-Album Details- Title: Chocobo’s Mystery Dungeon EVERY BUDDY! Original Soundtrack Publisher: Square Enix Music Catalog Number: SQEX-10710 Release Date: April 24th, 2019 Ripped by: Razakin -Info- Khew!  Some classic FF tracks arranged again for a Chocobo-game, the 2019 remaster of Final Fantasy Fables: Chocobo’s Dungeon. Enjoy. Purchase Link(s) CDJapan

A review by Rob Cranley (9). A great flight sim that absorbed many, many hours of my youth

A review by ALLEN HALL (6). Excellently showcased what a computer could offer a gamer over a board game

A review by Medio DeCritici (165). A 2020 Review - Aliens Versus Predator (PC, 1999)

A review by SomeRandomHEFan (46). Getting closer

A review by SomeRandomHEFan (46). One of Humongous Entertainment's weaker attempts at conventional edutainment

A review by Medio DeCritici (165). A 2020 Review - Aliens vs. Predator (PC, 2010)

A review by Medio DeCritici (165). A 2020 Review - Alpha Protocol (PC, 2010)

A review by krisko6 (740). After 13 years, Half-Life has returned

A review by Medio DeCritici (165). What I Can Remember - 90s Arcade & The Simpsons (Arcade, 1991)

A review by piltdown_man (179399). A good story, well told

A review by piltdown_man (179399). A short but enjoyable bit of perversion

A review by SomeRandomHEFan (46). An excellent showcase of Humongous Entertainment's sense of humour. And I guess there's an acceptable edutainment game in there somewhere, too.

A review by raiden_is_dj (2). Real fun in this game

OK, let’s pick up our discussion where we left off last week, at feasibility.  You did it. You successfully convinced a room full of vice presidents and directors, or maybe even the CEO that they should take your fabulous product idea to the next level.  You’ve got marketing on board, excited to promote it and now it’s time for the work to begin.You are the lead scientist s; (read more)

Source: Suzy - Discipline: BioTech

“Even after weeks of staying home, my kids are just not interested in all the stuff we have. Let’s be honest. If a toy isn’t getting any action amid this distraction-free, stuck-at-home living, chances are it’s never getting touched again.” Liz Russell figures out what really engages and changes kids during the quarantine, and will […]

At least for some kids, yes, being flung from the stress of a super-structured, super-supervised existence is having a calming, life-expanding effect. I discuss this amazing phenom in this Big Think article, including six short essays by kids themselves, and also in this interview with Bored Panda,  the  pop culture site, where I note that […]

Parents, kids: Fear not the silica gel pack. Sure it says DO NOT EAT and THROW AWAY. But you should only follow one of those rules.    Instead, save the packs and use them a whole lot of ways: Place them on the car dashboard by the windshield to keep it from fogging up.   […]

Is the new normal a new normal for you?

The post Reel Review: What’s New with the Shimano Stella SW 2020? appeared first on Ocean Blue Fishing Adventures.

Although CEACAM1 (CC1) glycoprotein resides at the interface of immune liver injury and metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains elusive. We aimed to determine whether/how CEACAM1 signaling may affect hepatic ischemia-reperfusion injury (IRI) and OLT outcomes. In the mouse, donor liver CC1 null mutation augmented IRI-OLT (CC1-KO→WT) by enhancing ROS expression and HMGB1 translocation during cold storage, data supported by in vitro studies where hepatic flush from CC1-deficient livers enhanced macrophage activation in bone marrow–derived macrophage cultures. Although hepatic CC1 deficiency augmented cold stress–triggered ASK1/p-p38 upregulation, adjunctive ASK1 inhibition alleviated IRI and improved OLT survival by suppressing p-p38 upregulation, ROS induction, and HMGB1 translocation (CC1-KO→WT), whereas ASK1 silencing (siRNA) promoted cytoprotection in cold-stressed and damage-prone CC1-deficient hepatocyte cultures. Consistent with mouse data, CEACAM1 expression in 60 human donor liver biopsies correlated negatively with activation of the ASK1/p-p38 axis, whereas low CC1 levels associated with increased ROS and HMGB1 translocation, enhanced innate and adaptive immune responses, and inferior early OLT function. Notably, reduced donor liver CEACAM1 expression was identified as one of the independent predictors for early allograft dysfunction (EAD) in human OLT patients. Thus, as a checkpoint regulator of IR stress and sterile inflammation, CEACAM1 may be considered as a denominator of donor hepatic tissue quality, and a target for therapeutic modulation in OLT recipients.

