Hear about travel to Patagonia as the Amateur Traveler talks to Jackie Nourse about this region of southern Argentina.

Hear about travel to Israel and Palestine, and particularly the world heritage sites of that region, as the Amateur Traveler talks to Gary Arndt from everything-everywhere.com about his recent visit.
Gary just finished up a trip to Israel and Palestine.

Hear about the United States UNESCO World Heritage Sites as the Amateur Traveler talks to Gary Arndt from Everything-Everywhere.com and The Global Travel Conspiracy podcast about these best of the best sites.

Hear about travel to Chicago, Illinois as the Amateur Traveler talks to Francesca Mazurkiewicz about her hometown of Chicago.

Hear about travel to Madagascar as the Amateur Traveler talks to Corinne Vale from reflectionsenroute.com about her travel to this island nation off southern Africa.

Hear about travel to Patagonia in Chile as the Amateur Traveler talks to Talek Nantes about her recent trip to the bottom of South America.

Hear about travel to Central Europe (Prague, Krakow, Budapest) as the Amateur Traveler talks to 4 people who joined me on this year's Amateur Traveler trip: Darrell, Derrick, Loraine and Holly.

Hear about travel to Nagoya, Japan as the Amateur Traveler talks to Lena Yamaguchi from nagoyafoodie.com about her adopted home.

As long as we have garbage, we'll never run out of oil, thanks to a technology called thermal depolymerization process (TDP).

If you’ve been holding on to the presumption that gun confiscation will never take place in the United States, it’s time for you to wake up. Gun confiscation is already here, and it’s not slowing down anytime soon. As a result of the passage of red flag laws, 412 guns have been confiscated in Broward…

The post Op-Ed: The Case Against Red Flag Laws appeared first on The Western Journal.

A 5-year-old Utah boy shocked family and law enforcement when he grabbed the keys to his parents’ car and drove himself through the neighborhood and onto a freeway. Utah Highway Patrol Trooper Rick Morgan spotted the vehicle swerving dangerously on the freeway and initiated a stop, fully expecting to find a driver under the influence…

The post Cop Gets Shocking Surprise When He Finds Age 5 Boy Behind Wheel of Car Who Had Plans To Go Buy Lamborghini appeared first on The Western Journal.

Between having had more than enough of the not-so-great indoors and realizing that the grocery store might not always have meat, Americans are increasingly looking to feed themselves by hunting. “People are thinking about where they get their food and how they get their food,” Land Tawney, president of the advocacy group Backcountry Hunters and…

The post Facing Concerns of Meat Shortages, More Americans Turn to Hunting appeared first on The Western Journal.

A new year brings another run at my annual predictions: For 17 years now, I’ve taken a few hours to imagine what might happen over the course of the coming twelve months. And my goodness did I swing for the fences last year — and I pretty much whiffed. Batting .300 is great in the majors, but it … Continue reading "Predictions 2020: Facebook Caves, Google Zags, Netflix Sells Out, and Data Policy Gets Sexy"

If you’ve read Shoshana Zuboff’s Surveillance Capitalism, you likely agree that the most important asset for a data-driven advertising platform is consumer engagement. That engagement throws off data, that data drives prediction models, those models inform algorithms, those algorithms drive advertising engines, and those engines drive revenue, which drives profit. And profit, of course, drives … Continue reading "Zoom Is YouTube, Instagram, and WhatsApp – All in Two Months."

The Defense Department's Inspector General has opened an investigation into whether U.S. troops were discouraged from reporting the rape and sexual abuse of children by their Afghan allies.

Western powers are in a bind, analysts say, as ISIS is likely to continue pursuing attacks abroad in retaliation to the loss of territory in Iraq and Syria.

TL;DR: Give a meaningful gift during these difficult times with a Tribute Video Montage for $64.99, a 34% saving as of May 9.

A Zoom happy hour only goes so far.

If you're looking for a way to celebrate and send affection to your loved ones, regardless of the reason, check out Tribute Video Montage as an alternative to those wonky (and sometimes awkward) video calls. 

Sending a Tribute might just be one of the best morale-boosting presents you can send during these trying times. It's a way for friends and family to share their love and appreciation for someone they want to celebrate, whether for a major milestone, like a 50th anniversary or 30th birthday or just because. The platform is super easy to use and breaks a 10-hour process down to just 10 minutes. Read more...

