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Not exclusively the activity, but the sweet spot: a dehydrogenase point mutation synergistically boosts activity, substrate tolerance, thermal stability and yield

Org. Biomol. Chem., 2024, 22,3009-3018
DOI: 10.1039/D4OB00211C, Paper
Yu-Ke Cen, Lin Zhang, Yue Jiang, Xiang-Fu Meng, Yuan Li, Chao Xiang, Ya-Ping Xue, Yu-Guo Zheng
A single-point mutation of 7α-HSDH achieved the highest activity and synergistically improved substrate tolerance, thermal stability, cofactor affinity, and conversion rate.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Selective synthesis of an elusive C-functional bis-cyclam and study of its inhibition of the CXCR4 chemokine receptor

Org. Biomol. Chem., 2024, 22,3059-3067
DOI: 10.1039/D3OB02050A, Paper
Marie M. Le Roy, Sandra Claes, Nathalie Saffon-Merceron, Dominique Schols, Thibault Troadec, Raphaël Tripier
A rare example of C,C'-linked bis-cyclam has been synthesized with controlled manner in mild conditions thanks to the “bis-aminal” tool, and its good CXCR4-recognition properties could be demonstated in vitro.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Hydrosilylation of nitriles and tertiary amides using a zinc precursor

Org. Biomol. Chem., 2024, 22,3053-3058
DOI: 10.1039/D4OB00161C, Paper
Ravi Kumar, Rohan Kumar Meher, Himadri Karmakar, Tarun K. Panda
A competent and selective hydrosilylation of nitriles and tertiary amides catalyzed by zinc bis(hexamethyldisilazide) [Zn(HMDS)2] under solvent-free and mild conditions are reported, as a sustainable and desirable alternative to existing methods.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Unusual immunosuppressive pyridine-containing bisnor- (c23), tetranor- (c21) and pentanor- (c20) sesterterpenoids from Tibetan Leucosceptrum canum

Org. Biomol. Chem., 2024, 22,3019-3024
DOI: 10.1039/D4OB00334A, Paper
Man Li, Ling Feng, Han Zhang, Yan-Chun Liu, Ting-Ting Zhou, Yu Zheng, Kai Guo, Yan Liu, Sheng-Hong Li
Six unusual pyridine-containing bisnor- (C23), tetranor- (C21) and pentanor- (C20) sesterterpenoids were obtained from the medicinal plant Leucosceptrum canum of Tibetan origin. The immunosuppressive activities of these sesterterpenoids were observed.
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Palladium-catalyzed (Z)-selective allylation of phosphine oxides with vinylethylene carbonates to construct phosphorus allyl alcohols

Org. Biomol. Chem., 2024, 22,3068-3072
DOI: 10.1039/D4OB00354C, Paper
Hua Huang, Yi-Qi Wu, Lu-Yao Han, Lu Jiang, Zhuo-Zhuo Zhang, Xiang Zhang, Bo Han, Wei Huang, Jun-Long Li
A general and efficient method for the highly stereoselective synthesis of (Z)-phosphorus allylalcohols has been developed using the Pd-catalyzed cross-coupling of phosphine oxides with vinylethylene carbonates.
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Charge-transfer inclusion complex formation of the tropylium cation with prism[6]arenes

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00423J, Communication
Guojiao Zhang, Channi Cheng, Zhengxiang Li, Dezhi Zhao, Chengyou Han
We report that charge-transfer (CT) inclusion complexes were formed between prism[6]arenes and tropylium cation. Additionally, the CT complex showed Cl/Ag+ responsiveness which can be easily monitored by the naked eye.
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TEMPO/PhI(OAc)2 promotes the α-aminophosphinoylation of alcohols with amines and H-phosphine oxides in aqueous medium

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00302K, Communication
Qiang Huang, Xin Jin, Lvjia Wu, Jiangdong Li, Qianlu Xing, Xianheng Wang, Changkuo Zhao
The aminophosphinoylation of alcohols with amines and H-phosphine oxides provides an efficient and mild approach to access various α-aminoalkylphosphine oxides in good yields with good tolerance of functional groups using H2O as a clean solvent.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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An FeCl3-catalyzed three-component reaction for the synthesis of β-(1,2,3-triazolyl)-ketones using DMF as a one-carbon source

