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Facile one-pot synthesis of novel imidates as multifunctional organic fluorescent materials

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01628A, Research Article
Feng-Ting Liu, Shuo Wang, Yong-Shun Chen, Jun-Ying Miao, Bao-Xiang Zhao, Zhao-Min Lin
A novel one-pot synthesis of multifunctional organic fluorescent imidates from quinolinium salt derivatives, nitrosoarenes and alcohols was presented. This method had a wide substrate scope and excellent isolated yields.
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Photoinduced cobaloxime catalysis for allylic mono- and diphosphinylation of alkenes with hydrogen evolution

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01638F, Research Article
Aijun Zhang, Miao-Miao Li, Lei Guo, Huaixiang Yang, Jiefei Guo, Da Xu, Wei Ding
A highly efficient allylic radical mono- and diphosphinylation of alkenes with secondary phosphine oxides is developed, via visible-light-induced cobaloxime catalysis.
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Total synthesis of spiro Ganoderma meroterpenoids spiroapplanatumines B, D, F, and H

Org. Chem. Front., 2024, 11,6333-6339
DOI: 10.1039/D4QO01147C, Research Article
Jia-Hao Zhang, Wen-Cai Luo, Wen-Tao Chen, Yu-Tao He, Ya-Jian Hu
The first total synthesis of spiroapplanatumines B, D, F, and H as well as the possibly undiscovered natural product spiroapplanatumine R has been achieved.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Transition-metal-catalyzed regiodivergent sulfonylation of aziridrines for the synthesis of β-amino sulfones

Org. Chem. Front., 2024, 11,6340-6346
DOI: 10.1039/D4QO01376J, Research Article
Qinqiong Zeng, Yujia Gong, Xiaochun He, Xuemei Zhang, Zhong Lian
We developed the first transition-metal-catalyzed, regiodivergent sulfonylation of aziridines, enabling the efficient synthesis of diverse β-amino sulfones under mild conditions with broad substrate compatibility and high regioselectivity.
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Chiral synthetic unprecedented spiro[indoline-2,3'-thiophen]-3-ones via an organocatalytic asymmetric sulfa-Michael/aldol cascade reaction

Org. Chem. Front., 2024, 11,6426-6436
DOI: 10.1039/D4QO01551G, Research Article
Mao Zhang, Xing-Hai Fei, Gui-Ping Yang, Cheng Lin, Wen-Jie Li, Ming-Liang Rao, Meng Zhou, Chong Zhao, Bin He, Yong-Long Zhao
A cinchona-derived squaramide-catalyzed asymmetric sulfa-Michael/aldol cascade reaction of 2-ylideneoxindoles with 1,4-dithiane-2,5-diol was developed to realize the chiral synthesis of spiro[indoline-2,3'-thiophen]-3-ones.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Asymmetric synthesis of (aza)flavanones by the evolution of CarOx ligands

Org. Chem. Front., 2024, 11,6444-6449
DOI: 10.1039/D4QO01345J, Research Article
Juan Yang, Wenlong Kong, Mingxin Chang, Jixing Lai, Shengkun Li
Amino-pyridine-oxazoline (NHPyOx) is conceived as an unprecedented model via the core-emulating optimization of CarOx ligands.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Well-defined chiral dinuclear copper-catalyzed tandem asymmetric propargylic amination–carboxylative cyclization sequence toward chiral 2-oxazolidinone derivatives

Org. Chem. Front., 2024, 11,6319-6326
DOI: 10.1039/D4QO01368A, Research Article
Yu Lan, Peng Liu, Zekai Fang, Lili Shao, Qilong Cai, Xiaoming Wang
A variety of chiral 2-oxazolidinones was obtained via a dinuclear copper-catalyzed asymmetric propargylic amination–carboxylative cyclization sequence of propargylic esters with alkyl amine hydrochlorides and CO2.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Activation of donor–acceptor cyclopropanes under basic conditions: ring opening of 2-(p-siloxyaryl)cyclopropane 1,1-dicarboxylates with nitro compounds and other C-nucleophiles

Org. Chem. Front., 2024, 11,6483-6494
DOI: 10.1039/D4QO01472C, Research Article
Yulia A. Antonova, Andrey A. Tabolin
A new activation mode for donor–acceptor cyclopropanes was proposed and implemented in their reaction with nitro compounds and other common C-nucleophiles.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Anomalous magnetic behaviour induced by a structural phase transition with anisotropic thermal expansion in a spirodiradical

