Date: May 1, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2018 Doodle game celebrating Garden Gnomes!
 

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Location: Global

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Date: May 4, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2016 Doodle game celebrating Wilbur Scoville!
 

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Date: May 5, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2019 Doodle game celebrating Lotería!
 

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Date: May 6, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2016 Doodle game celebrating Halloween!
 

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Location: Global

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Date: May 7, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2017 Doodle game celebrating the birth of Hip Hop!
 

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Location: Global

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Date: May 8, 2020

As COVID-19 continues to impact communities around the world, people and families everywhere are spending more time at home. In light of this, we’re launching a throwback Doodle series looking back at some of our popular interactive Google Doodle games!

Stay and play at home with today’s featured throwback: 

Our 2010 Doodle game celebrating PAC-MAN!
 

Help stop the spread of COVID-19 by following these steps.  
 

Learn more here about the latest ways we’re responding, and how our products can help people stay connected during this time.

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Although CEACAM1 (CC1) glycoprotein resides at the interface of immune liver injury and metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains elusive. We aimed to determine whether/how CEACAM1 signaling may affect hepatic ischemia-reperfusion injury (IRI) and OLT outcomes. In the mouse, donor liver CC1 null mutation augmented IRI-OLT (CC1-KO→WT) by enhancing ROS expression and HMGB1 translocation during cold storage, data supported by in vitro studies where hepatic flush from CC1-deficient livers enhanced macrophage activation in bone marrow–derived macrophage cultures. Although hepatic CC1 deficiency augmented cold stress–triggered ASK1/p-p38 upregulation, adjunctive ASK1 inhibition alleviated IRI and improved OLT survival by suppressing p-p38 upregulation, ROS induction, and HMGB1 translocation (CC1-KO→WT), whereas ASK1 silencing (siRNA) promoted cytoprotection in cold-stressed and damage-prone CC1-deficient hepatocyte cultures. Consistent with mouse data, CEACAM1 expression in 60 human donor liver biopsies correlated negatively with activation of the ASK1/p-p38 axis, whereas low CC1 levels associated with increased ROS and HMGB1 translocation, enhanced innate and adaptive immune responses, and inferior early OLT function. Notably, reduced donor liver CEACAM1 expression was identified as one of the independent predictors for early allograft dysfunction (EAD) in human OLT patients. Thus, as a checkpoint regulator of IR stress and sterile inflammation, CEACAM1 may be considered as a denominator of donor hepatic tissue quality, and a target for therapeutic modulation in OLT recipients.

Organ shortage continues to limit the lives of patients who require liver transplantation. While extending criteria for liver organs provides a needed resource, tissue damage from prolonged ischemic injury can result in early allograft dysfunction and consequent rejection. In this issue of the JCI, Nakamura et al. used a mouse transplantation model with prolonged ex vivo cold storage to explore liver graft protection. The authors found that liver grafts with absent carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) exhibited increased ischemia-reperfusion injury inflammation and decreased function in wild-type recipients. The authors went on to correlate CEACAM1 levels with postreperfusion damage in human liver transplant recipients. Notably, this study identified a potential biomarker for liver transplant donor graft quality.