TL;DR: Skate just about anywhere you please with the lightweight Ubran E-Skateboard for $124.95, a 75% savings as of May 9.

When in doubt, skate it out. But not everyone is cut from the same cloth as Tony Hawk, and it won't make sense to try and skateboard if you know you're just going to fall flat on your butt. 

Luckily, the universe is on the side of frustrated skaters everywhere with the emergence of devices like the Urban E-Skateboard. Not only does it take all the guesswork out of skating, but it's eco-friendly, too. And for a limited time, you can get it on sale for $124.95.

At only 7 pounds and 17 inches, the Urban E-Skateboard makes it easy for you to transport it anywhere you go. When you're not, you know, skating, you can easily stuff it in your bag for fuss-free storage. It connects with a wireless remote that allows you to control your speed and choose between three speed modes, accommodating just about every rider's experience level. Read more...

The internet is a scary enough place as it is, and now with the added misinformation and panic surrounding the coronavirus pandemic, it's even scarier. Thanks to the United Nations and dozens of artists, however, the internet just got a little more beautiful. 

In late March, the UN put a call out to artists to help combat the spread of COVID-19. They sought creatives to create content around six areas of WHO and UN priority actions: personal hygiene, social distancing, knowing the symptoms, spreading kindness, myth-busting, and doing more/donating. Tens of thousands of artists answered the call in two weeks, and now the COVID-19 Response Creative Content Hub is available for browsing.  Read more...

If you’re already a software product manager (PM), you have a head start on becoming a PM for artificial intelligence (AI) or machine learning (ML). You already know the game and how it is played: you’re the coordinator who ties everything together, from the developers and designers to the executives. You’re responsible for the design, […]

The Gothamist is reporting the sad news that Gem Spa, the iconic NY corner store that has been a fixture at St. Marks Place and Second Avenue for around 100 years is being forced to shutter its doors and windows for the last time. The Spa has been struggling to keep up with increasing rent prices and COVID-19 has apparently proven to be the final nail in its coffin.

"It’s where Robert Mapplethorpe bought Patti Smith an egg cream on the day they met. It’s on the back cover of the New York Dolls’ 1973 debut (and where, according to lore, Johnny Thunders and others went for post-heroin sugar fixes between sets at CBGB). Before that, it was where Abbie Hoffman gathered Yippies to rain money on the New York Stock Exchange. It’s where Allen Ginsberg, Ted Berrigan, and other neighborhood poets went to pick up the Sunday New York Times on Saturday nights (and which was inevitably commemorated in their poems)."

Read the rest.

Image: Alex Lozupone, CC BY-SA 4.0 Read the rest

A transit centre in north Edmonton was evacuated for about two hours Saturday morning due to a suspicious package.

11 Million Struggling to Pay Mortgage Payments and Rent

One day, a teacher entered her classroom and placed a glass jar on the table. She put two large rocks into the jar until no more could fit. She asked the class if the jar was full and they all said, “Yes.” She responded, “Really?” She pulled out a pile of small pebbles, added them […]

The post How to Become Great by Managing Procrastination appeared first on Dumb Little Man.

Technology has come a long way, and cyber protection is the most crucial factor in advancing the future of digital defense. Interestingly enough, cybersecurity was not always an issue in backup and storage; but as technology advances, so do the methods of hackers. Saying this, let’s take a walk down memory lane. The 1900s: Where […]

The post How Backup And Storage Led To Cybercrime appeared first on Dumb Little Man.

I was excited to finally get the word that an article I wrote sharing my love for my hometown – San Jose, California – is out in Delta Sky Magazine this month! Time Out: San José (Are you flying Delta this month? If so, pick up a copy for me! I’d love to see it […]

The article EIT Elsewhere | “Time Out: San José” in Delta Sky Magazine originated at EverInTransit.com

For those long, long travel days when you can't be bothered to change your socks ... you need the odorless, antibacterial MP Magic Socks.

The post Are These “Magic” Socks the Best Odorless Socks for Travelers? appeared first on Vagabondish.

The DML News App offers the best in news reporting.

The post VIDEO: AG Barr criticizes Mueller’s handling of Steele dossier appeared first on Dennis Michael Lynch.

The DML News App offers the best in news reporting.

The post REPORT: Recent documents reveal number of Secret Service agents with COVID-19 appeared first on Dennis Michael Lynch.

While infection rates remain steady across the region, the Simcoe Muskoka District Health Unit is reporting more than half of all 360 cases have now recovered.