BACKGROUND Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, and is now becoming a global threat. We aimed to delineate and compare the immunological features of severe and moderate COVID-19.METHODS In this retrospective study, the clinical and immunological characteristics of 21 patients (17 male and 4 female) with COVID-19 were analyzed. These patients were classified as severe (11 cases) and moderate (10 cases) according to the guidelines released by the National Health Commission of China.RESULTS The median age of severe and moderate cases was 61.0 and 52.0 years, respectively. Common clinical manifestations included fever, cough, and fatigue. Compared with moderate cases, severe cases more frequently had dyspnea, lymphopenia, and hypoalbuminemia, with higher levels of alanine aminotransferase, lactate dehydrogenase, C-reactive protein, ferritin, and D-dimer as well as markedly higher levels of IL-2R, IL-6, IL-10, and TNF-α. Absolute numbers of T lymphocytes, CD4+ T cells, and CD8+ T cells decreased in nearly all the patients, and were markedly lower in severe cases (294.0, 177.5, and 89.0 × 106/L, respectively) than moderate cases (640.5, 381.5, and 254.0 × 106/L, respectively). The expression of IFN-γ by CD4+ T cells tended to be lower in severe cases (14.1%) than in moderate cases (22.8%).CONCLUSION The SARS-CoV-2 infection may affect primarily T lymphocytes, particularly CD4+ and CD8+ T cells, resulting in a decrease in numbers as well as IFN-γ production by CD4+ T cells. These potential immunological markers may be of importance because of their correlation with disease severity in COVID-19.TRIAL REGISTRATION This is a retrospective observational study without a trial registration number.FUNDING This work is funded by grants from Tongji Hospital for the Pilot Scheme Project, and partly supported by the Chinese National Thirteenth Five Years Project in Science and Technology for Infectious Disease (2017ZX10202201).

Treating neuropathic pain is challenging and novel non–opioid-based medicines are needed. Using unbiased receptomics, transcriptomic analyses, immunofluorescence, and in situ hybridization, we found that the expression of the orphan GPCR Gpr160 and GPR160 increased in the rodent dorsal horn of the spinal cord following traumatic nerve injury. Genetic and immunopharmacological approaches demonstrated that GPR160 inhibition in the spinal cord prevented and reversed neuropathic pain in male and female rodents without altering normal pain response. GPR160 inhibition in the spinal cord attenuated sensory processing in the thalamus, a key relay in the sensory discriminative pathways of pain. We also identified cocaine- and amphetamine-regulated transcript peptide (CARTp) as a GPR160 ligand. Inhibiting endogenous CARTp signaling in spinal cord attenuated neuropathic pain, whereas exogenous intrathecal CARTp evoked painful hypersensitivity through GPR160-dependent ERK and cAMP response element–binding protein (CREB). Our findings de-orphanize GPR160, identify it as a determinant of neuropathic pain and potential therapeutic target, and provide insights into its signaling pathways. CARTp is involved in many diseases including depression and reward and addiction; de-orphanization of GPR160 is a major step forward understanding the role of CARTp signaling in health and disease.

Apple has been selling audio accessories since December 2016 when the original AirPods launched. We now have the ‌AirPods‌ 2 and the AirPods Pro, and Apple is planning to add to its lineup with new over-ear Apple-branded headphones.

Apple already sells over-ear headphones under its Beats brand, but as with the ‌AirPods‌, Apple is also working on headphones that will be Apple branded rather than Beats branded. These headphones are said to be aimed at the high-end market.

