ba Your Pet Loss StoriesWaggy Boy Baron By www.pet-loss-matters.com Published On :: Mon, 24 Jun 2013 07:57:04 -0400 I had to say goodbye to my happy waggy boy Baron May 1st. Before me he had a hard life, he'd been a research dog, heavily hw infested, resulting in CHF, Full Article
ba Your Pet Tributes'Saffron Badaffron Woof Woof Prescott' By www.pet-loss-matters.com Published On :: Sun, 21 Jul 2013 11:41:20 -0400 Saffron, you were the most perfect being that I could ever envision. You were my sunshine. I miss you beyond words, my little Spoopa Roopa. How can we Full Article
ba What's the word on word balloons? By www.sheldoncomics.com Published On :: Thu, 30 Apr 2020 09:41:52 -0700 EPISODE SUMMARY This week, Dave and Brad drill down deep on a crucial topic in comics — word balloons! Then Dave talks about his recent Kickstarter, and why it didn't fund. Plus... how will the global pandemic affect comic ships, distributors, the USPS and ... webcomics? EPISODE NOTES Today's show is brought to you by Wacom — makers of the incredible Wacom One! This week, Dave and Brad drill down deep on a crucial topic in comics — word balloons! Then Dave talks Full Article Post
ba Creating a simple link registry - Matthias Noback By matthiasnoback.nl Published On :: Tue, 28 Apr 2020 07:45:00 +0000 The problem: if you publish any document as PDF, in print, etc. and the text contains URLs, there is a chance that one day those URLs won't work anymore. There's nothing to do about that, it happens. Luckily, this is a solved problem. The solution is to link to a stable and trustworthy website, that is, one that you maintain and host (of course, you're trustworthy!). Then in the document you link to that website, and the website redirects visitors to the actual location. An example: my book contains a link to https://enjoy.gitstore.app/repositories/matthiasnoback/read-with-the-author. When I moved that repository to a new organization on GitHub, this link resulted in a 404 Page not found error. The proper URL is now https://enjoy.gitstore.app/repositories/read-with-the-author/read-with-the-author. Chris from Gitstore was able to save the day by setting up a redirect on their site, but I wanted to make sure this kind of problem would never be a problem for me again. The ingredients for the solution: A domain name (I registered advwebapparch.com) A simple website that can redirect visitors to the actual locations I wanted to hook this new website into my existing Docker-based setup which uses Traefik to forward traffic to the right container based on labels. It turns out, with a simple Nginx image and some custom setup we can easily set up a website that is able to redirecting visitors. The Dockerfile for such an image: FROM nginx:stable-alpine COPY default.conf /etc/nginx/conf.d/default.conf Where default.conf looks like this: server { listen 80 default_server; index index.html; root /srv; error_page 404 /404.html; rewrite /repository https://enjoy.gitstore.app/repositories/read-with-the-author/read-with-the-author redirect; } This already works, and when I deploying the resulting image to the server that receives traffic for advwebapparch.com, a request for /repository will indeed redirect a visitor to https://enjoy.gitstore.app/repositories/read-with-the-author/read-with-the-author using a temporary redirect. Generating the Nginx configuration from a text file When I'm working on my book, I don't want to manually update a server configuration file every time I'm adding a URL. Instead, I'd like to work with a simple text file. Let's name this file forwards.txt: /repository https://enjoy.gitstore.app/repositories/read-with-the-author/read-with-the-author /blog https://matthiasnoback.nl And then I want the Docker image build process to add rewrite rules automatically, So I wrote a little PHP script that does this runs during the build. Here's what the Dockerfile looks like. It uses a multi-stage build: FROM php:7.4-alpine as php # This will copy build.php from the build context to the image COPY . . # This will generate default.conf based on template.conf RUN php build.php FROM nginx:stable-alpine # Copy the default.conf from the php image to the nginx image COPY --from=php default.conf /etc/nginx/conf.d/default.conf Here's what happens inside the PHP script: function insertRewritesInNginxConf(string $conf): string { $rewrites = []; foreach (file('forwards.txt') as $line) { $line = trim($line); if (empty($line)) { continue; } $rewrites[] = ' ' . 'rewrite ' . $line . ' redirect;'; } return str_replace( '%INSERT_URL_REWRITES_HERE%', implode(" ", $rewrites), $conf ); } /* * Generate the Nginx configuration which includes all the actual * redirect instructions */ file_put_contents( 'default.conf', insertRewritesInNginxConf(file_get_contents('template.conf')) ); We should add a bit of validation for the data from the forwards.txt file so we don't end up with a broken Nginx configuration, but otherwise, this works just fine. Generating an html page which can be crawled for broken links I don't want to manually check that all the links that are inside the "link registry" still work. Instead, I'd like to use Oh Dear for that, which does uptime monitoring and checks for broken links as well. For this purpose I added another function to the PHP script, which, basedTruncated by Planet PHP, read more at the original (another 1844 bytes) Full Article