Org. Chem. Front., 2024, 11,6495-6502
DOI: 10.1039/D4QO01098A, Research Article
Open Access
Takuya Kanetomo, Daigo Matsunaga, Shinichi Ogawa, Masaya Enomoto
A Ge-centred spirodiradical exhibited anomalous magnetic behaviour, influenced by two key structural factors: negative thermal expansion and a structural phase transition.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Sulfenylation of bioactive maleimides, acrylates and cyclohexenones under ambient organophotocatalysis

Org. Chem. Front., 2024, 11,6503-6509
DOI: 10.1039/D4QO01342E, Research Article
Debanjana Bag, Rajjakfur Rahaman, Anindya S. Manna, Subhasis Pal, Rajesh Nandi, Shobhon Aich, Narendra Nath Ghosh, Dilip K. Maiti
A novel visible light-induced sulfenylation of biologically important maleimides, acrylates and cyclohexenones has been developed using cheap and easily available organophotoredox catalyst Eosin Y with thiols under ambient conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Cobalt-catalyzed enantioselective reductive addition of ketimine with cyclopropyl chloride to construct chiral amino esters bearing cyclopropyl fragments

Org. Chem. Front., 2024, 11,6311-6318
DOI: 10.1039/D4QO01474J, Research Article
Jiangtao Hu, Tingting Xia, Xianqing Wu, Hongrui Feng, Jingping Qu, Yifeng Chen
Co-catalyzed asymmetric reductive addition of ketimine with cyclopropyl chloride has been realized to access diverse chiral amino esters bearing cyclopropyl fragments with broad functional group tolerance and excellent enantioselectivities.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Enantioselective Addition of 3-hydroxyquinolin-2(1H)-one to Isatin and Pyrazole-4,5-dione Derived Ketimines

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01895H, Research Article
Yue Wei, Guishun Bai, Jiamin Wu, Yi Hua, Tao Zhang, Congyong Yue, Hong Wang, Xiaoze Bao
The enantioselective reactivity of 3-hydroxyquinolin-2(1H)-ones was developed through their addition to isatin and pyrazole-4,5-dione derived ketimines, affording novel architectures featuring multiple natural products scaffolds in high yield with excellent enantioselectivities....
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DABSO-Mediated Pummerer Reaction Enables One-Pot Synthesis of Pyrroloquinolines for Accessing Marinoquinolines: Mechanistic, Photophysical and Pharmacological Investigations

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01512F, Research Article
Rahimuddin Khan, Dipun Kumar Penthi, Aditi Chatterjee, Chandrakanta Sahoo, Shanti Gopal Patra, Viswanathan Arun Nagaraj, Tabrez Khan
A new one-pot acid- and exogenous oxidant-free synthesis of pyrrolo[2,3-c]quinolines has been developed. The strategy involves chemoselective reduction of the 3-(2-nitrophenyl)-1H-pyrroles (pyrrolnitrin derivatives) and subsequent DABSO-facilitated Pummerer reaction in the...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Charge Transfer Complex Enabled Mechanochemical Synthesis of Chalcogenoacetylenes via Alkynyl Radicals

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01827C, Research Article
Open Access
Fang Tan, Chang-Zhen Fang, Bing-Sheng Qiu, He Sheng, Yong-Liang Tu, Xiang-Yu Chen
Mechanochemistry has become an appealing strategy to enable numerous organic transformations. While significant advances have been achieved, the radical coupling reaction under mechanochemical conditions is still in its infancy. In...
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Copper(II)-catalyzed synthesis of sulfonyl-functionalized quinone-fused cyclopenta[b]indoles via four-component cascade annulation

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01560F, Research Article
Hong Xu, Jie Liao, Fei Ren, Chuan-Rong Zhou, Xiao-Zhuo Liu, Yao Xiao, Dong-Wei Hang, Fuyu Li, Bei Wang, Ji-Yu Wang
Through crucial selective radical tandem process and intramolecular nucleophilic addition, a facile copper-catalyzed four-component cascade has been realized to selectively construct novel sulfonyl-functionalized quinone-fused cyclopenta[b]indole.
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Catalyst-free C–H methylation of heteroarenes enabled by electron donor–acceptor complex photoactivation

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01309C, Research Article
Jiayang Wang, Baoer Shao, Haixia Ge, Huiyu Xue, Xiangyuan Ding, Yuqi Li, Peiyao Sheng
A visible-light-induced direct C–H methylation of heterocycles (including quinoxalinones, pyrazinones, quinolinones and coumarins) with methylamines via EDA complex photoactivation was developed.
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Facile single-step synthesis of pentaaryl-substituted pyrano[3,2-b]pyrrol-5(1H)-ones showing aggregation-induced emission