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00207E, Communication
Ruilin Fang, Lei Zheng, Xuyang Chen, Can Wang, Yunfeng Chen
FeCl3-catalyzed oxidative condensation of NH-1,2,3-triazoles and aryl methyl ketones and DMF has been reported.
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Sustainable preparation of 2-acylbenzothiazoles under the cooperation of ionic liquids and microwave irradiation

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00315B, Paper
Shoushun Wang, Mengjie Liu, Yiyuan Yue, Xiude Hu, Yalin Zhang, Guodong Shen, Ruiguo Dong, Lilong Shi, Bing Yu, Xianqiang Huang
A series of 2-acylbenzothiazole derivatives were sustainably synthesized for the first time under the cooperation of ionic liquids and microwave irradiation, metal- and extra-additives-free conditions.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Regioselective synthesis of 4-arylamino-1,2-naphthoquinones in eutectogel as a confined reaction medium using LED light

Org. Biomol. Chem., 2024, Advance Article
DOI: 10.1039/D4OB00140K, Communication
R. Vara Prasad, Yogendra Kumar, R. Arun Kumar, Tohira Banoo, Subbiah Nagarajan
The use of a simple carbohydrate-derived eutectogel facilitating a LED-light-induced regioselective synthesis of 4-arylamino-1,2-naphthoquinones in good yields is reported.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Getting Started with CSS Shapes: Wrapping content around custom paths

Using CSS Shapes we can create experiences that we have never been able to create on the web before.




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Introduction to Service Worker: How to use Service Worker

Service Worker will revolutionize the way we build for the web. Learn about what it is, why it is important and how to use it.




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A time when hijackings were dime-a-dozen in the US

Unthinkable in today’s hyper-security post-9/11 environment, forced diversions were commonplace in the ’60s




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‘The challenge was in getting the aircraft’s custom clearance’

Private jet operator JetSetGo’s CEO Kanika Tekriwal describes the intricacies of directly importing and leasing an aircraft




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Airbus responds to COP26




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A380: How Airbus forecast misfired

Sinks $25 billion in the process




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Robust flight plans can keep airlines afloat




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Deep tech is helping airlines sustain operations during Covid

Integrated biometric-enabled frameworks for real-time test results, travel details and vaccine status are key to making air travel safe




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As India builds its newest airports, it needs robust, fail-proof SOPs

A near air mishap on Bengaluru skies that put the lives of 430 people in danger shows safety risk norms require constant refresh




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Next order of business for Tata Sons

How will Tata Sons turn around all the airlines under its fold, except maybe the Kochi-based Air India Express?




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Aviation industry shifts focus to digital

The pandemic has helped usher in automated touchpoints for tech-savvy flight passengers




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Domestic airline industry may face a rejig

The pandemic laid bare fault-lines within India’s airlines




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Sustainable aviation fuels could be a game-changer

But adopting it in Indian aviation could take time




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Thrust reversal in aircraft

It functions by directing the thrust produced by the plane’s jet engines forward, rather than backwards




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Will Akasa Air’s contra bet on Boeing 737 Max instead of Airbus pay off?

Rakesh Jhunjhunwala’s Akasa airline has gone against the tide, placing its bets on Boeing aircrafts; it now needs to carve out a niche for itself 




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5 things Indian airlines must do to break their way out of pandemic blues

Post pandemic, the airlines must revamp strategies and resort to long-term measures to recover from the crisis 




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Mission to Net Zero: Aviation’s focus on making sustainable connections 

Flying the cleanest, greenest, youngest fleet possible can be a way towards the goal 




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Reviving businesses will benefit from air cargo’s growth

India’s air cargo industry is well positioned to scale up further, thanks to a strong airport cargo infrastructure




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Zomato users can now schedule order 2 days in advance

Zomato’s order scheduling is available at more than 35,000 restaurants across 30 cities




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Google brings AI-powered Gmail writing tools and ‘Polish’ to more users