Design

The headphones will feature an all-new design, and while we don't know a lot about it, we do know some details shared by Bloomberg.

Apple is said to be working on two versions of the high-end over-ear headphones, including a premium version with leather-like fabrics and a fitness-focused model that uses lighter, breathable materials with small perforations for better airflow.

Prototypes of the headphones have been described as having a retro-like look with over-ear cups that swivel along with a headband connected with thin metal arms.

Apple is planning to attach the ear pads and the head padding to the headphone's frame magnetically, allowing users to swap different colors and variants in and out for customization purposes.

An icon representing the headphones was found in the code in a leaked version of iOS 14, but little detail can be gleaned from the imagery.

Rumored Features

According to Apple analyst Ming-Chi Kuo, Apple's over-ear headphones will feature Active Noise Cancellation, a high-end feature baked into the Beats Studio 3 headphones, Solo Pro headphones, and the ‌AirPods Pro‌.

Active Noise Cancellation is designed to cut down on ambient noise so you can focus on what you're listening to. If it mimics ANC on the ‌AirPods Pro‌, there will be a transparency mode that will enable noise cancelling features, but with an option to continue to hear what's going on around you.

Sound quality is expected to be better than the sound quality of the ‌AirPods‌.

Pricing

Apple could price the new headphones at around $350.

Launch Date

Current rumors indicate the headphones will launch at some point in 2020, though a specific date has not yet been nailed down. Mass production on the headphones is scheduled to begin in mid-2020, which perhaps suggests a fall 2020 launch.

There were rumors indicating that Apple initially planned to launch the headphones at some point in 2019, but that did not happen.

Over-Ear Headphones Rumor History

• Mass Production on Apple's High-End Headphones Rumored to Start in Mid-2020


• Apple to Unveil High-End Over-Ear Wireless Headphones With Magnetically Swappable Parts Later This Year


• Apple Reportedly Targeting WWDC for Over-Ear Headphones Launch, New 'AirPods X' Later in the Year


• Icon for Apple's Rumored Over-Ear Noise Canceling Headphones Discovered in Leaked iOS 14 Code


• Apple-Branded Over-Ear Headphones Said to Launch as Early as Second Half of 2019


• Apple's Upcoming Over-Ear Wireless Headphones to Target High-End Noise-Canceling Market


• KGI: Apple Developing High-End Over-Ear Headphones, Launching Late 2018 at the Earliest

Guide Feedback

Have a question about Apple's over-ear headphones, know of something we left out, or want to offer feedback? Send us an email here.
This article, "Apple's Work on High-End Over-Ear Headphones: Everything We Know" first appeared on MacRumors.com

Discuss this article in our forums

A new NFC specification announced this week by the NFC Froum will allow future NFC enabled devices to offer wireless charging capabilities, which means a smartphone could be used to charge a small accessory like headphones.


According to the NFC Forum, the Wireless Charging Specification (WLC) will allow smartphones or other NFC charging devices to wirelessly charge small, battery-powered consumer and IoT devices at a power transfer rate of up to one watt.

The 1W rating is much slower than the Qi-based standard used by iPhones and other smartphones. Qi-based wireless charging on the iPhone maxes out at 7.5W, but is even faster on some Android devices.

Charging over NFC would require new hardware, and it's not a feature that can be added to existing devices. The NFC Forum believes the WLC specification could be used to complement Qi-based wireless charging.

It works using a single antenna to manage communications and charging, which is convenient for low-power devices like smart watches, fitness trackers, and earbuds that already use NFC for connectivity because there's no need to build in Qi support.

"The NFC Forum's Wireless Charging Technical Specification allows for wireless charging of small battery-powered devices like those found in many of the estimated 36 billion IoT devices in use today," said Koichi Tagawa, chair, NFC Forum. "NFC wireless charging is truly transformative because it changes the way we design and interact with small, battery-powered devices as the elimination of plugs and cords enables the creation of smaller, hermetically-sealed devices."

Apple in 2015 joined the NFC Forum and participates in the approval of new NFC specifications and developments.