ba No, Congress Can't Fix The Broken US Broadband Market In A Mad Dash During A Pandemic By www.techdirt.com Published On :: Thu, 7 May 2020 11:14:01 PDT COVID-19 has shone a very bright light on the importance of widely available, affordable broadband. Nearly 42 million Americans lack access to any broadband whatsoever--double FCC estimates. And millions more can't afford service thanks to a lack of competition among very powerful, government pampered telecom monopolies. As usual, with political pressure mounting to "do something," DC's solution is going to be to throw more money at the problem: "The plan unveiled Thursday would inject $80 billion over five years into expansion of broadband infrastructure into neglected rural, suburban and urban areas, with an emphasis on communities with high levels of poverty. It includes measures to promote rapid building of internet systems, such as low-interest financing for infrastructure projects." To be clear, subsidies often do help shore up broadband availability at coverage. The problem is that the United States government, largely captured by telecom giants with a vested interest in protecting regional monopolies, utterly sucks at it. Despite ample pretense to the contrary, nobody in the US government actually knows where broadband is currently available. Data supplied by ISPs has never been rigorously fact-checked by a government fearful of upsetting deep-pocketed campaign contributors (and valued NSA partners). As a result, our very expensive ($350 million at last count) FCC broadband coverage map creates a picture of availability and speed that's complete fantasy. It's theater designed to disguise the fact that US broadband is mediocre on every broadband metric that matters. Especially cost. While there has been some effort to fix the mapping problem via recent legislation, the FCC still needs several years (and more money) to do so. And while you'd think this would be more obvious, you can't fix a problem you can't even effectively measure. There's also not much indication that the $80 billion, while potentially well intentioned, would actually get where it needs to go. Especially right now, when federal oversight is effectively nonexistent. You may or may not have noticed this, but US telecom is a corrupt, monopolized mess. Giants like AT&T and Comcast all but own state and federal legislatures and, in many instances, literally write the law. Feckless regulators bend over backward to avoid upsetting deep-pocketed campaign contributors. So when subsidies are doled out, they very often don't end up where regulators and lawmakers intended. There's an endless ocean of examples where these giants took billions in taxpayer subsidies to deploy fiber networks that are never fully delivered. If you were to do meaningful audit (which we've never done because again we're not willing to adequately track the problem or stand up to dominant incumbent corporations) you'd very likely find that American taxpayers already paid for fiber to every home several times over. That's not to say is that there aren't things Congress could do to help the disconnected during COVID-19. Libraries for example have been begging the FCC for the ability to offer expanded WiFi hotspot access (via mobile school buses) to disconnected communities without running afoul of FCC ERate rules. But while the FCC said libraries can leave existing WiFi on without penalty, it has been mute about whether they can extend coverage outside of library property. Why? As a captured agency, the FCC doesn't like anything that could potentially result in Comcast or AT&T making less money. None of this is to say that we shouldn't subsidize broadband deployment once we get a handle on the mapping problem. But it's a fantasy to think we're going to immediately fix a 30 year old problem with an additional $80 billion in a mad dash during a pandemic. US broadband dysfunction was built up over decades. It's the product of corruption and rot that COVID-19 is exposing at every level of the US government. The only way to fix it is to stand up to industry, initiate meaningful reform, adopt policies that drive competition to market, and jettison feckless lawmakers and regulators whose dominant motivation is in protecting AT&T, Verizon, Comcast, and Spectrum revenues. Maybe the pandemic finally provides the incentive to actually do that, but until the US does, these subsidization efforts are largely theater. Full Article
ba COVID-19 Is Exposing A Virulent Strain Of Broadband Market Failure Denialism By www.techdirt.com Published On :: Fri, 8 May 2020 06:33:27 PDT A few weeks ago, the US telecom industry began pushing a bullshit narrative through its usual allies. In short, the claim revolves around the argument that the only reason the US internet still works during a pandemic was because the Trump FCC ignored the public, ignored most objective experts, and gutted itself at the behest of telecom industry lobbyists. The argument first popped up over at AEI, then the Trump FCC, then the pages of the Wall Street Journal, and has since been seen in numerous op-eds nationwide. I'd wager that's not a coincidence, and I'd also wager we'll be seeing a lot more of them. All of the pieces try to argue that the only reason the US internet works during a pandemic is because the FCC gutted its authority over telecom as part of its "restoring internet freedom" net neutrality repeal. This repeal, the story goes, drove significant investment in US broadband networks (not remotely true), resulting in telecom Utopia (also not true). The argument also posits that in Europe, where regulators have generally taken a more active role in policing things like industry consolidation and telecom monopolies, the internet all but fell apart (guess what: not true). Usually, like in this op-ed, there's ample insistence that the US broadband sector is largely wonderful while the EU has gone to hell: "Unlike here, European networks are more heavily regulated. This has led to less investment and worse performance for consumers for years. American consumers are being generally well served by the private sector." Anybody who has spent five minutes talking to Comcast customer support -- or tried to get scandal-plagued ISP like Frontier Communications to upgrade rotten DSL lines -- knows this is bullshit. Still, we penned a lengthy post exploring just how full of shit this argument is, and how there's absolutely zero supporting evidence for the claims. The entire house of cards is built on fluff and nonsense, and it's just ethically grotesque to use a disaster to help justify regulatory capture and market failure. While it's true that the US internet, in general, has held up relatively well during a pandemic, the same can't be said of the so called "last mile," or the link from your ISP's network to your home. Yes, the