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01600A, Research Article
Yongfeng Wang, Ruijun Chu, Yanxiao Wang, Mengyuan Zhou, Yuan Chen, Cheng Xu, Jingyu Sun, Guodong Yin
A novel class of heterocyclic AIEgens has been synthesized via a multicomponent reaction of isatins, 2,3-diaryl cyclopropenones, and alkyl bromides.
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A Stereoselective Organocatalyzed C-Glycosylation of Indole: Implications of Acceptor-Catalyst-Donor Interaction

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01873G, Research Article
Lihuang Xie, Wenchao Liu, Zhenbo Guo, Qinbo Jiao, Xiaomin Shen, Tianfei Liu, Chunfa Xu
A stereoselective pyridinium hexafluorophosphate-catalyzed C-glycosylation of indole is presented, featuring the plausible formation of a catalyst-acceptor complex and a crucial H-bond between the indole N-H and the oxygen at C6...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Thiocyanoalkylation of Alkenes via Dual Photoredox and Copper Catalysis

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01864H, Research Article
Xu Wang, Bi-Yin Xiao, Qi-Xuan Jiang, Wei Huang, Feng-Hua Zhang
Organic thiocyanates are commonly used as an essential organic synthesis intermediate and widely present in various drug molecules and bioactive molecules. Herein, a copper and photoredox catalyzed thiocyanoalkylation reaction of...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Iridium-catalyzed asymmetric cascade allylation/lactonization of methyl salicylates: enantioselective construction of chiral benzodioxepinones

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01771D, Research Article
Bendu Pan, Yunru Wu, Yaqi Zhang, Xiaobo He, Long Jiang, Liqin Qiu
An efficient asymmetric cascade allylation/lactonization of methyl salicylates is achieved. The utilization of chiral-bridged biphenyl phosphoramidite ligand resulted in good results for the construction of a wide range of chiral benzodioxepinones.
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Magic effect of diphenylprolinol silyl ether for the enantioselective allenation of 2-alkynals

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00984C, Research Article
Guolin Wu, Zhen Liu, Shiwen Fan, Wenyao Li, Xue Zhang, Hui Qian, Shengming Ma
Chiral diphenylprolinol silyl ethers have been successfully identified for the enantioselective allenation reaction of terminal alkynes and 2-alkynals, delivering a diverse set of chiral allenynes with high efficiency.
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Visible-light responsive defluorination-acyl fluoride exchange for photoclick labeling based on phenoxazine chromophores

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01870B, Research Article
Lijun Deng, Sitong Li, Cefei Zhang, Yuqiao Zhou, Zhishan Su, Changwei Hu, Xiaohu Zhao, Zhipeng Yu
We developed a new generation of photo-DAFEx reagents to realize photoaffinity labeling for drug discovery under 405 nm light control.
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Palladium-catalyzed cascade decarboxylative cyclization of alkyne-tethered aryl iodides with o-bromobenzoic acids for the synthesis of fused isoquinolinones

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01573H, Research Article
Zhaolin Quan, Yubo Duan, Zhengkai Chen
A straightforward approach for the preparation of fused isoquinolinone derivatives via palladium-catalyzed cascade decarboxylative cyclization of alkyne-tethered aryl iodides with o-bromobenzoic acids is described.
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Synthesis of oxa-bridged carbocycles via rhodium/Lewis acid catalyzed [3 + 3] and [4 + 3] cycloadditions of carbonyl ylides with donor–acceptor strained carbocycles

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO01831A, Research Article
Jiale Li, Lingfei Wang, Pei-Nian Liu, Xingguang Li
A method for cooperative rhodium/Lewis acid-catalyzed cycloadditions of carbonyl ylides with donor–acceptor (D–A) strained carbocycles is described. It affords structurally diverse oxa-bridged carbocycles with high efficiency and stereoselectivity.
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PIFA-Mediated cyclization of methyl(2-(1-phenylvinyl)phenyl)sulfane for the concise, flexible, and scalable de novo synthesis of C3-arylated benzo[b]thiophenes

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO01589D, Research Article
Xinya Liu, Olivier Provot, Christine Tran, Jean-Francois Soule, Abdallah Hamze
The well-decorated arylated benzo[b]thiophene scaffold is a pivotal structural motif with diverse applications in medicinal chemistry. This paper outlines a de novo synthesis of C3-arylated benzo[b]thiophenes, showcasing its flexibility and...
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Rhodium-catalyzed synthesis of N-substituted 3-acylpyrroles from enaminones and vinylene carbonate

