'Seriously sometimes seems Google's moderators are only optimized to respond to social media outrage'

Three weeks after Google removed 49 Chrome extensions from its browser's software store for stealing crypto-wallet credentials, 11 more password-swiping add-ons have been spotted – and some are still available to download.…

Cracks the 150,000-employee mark as revenue falls just short of $10bn

Indian services giant HCL Technologies has wound up its 19/20 financial year by reporting 15 percent annual growth but a flat Q4.…

Компания Xiaomi, неожиданно для всех, объявила дату анонса очередного смартфона из линейки Redmi K30.

Компания Meizu провела в Китае мероприятие, на котором анонсировала свою новую флагманскую линейку смартфонов — Meizu 17.

Drive more reaction when you fabricate your image story at the purpose of decision. A point of decision is where a possibility or purchaser will make a move activity to move to the subsequent stage in the purchasing procedure. Research,… Continue Reading →

The incentive to automate will be enormous for $15 per hour minimum wage. Of America’s nearly 16 million retail workers, the biggest group — 4.6 million — are salespeople. Their average wage is $10.47 an hour. After that, the country has another 3.4 million cashiers, and their average wage is $9.28 an hour. Only a quarter of salespeople earn more than $14 — and only 10 percent earn more than $19. The figures are worse for cashiers. But in the race to automate there will be a clear winner: Amazon. Why: Amazon can automate more easily than can physical stores. It is analogous to why long haul trucking can be automated before taxis: Just as highways are simpler places than...

Nitrozac had to undergo an emergency endodontic procedure, *ouch*, so she is off for a few days to let her recover. We'll be back with a new smile soon, in the meantime, here's one of our fave retros...

On accorde "The World of Art Award" (WAA) aux artistes, aux galeries et aux musées qui poursuivent les "meilleures pratiques" dans l'art et la culture. Cette concurrence cherche à attirer dies artistes, galeries, les musées qui redéfinissent des normes de l'excellence d'art. Ceux qui défie des trends et des tendances existantes dans l'art et la culture.

A wealthy Catholic man travels to the Vatican City to see the Bishop of Rome in person, and hopes to meet this leader of the worldwide Catholic Church. Wearing his finest suit, he prays to God that he might be able to meet the Holy Father. During the morning’s Papal procession, he manages to work […]

The post From Riches to Rags appeared first on Funny & Jokes.

Curing HIV infection will require the elimination of a reservoir of infected CD4+ T cells that persists despite HIV-specific cytotoxic T cell (CTL) responses. Although viral latency is a critical factor in this persistence, recent evidence also suggests a role for intrinsic resistance of reservoir-harboring cells to CTL killing. This resistance may have contributed to negative outcomes of clinical trials, where pharmacologic latency reversal has thus far failed to drive reductions in HIV reservoirs. Through transcriptional profiling, we herein identified overexpression of the prosurvival factor B cell lymphoma 2 (BCL-2) as a distinguishing feature of CD4+ T cells that survived CTL killing. We show that the inducible HIV reservoir was disproportionately present in BCL-2hi subsets in ex vivo CD4+ T cells. Treatment with the BCL-2 antagonist ABT-199 was not sufficient to drive reductions in ex vivo viral reservoirs when tested either alone or with a latency-reversing agent (LRA). However, the triple combination of strong LRAs, HIV-specific T cells, and a BCL-2 antagonist uniquely enabled the depletion of ex vivo viral reservoirs. Our results provide rationale for novel therapeutic approaches targeting HIV cure and, more generally, suggest consideration of BCL-2 antagonism as a means of enhancing CTL immunotherapy in other settings, such as cancer.

The pandemic coronavirus infectious disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading across the globe. In this issue of the JCI, Chen and colleagues compared the clinical and immunological characteristics between moderate and severe COVID-19. The authors found that respiratory distress on admission is associated with unfavorable outcomes. Increased cytokine levels (IL-6, IL-10, and TNF-α), lymphopenia (in CD4+ and CD8+ T cells), and decreased IFN-γ expression in CD4+ T cells are associated with severe COVID-19. Overall, this study characterized the cytokine storm in severe COVID-19 and provides insights into immune therapeutics and vaccine design.