core internet and most primary transit routes, designed to handle massive capacity spikes during events like the Superbowl, has handled the load relatively well. The problem, as Sascha Meinrath correctly notes here, is sluggish speeds on consumer and business lines that, for many, haven't been upgraded in years: "Right now, an international consortium of network scientists is collecting 750,000 U.S. broadband speed tests from internet service provider (ISP) customers each day, and we’ve been tracking a stunning loss of connectivity speeds to people’s homes. According to most ISPs, the core network is handling the extra load. But our data show that the last-mile network infrastructure appears to be falling down on the job." Again, your 5 Mbps DSL line might be ok during normal times, but it's not going to serve you well during a pandemic when your entire family is streaming 4K videos, gaming, and Zooming. And your DSL line isn't upgraded because there's (1) very little competition forcing your ISP to do so, and (2) the US government is filled to the brim with sycophants who prioritize campaign contributions and ISP revenues over the health of the market and consumer welfare. And while there's a contingency of industry-linked folks who try very hard to pretend otherwise, this is a policy failure that's directly tied to mindless deregulation, a lack of competition, and, more importantly, corruption. In short, the complete opposite of the industry's latest talking point. For years we've been noting how US telcos have refused to repair or upgrade aging DSL lines because it's not profitable enough, quickly enough for Wall Street's liking. Facing no competition and no regulatory oversight, there's zero incentive for a giant US broadband provider to try very hard. Similarly, because our lawmakers and regulators are largely of the captured, revolving door variety, they rubber stamp shitty mergers, turn a blind eye to very obvious industry problems, routinely throwing billions in taxpayer money at monopolies in exchange for fiber networks that are usually only partially deployed -- if they're deployed at all. Meanwhile, US telcos that have all but given up on upgrading aging DSL lines have helped cement an even bigger Comcast monopoly across vast swaths of America. It's a problem that the telecom sector, Trump FCC, and various industry apologists will ignore to almost comical effect. Also ignored is the fact that this results in US broadband subscribers paying some of the highest prices for broadband in the developed world: "Numerous studies, including those conducted by the FCC itself, show that broadband pricing is the second-largest barrier to broadband adoption (availability is the first). It’s obvious that if people are being charged a lot for a service, they’re less likely to purchase it. And independent researchers have already documented that poor areas often pay more than rich communities for connectivity. Redlining of minority and rural areas appears to be widespread, and we need accurate pricing data from the FCC to meaningfully address these disparities." Try to find any instance where Ajit Pai, or anybody in this chorus of telecom monopoly apologists, actually admits that the US broadband market isn't competitive and, as a result, is hugely expensive for businesses and consumers alike. You simply won't find it. What you will find are a lot of excuses and straw men arguments like this latest one, designed to distract the press, public, and policymakers from very obvious market failure. Market failure that was a major problem in normal times, and exponentially more so during a pandemic where broadband is an essential lifeline. Full Article
ba It's Not Even Clear If Remdesivir Stops COVID-19, And Already We're Debating How Much It Can Price Gouge By www.techdirt.com Published On :: Fri, 8 May 2020 12:09:33 PDT You may recall in the early days of the pandemic, that pharma giant Gilead Sciences -- which has been accused of price gouging and (just last year!) charging exorbitant prices on drug breakthroughs developed with US taxpayer funds -- was able to sneak through an orphan works designation for its drug remdesevir for COVID-19 treatment. As we pointed out, everything about this was insane, given that orphan works designations, which give extra monopoly rights to the holders (beyond patent exclusivity), are meant for diseases that don't impact a large population. Gilead used a loophole: since the ceiling for infected people to qualify for orphan drug status is 200,000, Gilead got in its application bright and early, before there were 200,000 confirmed cases (we currently have over 1.3 million). After the story went, er... viral, Gilead agreed to drop the orphan status, realizing the bad publicity it was receiving. After a brief dalliance with chloroquine, remdesivir has suddenly been back in demand as the new hotness of possible COVID-19 treatments. Still, a close reading of the research might give one pause. There have been multiple conflicting studies, and Gilead's own messaging has been a mess. On April 23, 2020, news of the study’s failure began to circulate. It seems that the World Health Organization (WHO) had posted a draft report about the trial on their clinical trials database, which indicated that the scientists terminated the study prematurely due to high levels of adverse side effects. The WHO withdrew the report, and the researchers published their results in The Lancet on April 29, 2020. The number of people who experienced adverse side effects was roughly similar between those receiving remdesivir and those receiving a placebo. In 18 participants, the researchers stopped the drug treatment due to adverse reactions. But then... However, also on April 29, 2020, the National Institute of Allergy and Infectious Diseases (NIAID) announced that their NIH trial showed that remdesivir treatment led to faster recovery in hospital patients with COVID-19, compared with placebo treatment. “Preliminary results indicate that patients who received remdesivir had a 31% faster time to recovery than those who received placebo,” according