Org. Chem. Front., 2025, Accepted Manuscript
DOI: 10.1039/D4QO01816H, Research Article
Sheng-Jiao Yan, Jian-Bo Ma, Yi-Mai Yin, Xing-Mei Hu, Bi-Na Shao, Kun Huang, Qing-Sheng Zhao
Skeletal editing is a highly efficient strategy for modifying the core scaffolds of drug molecules, with multi-atomic editing as an emergent approach. Herein, we present a protocol for constructing N-substituted...
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π-extended regioisomeric dithienoacenes fused pyrenes: structures, properties, and application in field-effect transistors

Org. Chem. Front., 2025, Accepted Manuscript
DOI: 10.1039/D4QO01592D, Research Article
Bin Lu, Shiqian Zhang, Dong Liu, Wendong Jin, Dalin Li, Zhiqiang Liu, Tao He
The development of π-conjugated semiconducting molecules with fused rings has been a focus of research in organic electronics. In this study, optoelectronic and field-effect transistors (FET) properties of two novel...
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Mechanistic insights into rhodium-catalyzed C−H activation and annulation using vinyl acetate to access cinnolines and cinnolin-4(1H)-ones

Org. Chem. Front., 2025, Accepted Manuscript
DOI: 10.1039/D4QO01734J, Research Article
Yuqin Wang, Yiling Zeng, Ya-Nan Tian, Zheng Liu, Jinhua Wang, Shuyou Chen, Shiqing Li
Transition metal-catalyzed C−H activation and annulation involving vinyl acetate remains a significant challenge, and the mechanistic process following vinyl insertion is ambiguous. Herein, we report the Rh(III)-catalyzed two-fold C−H activation...
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At Via Milano in Hyderabad, the pizza can wait, go for the chops




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TGSRTC Karimnagar region to operate special buses to Arunachala Hill in Tamil Nadu on November 13




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HYDRAA created fear among encroachers and big builders and not common people: Telangana CM




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Owaisi hails Supreme Court ruling on AMU’s minority status

The Modi government should take this judgement in its stride, says Asad




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No more parties without permission: Telangana Excise Dept. to farmhouse owners




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Varun Tej: ‘Matka’ entertains but does not glorify the gambler

Actor Varun Tej discusses his new Telugu film ‘Matka’, a fictional tale inspired by Ratan Khatri, set in Visakhapatnam of the 1960s and 70s




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Man arrested for kidnapping, marrying, sexually assaulting minor




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Guru Nanak’s 555th birth anniversary celebrations to begin in Hyderabad on November 11




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CM Revanth Reddy announces resolve to complete pending projects of Palamuru district

Criticises opposition parties for trying to create obstacles in district development  




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Nodal officers appointed for the caste survey in Greater Hyderabad




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Telangana to repair 9,000 km of roads using advanced technology: Minister Komatireddy




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Cyberabad police impose restrictions near exam centres on November 17 and 18




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66% of gamers in India are from non-metro cities: Lumikai annual report

Average weekly time spent on gaming increased by 30% to 13 hours




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Ind vs NZ 3rd Test: One of the better knocks I have played in Tests, says Shubman Gill

The conversation with the coach was just having more repetitions on what I think is the best idea for me to be able to play spinners, says Shubman Gill after the second day of the third test against New Zealand




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IND vs NZ third Test: Don’t know how the Pant decision was overturned, says Rohit Sharma

New Zealand captain Tom Latham stated his troupe was confident it had heard two sounds.




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Wriddhiman Saha announces retirement from cricket after this year's Ranji Trophy

Veteran cricketer Wriddhiman Saha announces retirement, last season in Ranji Trophy, ending a cherished journey in cricket




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IPL auction set to be held in Riyadh at end of November

This year's auction is a mega one with high profile India stars like Rishabh Pant, KL Rahul, Shreyas Iyer and Arshdeep Singh are going to go under the hammer




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Shami's return to competitive cricket delayed; not to play for Bengal against Karnataka, M.P.

Other than Shami, Bengal will also miss the services of prolific opener Abhimanyu Easwaran, wicketkeeper batter Abhishek Porel and pacer Mukesh Kumar, who are with India A squad in Australia.




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IPL mega auction to be held in Jeddah in Saudi Arabia on November 24, 25: BCCI

The player registration officially closed and a total of 1,574 cricketers (1,165 Indian and 409 overseas) have been signed up for the auction




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James Anderson wants to grow his 'knowledge of the game' through IPL

In a surprising move, James Anderson, who last played a T20 match in 2014 and never played a match in the IPL, registered himself for the auction




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BCCI vs PCB spar on CT venue as Mohsin Naqvi denies receiving any official note from Indian board

The Hybrid Model was followed during 2023 Asia Cup where Pakistan played its matches at home but India played its matches in Sri Lanka.




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