Google is expanding its generative AI-powered email drafting tools to more users with new and enhanced shortcuts on web and mobile




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Google ad change could affect millions of small businesses

Google is changing the way its Google Local Services ads work, which could affect millions of small businesses




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Elon Musk's xAI in talks to raise funding valuing it at $40 billion: Report

Earlier in October, OpenAI raised $6.6 billion in funding from investors which could value the company at $157 billion




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Google Maps adds AI features to help users explore and navigate the world around them

Google Maps is heading down a new road steered by artificial intelligence




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Chinese researchers develop AI model for military use on back of Meta's Llama

ChatBIT was fine-tuned and "optimised for dialogue and question-answering tasks in the military field", the paper said




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OpenAI CEO Sam Altman says next big AI model launch pushed due to compute challenges

Altman also said that the next update for DALL-E was still in the works with no release date yet




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Karnataka government plans to start 11 medical colleges under contentious PPP model

As of now, the State has 22 government medical colleges in 22 districts while 11 others have no government medical colleges; the PPP model however has been criticised by some experts




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Why did the Centre sanction a 50% hike in prices of commonly-used drugs?

According to the government the recent 50% hike in prices of eight drugs was sanctioned keeping in mind the larger public interest and to ensure continued availability of drugs




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For type 2 diabetes, focusing on when you eat – not what – can help control blood sugar

Time-restricted eating, also known as the 16:8 diet, became popular for weight loss around 2015. Studies have since shown it is also an effective way for people with type 2 diabetes to manage blood glucose




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OpenAI’s Whisper transcription tool used in hospitals invents things no one ever said, researchers claim

Whisper is a popular transcription tool powered by artificial intelligence, but it has a major flaw




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Roll back approval to import used medical devices, med-tech industry urges PM

The group said the move puts at risk patient safety and undermines the domestic med-tech sector. It said that refurbished machines are not subject to stringent quality checks applicable to new devices.




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Ayushman Bharat: All seniors above 70 can avail health coverage except those in Delhi, West Bengal

Senior citizens eligible for PM-JAY regardless of income; Ayushman Vaya Vandana card will help cut out-of-pocket health spends; on Ayurveda Day, PM launches initiatives to validate traditional herbal medicine, promote Indian medical systems




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Lifestyle changes a major cause for stroke, say doctors

Speaking at a public awareness meeting organised at GRH on the occasion of World Stroke Day on Tuesday, Dr. Murugan, attributed these negative factors to a sedentary lifestyle because of the youth’s job nature and location




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Air passenger with suspected mpox symptoms isolated at Tiruchi govt. hospital

When contacted, a senior hospital official told The Hindu that the patient’s blood sample has been sent for further testing




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Stop abuse of patent monopolies in rare diseases, say patient representatives and treatment activists 

They seek urgent intervention by government, courts, and lawmakers into the issue  




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'Sushant's death needs a CBI inquiry'

'This is not a fight just for Sushant, it is a fight against a system that suppresses genuine talent and forces them to take extreme steps.'




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EXCLUSIVE! Honey Irani: My Son Farhan Akhtar

'He was an extremely naughty child, always in trouble and creating trouble.''He wanted to fly a kite at night, and sometimes, bunk school.''When I insisted on sending him, we could get a call from school that he had fainted.'




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'My struggle was because I'm a woman'

'You are constantly trying to get things made. You keep meeting people, knocking on their door. And time goes by.'




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'I have no fear of failure because...'

'...when you hit rock bottom, you can't go any lower than that.'And I've been to rock bottom.''But that's what made me the actor I am today. I'm fearless.'




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'Fireworks between Sushmita and me'

'People started noticing me again. OTT is a good platform for serious actors. In the olden days, unless you are the heroine, actors would have screen deaths. But now, there are so many good roles for women.'




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A Must Watch Film About Sexual Awakening

'I went to a school in Baroda, where if the boys harassed us, the teachers pulled the girls aside and said, "Oh, your skirts are too short".' 'They made us feel ashamed of having any sexual feelings or having bodies that were growing up to be a young women.'