BACKGROUND Preclinical experiments have shown that donor blood cells, modified in vitro by an alkylating agent (modified immune cells [MICs]), induced long-term specific immunosuppression against the allogeneic donor.METHODS In this phase I trial, patients received either 1.5 × 106 MICs per kg BW on day –2 (n = 3, group A), or 1.5 × 108 MICs per kg BW on day –2 (n = 3, group B) or day –7 (n = 4, group C) before living donor kidney transplantation in addition to post-transplantation immunosuppression. The primary outcome measure was the frequency of adverse events (AEs) until day 30 (study phase) with follow-up out to day 360.RESULTS MIC infusions were extremely well tolerated. During the study phase, 10 treated patients experienced a total of 69 AEs that were unlikely to be related or not related to MIC infusion. No donor-specific human leukocyte antigen Abs or rejection episodes were noted, even though the patients received up to 1.3 × 1010 donor mononuclear cells before transplantation. Group C patients with low immunosuppression during follow-up showed no in vitro reactivity against stimulatory donor blood cells on day 360, whereas reactivity against third-party cells was still preserved. Frequencies of CD19+CD24hiCD38hi transitional B lymphocytes (Bregs) increased from a median of 6% before MIC infusion to 20% on day 180, which was 19- and 68-fold higher, respectively, than in 2 independent cohorts of transplanted controls. The majority of Bregs produced the immunosuppressive cytokine IL-10. MIC-treated patients showed the Immune Tolerance Network operational tolerance signature.CONCLUSION MIC administration was safe and could be a future tool for the targeted induction of tolerogenic Bregs.TRIAL REGISTRATION EudraCT number: 2014-002086-30; ClinicalTrials.gov identifier: NCT02560220FUNDING Federal Ministry for Economic Affairs and Technology, Berlin, Germany, and TolerogenixX GmbH, Heidelberg, Germany.

Systemic sclerosis (SSc) is an autoimmune fibrotic disease whose pathogenesis is poorly understood and lacks effective therapies. We undertook quantitative analyses of T cell infiltrates in the skin of 35 untreated patients with early diffuse SSc and here show that CD4+ cytotoxic T cells and CD8+ T cells contribute prominently to these infiltrates. We also observed an accumulation of apoptotic cells in SSc tissues, suggesting that recurring cell death may contribute to tissue damage and remodeling in this fibrotic disease. HLA-DR–expressing endothelial cells were frequent targets of apoptosis in SSc, consistent with the prominent vasculopathy seen in patients with this disease. A circulating effector population of cytotoxic CD4+ T cells, which exhibited signatures of enhanced metabolic activity, was clonally expanded in patients with systemic sclerosis. These data suggest that cytotoxic T cells may induce the apoptotic death of endothelial and other cells in systemic sclerosis. Cell loss driven by immune cells may be followed by overly exuberant tissue repair processes that lead to fibrosis and tissue dysfunction.

BACKGROUND Glucose-6-phosphate dehydrogenase (G6PD) deficiency decreases the ability of red blood cells (RBCs) to withstand oxidative stress. Refrigerated storage of RBCs induces oxidative stress. We hypothesized that G6PD-deficient donor RBCs would have inferior storage quality for transfusion as compared with G6PD-normal RBCs.METHODS Male volunteers were screened for G6PD deficiency; 27 control and 10 G6PD-deficient volunteers each donated 1 RBC unit. After 42 days of refrigerated storage, autologous 51-chromium 24-hour posttransfusion RBC recovery (PTR) studies were performed. Metabolomics analyses of these RBC units were also performed.RESULTS The mean 24-hour PTR for G6PD-deficient subjects was 78.5% ± 8.4% (mean ± SD), which was significantly lower than that for G6PD-normal RBCs (85.3% ± 3.2%; P = 0.0009). None of the G6PD-normal volunteers (0/27) and 3 G6PD-deficient volunteers (3/10) had PTR results below 75%, a key FDA acceptability criterion for stored donor RBCs. As expected, fresh G6PD-deficient RBCs demonstrated defects in the oxidative phase of the pentose phosphate pathway. During refrigerated storage, G6PD-deficient RBCs demonstrated increased glycolysis, impaired glutathione homeostasis, and increased purine oxidation, as compared with G6PD-normal RBCs. In addition, there were significant correlations between PTR and specific metabolites in these pathways.CONCLUSION Based on current FDA criteria, RBCs from G6PD-deficient donors would not meet the requirements for storage quality. Metabolomics assessment identified markers of PTR and G6PD deficiency (e.g., pyruvate/lactate ratios), along with potential compensatory pathways that could be leveraged to ameliorate the metabolic needs of G6PD-deficient RBCs.TRIAL REGISTRATION ClinicalTrials.gov NCT04081272.FUNDING The Harold Amos Medical Faculty Development Program, Robert Wood Johnson Foundation grant 71590, the National Blood Foundation, NIH grant UL1 TR000040, the Webb-Waring Early Career Award 2017 by the Boettcher Foundation, and National Heart, Lung, and Blood Institute grants R01HL14644 and R01HL148151.