Landlords who are missing thousands of dollars in rent or who find their properties damaged or strewn with garbage are concerned some tenants are taking advantage of the eviction ban put in place during the pandemic.

The following article, BREAKING: CBS News Allegedly Staged Fake COVID19 Testing In MI…Makes Dem Gov Whitmer Look Like She’s Doing More To Help Citizens Than Fed Government [VIDEO], was first published on 100PercentFedUp.com.

Project Veritas founder James O’Keefe has done it again. He’s uncovered yet another deceitful piece of coverage on the Wuhan coronavirus pandemic in America by CBS News. O’Keefe begins his interview with a man whose identity is being hidden, “You’re telling me—you’re 100% certain, that CBS News, CBS News Corporation national—staged a fake event. They […]

Continue reading: BREAKING: CBS News Allegedly Staged Fake COVID19 Testing In MI…Makes Dem Gov Whitmer Look Like She’s Doing More To Help Citizens Than Fed Government [VIDEO] ...

The following article, BREAKING: Sen Marsha Blackburn Introduces Stop COVID Act…Allowing US Citizens To Sue Communist China For Damage They’ve Inflicted On Our Nation, was first published on 100PercentFedUp.com.

Yesterday, Senator Marsha Blackburn (R-TN), along with Senator Martha McSally (R-AZ) introduced the Stop COVID Act, giving Americans the ability to sue Communist China for the damage they’ve inflicted on our nation. Senator Blackburn appeared on Fox News with host Judge Jeanine where she explained the act to Jeanine Pirro. Blackburn told the Fox News […]

Continue reading: BREAKING: Sen Marsha Blackburn Introduces Stop COVID Act…Allowing US Citizens To Sue Communist China For Damage They’ve Inflicted On Our Nation ...

The following article, Legal Immigrant in Michigan Sends a Message to MI Gov Whitmer and Media Criticizing Freedom-Loving Protesters, was first published on 100PercentFedUp.com.

The media and even some governors are trying to paint the Americans who are protesting to open businesses up as racists and even Nazis. The Governor of Michigan recently made a derogatory statement about the protesters implying they are racists. Painting a negative picture of the people who want their freedom and businesses demonizes our […]

Continue reading: Legal Immigrant in Michigan Sends a Message to MI Gov Whitmer and Media Criticizing Freedom-Loving Protesters ...

The following article, Breaking: Texas AG Calls for Immediate Release of Salon Owner Jailed for Opening…Texas Lt Gov Offers to Pay Salon Owner’s $7k Fine, was first published on 100PercentFedUp.com.

Salon A La Mode owner Shelley Luther opened her salon in defiance of the lockdown order for salons to stay closed during the coronavirus crisis. She boldly ripped. up the citation she was given by the police and refused to shut her doors. Luther hired a lawyer and went to court where an activist judge […]

Continue reading: Breaking: Texas AG Calls for Immediate Release of Salon Owner Jailed for Opening…Texas Lt Gov Offers to Pay Salon Owner’s $7k Fine ...

The following article, Chicago Inmate Switches Identities While Wearing Mask…Is Released from Jail, was first published on 100PercentFedUp.com.

A Cook County, Chicago inmate, was able to switch identities with another inmate allowing the wrong inmate to be released. How did they carry that off without anyone catching them? The inmate was wearing a mask when he was released, so it wasn’t as easy to identify him. Last Saturday, Quintin Henderson (pictured below), 28, […]

Continue reading: Chicago Inmate Switches Identities While Wearing Mask…Is Released from Jail ...

The following article, MSNBC’s Brian Williams Chuckles With Dem Strategist as He Gloats, Mocks Trump About Tragic Downturn in Economy: “They were going to lose before this hit. They’re just going to lose worse now”, was first published on 100PercentFedUp.com.

James Carville spoke out before the coronavirus crisis to say that there is no way  Joe Biden has a chance at beating President Trump in the 2020 election. Well, He’s singing a different tune now at the expense of Americans suffering through this horrible pandemic and economic crisis. James Carvill is a Democratic strategist who […]

Continue reading: MSNBC’s Brian Williams Chuckles With Dem Strategist as He Gloats, Mocks Trump About Tragic Downturn in Economy: “They were going to lose before this hit. They’re just going to lose worse now” ...

The following article, BREAKING: Michigan’s Radical Governor Extends Lockdown AGAIN…Only One Day After Church Leaders and MI Lawmakers File Suit Against Her, was first published on 100PercentFedUp.com.