Colitis caused by Clostridium difficile infection is a growing cause of human morbidity and mortality, especially after antibiotic use in health care settings. The natural immunity of newborn infants and protective host immune mediators against C. difficile infection are not fully understood, with data suggesting that inflammation can be either protective or pathogenic. Here, we show an essential role for IL-17A produced by γδ T cells in host defense against C. difficile infection. Fecal extracts from children with C. difficile infection showed increased IL-17A and T cell receptor γ chain expression, and IL-17 production by intestinal γδ T cells was efficiently induced after infection in mice. C. difficile–induced tissue inflammation and mortality were markedly increased in mice deficient in IL-17A or γδ T cells. Neonatal mice, with naturally expanded RORγt+ γδ T cells poised for IL-17 production were resistant to C. difficile infection, whereas elimination of γδ T cells or IL-17A each efficiently overturned neonatal resistance against infection. These results reveal an expanded role for IL-17–producing γδ T cells in neonatal host defense against infection and provide a mechanistic explanation for the clinically observed resistance of infants to C. difficile colitis.

Approximately half of the world’s population is infected with the stomach pathogen Helicobacter pylori. Infection with H. pylori is the main risk factor for distal gastric cancer. Bacterial virulence factors, such as the oncoprotein CagA, augment cancer risk. Yet despite high infection rates, only a fraction of H. pylori–infected individuals develop gastric cancer. This raises the question of defining the specific host and bacterial factors responsible for gastric tumorigenesis. To investigate the tumorigenic determinants, we analyzed gastric tissues from human subjects and animals infected with H. pylori bacteria harboring different CagA status. For laboratory studies, well-defined H. pylori strain B128 and its cancerogenic derivative strain 7.13, as well as various bacterial isogenic mutants were employed. We found that H. pylori compromises key tumor suppressor mechanisms: the host stress and apoptotic responses. Our studies showed that CagA induces phosphorylation of XIAP E3 ubiquitin ligase, which enhances ubiquitination and proteasomal degradation of the host proapoptotic factor Siva1. This process is mediated by the PI3K/Akt pathway. Inhibition of Siva1 by H. pylori increases survival of human cells with damaged DNA. It occurs in a strain-specific manner and is associated with the ability to induce gastric tumor.

Hypoxia-inducible factor (HIF) is strikingly upregulated in many types of cancer, and there is great interest in applying inhibitors of HIF as anticancer therapeutics. The most advanced of these are small molecules that target the HIF-2 isoform through binding the PAS-B domain of HIF-2α. These molecules are undergoing clinical trials with promising results in renal and other cancers where HIF-2 is considered to be driving growth. Nevertheless, a central question remains as to whether such inhibitors affect physiological responses to hypoxia at relevant doses. Here, we show that pharmacological HIF-2α inhibition with PT2385, at doses similar to those reported to inhibit tumor growth, rapidly impaired ventilatory responses to hypoxia, abrogating both ventilatory acclimatization and carotid body cell proliferative responses to sustained hypoxia. Mice carrying a HIF-2α PAS-B S305M mutation that disrupts PT2385 binding, but not dimerization with HIF-1β, did not respond to PT2385, indicating that these effects are on-target. Furthermore, the finding of a hypomorphic ventilatory phenotype in untreated HIF-2α S305M mutant mice suggests a function for the HIF-2α PAS-B domain beyond heterodimerization with HIF-1β. Although PT2385 was well tolerated, the findings indicate the need for caution in patients who are dependent on hypoxic ventilatory drive.

Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, the impact of vascular permeability on neutrophil trafficking is unknown. Here, through the application of confocal intravital microscopy, we report that vascular permeability–enhancing stimuli caused a significant frequency of neutrophil reverse transendothelial cell migration (rTEM). Furthermore, mice with a selective defect in microvascular permeability enhancement (VEC-Y685F-ki) showed reduced incidence of neutrophil rTEM. Mechanistically, elevated vascular leakage promoted movement of interstitial chemokines into the bloodstream, a response that supported abluminal-to-luminal neutrophil TEM. Through development of an in vivo cell labeling method we provide direct evidence for the systemic dissemination of rTEM neutrophils, and showed them to exhibit an activated phenotype and be capable of trafficking to the lungs where their presence was aligned with regions of vascular injury. Collectively, we demonstrate that increased microvascular leakage reverses the localization of directional cues across venular walls, thus causing neutrophils engaged in diapedesis to reenter the systemic circulation. This cascade of events offers a mechanism to explain how local tissue inflammation and vascular permeability can induce downstream pathological effects in remote organs, most notably in the lungs.

Brown and beige adipose tissues contain thermogenic fat cells that can be activated by β3-adrenergic receptor agonists. In rodents, such drugs both diminish obesity and improve glucose homeostasis. In this issue of the JCI, O’Mara et al. and Finlin and Memetimin et al. report that chronic administration of the approved β3 agonist mirabegron to human subjects was without effect on body weight or fat mass, but improved several measures of glucose homeostasis. Though the mechanisms mediating these metabolic effects are uncertain, the data suggest that β3 agonists could have therapeutic utility in disorders of glucose homeostasis.

BACKGROUND Beige adipose tissue is associated with improved glucose homeostasis in mice. Adipose tissue contains β3-adrenergic receptors (β3-ARs), and this study was intended to determine whether the treatment of obese, insulin-resistant humans with the β3-AR agonist mirabegron, which stimulates beige adipose formation in subcutaneous white adipose tissue (SC WAT), would induce other beneficial changes in fat and muscle and improve metabolic homeostasis.METHODS Before and after β3-AR agonist treatment, oral glucose tolerance tests and euglycemic clamps were performed, and histochemical analysis and gene expression profiling were performed on fat and muscle biopsies. PET-CT scans quantified brown adipose tissue volume and activity, and we conducted in vitro studies with primary cultures of differentiated human adipocytes and muscle.RESULTS The clinical effects of mirabegron treatment included improved oral glucose tolerance (P < 0.01), reduced hemoglobin A1c levels (P = 0.01), and improved insulin sensitivity (P = 0.03) and β cell function (P = 0.01). In SC WAT, mirabegron treatment stimulated lipolysis, reduced fibrotic gene expression, and increased alternatively activated macrophages. Subjects with the most SC WAT beiging showed the greatest improvement in β cell function. In skeletal muscle, mirabegron reduced triglycerides, increased the expression of PPARγ coactivator 1 α (PGC1A) (P < 0.05), and increased type I fibers (P < 0.01). Conditioned media from adipocytes treated with mirabegron stimulated muscle fiber PGC1A expression in vitro (P < 0.001).CONCLUSION Mirabegron treatment substantially improved multiple measures of glucose homeostasis in obese, insulin-resistant humans. Since β cells and skeletal muscle do not express β3-ARs, these data suggest that the beiging of SC WAT by mirabegron reduces adipose tissue dysfunction, which enhances muscle oxidative capacity and improves β cell function.TRIAL REGISTRATION Clinicaltrials.gov NCT02919176.FUNDING NIH: DK112282, P30GM127211, DK 71349, and Clinical and Translational science Awards (CTSA) grant UL1TR001998.

iFixit hasn't yet done a full teardown of the new Magic Keyboard designed for the new iPad Pro models, but the repair site today partnered with x-ray company Creative Electron to create Magic Keyboard x-rays that give us a view of just what's inside.


The Magic Keyboard uses scissor switch keys instead of butterfly keys, which have now been effectively eliminated from Apple's product lineup. The scissor switch mechanism is clearly visible in the x-ray view, and iFixit calls it the simplest mechanism in the accessory, but the biggest improvement compared to the Smart Keyboard.

Below the keyboard, there are metal plates that iFixit believes are for reinforcing the keyboard's body against bending, and the trackpad is a new design that's different from MacBook trackpads.

There appear to be multiple buttons under the trackpad to capture presses, while the MacBook Trackpads have no buttons and simulate presses with haptic feedback.


