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Conjugating biomaterials with photosensitizers: advances and perspectives for photodynamic antimicrobial chemotherapy

Photochem. Photobiol. Sci., 2020, 19,445-461
DOI: 10.1039/C9PP00398C, Paper
Nidia Maldonado-Carmona, Tan-Sothea Ouk, Mário J. F. Calvete, Mariette M. Pereira, Nicolas Villandier, Stephanie Leroy-Lhez
In this review we present the most recent examples of biomaterials, for the conjugation of photosensitizers for photodynamic antimicrobial chemotherapy.
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Multifunctional cubic liquid crystalline nanoparticles for chemo- and photodynamic synergistic cancer therapy

Photochem. Photobiol. Sci., 2020, Advance Article
DOI: 10.1039/C9PP00449A, Paper
Sébastien Jenni, Giacomo Picci, Marco Fornasier, Marianna Mamusa, Judith Schmidt, Yeshayahu Talmon, Angélique Sour, Valérie Heitz, Sergio Murgia, Claudia Caltagirone
Multifunctional lipidic cubic liquid crystalline nanoparticles for potential cancer therapy were engineered by conjugating a porphyrin-based photosensitizer to the block copolymer Pluronic F108 and loading them with the antineoplastic drug Docetaxel.
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Palladium porphyrin complexes for photodynamic cancer therapy: effect of porphyrin units and metal

Photochem. Photobiol. Sci., 2020, Advance Article
DOI: 10.1039/C9PP00363K, Paper
Jingran Deng, Haolan Li, Mengqian Yang, Fengshou Wu
The ROS generation ability and photocytotoxicity of the synthesized porphyrin compounds were enhanced with the number of porphyrin units in the photosensitizers.
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In vitro photodynamic treatment of cancer cells induced by aza-BODIPYs

Photochem. Photobiol. Sci., 2020, Advance Article
DOI: 10.1039/D0PP00026D, Paper
Miryam Chiara Malacarne, Stefano Banfi, Enrico Caruso
Two new aza-BODIPY photosensitizers featuring an iodine atom on each pyrrolic unit of their structure, were synthesized in fairly good yields and tested in vitro on two human cancer cell lines to assess their photodynamic efficacy.
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Turn-on mode fluorescent diarylethenes: Effect of electron-donating and electron-withdrawing substituents on photoswitching performance

Photochem. Photobiol. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0PP00064G, Paper
Ryota Iwai, Masakazu Morimoto, Masahiro Irie
Diarylethene derivatives having benzothiophene S,S-dioxide groups undergo turn-on mode fluorescence photoswitching. For the practical application to super-resolution fluorescence microscopy, the photoswitchable fluorescent molecules are desired to be resistant against photodegradation....
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Initial Management of Acute Pancreatitis

This JAMA Clinical Guidelines Synopsis summarizes the American Gastroenterological Association Institute’s 2018 guideline on initial management of acute pancreatitis.




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My Friend Claims Her Second Round of Cancer

As my Italian father would say, since the house is burning      let us warm ourselves, and so




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Full Circle: How Medicine Enabled Avoidance and Acceptance

In this narrative medicine essay, a psychiatrist used her residency to avoid grieving the loss of her brother to suicide but through participation in a grief support group during training she began to thaw enough to remember her brother, watch videos of ephemeral moments like celebrating his fourth birthday, an act that allowed her to see him and her family again.




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An efficient strategy for circulating tumor cell detection: surface-enhanced Raman spectroscopy

J. Mater. Chem. B, 2020, 8,3316-3326
DOI: 10.1039/C9TB02327E, Review Article
Jie Lin, Jianping Zheng, Aiguo Wu
Circulating tumor cells (CTCs) are circulating cancer cells that shed from tumor tissue into blood vessels and circulate in the blood to invade other organs, which results in fatal metastases. Surface-enhanced Raman scattering (SERS) has great potentials in CTCs detection.
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Recent advances of tissue-interfaced chemical biosensors

J. Mater. Chem. B, 2020, 8,3371-3381
DOI: 10.1039/C9TB02476J, Review Article
Chuanrui Chen, Yue Guo, Peining Chen, Huisheng Peng
This review discusses recent advances of tissue interfaced chemical biosensors, highlights current challenges and gives an outlook on future possibilities.
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Advances in functional nucleic acid based paper sensors

J. Mater. Chem. B, 2020, 8,3213-3230
DOI: 10.1039/C9TB02584G, Review Article
Rudi Liu, Erin M. McConnell, Jiuxing Li, Yingfu Li
This article provides an extensive review of paper-based sensors that utilize functional nucleic acids, particularly DNA aptamers and DNAzymes, as recognition elements.
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Enhanced biosensing strategies using electrogenerated chemiluminescence: recent progress and future prospects

J. Mater. Chem. B, 2020, 8,3192-3212
DOI: 10.1039/C9TB02578B, Review Article
Rashaad A. Husain, Snigdha Roy Barman, Subhodeep Chatterjee, Imran Khan, Zong-Hong Lin
An overview of enhancement strategies for highly sensitive ECL-based sensing of bioanalytes enabling early detection of cancer.
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Stable Anchoring of Bacteria-based Protein Nanoparticles for Surface Enhanced Cell Guidance

