k

Goalpara Sainik school gave countless cadets to country: Assam Guv




k

'PM Modi's govt gives highest priority to over 35 mn Indian diaspora', says EAM Jaishankar on website launch for Pravasi Bharatiya Divas




k

Vistara's last flight from Odisha takes off for Delhi ahead of merger with Air India




k

Assam: Army celebrates 'National Education Day' with students in Tinsukia




k

UP: Devotees celebrate 'Tulsi Vivah' at Balua Ghat in Prayagraj, marking sacred union of Lord Vishnu, Vrinda




k

BRO rescues 20 vehicles stuck in snow in J-K's Bandipora




k

Defence Space Agency hosts first ever space exercise 'Antariksha Abhyas - 2024' in Delhi




k

There will be census in country but not based on caste: Union Minister Shobha Karandlaje




k

Akashteer: Transforming India's air defence with cutting-edge technology




k

Union Jal Shakti Minister CR Paatil chairs 13th high-powered review meeting of Brahmaputra Board




k

AI and hi-tech technologies will be used in CCTV arrangements: UP DGP Prashant Kumar on Mahakumbh 2025 preparations




k

Assam Governor attends Sainik school Goalpara's Diamond Jubilee celebrations




k

DRDO conducts maiden flight test of Long-Range Land Attack Cruise Missile (LRLACM)




k

HC modifies the status quo order on maintaining constructions for Tent City in two islands of Lakshadweep




k

No gaps in management of biodegradable waste, Kerala tells NGT




k

Afghanistan attends U.N. climate talks for first time since Taliban return to power

Afghanistan’s first delegation at United Nations climate talks since the Taliban’s return to power in 2021 has arrived in Baku, Azerbaijan




k

China's largest air show takes off with fighter jets, attack drones

China has poured resources into modernising and expanding its aviation capabilities as it faces off against the United States and others around regional flashpoints like Taiwan.




k

Uzbekistan to make media, songs and films pass 'moral test'

President Shavkat Mirziyoyev has introduced some reforms since coming to power after the 2016 death of dictator Islam Karimov, but rights groups say the country remains deeply authoritarian




k

Cold War-era H-6 bomber enhances China’s ability to strike U.S. bases

The H-6 long-range bomber was used in China’s October war games around Taiwan; it flew close to the U.S. mainland for first time in June




k

5.3 magnitude earthquake jolts parts of Pakistan

No casualties have been reported so far for the earthquake that had its epicentre around the Hindukush mountain range




k

Lebanon media claims Israeli strike hit apartment south of Beirut

Israeli warplanes launched a strike at dawn targeting a residential apartment in a building in the Dawhet




k

Sri Lanka to hold key parliamentary vote on November 14

President Anura Kumara Dissanayake’s ruling alliance is looking to secure a majority in Parliament




k

Senior Russian naval officer killed in car bombing claimed by Kyiv

Russia's state Investigative Committee said in a statement that an improvised explosive device had detonated in an act of terrorism, killing a serviceman whom it did not identify




k

Stachydrine, a pyrrole alkaloid with promising therapeutic potential against metabolic syndrome and associated organ dysfunction

RSC Med. Chem., 2024, 15,3652-3673
DOI: 10.1039/D4MD00425F, Review Article
Semim Akhtar Ahmed, Prasenjit Manna, Jagat Chandra Borah
Metabolic syndrome is a multifaceted condition marked by interconnected risk factors, significantly increasing the risk of serious diseases like cardiovascular disease, type 2 diabetes, and stroke.
The content of this RSS Feed (c) The Royal Society of Chemistry




k

Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells

RSC Med. Chem., 2024, 15,3728-3745
DOI: 10.1039/D4MD00476K, Research Article
Vincent Ouellette, Chahrazed Bouzriba, Atziri Corin Chavez Alvarez, Quentin Bruxelles, Geneviève Hamel-Côté, Sébastien Fortin
New water soluble antimitotic CYP1A1-activated prodrugs named PYRAIB-SOs and their hydrochlorides targeting breast cancers.
The content of this RSS Feed (c) The Royal Society of Chemistry




k

Prediction of synergistic gemcitabine-based combination treatment through a novel tumor stemness biomarker NANOG in pancreatic cancer