to the press release. “Specifically, the median time to recovery was 11 days for patients treated with remdesivir compared with 15 days for those who received placebo.” The mortality rate in the remdesivir treatment group was 8%, compared with 11.6% in the placebo group, indicating that the drug could improve a person’s chances of survival. These data were close to achieving statistical significance. And then... “In addition, there is another Chinese trial, also stopped because the numbers of new patients with COVID-19 had fallen in China so they were unable to recruit, which has not yet published its data,” Prof. Evans continues. “There are other trials where remdesivir is compared with non-remdesivir treatments currently [being] done and results from some of these should appear soon.” Gilead also put out its own press release about another clinical trial, which seems more focused on determining the optimal length of remdesivir treatment. Suffice it to say, there's still a lot of conflicting data and no clear information on whether or not remdesevir actually helps. Still, that hasn't stopped people from trying to figure out just how much Gilead will price gouge going forward: The Institute for Clinical and Economic Review (ICER), which assesses effectiveness of drugs to determine appropriate prices, suggested a maximum price of $4,500 per 10-day treatment course based on the preliminary evidence of how much patients benefited in a clinical trial. Consumer advocacy group Public Citizen on Monday said remdesivir should be priced at $1 per day of treatment, since “that is more than the cost of manufacturing at scale with a reasonable profit to Gilead.” Some Wall Street investors expect Gilead to come in at $4,000 per patient or higher to make a profit above remdesivir’s development cost, which Gilead estimates at about $1 billion. So... we've got a range of $10 to $4,500 on a treatment that we don't yet know works, and which may or may not save lives. But, given that we're in the midst of a giant debate concerning things like "reopening the economy" -- something that can really only be done if the public is not afraid of dying (or at least becoming deathly ill) -- the value to the overall economy seems much greater than whatever amount Gilead wants to charge. It seems the right thing to do -- again, if it's shown that remdesevir actually helps -- is to just hand over a bunch of money to Gilead, say "thank you very much" and get the drug distributed as widely as possible. Though, again, it should be noted that a decent chunk of the research around remdesevir was not done or paid for by Gilead, but (yet again) via public funds to public universities, which did the necessary research. The idea that it's Gilead that should get to reap massive rewards for that seems sketchy at best. But the absolute worst outcome is one in which Gilead sticks to its standard operating procedure and prices the drug in a way that millions of Americans can't afford it, and it leads to a prolonging/expanding of the pandemic. Full Article
ba Good Fruit, Bad Fruit, and the Unforgivable Sin (Matthew 12:33-37) By redeeminggod.com Published On :: 2020-04-23T17:00:21Z In Matthew 12:33-37, in the context of warning the religious leaders about the sin of blasphemy against the Holy Spirit, Jesus talks about good fruit and bad fruit. Is Jesus telling people to look at the lives of other teachers to see if they have good works? No! Not at all. Listen to the study to see what Jesus IS teaching and why this is important for properly understanding the gospel. Full Article One Verse Redeeming Scripture Redeeming Theology z blasphemy against the Holy Spirit false teachers good fruit good words good works heresy Luke 6:43-45 Matthew 12:33-37 Unforgivable Sin
ba #441011 - Baked Monterey Chicken Recipe By www.tastespotting.com Published On :: Baked Monterey Chicken [recipe]craving more? check out TasteSpotting Full Article
ba #441015 - Indian Kachumbar Salad Recipe By www.tastespotting.com Published On :: This Indian Kachumber Salad is a side dish to almost all indian recipes! It's fresh, incredibly healthy and tastes delicious! The best part is that it can be ready to serve in just 5 minutes!craving more? check out TasteSpotting Full Article
ba #441018 - Best Best Banana Bread Recipe By www.tastespotting.com Published On :: Best of the Best Banana Bread recipes - perfectly uncomplicated, which is exactly what we need during these times [recipe]craving more? check out TasteSpotting Full Article
ba California’s privacy warriors are back – and this time they want to take their fight all the way to the ballot box By go.theregister.co.uk Published On :: Wed, 06 May 2020 22:53:06 GMT Politicos watered down earlier efforts, so data defenders will fight to the end The small group of policy wonks that forced California’s legislature to rush through privacy legislation two years ago are back – and this time they want a ballot.… Full Article
ba American tech goliaths decide innovation is the answer to Chinese 5G dominance, not bans, national security theater By go.theregister.co.uk Published On :: Thu, 07 May 2020 01:51:06 GMT Microsoft, Cisco, Google etc gang up to form Open RAN Policy Coalition Some of America’s super-corps have remembered how the US became the dominant global technology force it is, and have vowed to use innovation over threats to counter Chinese dominance in 5G markets.… Full Article
ba Forever mothballed: In memoriam Apple Butterfly Keyboard (2015-2020) By go.theregister.co.uk Published On :: Thu, 07 May 2020 09:45:11 GMT At last, we can write headlines with all the letters intact For a company defined by design and attention to detail, the Butterfly keyboard was a tremendous humiliation for Apple. Conceived in 2015, it replaced the previous scissor-switch mechanism for one with a smaller profile, allowing Cupertino to continue shrinking already-svelte laptops.… Full Article
ba Zoom bomb: Vid conf biz to snap up Keybase as not-a-PR-move move gets out of hand By go.theregister.co.uk Published On :: Thu, 07 May 2020 14:57:05 GMT Things will change forever, nods ex-Facebooker Alex Stamos Video conferencing software biz Zoom has bought Keybase in a surprise move just weeks after hiring Facebook's one-time CSO.… Full Article