Rumors in 2019 suggested that Apple was working on bilateral wireless charging that would allow its iPhones to charge the AirPods and the Apple Watch, but the feature was ultimately nixed. At the time, Apple analyst Ming-Chi Kuo said that the two-way wireless charging feature Apple was exploring did not meet Apple's requirements.

Samsung has implemented bilateral wireless charging in its smartphones, but the Wireless PowerShare option does not use NFC and is powered by the Qi-based charging coils in the device. Samsung's smartphones can charge other smartphones or accessories like headphones that support Qi wireless chargers.
This article, "New NFC Specification Will Let Smartphones Charge Small Devices" first appeared on MacRumors.com

Discuss this article in our forums

Animal Crackers (trailer) is a 94-minute computer-animated children's movie. The brainchild of Scott Sava, it caught the early attention of furry fandom at least as far back as 2015. Concept animation showed a guy haphazardly munching on animal-shaped cookies that turned him into the animals. As time went on, Sava brought in financial backers, a co-director (Tony Bancroft, who'd worked on several Disney movies), and a co-writer (Dean Lorey). The finished product premiered at the Annecy Film Festival in 2017... and then vanished.

It turns out that Sava had made the mistake of not securing a distributor ahead of time. With very little bargaining power, it eventually got shown in China in 2018, and some other countries in 2019.

read more

A great many people only experience science fiction by what my mother and millions of others referred to as "monster movies". From Frankenstein to Aliens and beyond, the unknown and the unexplored are often our undoing. Bleak Horizons, edited by Tarl Hoch, is a wonderful collection of 15 stories that mix SF and Horror with various levels of anthropomorphic settings and characters. And, full disclosure, one of those stories is mine. Happily, the mix includes more than just blood thirsty monsters and end of the universe scenarios.

Overall my favorite stories in this anthology are Hardwire, Pentangle, and The Ouroboros Plate. My least favorites are 4/13/2060 and Not Like Us. Below is a short review of all the pieces. I think you should snag a copy, if only to read my favorites and have a taste for this genre. However, I also really enjoyed Carmen Miranda's Ghost Is Haunting Space Station 3 so you have every right to question my taste.

read more

Fortnite Battle Royale (or just Fortnite) is a “battle royale” shooter that has been around since 2017, and while its getting a bit long in the tooth, it’s still hanging around and still free to play. Last year, the game finally implemented skill-based matchmaking, which means for casual and new players, it’s never been easier to get into. In many ways, it is comparable to Nintendo properties such as Super Smash Bros. or Mario Kart, taking a more traditionally “hardcore” video game genre and making it more accessible with gimmicky gameplay, goofy items, cartoony visuals and massive amounts of RNG.

Of course, the game isn’t exactly furry in and of itself, but the game makes its money selling cosmetic upgrades to player’s in game characters, and quite a few of them feature either characters in animal costumes, or, more recently, straight up anthropomorphic animals. In the time-honored tradition of clickbait listicals, here is my ranking of those skins.

read more

The Voyages of Cinrak the Dapper is a collection of seven short stories written by A. J. Fitzwater centred around Cinrak, a lesbian, capybara pirate. It has a couple of strong elements as well as several weak points. I struggled with my thoughts as I read it and, in the end, I would say that, overall, I found it frustrating.

I will start this review briefly talking about politics. It might seem like an unusual starting point but the introduction makes clear that the book is political and it touches on several hot button issues.

Come for handsome, huggable Cinrak in a dapper three-piece, stay for her becoming a house-ship Mother to an enormous found family, the ethical polyamory, trans boy chinchilla, genderqueer rat mentor, fairy, and whale, drag queen mer, democratic monarchy, socialist pirates, and strong unionization.