There are at least two spring loaded hinge designs at the folding point, featuring both a small coil and a larger coil, plus there are two cables for connecting the Smart Connector to the keyboard for power and data transfer.

Lots and lots of magnets are visible in the x-ray, with the magnets used to hold the Magic Keyboard on the ‌iPad Pro‌. There's a whole ring of tiny magnets around the camera cutout, which iFixit said was a "lot of little polarized bits" to line up, space out, and configure with the ‌iPad Pro‌ components.

According to iFixit, there's more going on in the Magic Keyboard than there is in many laptops, which could explain its price point. Apple charges $299 for the 11-inch Magic Keyboard and $349 for the 12.9-inch version.

Apple has launched a new web page that brings together links and information about its online services for customers shopping from home during the global health crisis.


Titled "Everything you love about our stores is online," the new catch-all page links from the Apple.com home page and includes details about no-contact delivery options, Apple Specialist help, financing and credit options, Apple Trade In, Apple Card, order status checking, service and support.

The page also links out to "Today at Apple - At home," a series of fun how-to videos to help users get creative during the ongoing stay-at-home measures, and there's a series of category links for customers to explore products on Apple's online store.

Apple has been gradually re-opening its retail stores in countries where lockdowns have eased, although some are operating on limited hours.

Apple CEO Tim Cook last week said that Apple was going to reopen stores in Austria and Australia this week, and Apple's sole Apple Store in Vienna will be reopening on Tuesday, May 5.

We're still waiting to hear exactly when stores in North America will reopen, but Cook also said that Apple is planning to reopen a few stores in the U.S. starting in May. Store openings will be staggered, with Apple evaluating data that includes local guidelines and recommendations before reopening.
This article, "New Apple Web Page Directs Customers to Its Online Shopping Services" first appeared on MacRumors.com

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Dan Avidan, after years of dancing around topic of being a furry and which he would be, seems to have settled on his fursona of a cyberpunk wolf in a recently released music video. The video features animal characters with trans-humanist enhancements. The coloration has a signature bleed of 80s style animation.

The story portrays a pack of wolves seeking vengeance against a stag mogul after having their kin slaughtered at his hand. The style of animation and situation has some striking similarities to that of Caravan Palace's music video for Lone Digger.

This was brought to my attention by Majira Strawberry who asked why know one was talking about it. The answer to that in my case is object pertinence.

For those who are fans of cyberpunk and animation this is certainly worth the watch.

The Voyages of Cinrak the Dapper is a collection of seven short stories written by A. J. Fitzwater centred around Cinrak, a lesbian, capybara pirate. It has a couple of strong elements as well as several weak points. I struggled with my thoughts as I read it and, in the end, I would say that, overall, I found it frustrating.

I will start this review briefly talking about politics. It might seem like an unusual starting point but the introduction makes clear that the book is political and it touches on several hot button issues.

Come for handsome, huggable Cinrak in a dapper three-piece, stay for her becoming a house-ship Mother to an enormous found family, the ethical polyamory, trans boy chinchilla, genderqueer rat mentor, fairy, and whale, drag queen mer, democratic monarchy, socialist pirates, and strong unionization.

What I do like about the way politics is handled in this book, is that it is not set up as a conflict between opposing ideologies; the book presents its favoured way of seeing the world and just leaves it as that. Even the religious character (and there is a fascinating take on religion inside) is played off sympathetically. However, by taking the stances it does, the book is also going to be, though it has no regrets about it, alienating for certain readers. If you can not tolerate a heavy emphasis on, and I quote, LGBTQIA characters, then this book is definitely not for you and you may as well stop here. On the other hand, if that’s what you crave, it may be exactly what you want and you should read further.