ba Backup and restore on AWS is a nightmare – is there a way to speed it up? By go.theregister.co.uk Published On :: Fri, 08 May 2020 17:00:13 GMT Apparently. But we’re so incredulous, we’re gonna test those claims on live internet TV… Webcast “The journey to cloud” echoes through all organisations. It’s a Bildungsroman – a story of empowerment and betterment. A shiny, towering cityscape of gleaming edifices and elegant spires. It’s like an ascension into the actual clouds. Like dying and waking up in heaven.… Full Article
ba One malicious MMS is all it takes to pwn a Samsung smartphone: Bug squashed amid Android patch batch By go.theregister.co.uk Published On :: Fri, 08 May 2020 23:42:33 GMT Zero-click remote-code exec hole found by Googler, updates emitted Samsung has patched a serious security hole in its smartphones that can be exploited by maliciously crafted text messages to hijack devices.… Full Article
ba 01/25/15 - Warm breath on the back of my neck By www.tinyghosts.com Published On :: Mon, 26 Jan 2015 Full Article
ba 11/06/16 - Someone who loves me back By www.tinyghosts.com Published On :: Monday, 07 Nov 2016 Full Article
ba 10/21/18 - Back when most of my friends were alive By www.tinyghosts.com Published On :: Monday, 22 Oct 2018 Full Article
ba Review of The Battle of Chickamauga (Atari 8-bit) By www.mobygames.com Published On :: Fri, 24 Apr 2020 11:28:52 +0000 A review by ALLEN HALL (6). Excellently showcased what a computer could offer a gamer over a board game Full Article
ba Global Warming: We Will Need Climate Engineering By www.futurepundit.com Published On :: 2016-08-27T14:27:44-08:00 By 2060 Phoenix Arizona will have 132 days a year over 100F. Dallas will 55 and Pecos Texas 101 days. My view about problems: We should solve them. If the Earth really does heat up substantially then we should pull the CO2 back out of the atmosphere while also releasing cooling gases. If its practical we should also raise the albedo (surface reflectivity) of the planet. Right now cities should change their zoning laws and roads policies to make buildings, roads, and other surfaces more reflective. No more dark buildings. Use light colors of concrete, white shingles, and other surfaces that reflect more light. That would be beneficial even if the Earth was not heating up. Hot cities are unpleasant... Full Article
ba Job Automation And Universal Basic Income By www.futurepundit.com Published On :: 2016-12-03T20:39:39-08:00 Elon Musk thinks a universal basic income is inevitable. Musk doesn't see plausible alternatives. I hope not. So here's the optimistic scenario: On the one hand, manual and low skilled work will mostly get automated out of existence. So one could imagine why demand for people at lower skill levels and lower levels of cognitive ability could just evaporate. On the other hand, automation will cut costs and boost the wealth of those still employed. Even if the pay of manual laborers is low the goods a manual laborer will need to survive should become very cheap. So any upper class people who can find a use for them might pay them enough to survive. But I see a stronger... Full Article
ba Utility Battery Projects Driven By Price Drops By www.futurepundit.com Published On :: 2017-02-04T12:40:18-08:00 For large electric power storage projects the cost of batteries has plummeted. 2008, when battery prices were 10 times higher than they are today. This advance is timely as photovoltaic electric power prices have dropped so far that in SoCal PV is causing a growing drop in mid-day demand and therefore a much bigger spike in evening demand. Therefore there's a growing need for a cheaper way to store power generated in mid day and deliver it in the evening. You can see how much solar power output surges each day in California by clicking on some of the Daily Renewables Watch links at the Cal ISO site (the organization that manages California's electric grid). The growing supply of wind... Full Article
ba JoT #2695: FaceTime background humiliation. By www.geekculture.com Published On :: Mon, 30 Mar 2020 19:52:23 -0800 It's hard to keep up with the Zoomers! Full Article Comics
ba Getting Bank of America By The Balls By www.funnyandjokes.com Published On :: Tue, 22 Nov 2011 01:27:11 +0000 A little old lady walks into Bank of America and asks to open a savings account. The new accounts receptionist first thinks this is strange, probably because everyone is leaving them for credit unions now. At any rate, the accounts person asks her how much she wanted to deposit to open the account, and the […] The post Getting Bank of America By The Balls appeared first on Funny & Jokes. Full Article Dirty Jokes Jokes
ba A Man Walks Into A Bar With An Alligator On A Leash By www.funnyandjokes.com Published On :: Fri, 03 Feb 2012 20:23:03 +0000 The bartender says “You can’t have that thing in here! Get out!” The guy says “It’s okay, this Alligator is highly trained. Just give me a few seconds and I’ll show you.” The bartender, intrigued, gives him the go-ahead. The man gingerly lifts the alligator up onto a table. By this point, everybody in the […] The post A Man Walks Into A Bar With An Alligator On A Leash appeared first on Funny & Jokes. Full Article Bar Jokes Jokes
ba Fishing Footwear Basics: Keeping Your Feet Neat and Safe By www.oceanbluefishing.com Published On :: Mon, 20 Apr 2020 08:03:30 +0000 Fishing Footwear Basics: Keeping Your Feet Neat and Safe The post Fishing Footwear Basics: Keeping Your Feet Neat and Safe appeared first on Ocean Blue Fishing Adventures. Full Article Featured Post Gear & Boats best fishing shoes fishing footwear fishing gear fishing sandals fishing shoes Vanuatu Fishing