The internet was seen as a major catalyst for the furry fandom finding one another during the times before we held conventions. During that earlier period in the 1990s, conventions and meets were rare, and finding one another was done mostly through the chat rooms and message boards of the past. There was no bandwidth for video or sharing major animation projects, therefore most of our intimate conversations were textual.

For many younger furries, it was a time that was lost in the annals of a distant history. Instead they found themselves joining in amongst a wave of growing conventions being held in various places around the world on any given weekend. Ones where those in custom fursuits march out in the streets openly rather than feeling a stifling isolation of being cooped up in hotel spaces, with a handful of home made creations, being wary of a hostile media looking for a freak show.

Coming out of 2019, it seemed that the time where furry was just an internet thing was fully behind it. However a series of unfortunate events were in line for 2020, a year that has led humanity to be forced into their rooms by an irate Mother Nature as an easily spread virus has forced governments around the globe to take drastic measures to slow its spread and put strict limits on social gatherings. A situation which has forced both the furry fandom, and the internet that brought it together, back to their roots.

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Is your standard charge for a speech $300,000?  According to an article appearing on the website of the Las Vegas Review-Journal, and a May 31, 2013 email, Clinton’s standard contract usually includes: Round-trip transportation on a chartered private jet “e.g., a Gulfstream … Continue reading →

Does a stooge prepare your income tax returns? Watch the Three Stooges prepare a tax return and learn from them. Don't be a stooge: hire a CPA to prepare your next tax return! Continue reading →

Hillary Faces Questions About Cash Donations to Clinton Foundation. Continue reading →

Clinton Cash - do you trust Bill and Hillary Clinton in positions of power Continue reading →

Senator Bernie Sanders does not think that Hillary Clinton can stand up and fight for the middle class. Continue reading →

Bernie Sanders does not have to win the Iowa primary; however, if the gets 35%, 40%, or 45% of the vote, that would set him up nicely for the New Hampshire primary, next door to his state of Vermont. Continue reading →

An Offer in Compromise is an agreement between the taxpayer and the government that settles a tax liability for payment of less than the full amount owed. The Internal Revenue Service will generally accept an Offer in Compromise when it … Continue reading →

Eyewitness News has learned that the Berlin High School football recruiting scandal may have cost Berlin taxpayers tens of thousands of dollars. Continue reading →

Green Party's Jill Stein says that what we Fear from Donald Trump is what we have already seen from Hillary Clinton. Continue reading →

Leaders of political revolutions never quit before the official battle begins, and say that they will vote for and support their enemies. When the moment arrived of walking all that endless talk of Bernie Sanders about fighting his political revolution, he caved out of self interest Continue reading →

'Lesser of Two Evils' argument is not resonating with DNC protestors. Salon.com's Ben Norton says grassroots movements will be more mobilized under a Republican candidacy. "There?s no question that Trump would be horrific as a candidate but if we have 4 or 8 years of Clinton of more wars, of more austerity, of another economic crisis, and potential bailouts of banks and large corporations etc., you know you think Trump is bad now? Wait for what we'?ll see in 4 or 8 years." Continue reading →

Bernie Sanders and Jane Sanders are mere actors serving as pressure valves which release from time to time all excess heat emanating from failed policies, scandals, and the worsening economic conditions, so that a catastrophic systems’ collapse can be prevented. They are sheepdogs for Hillary Clinton, preventing progressives from supporting a third party progressive candidate and to herd them back into the corral of the Democratic Party. Continue reading →