Michigan was the first state to see protests against draconian lockdown measures by an overreaching governor. On April 15, the Michigan Conservative Coalition organized an in-vehicle protest in Lansing, MI that drew an estimated 15,000 vehicles. Since that time, several protests by Michigan workers who are being devastated by the one-size-fits-all shut down of the […]

Continue reading: BREAKING: Michigan’s Radical Governor Extends Lockdown AGAIN…Only One Day After Church Leaders and MI Lawmakers File Suit Against Her ...

The following article, Woman Shoots Three Teenage McDonald’s Workers For Telling Her She Couldn’t Eat In Dining Room Over COVID19 Restrictions, was first published on 100PercentFedUp.com.

An angry Oklahoma woman shot at a group of teenagers working at a local McDonald’s after they explained to her that the dining room was closed due to coronavirus restrictions. 32-year-old Gloricia Woody was arrested by the Oklahoma City Police and charged with the shooting. From the Oklahoma City Police -Last night, officers were called […]

Continue reading: Woman Shoots Three Teenage McDonald’s Workers For Telling Her She Couldn’t Eat In Dining Room Over COVID19 Restrictions ...

The following article, Greg Gutfeld Levels Ilhan Omar With Epic Response To Her Claim That “White Privilege” Is Reason Charges Were Dropped Against General Flynn, was first published on 100PercentFedUp.com.

Yesterday, after 3 1/2 years of having his character and integrity called into question, President Trump's first NSA, General Michael Flynn was finally...

Continue reading: Greg Gutfeld Levels Ilhan Omar With Epic Response To Her Claim That “White Privilege” Is Reason Charges Were Dropped Against General Flynn ...

In Lakeshore, it may be a little while longer before a retail cannabis store opens.

At a time when store front vacancies are growing thanks to COVID-19, a new retail cannabis store in Pillette Village is hoping to open soon.

Prostate cancer (PCa) cells heavily rely on an active androgen receptor (AR) pathway for their survival. Enzalutamide (MDV3100) is a second-generation antiandrogenic drug that was approved by the Food and Drug Administration in 2012 to treat patients with castration-resistant prostate cancer (CRPC). However, emergence of resistance against this drug is inevitable, and it has been a major challenge to develop interventions that help manage enzalutamide-resistant CRPC. Erythropoietin-producing human hepatocellular (Eph) receptors are targeted by ephrin protein ligands and have a broad range of functions. Increasing evidence indicates that this signaling pathway plays an important role in tumorigenesis. Overexpression of EPH receptor B4 (EPHB4) has been observed in multiple types of cancer, being closely associated with proliferation, invasion, and metastasis of tumors. Here, using RNA-Seq analyses of clinical and preclinical samples, along with several biochemical and molecular methods, we report that enzalutamide-resistant PCa requires an active EPHB4 pathway that supports drug resistance of this tumor type. Using a small kinase inhibitor and RNAi-based gene silencing to disrupt EPHB4 activity, we found that these disruptions re-sensitize enzalutamide-resistant PCa to the drug both in vitro and in vivo. Mechanistically, we found that EPHB4 stimulates the AR by inducing proto-oncogene c-Myc (c-Myc) expression. Taken together, these results provide critical insight into the mechanism of enzalutamide resistance in PCa, potentially offering a therapeutic avenue for enhancing the efficacy of enzalutamide to better manage this common malignancy.

26 February 2020

Over the past two decades, China has increased its presence in North Africa in terms of trade and investment. This paper looks at China’s policy within the context of its Africa and Middle East policies to better understand its approach to Morocco and Tunisia.

Research Event

Event participants

Osamah Al Rawhani, Deputy Director, Sana’a Center for Strategic Studies
Moderator: Nadim Houry, Executive Director, Arab Reform Initiative

Research Event

Event participants

Fadi El-Jardali, Professor of Health Policy and Systems, American University of Beirut
Moderator: Nadim Houry, Executive Director, Arab Reform Initiative

Chatham House named think-tank of the year at Prospect magazine’s annual think-tank awards.

Corporate Members Event Nominees Breakfast Briefing Partners and Major Corporates

Event participants

Robert Yates, Head, Centre on Global Health Security, Chatham House
Chair: Professor David R Harper, Senior Consulting Fellow, Centre on Global Health Security, Chatham House; Managing Director, Harper Public Health Consulting Limited