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00702A, Paper
Open Access
Imma Ratera, Marc Martínez-Miguel, Adriana Kyvik, Lena Montaña, Albert Martínez-Moreno, Olivia Cano-Garrido, Elena Garcia-Fruitos, Esther Vazquez, Nora Ventosa, Judith Guasch, Jaume Veciana, Antonio Villaverde
In tissue engineering, biological, physical, and chemical inputs have to be combined to properly mimic cellular environments and successfully build artificial tissues, which can be designed to fulfil different biomedical...
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Thin platelet-like COF nanocomposites for blood brain barrier transport and inhibition of brain metastasis from renal cancer

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00724B, Paper
Guiyang Zhang, Bo Jiang, Chunyong Wu, Yanfeng Liu, Yidan He, Xin Huang, Wei Chen, Kai Xi, Hongqian Guo, Xiaozhi Zhao, Xudong Jia
A drug-loaded polymer–COF nanocomposite has been developed to cross the blood brain barrier and treat brain metastasis from renal cancer.
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Seedless Synthetic Branched Gold Nanoshell for Chemo-thermal Antitumor Therapy

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00891E, Paper
Lei Li, Yihan Fu, Zichuang Xu, Xuwu Zhang, Zining Hao, Yaqian He, Wenbin Gao, Dawei Gao
Gold nanomaterials (GNMs) were used in photothermal therapy due to their superior optical properties and excellent biocompatibility. However, the complex preparation process of seed-mediated growth limits further clinical applications of...
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Recent advances of nanomedicines for liver cancer therapy

J. Mater. Chem. B, 2020, 8,3747-3771
DOI: 10.1039/C9TB02871D, Review Article
Xiaoqin Chi, Kun Liu, Xiangjie Luo, Zhenyu Yin, Hongyu Lin, Jinhao Gao
This review highlights recent advancements in nanomedicines for liver cancer therapy.
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Alendronate/folic acid-decorated polymeric nanoparticles for hierarchically targetable chemotherapy against bone metastatic breast cancer

J. Mater. Chem. B, 2020, 8,3789-3800
DOI: 10.1039/D0TB00046A, Paper
Shih-Hong Chen, Te-I Liu, Cheng-Lin Chuang, Hsin-Hung Chen, Wen-Hsuan Chiang, Hsin-Cheng Chiu
Through hierarchically targeting bone matrix and tumor cells, PTX-carrying ALN/FA-nanoparticles substantially accumulate in bone metastases and improve mice survival rate.
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Tumor-mediated shape-transformable nanogels with pH/redox/enzymatic-sensitivity for anticancer therapy

J. Mater. Chem. B, 2020, 8,3801-3813
DOI: 10.1039/D0TB00143K, Paper
Dong Zhou, Sainan Liu, Yongjun Hu, Shiwei Yang, Bing Zhao, Kaikai Zheng, Yuhong Zhang, Peixin He, Guoyan Mo, Yulin Li
Tumor-mediated shape-cleavable nanogels can release drug-carrying ultrasmall nanovesicles through tumor tissue depth, which together with their pH/redox/enzymatic-multistimulative drug release smartness results in a synergistic antitumor efficacy.
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Fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy

J. Mater. Chem. B, 2020, 8,3772-3788
DOI: 10.1039/D0TB00262C, Review Article
Yu Huang, Feng Qiu, Rongjun Chen, Deyue Yan, Xinyuan Zhu
In this Review, recent advances in fluorescence resonance energy transfer-based drug delivery systems for enhanced photodynamic therapy are described, and the current challenges and perspectives in this emerging field are also discussed.
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Human serum albumin-based doxorubicin prodrug nanoparticles with tumor pH-responsive aggregation-enhanced retention and reduced cardiotoxicity

J. Mater. Chem. B, 2020, 8,3939-3948
DOI: 10.1039/D0TB00327A, Paper
Boya Zhang, Shiyu Wan, Xinyu Peng, Mingying Zhao, Sai Li, Yuji Pu, Bin He
A nano-assembly of pH-sensitive doxorubicin prodrug and human serum albumin shows tumor pH-responsive aggregation, enhanced tumor retention and reduced cytotoxicity.
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Boron-based nanosheets for combined cancer photothermal and photodynamic therapy

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00070A, Paper
Yong Kang, Xiaoyuan Ji, Zhengjun Li, Zhiguo Su, Songping Zhang
Tumor phototherapy is of great significance for the expansion and advancement of cancer treatment methods.
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Nanoscale dual-enzyme cascade metal–organic frameworks through biomimetic mineralization as ROS generators for synergistic cancer therapy

J. Mater. Chem. B, 2020, Advance Article
DOI: 10.1039/D0TB00357C, Paper
Shuiling Jin, Lanling Weng, Zhi Li, Zhenzhen Yang, Lili Zhu, Jianxiang Shi, Wenxue Tang, Wang Ma, Hong Zong, Wei Jiang
Chemodynamic therapy (CDT) has been critically challenged by insufficient H2O2 in cancer tissues and inefficient reactive oxygen species (ROS) production.
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Coaxial mussel-inspired biofibers: Making of a robust and efficacious depot for cancer drug delivery