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Thinking of using TurboTax to file your tax returns? Think again. The Minnesota Department of Revenue advises against using Intuit software to file tax returns! It found unacceptable errors in Intuit tax software, including TurboTax, ProSeries, Lacerte, and Intuit online. Continue reading →

The Senate considered H.R. 1314, the legislative vehicle for trade promotion authority reauthorization.?It would give the president broad fast-track authority when negotiating trade agreements and require Congress to consider treaties without an amendment process. Senator Bernie Sanders speaks out against this bill before the Senate on May 12, 2015. Continue reading →

THE AMERICAN PEOPLE IN THIS PARTICULAR MOMENT IN OUR HISTORY MUST MAKE A VERY FUNDAMENTAL DECISION, AND THAT DECISION IS DO WE CONTINUE THE STATUS QUO WHICH INCLUDES A 40-YEAR DECLINE OF OUR MIDDLE CLASS AND A HUGE AND GROWING GAP BETWEEN THE VERY, VERY RICH AND EVERYONE ELSE, OR DO WE FIGHT FOR A BOLD AND MEANINGFUL ECONOMIC AGENDA THAT CREATES JOBS, RAISES WAGES, PROTECTS OUR ENVIRONMENT AND PROVIDES HEALTH CARE FOR EVERY AMERICAN Continue reading →

Video and transcript of Farron Cousins' discussion of Hillary Clinton's fake populism on Ring of Fire TV, May 18, 2015. Continue reading →

Bernie Sanders calls out Hillary Clinton to announce her position on the Trans-Pacific Partnership (TPP) agreement; however, Hillary Clinton refuses to reveal her position, hoping that the agreement will be passed and she won't have to take a position. Continue reading →

December 6, 2015, 10:50 AM|Senator Bernie Sanders, I-Vermont, believes there must be an international coalition led by Arab nations in the fight against ISIS. Continue reading →

Grow a spine. Bernie Sanders, when are you going to risk losing your friendship with the Democrats to help your country? When are you going to risk doing that? You had a stupid secret agreement not to attack Hillary Clinton, and you stayed by it, and then when the country needed you to do something with your movement, you told them to go work for the Machine. And now you're telling them to back Chuck Schumer. Continue reading →

Jimmy Dore: The intelligence agencies have been releasing the reports to convince us that we should be upset at Russia because they hacked our election. First of all, who gives a shit if they did? The United States tapped Angela Merkel’s … Continue reading →

The sweetheart deal that Governor Malloy and his fellow Democrats in the General Assembly cut with state employee unions, the so-called SEBAC agreement, is protected by contract for a full decade —leaving meaningful reforms waaay down the road. The contract is the mother of all can-kicks. Continue reading →

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Лидер RAGE Peavy Wagner сообщил о том, что гитарист группы, Marcos Rodríguez, больше не является участником коллектива по личным причинам. Никаких разногласий, стороны остаются друзьями, просто пути расходятся. Также по словам лидера команды, он думает о варианте возвращения к квартету и скоро объявит о своем окончательном решении. #Rage #PowerMetal #Power_Metal #SymphonicMetal #Symphonic_Metal

Century Media Records совместно с EMP организовали онлайн-фестиваль, получивший название The Century Media Isolation Festival, который пройдет на официальном YouTube-канале Century Media четырнадцатого мая, стартует в 8 PM, CET / 2 PM, EST / 11 AM, PST и продлится 24 часа.

В фестивале примут участие:

- Angelus Apatrida (Spain, Thrash Metal)
- Baest (Denmark, Death Metal)
- Bonded (Germany, Thrash Metal)
- Borknagar (Norway, Avantgarde Black Metal)
- Dead Lord (Sweden, Hard Rock)
- Deserted Fear (Germany, Death Metal)
- Hideous Divinity (Italy, Death Metal)
- Insomnium (Finland, Melodic Death Metal)
- Lucifer (Sweden, Heavy Rock)
- Omnium Gatherum (Finland, Melodic Death Metal)
- Svart Crown (France, Death/Black Metal)
- The Offering (USA, Progressive Metal)
- Voivod (Canada, Progressive Sci-Fi Metal) #V/A #Rock #_Rock #FolkRock #Folk_Rock #PopRock #Pop_Rock #DeathRock #Death_Rock #HardRock #Hard_Rock #PostRock #Post_Rock #SymphonicRock #Symphonic_Rock #ArtRock #Art_Rock #Adult OrientedRock #Adult Oriented_Rock #Folk #_Folk #GothicFolk #Gothic_Folk #DarkFolk #Dark_Folk #Metal #_Metal #FolkMetal #Folk_Metal #InstrumentalMetal #Instrumental_Metal #GothicMetal #Gothic_Metal #AlternativeMetal #Alternative_Metal #BlackMetal #Black_Metal #DeathMetal #Death_Metal #DoomMetal #Doom_Metal #HeavyMetal #Heavy_Metal #NuMetal #Nu_Metal #PostMetal #Post_Metal #PowerMetal #Power_Metal #ThrashMetal #Thrash_Metal #VikingMetal #Viking_Metal #GrindCore #Grind_Core #IndustrialElectro #Industrial_Electro #Gothic #_Gothic #EthnoGothic #Ethno_Gothic #ElectroGothic #Electro_Gothic #InstrumentalClassic #Instrumental_Classic #NoiseIndustrial #Noise_Industrial #ElectroIndustrial #Electro_Industrial #DarkAmbient #Dark_Ambient #Hard 'n' Heavy #_Hard 'n' Heavy

В рамках интервью для Rolling Stone барабанщик METALLICA Lars Ulrich ответил на вопрос о том, какая музыка его зацепила за последнее время:

«Я бы назвал Fiona Apple — её пластинка ["Fetch the Bolt Cutters"] просто сногсшибательна. В тот день, когда альбом только вышел, я его слушал часа три-четыре подряд и читал тексты. Честно говоря, я был поражён тем, насколько это необычно и гениально, потому что это так нестандартно. Каждые несколько лет выходит пластинка с другим звучанием. Я думаю, что последние ARCTIC MONKEYS, выпущенные года два назад ["Tranquility Base Hotel & Casino"], также имели схожий эффект, когда ты получаешь совсем не то, что ожидаешь, потом слушаешь это и просто говоришь: "Вау, это всё ещё возможно — сделать что-то музыкальное и не так, как у всех, ты ощущаешь уникальность, свежесть и неожиданность". Так что я бы сказал, что альбом Fiona Apple определённо из этой категории. Мне также нравится альбом Ed'a O'Brien'а. И его выступление на "Kimmel" — мы смотрели его достаточно часто.

В остальном, я думаю, вы заметили, что я больше обращаюсь ко многим своим старым друзьям [в музыкальном плане]. Пожалуй, музыка, которую я слушал больше всего за последние два-три месяца, — это RAGE AGAINST THE MACHINE. Неужели я единственный, кто думает, что их музыка с каждым днём становится всё более и более актуальной? Она всё больше и больше ассоциируется с тем, что происходит в мире. Просто такое ощущение, что все четыре этих альбома были записаны на прошлой неделе. И когда я делаю свои жалкие слабенькие упражнения, надеваю наушники и начинаю заниматься, я выдаю что-то типа: "Охренеть", когда просто слышу что-то в "Calm Like A Bomb", "Sleep Now In The Fire" или "Bombtrack", и думаю: "Не, ну правда, что ли? Какого хрена? Откуда это вообще взялось?" Так что RAGE AGAINST THE MACHINE никогда не подведут!»

Ulrich также рассказал, что слушают члены его семьи:

«В доме довольно часто можно услышать Radiohead. Radiohead начали делать что-то вроде того, что делает Metallica, — они транслируют концерты, так что у нас дом фанатов Radiohead».

На вопрос о том, чем он заполняет своё время в период самоизоляции, Lars ответил:

«Я пытаюсь оставаться здоровым и здравомыслящим и быть как можно более продуктивным. Я пытаюсь быть более физически активным, чем несколько месяцев назад, занимаясь тренировками и играя, вместо того, чтобы валяться на диване. Это помогает чувствовать себя лучше в психологическом плане». #Metallica #ModernRock #Modern_Rock #AvantgardeRock #Avantgarde_Rock #HeavyMetal #Heavy_Metal #SymphonicMetal #Symphonic_Metal #ThrashMetal #Thrash_Metal