What I do like about the way politics is handled in this book, is that it is not set up as a conflict between opposing ideologies; the book presents its favoured way of seeing the world and just leaves it as that. Even the religious character (and there is a fascinating take on religion inside) is played off sympathetically. However, by taking the stances it does, the book is also going to be, though it has no regrets about it, alienating for certain readers. If you can not tolerate a heavy emphasis on, and I quote, LGBTQIA characters, then this book is definitely not for you and you may as well stop here. On the other hand, if that’s what you crave, it may be exactly what you want and you should read further.

read more

Erowid Exp98591

Thinking of using TurboTax to file your tax returns? Think again. The Minnesota Department of Revenue advises against using Intuit software to file tax returns! It found unacceptable errors in Intuit tax software, including TurboTax, ProSeries, Lacerte, and Intuit online. Continue reading →

Have you ever noticed that the Internal Revenue Service's regulations often are illogical? Does anyone at the IRS think through its regulations? Continue reading →

Even though Corporate America has anointed Hillary Clinton as its next President, Senator Bernie Sanders' populist message is already in a week's time raising individual contributions totaling millions of dollars from hundreds of thousands of people! Continue reading →

The evidence is adding up that this election is a SHAM! Exit polls do not add up on the Democratic side and regularly predict better results for Bernie than the voting machines are telling us! The mainstream media won't even come close to touching this, and in fact they're even attacking Lee Camp for bringing it up. Don't miss this segment of Redacted Tonight! Continue reading →

Bernie Sanders and Jane Sanders are mere actors serving as pressure valves which release from time to time all excess heat emanating from failed policies, scandals, and the worsening economic conditions, so that a catastrophic systems’ collapse can be prevented. They are sheepdogs for Hillary Clinton, preventing progressives from supporting a third party progressive candidate and to herd them back into the corral of the Democratic Party. Continue reading →

"Well, reducing the election to personalities is kind of infantile at this point. The fact is, we live in a system that Sheldon Wolin calls inverted totalitarianism. It’s a system where corporate power has seized all of the levers of control. There is no way to vote against the interests of Goldman Sachs or ExxonMobil or Raytheon." Continue reading →

Bernie Sanders' voting record is not progressive. It has been reported on Facebook that Bernie has voted 98% of the time in agreement with Senate Democrats and 93% of the time in agreement with Hillary Clinton. And here is Bernie Sanders' illustrious "progressive" voting record...LOL. Show this to all his crazed cult followers who claim he is a progressive and has done so much for us...LOL. Continue reading →

В июле 2020 состоится релиз автобиографии гитарист GENESIS STEVE'a HACKETT'a, которая получила название "A Genesis In My Bed". Steve рассказывает в ней о своей жизни в детстве и юношестве, о времени в GENESIS и детально об отношении с остальными участниками команды, давай возможность узнать о том, каковы были отношения в одной из самых известных рок групп мира. #Steve_Hackett #SteveHackett #ProgressiveRock #Progressive_Rock #AvantgardeRock #Avantgarde_Rock

I recently had the pleasure of talking with Sven of the KidsLab podcast and the Evil Mad Scientist episode is now live! KidsLab is “a podcast for parents, educators and everybody passionate about #STEAM education.”

It’s weird to me to look at my blog and realize that I haven’t posted anything to it since the end of May, as so much has happened since then and I have spent so much time since then writing … Continue reading →

We were not really sure that the world needed another adaptation of Emma. There are already several, not bad if not spectacular, although none are really the definitive adaptation that fans of the novel hoped for; but all enjoyable in their way. One can nitpick at all of them, but we don’t find any of…

An updated Disaster Resilience Scorecard to help cities and local government agencies improve their preparedness and reduce risks from disasters was launched today at the Global Platform for Disaster Risk Reduction. Developed for the UN Office for Disaster Risk Reduction by AECOM, IBM with support from USAID and the European Commission, the Scorecard gives better access to information, knowledge resources, and tools to effectively reduce risks from the impacts of natural hazards and climate change.

Today, IBM announced that it achieved two major commitments four years ahead of schedule in its effort to help combat climate change.

The Joker 80th Anniversary 100-Page Super Spectacular #1 will feature an all-star creative team including James Tynion IV, Dan Mora, Tom Taylor, and many more

The post PREVIEW: The origin of Punchline is revealed in the JOKER 80TH ANNIVERSARY SPECIAL appeared first on The Beat.