prominently in the Kentucky governor's race, where teachers organized to unseat a combative incumbent who'd sparred with them.

The U.S. Supreme Court took up the question of whether courts must find a juvenile offender permanently incorrigible before a sentence of life without parole.

A West Virginia official turns up the heat on financial disclosure for the state’s beleaguered schools, and ruffles feathers in the process.

Academic and health offerings have increased in McDowell County, W.Va., due to a private-public partnership.

The legislature sent a proposal last week to Gov. Jim Justice's desk to shutter the state's advisory education and the arts department, leaving the Gayle Manchin and her staff in the lurch.

After a couple years of clashes with teachers in the state, West Virginia Senate President Mitch Carmichael was ousted in Tuesday's Republican primary election by a teacher.

In this third installment on the growth in dual-language learning, one expert says broad access to programs is important, but that students need an early start to reap the benefits.

In the aftermath of this spring's teacher protests, more educators are running for state office—and the National Education Association is seizing on the political moment.

Lawmakers in Illinois are considering a bill that would require children to start kindergarten if they are 5 on or before May 31, with exceptions for summer birthdays.

It's Oregon women's basketball vs. Baylor in a marquee nonconference college basketball matchup. Follow for live score updates, game highlights.

Purdue women's basketball suffered its first defeat of the season on Sunday night as No. 6 Notre Dame came into Mackey Arena and handed the Boilermakers a 102-58 loss. The Boilermakers have now lost nine straight games to the Fighting Irish, since taking a 14-5 lead in the series back in 2005. The in-state rivalry was halted, playing just once between 2012 and 2023, but the Fighting Irish resumed their success over the Boilermakers in each of the last two seasons.

If an opponent isn't contending for an ACC or national championship, Notre Dame is likely to run it out of the gym. That's exactly what happened during the Irish's first road game of the season against Purdue. Much like with the football team less than two months earlier,…

Wisconsin's Ronnie Porter established a new scoring high and Serah Williams and Carter McCray posted double-doubles in win over Georgetown Sunday.

Jacy Sheldon and Katie Smith are both returning to their alma mater to join the staff ran by Kevin McGuff.

South Carolina a unanimous No. in women's AP Top 25 after 2 wins to open repeat bid; Stanford, Oregon crack rankings.

The Gamecocks earned a hard-fought six-point win over Michigan in Las Vegas to open the season and beat then-No. 9 North Carolina State on Sunday by 14. The two victories made the defending champions a unanimous choice from the 31-member national media panel. In the preseason poll, No. 2 UConn got two first-place votes and No. 3 USC one.

Nov. 11—CHAMPAIGN — The Illinois women's basketball team's season-opening win against Florida State, plus Sunday's grind-it-out victory against Marquette, pushed the Illini into the Associated Press Top 25 on Monday. Illinois makes its season debut in the poll at No. 23 and knocked the Seminoles out of the top 25 with the 83-74 victory. Adding a 65-53 win against the Golden Eagles assured the ...

Some big games on the horizon as Notre Dame women's basketball is at No. 5 in latest Coaches Poll

Five-star wing Deniya Prawl has committed to Lady Vols basketball, marking a significant recruiting win in Kim Caldwell's first year at Tennessee.

Freshman had a season-high 13 points off bench while contributing to Spartans' win over Eastern Michigan.

AMERICUS, Ga. — Georgia Southwestern State University graduate guard Destiny Garrett was named the Peach Belt Conference Women's Basketball Player of the Week this afternoon by the league office. Garrett set a school record with 13 assists in the 17th-ranked Lady Hurricanes 85-61 win over Florida Tech on Saturday and completed her first-ever double-double with a career-best 21 points. Garrett ...

LSU women's basketball hosts Charleston Southern on Tuesday morning for a nonconference game. Here's how to watch.

Onward State published a story this week that contained on-the-record comments from former Marquette players about Carolyn Kieger's coaching style.

Nov. 12—THE ASSOCIATED PRESS TOP 25 The top 25 teams in The Associated Press' women's college basketball poll, with first-place votes in parentheses, and total points based on 25 points for a first-place vote through one point for a 25th-place vote and previous ranking. Rk., Team ReC. Pts Prv 1. South Carolina (31) 2-0 775 1 2. Connecticut 2-0 733 2 3. Southern Cal 2-0 703 3 4. Texas 1-0 665 4 ...

LSU women's basketball bucked a bit of a slow start to blowout Charleston Southern Tuesday morning.