RSC Med. Chem., 2024, 15,3853-3861
DOI: 10.1039/D4MD00165F, Research Article
Jiongjia Cheng, Ting Zhu, Shaoxian Liu, Jiayu Zhou, Xiaofeng Wang, Guangxiang Liu
The synergistic effect observed in gemcitabine-based combination therapies targeting pancreatic cancer stem cells was correlated with the inhibiting effect on the expression of stemness-related gene NANOG.
The content of this RSS Feed (c) The Royal Society of Chemistry




k

Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

RSC Med. Chem., 2024, 15,3746-3758
DOI: 10.1039/D4MD00122B, Research Article
Open Access
Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li
We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.
The content of this RSS Feed (c) The Royal Society of Chemistry




k

Design and synthesis of novel 8-(azaindolyl)-benzoazepinones as potent and selective ROCK inhibitors

RSC Med. Chem., 2024, 15,3862-3879
DOI: 10.1039/D4MD00313F, Research Article
Daniele Pala, David Clark, Christine Edwards, Elisa Pasqua, Laura Tigli, Barbara Pioselli, Piotr Malysa, Fabrizio Facchinetti, Fabio Rancati, Alessandro Accetta
This study reports a novel, potent and selective series of ROCK inhibitors based on 8-(azaindolyl)-benzoazepinones identified through a core-hopping strategy.
The content of this RSS Feed (c) The Royal Society of Chemistry




k

AIADMK will not form an alliance with BJP in 2026 polls, reiterates Palaniswami

“During the Lok Sabha election, it was said at the party headquarters and in press bytes that the AIADMK will not have alliance with the BJP in the [2026] Assembly election,” he said




k

T.N. govt. to take a call on verifying criminal antecedents before appointing schoolteachers

It also assures Madras High Court of putting in place an effective complaint redressal mechanism in the interest of school students




k

Leaders of various parties condemn attack on govt. doctor




k

Four Swedish companies, including IKEA, looking to set up base in Tamil Nadu: Swedish Ambassador to India

There are 70 Swedish companies in Tamil Nadu, employing about 25,000 people. But we want to do more, says Jan Thesleff




k

SBI, HDFC Bank, ICICI Bank figure in RBI’s 2024 list of Domestic Systemically Important Banks (D-SIBs)

Higher D-SIB surcharge fixed for SBI and HDFC Bank, will be applicable from April 01, 2025




k

Rival Zomato's CEO congratulates Swiggy on stock market listing

Swiggy got listed at ₹420, a jump of nearly 8% from the issue price on the NSE




k

Wall Street makes wagers on the likely winners and losers in a second Trump term

Wall Street is already making big bets on what take two for a White House led by Donald Trump will mean for the economy and markets




k

Developed nations need to triple their contribution to make climate finance credible: Avinash Persaud

Currently, developed nations are expected to pay $100 billion a year but they haven’t stuck to agreed targets, and this system ends next year.




k

SKDRDP provides desks and benches worth ₹2.75 crore to 507 government primary schools in four districts of Karnataka

Rajya Sabha MP Veerendra Heggade urges parents to get their wards admitted to government schools as they now have better facilities




k

Free and fair inquiry sought into death of snakebite victim in Srikakulam district

Son of the victim alleges that local medical and health officials misleading higher-ups regarding the incident




k

Fervour marks ‘Kaisika Dwadasi’ at Tirumala




k

New counters opened at Tirumala for issuing Srivani darshan tickets

Decision to open new counters taken following reports of devotees experiencing discomfort in queue at the previous counter, particularly during inclement weather, says TTD Additional EO




k

Sakhi centre inaugurated at Vizianagaram Collectorate




k

Target is to to make 30,000 MT of sand available every day in East Godavari district, says Collector

P. Prasanthi warns boatmen associations of stringent action if they attempt to prevent vehicles transporting sand from the sand reaches




k

All set for Urus festival at Pedda Dargah in Kadapa

Thousands of devotees from across Andhra Pradesh, Tamil Nadu, Karnataka and Maharashtra expected to converge at the famous Sufi shrine for the week-long event starting on November 16




k

Devotees offer special prayers at Sri Kalyana Venkateswara Swamy temple in Srikakulam




k

Andhra Pradesh Govt. weighing options on how to utilise Mahila Samrakshana Karyadarshis, says Home Minister 

Ambiguity in overall control of their duties and service matters resulted in immense distress for the MSKs, says Home Minister




k

117 applications received at Kuppam’s first ‘Praja Darbar’




k

Andhra Pradesh govt. reaffirms commitment to ‘irrigating every acre of farmland’ in State through river-interlinking projects




k

Police book Sri Reddy for posting ‘defamatory content’ against Chandrababu Naidu, Pawan Kalyan




k

Varun Hospitality announces eco-friendly mixed-use project to replace The Gateway Hotel in Visakhapatnam




k

Andhra Pradesh High Court strikes down PIL seeking to restrain police from taking action on ‘abusive content on social media’