Pulitzer Prize-winning reporter James Grimaldi of The Wall Street Journal, who has covered the Clinton Foundation for years, looks at the relationship between the Clinton Foundation and the State Department during Hillary Clinton’s time as secretary of state, and what it would be if she became president. Newly released State Department emails include exchanges between top members of the Clinton Foundation and Clinton’s top State Department advisers, including Huma Abedin and Cheryl Mills. The FBI reportedly wanted to investigate the Clinton Foundation earlier this year, but U.S. Attorney General Loretta Lynch pushed back. Continue reading →

Questions surrounding Hillary Clinton and the Clinton Foundation continue to grow. On Sunday, Democratic National Committee interim chairperson Donna Brazile defended Clinton’s meetings as secretary of state with Clinton Foundation donors, saying, "When Republicans meet with their donors, with their supporters, their activists, they call it a meeting. When Democrats do that, they call it a conflict." Donna Brazile’s comments come in response to an Associated Press investigation revealing that while Hillary Clinton served as secretary of state, more than half of the private citizens she met with during the reporting period had donated to the Clinton Foundation. The AP investigation comes after a three-year battle to gain access to State Department calendars. The analysis shows that at least 85 of 154 people Hillary Clinton had scheduled phone or in-person meetings with were foundation donors. We speak to Pulitzer Prize-winning journalist Glenn Greenwald of The Intercept. His most recent piece is headlined "Why Did the Saudi Regime and Other Gulf Tyrannies Donate Millions to the Clinton Foundation?" Continue reading →

Jimmy Dore says that voting your conscience means voting for Jill Stein if you are a progressive. Continue reading →

Jill Stein thinks that Hillary Clinton is scarier than Donald Trump: "On this issue of war and nuclear war, Hillary is much scarier." Continue reading →

The Brainwashing Of Hillary Voters Is Complete. Hillary Clinton voters are either getting paid or have been brainwashed into defending her pro-corporate status quo policies. Jimmy Dore breaks it down on his broadcast, October 20, 2016. Continue reading →

There's got to be a reason for the Democrats to suppose to exist. And the reason the Democrats are supposed to exist is to be an opposition party to the Republicans. If you're in bed with the same people, taking money from the same people, you're no longer an opposition party. There's no reason for you to exist. And guess what? Don't be surprised that people don't vote for you. Continue reading →

Donald Trump sold out his supporters and the 99% by selecting Wall Streeters and war mongers for his top cabinet positions. Continue reading →

The DNC is a one big capitalistic gangbang of Democrats and corporate donors and lobbyists. Guess who is getting screwed? Continue reading →

Connecticut General Assembly Majority Leader Joe Aresimowicz speaking at the 2014 CEUI Convention. Joe Aresimowicz, in speaking to a governmental employee union group in 2014, assured governmental union employees that he would be looking out for them: "You guys have one of your own that sits in the caucus room of the General Assembly. You cannot replicate that." "I will never allow an anti-collective bargaining bill to be called to the House floor. I'm the majority leader. I can make that guarantee." "Please, stand together, stand as brothers and sisters, and be a family. And make sure we are looking out for our own." Continue reading →

Вокалист SHINEDOWN Brent Smith опубликовал в своём аккаунте в Инстаграм фрагмент с выступления группы и написал:

«Я так же сильно, как и любой из вас, хочу, чтобы такие моменты, как этот, вернулись. Я люблю выступать, и я люблю #massgatherings или, как я люблю называть их, #familyreunions. Так что, сказав это, я хотел бы воспользоваться моментом, чтобы поделиться чем-нибудь со всеми вами по всему миру.

Такие моменты, как этот, обязательно вернутся. Все мы сможем пойти и посмотреть на выступление нашего любимого артиста вживую, на соревнования наших любимых спортивных команд, и да — это будет безопасно.

В течение последних 72 часов я наблюдал, как части #usa начинают открываться заново, а также другие страны за рубежом начинают процесс снятия некоторых ограничений, и я наблюдаю, как много взволнованных и благодарных людей, готовых вырваться в мир, который они так любят, но, я также вижу, что есть люди, которые имеют серьёзные опасения из-за открытия различных регионов.