LSU women's basketball coach Kim Mulkey provided updates for Shayeann Day-Wilson and Last-Tear Poa on Tuesday after LSU's win vs Charleston Southern.

On Wednesday at Moody Center, a Lamar team that went 24-7 last season should provide a tougher test for the Longhorns than in their season opener.

It was Louisville women's basketball vs UT Martin at the Kathleen and Tom Elam Center. See score updates and highlights from the road clash.

Nov. 12—The Gonzaga women's basketball team has much to learn after a challenging loss at Stanford on Sunday. Losses have a way of exposing a team's shortcomings. And there is much to learn from the worst loss (89-58) in coach Lisa Fortier's 11 seasons. Stanford, unranked in the preseason poll for the first time since 1999-2000, is unranked no more. The Cardinal (3-0) entered at No. 24 in the ...

Holly Oakley
Oct 4, 2006; 26:10129-10140
Neurobiology of Disease

Sharon G. Kujawa
Nov 11, 2009; 29:14077-14085
BehavioralSystemsCognitive

Randy L. Buckner
Aug 24, 2005; 25:7709-7717
Neurobiology of Disease

Holly Oakley
Oct 4, 2006; 26:10129-10140
Neurobiology of Disease

Targeting altered expression and/or activity of GABA (-aminobutyric acid) transporters (GATs) provide therapeutic benefit for age-related impairments, including cognitive dysfunction. However, the mechanisms underlying the transcriptional regulation of GATs are unknown. In the present study, we demonstrated that the stimulator of interferon genes (STING) upregulates GAT1 and GAT3 expression in the brain, which resulted in cognitive dysfunction. Genetic and pharmacological intervention of STING suppressed the expression of both GAT1 and GAT3, increased the ambient GABA concentration, and therefore, enhanced tonic GABA_A inhibition of principal hippocampal neurons, resulting in spatial learning and working memory deficits in mice in a type I interferon-independent manner. Stimulation of the STING->GAT pathway efficiently restored cognitive dysfunction in STING-deficient mice models. Our study uncovered for the first time that the STING signaling pathway regulates GAT expression in a cell autonomous manner and therefore could be a novel target for GABAergic cognitive deficits.

The capabilities of the human ear are remarkable. We can normally detect acoustic stimuli down to a threshold sound-pressure level of 0 dB (decibels) at the entrance to the external ear, which elicits eardrum vibrations in the picometer range. From this threshold up to the onset of pain, 120 dB, our ears can encompass sounds that differ in power by a trillionfold. The comprehension of speech and enjoyment of music result from our ability to distinguish between tones that differ in frequency by only 0.2%. All these capabilities vanish upon damage to the ear's receptors, the mechanoreceptive sensory hair cells. Each cochlea, the auditory organ of the inner ear, contains some 16,000 such cells that are frequency-tuned between ~20 Hz (cycles per second) and 20,000 Hz. Remarkably enough, hair cells do not simply capture sound energy: they can also exhibit an active process whereby sound signals are amplified, tuned, and scaled. This article describes the active process in detail and offers evidence that its striking features emerge from the operation of hair cells on the brink of an oscillatory instability—one example of the critical phenomena that are widespread in physics.

Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide opportunities to use computational approaches for such studies. Here, we devised a novel disease gene identification (digID) computational framework that consists of a semi-supervised deep learning classifier to predict AD-associated genes and a protein–protein interaction (PPI) network-based analysis to prioritize the importance of these predicted genes in AD. digID predicted 1,529 AD-associated genes and revealed potentially new AD molecular mechanisms and therapeutic targets including GNAI1 and GNB1, two G-protein subunits that regulate cell signaling, and KNG1, an upstream modulator of CDC42 small G-protein signaling and mediator of inflammation and candidate coregulator of amyloid precursor protein (APP). Analysis of mRNA expression validated their dysregulation in AD brains but further revealed the significant spatial patterns in different brain regions as well as among different subregions of the frontal cortex and hippocampi. Super-resolution STochastic Optical Reconstruction Microscopy (STORM) further demonstrated their subcellular colocalization and molecular interactions with APP in a transgenic mouse model of both sexes with AD-like mutations. These studies support the predictions made by digID while highlighting the importance of concurrent biological validation of computationally identified gene clusters as potential new AD therapeutic targets.

FAO Director-General José Graziano da Silva today praised UN Secretary-General Ban Ki Moon for his support in the fight against hunger at a meeting with FAO member countries, the Committee [...]

FAO Director-General José Graziano da Silva today called on countries to put nutrition high on their national and international agendas, and to take a lead role in the upcoming Second [...]