ba Helicobacter pylori: preying on SIVA for survival in the stomach By www.jci.org Published On :: Infection with the Gram-negative bacterium Helicobacter pylori remains the most important modifiable risk factor for the development of gastric cancer, a leading cause of cancer-related deaths worldwide. How the interactions between H. pylori and its host shape the gastric environment during chronic infection warrants further investigation. In this issue of the JCI, Palrasu et al. used human cell lines and mouse models to provide mechanistic insight into H. pylori’s ability to delay apoptosis in gastric epithelial cells by actively driving the degradation of a proapoptotic factor, SIVA1. Their findings suggest that promoting the survival of gastric epithelial cells has implications not only for H. pylori pathogenesis but for host tumorigenesis. Full Article
ba Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells By www.jci.org Published On :: Approximately half of the world’s population is infected with the stomach pathogen Helicobacter pylori. Infection with H. pylori is the main risk factor for distal gastric cancer. Bacterial virulence factors, such as the oncoprotein CagA, augment cancer risk. Yet despite high infection rates, only a fraction of H. pylori–infected individuals develop gastric cancer. This raises the question of defining the specific host and bacterial factors responsible for gastric tumorigenesis. To investigate the tumorigenic determinants, we analyzed gastric tissues from human subjects and animals infected with H. pylori bacteria harboring different CagA status. For laboratory studies, well-defined H. pylori strain B128 and its cancerogenic derivative strain 7.13, as well as various bacterial isogenic mutants were employed. We found that H. pylori compromises key tumor suppressor mechanisms: the host stress and apoptotic responses. Our studies showed that CagA induces phosphorylation of XIAP E3 ubiquitin ligase, which enhances ubiquitination and proteasomal degradation of the host proapoptotic factor Siva1. This process is mediated by the PI3K/Akt pathway. Inhibition of Siva1 by H. pylori increases survival of human cells with damaged DNA. It occurs in a strain-specific manner and is associated with the ability to induce gastric tumor. Full Article
ba Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model By www.jci.org Published On :: Seizures often herald the clinical appearance of gliomas or appear at later stages. Dissecting their precise evolution and cellular pathogenesis in brain malignancies could inform the development of staged therapies for these highly pharmaco-resistant epilepsies. Studies in immunodeficient xenograft models have identified local interneuron loss and excess glial glutamate release as chief contributors to network disinhibition, but how hyperexcitability in the peritumoral microenvironment evolves in an immunocompetent brain is unclear. We generated gliomas in WT mice via in utero deletion of key tumor suppressor genes and serially monitored cortical epileptogenesis during tumor infiltration with in vivo electrophysiology and GCAMP7 calcium imaging, revealing a reproducible progression from hyperexcitability to convulsive seizures. Long before seizures, coincident with loss of inhibitory cells and their protective scaffolding, gain of glial glutamate antiporter xCT expression, and reactive astrocytosis, we detected local Iba1+ microglial inflammation that intensified and later extended far beyond tumor boundaries. Hitherto unrecognized episodes of cortical spreading depolarization that arose frequently from the peritumoral region may provide a mechanism for transient neurological deficits. Early blockade of glial xCT activity inhibited later seizures, and genomic reduction of host brain excitability by deleting MapT suppressed molecular markers of epileptogenesis and seizures. Our studies confirmed xenograft tumor–driven pathobiology and revealed early and late components of tumor-related epileptogenesis in a genetically tractable, immunocompetent mouse model of glioma, allowing the complex dissection of tumor versus host pathogenic seizure mechanisms. Full Article
ba Bamboo and Rose By www.jigcardgallery.com Published On :: Play the daily online jigsaw puzzle. Full Article
ba Apple Arcade's Latest Game Combines Turn-Based RPG With Strategy Board Game By www.macrumors.com Published On :: Fri, 08 May 2020 07:24:28 PDT The Label's "The_Otherside" is this week's addition to Apple Arcade on the iPhone, iPad, and Apple TV. The game is described as both a turn-based RPG and a strategy board game:Otherside is a turn based RPG and strategy board game where you will control four survivors who hope to push back the shadowy threat. Make your way through each level solving puzzles, fighting monsters, and destroying the spirit anchors that threaten our dimension. Do you have what it takes to restore the town back to normal and save the day?"The_Otherside" is available on the App Store with an Apple Arcade subscription. The service provides iPhone, iPad, Apple TV, and Mac users with access to over 100 games with no in-app purchases or ads for $4.99 per month.Tag: Apple ArcadeThis article, "Apple Arcade's Latest Game Combines Turn-Based RPG With Strategy Board Game" first appeared on MacRumors.comDiscuss this article in our forums Full Article Blurb Apple Arcade
ba Base 13-Inch MacBook Pro vs. MacBook Air By www.macrumors.com Published On :: Sat, 09 May 2020 10:00:49 PDT Apple recently updated the 13-inch MacBook Pro, and the $1,299 base model remains a popular alternative to the $999 MacBook Air. To help with your buying decision, read our comparison of the notebooks below. The differences between the base 13-inch MacBook Pro and the MacBook Air are quite nuanced, with each notebook possessing some unique features. What's the Same13-inch Retina display with 227 pixels per inch and True Tone support Magic Keyboard with reliable scissor switch design Force Touch trackpad 2 × Thunderbolt 3 ports 3.5mm headphone jack 256GB of SSD storage standard, configurable up to 2TB Touch ID T2 security chip 720p webcam 802.11ac Wi-Fi, also known as Wi-Fi 5 Bluetooth 5.0 Three-microphone array with directional beamforming Dolby Atmos surround soundAdvantages of Base 13-Inch MacBook ProThe display supports the P3 wide color gamut for more vibrant and lifelike colors The display is brighter at up