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00052C, Paper
Javad Foroughi, Sepehr Talebian , In Kyoung Shim, Kara Vine, Song Cheol Kim, Geoffrey M Spinks
Biopolymer-based hydrogels have emerged as promising platforms for drug delivery systems (DDSs) due to their inherent biocompatibility, tunable physical properties and controllable degradability. Yet, drug release in majority of these...
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The Circadian Clock Gene PER2 Enhances Chemotherapeutic Efficacy in Nasopharyngeal Carcinoma When Combined with a Targeted Nanosystem

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00595A, Paper
Li Hou, Hailiang Li, Haiyan Wang, Dede Ma, Jing Liu, liqiong Ma, Zhihua Wang, Zhihua Yang, Faxuan Wang, Hechun Xia
Treatment failure occurs in more than 40% of advanced nasopharyngeal carcinoma (NPC) patients including local recurrence and distant metastasis due to chemoradioresistance. Circadian clock genes were identified as regulating cancer...
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High-performance non-enzymatic glucose detection: using conductive Ni-MOF as an electrocatalyst

J. Mater. Chem. B, 2020, Accepted Manuscript
DOI: 10.1039/D0TB00131G, Communication
Yanxia Qiao, Qian Liu, Siyu Lu, Guang Chen, Shuyan Gao, Wenbo Lu, Xuping Sun
Conductive metal−organic frameworks (MOFs) are studied extensively in applications like water electrolysis, gas storage, and supercapacitors due to their high conductivity and large pore volume, etc. In this communication, we...
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Media analysis techniques / Arthur Asa Berger, San Francisco State University

Berger, Arthur Asa, 1933-




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Financial journalism through financial crises : the reporting of three boom and bust periods / Sophie Elizabeth Knowles

Knowles, Sophie Elizabeth, author




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Advancing the story : journalism in a multimedia world / Debora Halpern Wenger, University of Mississippi, Deborah Potter, Newslab

Wenger, Debora Halpern




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Advancing the story : quality journalism in a digital world / Debora Halpern Wenger (University of Mississippi), Deborah Potter (NewsLab (Founder))

Wenger, Debora Halpern, author




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Essential psychopharmacology : the prescriber's guide / Stephen M. Stahl ; editorial assistant, Meghan M. Grady ; with illustrations by Nancy Muntner

Stahl, S. M




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Enhancement in drug delivery / edited by Elka Touitou, Brian W. Barry




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Chemistry, pharmacy and revolution in France, 1777-1809 / Jonathan Simon

Simon, Jonathan, 1964-




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Medical pharmacology at a glance / Michael J. Neal

Neal, M. J




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Dapsone exposure and Australian Vietnam service : mortality and cancer incidence / [E.J Wilson, K.W Horsley, R. van der Hoek]




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Medical pharmacology at a glance / Michael J. Neal

Neal, M. J




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Molecular targets and therapeutic uses of spices : modern uses for ancient medicine / Bharat B. Aggarwal, Ajaikumar B. Kunnumakkara [editors]




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A short history of the drug receptor concept / Cay-Rüdiger Prüll, Andreas-Holger Maehle, Robert Francis Halliwell

Prüll, Cay-Rüdiger




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An introduction to pharmacovigilance / Patrick Waller

Waller, Patrick




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Stockley's drug interactions : a source book of interactions, their mechanisms, clinical importance and management




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Inorganic drugs in deficiency and disease / edited by Helmut Sigel ; with the assistance of Astrid Sigel




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Frequently prescribed medications : drugs you need to know / [edited by] Michael A. Mancano and Jason C. Gallagher




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Drugs and behavior : an introduction to behavioral pharmacology / William A. McKim, Stephanie D. Hancock

McKim, William A., 1945-




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Antibiotics and antibiotic resistance / edited by Lynn L. Silver, LL Silver Consulting, LLC, Karen Bush, Indiana University




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Statistical methods for immunogenicity assessment / Harry Yang, Jianchun Zhang, Binbing Yu, Wei Zhao, MedImmune, LLC, Gaithersburg, Maryland, USA

Yang, Harry, author




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Frequently prescribed medications : drugs you need to know / [edited by] Michael A. Mancano, PharmD, Jason C. Gallagher, PharmD




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Acceptance / Jeff VanderMeer

VanderMeer, Jeff, author




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The English assassin : a romance of entropy / Michael Moorcock ; illustrated by Richard Glyn Jones

Moorcock, Michael, 1939-




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The entropy tango : a comic romance / Michael Moorcock ; pictures by Romain Slocombe ; lyrics by Michael Moorcock

Moorcock, Michael, 1939- author




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Throy / Jack Vance

Vance, Jack, 1916-2013, author




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Fantasms and magics : a science fantasy adventure / Jack Vance

Vance, Jack, 1916-2013, author