С самого начала блокировки я сделал одну вещь, которая действительно помогла мне лично сориентироваться в этой #pandemic, и это просвещает меня.

Мы должны уважать не только друг друга, но и позволять людям, которые работают круглосуточно и без выходных, обеспечивать нашу #safety и наше #future.

Я знаю, что мы все #Anxious и хотим вернуться к #Life, но я прошу всех нас быть уважительными друг к другу и не быть эгоистичными.

Я знаю, что это трудно, но, я обещаю вам, что если мы все будем работать #together, то и сможем #riseuptogether.

У всех нас в @shinedown — меня, @zmyersofficial, @bkerchofficial и @ebassprod есть поговорка, которая дорога нашим сердцам... И она звучит так: "Дело не в художнике, дело в картине".

Мы #love всех вас, и мы скоро будем вместе. #westandtall #atlasfalls #directrelief #shinedown #shinedownnation #shinedowncrew #shinedownfamily #respect». #Shinedown #AlternativeRock #Alternative_Rock #GrungeRock #Grunge_Rock

Посмотреть эту публикацию в Instagram

“FULL DISCLOSURE” This is MY opinion 👇 I want moments like this back just as much as anyone. I love performing, and I LOVE #massgatherings or as I like to call them #familyreunions 🤗. So that being said, I wanted to take a moment to share something with all of you around the world. Moments like this WILL happen again. All of us will be able to go, and see our favorite artist perform live, our favorite sports teams compete, and yes it will be safe to do so. For the last 72 hours, I have watched parts of the #usa begin to reopen, and also other countries abroad begin the process of lifting certain lockdown restrictions, and I can see so many people excited, and grateful, and running out into the world they love so much but, I am also seeing that there are people that have serious concerns in their eyes, as parts of the world begin to open back up. Since the very beginning of the lockdown, I have done one thing that has truly helped me personally navigate through this #pandemic, and that is educate myself. We must be respectful of not only each other, but also allowing the people that are working 24/7 around the clock to insure our #safety and our #future. I know we are all #Anxious and we want to get back to living #Life , but I ask all of us to be respectful of each other, and to not be selfish. I know this is difficult but, I promise you if we all work #together we will #riseuptogether. All of us in @shinedown myself, @zmyersofficial @bkerchofficial and @ebassprod have a saying that we hold dear to our hearts... And that is “It’s not about the painter, it’s about the painting 🌎”. We #love you ALL, and we will be together soon. ❤️⚠️❤️. #westandtall #atlasfalls #directrelief #shinedown #shinedownnation #shinedowncrew #shinedownfamily #respect Moving pictures by THE MAN!!! @sanjayparikhphoto

Публикация от @ thebrentsmith 3 Май 2020 в 2:10 PDT

Undone by Blood #3 is now due out June 10.

The post EXCLUSIVE: More meta revenge in UNDONE BY BLOOD #3 appeared first on The Beat.

Fake news, conspiracy theories, calls to stay calm. How can the media help contain the deadly spread?

Media confront a week of viral news as the pandemic sends us closer to lockdown. Plus, Tracy Grimshaw is left hanging by Josh Frydenberg. And Seven’s Mark Stevens brings us a news flash.

The critical media debate over easing the COVID-19 lockdown. Why we must not minimise the dangers.

The AFP’s media raid warrant gets slapped down by the High Court.  Plus, Trump and the media’s latest bout, Boris Johnson gets released from “prison”, the Daily Mail find a bogus Barnsey, and an angry shop keeper flips the bird.

IBM today announced that Clarient Global LLC (“Clarient”), a joint venture established to transform client data and document management in the financial services industry, has selected VMware Cloud Foundation on IBM Cloud to continue to enhance its existing SoftLayer private cloud implementation for its Clarient Entity Hub platform.