to 500 nits vs. 400 nits on MacBook Air Touch Bar Slightly better sounding speakersAdvantages of MacBook AirUp to 11 hours of battery life vs. 10 hours on base 13-inch MacBook Pro Weighs slightly less at 2.8 pounds vs. 3.1 pounds for base 13-inch MacBook Pro Faster RAM: 3733MHz LPDDR4X vs. 2133MHz LPDDR3 for base 13-inch MacBook Pro 6K display support vs. 5K on base 13-inch MacBook ProUnlike the MacBook Pro, the MacBook Air also has a gold color option.Performance Generally speaking, the MacBook Air remains best suited for lightweight day-to-day tasks like web browsing and creating spreadsheets, while the MacBook Pro is better equipped to handle more intensive tasks like rendering large video files. This is not only because the MacBook Pro has faster processors than the Air, but also because it has a more advanced thermal design for dissipating heat inside the computer. While the MacBook Air has been updated with Intel's latest 10th-generation processors, the base 13-inch MacBook Pro continues to use older 8th-generation processors. However, the Air uses lower-wattage Y-series chips with lower clock speeds, so the Pro still has faster overall performance, as confirmed by benchmarks. Geekbench 5 scores for the latest 13-inch MacBook Pro and MacBook Air configurations:MacBook Air / 1.1GHz dual-core Core i3: 1,002 single-core and 1,998 multi-core MacBook Air / 1.1GHz quad-core Core i5: 1,055 single-core and 2,645 multi-core MacBook Air / 1.2GHz quad-core Core i7: 1,102 single-core and 2,843 multi-core MacBook Pro / 1.4GHz quad-core Core i5: 927 single-core and 3,822 multi-core MacBook Pro / 1.7GHz quad-core Core i7: 1,036 single-core and 3,909 multi-core Takeaways:The base model 13-inch MacBook Pro for $1,299 has up to 91 percent faster multi-core performance than the base model MacBook Air for $999 If considering the MacBook Air, upgrading to the quad-core Core i5 option is well worth the extra $100, as it is up to 32 percent faster than the base model and more closely rivals the base 13-inch MacBook Pro Geekbench 5 scores are calibrated against a baseline score of 1,000, which is the score of an Intel Core i3-8100. Higher scores are better, with double the score indicating double the performance. Compare with other Mac benchmarks here. Bottom Line If you value portability and up to an extra hour of battery life, and are willing to sacrifice some performance, the MacBook Air is a relatively good value. Just remember to consider spending an extra $100 on the quad-core Core i5 processor option, as the $999 base model is equipped with a particularly sluggish dual-core processor. For more intensive tasks, the 13-inch MacBook Pro's faster processors and more advanced thermal design will allow you to push the limits more without the fans running obnoxiously. You'll also get the Touch Bar, a brighter and more vibrant display, and slightly better sounding speakers with high dynamic range.Related Roundups: MacBook Air, MacBook ProBuyer's Guide: MacBook Air (Buy Now), MacBook Pro (Caution)This article, "Base 13-Inch MacBook Pro vs. MacBook Air" first appeared on MacRumors.comDiscuss this article in our forums Full Article MacBook Air Retina MacBook Pro
ba Furry Fandom and the Internet forced back to roots by viral outbreak By www.flayrah.com Published On :: Thu, 26 Mar 2020 23:14:58 +0000 The internet was seen as a major catalyst for the furry fandom finding one another during the times before we held conventions. During that earlier period in the 1990s, conventions and meets were rare, and finding one another was done mostly through the chat rooms and message boards of the past. There was no bandwidth for video or sharing major animation projects, therefore most of our intimate conversations were textual. For many younger furries, it was a time that was lost in the annals of a distant history. Instead they found themselves joining in amongst a wave of growing conventions being held in various places around the world on any given weekend. Ones where those in custom fursuits march out in the streets openly rather than feeling a stifling isolation of being cooped up in hotel spaces, with a handful of home made creations, being wary of a hostile media looking for a freak show. Coming out of 2019, it seemed that the time where furry was just an internet thing was fully behind it. However a series of unfortunate events were in line for 2020, a year that has led humanity to be forced into their rooms by an irate Mother Nature as an easily spread virus has forced governments around the globe to take drastic measures to slow its spread and put strict limits on social gatherings. A situation which has forced both the furry fandom, and the internet that brought it together, back to their roots. read more Full Article conventions coronavirus Internet opinion
ba A Comprehensive List of Internet Based Furry Convention-like Gatherings By www.flayrah.com Published On :: Wed, 22 Apr 2020 03:26:38 +0000 While the pandemic has been chipping away at the furry convention scene, other furs have stepped forward to try and give those in the community events to look forward to over the now dormant weekends. This had started with a group of Furnal Equinox members creating a digital replacement for their late March convention called Keep Calm and Carry Con - Furnal Isolation. More have started to spring up this spring. They can have internet dealers dens, streaming dance competitions, and other staples that conventions are known for. Accessible from the safety of your own home. Below is a comprehensive list of conventions. Last updated May 2nd, 2020 12:18 ET. Please feel free to place any not listed here in the comments below and we will look into adding it if it appears legitimate. read more Full Article conventions
ba “Bad Parent – breakfast club” By dorkboycomics.com Published On :: Mon, 17 Feb 2020 23:50:51 +0000 Wow, talk about bad at updating, damian! I have continued posting comics and sketches and paintings and…you get the idea!! BUT….I have been posting them primarily on Instagram (I know, terrible) – sorry, things have been busy (as usual), and[…]↓ Read the rest of this entry... Full Article bad parent
ba “Bad Parent – stock up, don’t stockpile” By dorkboycomics.com Published On :: Sun, 22 Mar 2020 06:46:31 +0000 Hang in there, everyone. — seeya soon, boring details about today’s comic: made with: love Full Article
ba “Bad Parent – perhaps self-isolation is a good thing….” By dorkboycomics.com Published On :: Wed, 25 Mar 2020 07:25:07 +0000 — seeya soon, boring details about today’s comic: made with: Full Article
ba 'Loopy Mind-Hell', by Zanzibar (Amanitas - A. muscaria) By erowid.org Published On :: Fri, 01 May 2020 07:10:00 GMT Erowid Exp113948 Full Article Erowid : Experience :
ba Cenk Uygur says President Obama will definitely cut the entitlements of Social Security, Medicare, and Medicaid By www.cpa-connecticut.com Published On :: Tue, 02 Oct 2012 07:41:35 +0000 On the Young Turks, Cenk Uygur quotes passages from Bob Woodward's book, "The Price of Politics", quoting statements made by President Obama proving that he intends to cut entitlements like social security, medicare, and medicaid. Continue reading → Full Article Accountants CPA Hartford Articles Blue dog Democrats are conservative Blue dog Democrats are not progressive Bob Woodward book The Price of Politics Cenk Uygur Cenk Uygur says President Obama will definitely cut the entitlements of Social Security Medicare and Medicaid Obama said he would cut social security and Medicare and Medicaid Obama says he will bring Democrats along to cut entitlements President Obama is a blue dog Democrat President Obama to cut entitlements The Young Turks
ba President Obama says that he cannot change Washington from the inside By www.cpa-connecticut.com Published On :: Mon, 05 Nov 2012 01:05:05 +0000 After being elected in 2008 on "hope and change", "change you can believe in", and "change the way Washington works", President Obama now says that he cannot change Washington from the inside? Then why should we re-elect him in 2012? Continue reading → Full Article Accountants CPA Hartford Articles Cenk Uygur change the way Washington works change you can believe in Hope and change President Obama says that he cannot change Washington from the inside The Young Turks
ba Why you should not vote for Barack Obama for President, and why you need to vote for Rocky Anderson By www.cpa-connecticut.com Published On :: Tue, 06 Nov 2012 07:25:32 +0000 Barack Obama promised to change the way things work in Washington, and after four years, nothing has changed: Corporate money controls President Obama and Congress. We need real change: vote for Rocky Anderson. Continue reading → Full Article Accountants CPA Hartford Articles Barack Obama change the way Washington works Democrats eliminate special interest tax breaks lobbyists PACs Republicans Rocky Anderson President 2012 Rocky Anderson special interests video second Gilded Age in America Tim Russert Wall Street
ba Wearechange.org interview of Glenn Greenwald on the next four years with President Obama. Greenwald predicts “it’s all going to get much worse”. By www.cpa-connecticut.com Published On :: Fri, 16 Nov 2012 15:05:20 +0000 Glenn Greenwald predicts over the next four years that "it's all going to get much worse", with President Obama shifting politically more to the right while the Democratic base continues to support him. Continue reading → Full Article Accountants CPA Hartford Articles Bush administration counter-terroism policies Democrats Dick Cheney Glenn Greenwald on The Next 4 Years with Obama it's all going to get much worse liberals Michael Hayden President Obama Progressives transcript video wearechange.org
ba Amy Goodman interviews Tavis Smiley, Cornel West on the 2012 Election & Why Calling Obama “Progressive” Ignores His Record. Democracy Now: Friday, November 9, 2012. By www.cpa-connecticut.com Published On :: Fri, 16 Nov 2012 15:54:07 +0000 Cornel West and Tavis Smiley criticize President Barack Obama for being to the right of even President Richard Nixon. Continue reading → Full Article Accountants CPA Hartford Articles 2012 election Amy Goodman Cornel West Democracy Now Friday November 9 2012. interview Poverty President Barack Obama Progressive Tavis Smiley transcript video
ba Berlin High School football recruiting scandal cost Berlin Connecticut taxpayers tens of thousands of dollars By www.cpa-connecticut.com Published On :: Thu, 26 Nov 2015 22:50:33 +0000 Eyewitness News has learned that the Berlin High School football recruiting scandal may have cost Berlin taxpayers tens of thousands of dollars. Continue reading → Full Article Accountants CPA Hartford Articles BERLIN HIGH SCHOOL FOOTBALL RECRUITING SCANDAL COST BERLIN CONNECTICUT TAXPAYERS TENS OF THOUSANDS OF DOLLARS BERLIN HIGH SCHOOL FOOTBALL TEAM VIOLATIONS COST BERLIN CT TAXPAYERS TENS OF THOUSANDS OF DOLLARS EVERY YEAR Carol Argazzi Chanel 3 News Dennis House DR. KARISSA NIEHOFF John Capodice Matthew Campbell Stephanie Santa WFSB Eyewitness News
ba Is the DNC Afraid of Democracy? Clinton WH Counselor Says Party a “Dead Carcass” for Stifling Debate By www.cpa-connecticut.com Published On :: Mon, 21 Dec 2015 22:30:42 +0000 "This is supposed to be a political party. In a healthy society, there would be a democratic process in the Democratic Party, by which elected people would be overseeing these issues by making sure there wasn’t just nepotism and insider dealing," Curry says. "That the political party itself — which is supposed to be the progressive party — has become mortgaged to a small group of Washington insiders, who raise money from large corporate PACs, [and] has become just a dead carcass of what it once was, is the most important piece of information that this contretemps over the data files has emphasized. It’s time for progressives in this country to stand up and demand a genuinely democratic process." Continue reading → Full Article Accountants CPA Hartford Amy Goodman Bernie Sanders Bill Curry Debbie Wasserman-Schultz Democracy Now Democratic debates Democratic National Committee Democratic Party DNC Hillary Clinton Is the DNC Afraid of Democracy? Clinton WH Counselor Says Party a "Dead Carcass" for Stifling Debate