Finding antivirals to reduce coronavirus disease 2019 (COVID-19) morbidity and mortality has been challenging. Large randomized clinical trials that aimed to test four repurposed drugs, hydroxychloroquine, lopinavir-ritonavir, interferon beta 1a, and remdesivir, have shown that these compounds lack an impact on the COVID-19 course. Although the phase III COVID-19 vaccine trial results are encouraging, the search for effective COVID-19 therapeutics should not stop. Recently, plitidepsin (aplidin) demonstrated highly effective preclinical activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Its antiviral activity was 27.5-fold more potent than that of remdesivir (K. M. White, R. Rosales, S. Yildiz, T. Kehrer, et al., Science, 2021, https://science.sciencemag.org/content/early/2021/01/22/science.abf4058). Plitidepsin, a repurposed drug developed for the treatment of multiple myeloma, targets the host translation cofactor eEF1A. Plitidepsin has shown efficacy in animal models and phase I/II human trials. Although plitidepsin is administered intravenously and its toxicity profile remains to be fully characterized, this compound may be a promising alternative COVID-19 therapeutic.

Six OMers spent two weeks in the south of France sharing God's love with children as part of a large music festival.

French OMer Andre experiences that prayer can change the hearts of authorities regarding victims of human trafficking.

A French man met in the street prefered to live without God, thinking He would take away his freedom.

“I was not happy when the Lord told me to go to France,” recalls one American OM worker, who soon discovered Europe’s great spiritual needs.

A simple letter home to parents explaining a Texas 2nd grade teacher's no-homework policy has gone viral and is leading to more discussion about what's appropriate for elementary school students.

In this week's episode of SA Money Report, we delve into Eskom's latest plunge into darkness.

This week Carin Smith explains why Kulula.com operator Comair grounded its planes, and what it will take to get them back in the air.

Bayanda Maseko lost 2 000 chickens and more than R100 000 he invested in his farm in 2022, all because of load shedding.

The pace of the energy transition has accelerated exponentially in recent years and South Africa has failed to keep pace. But there is hope with legislative changes paving the way for a more competitive electricity market, says Nick Hedley.

As time passes for those devastated by fire in a Bangladesh slum, OM helps with essential support and love in variety of ways.

Young people in Bangladesh learn to combine sport with their love for God, and one programme participant explains his enthusiasm for the experience.

Despite having a degree, a young woman in Bangladesh finds it impossible to get a job until she completes an OM computer course.

OM brings starter schools to families in poor rural areas, benefiting both pupils and teachers in Bangladesh.

One woman’s risk of exploitation decreased when she learnt to read and write through OM's adult literacy programme in Bangladesh.

Thirteen years ago, two families wondered how God would use them to reach a town with no believers. Now, local small groups study God’s Word.

Believers begin a conversation with a local religious leader about Jesus.

Mothers and children in Bangladesh’s refugee camps tell horrifying stories from recent months, many needing a place where they can be reminded of hope.

The Penn State Board of Trustees’ Finance and Investment Committee advanced a proposal on Nov. 7 to construct a new Applied Research Laboratory Building on the University Park campus.  

A consistent bedtime may be more important to a child’s ability to control their emotions and behavior than the duration or quality of their sleep, according to a new publication by researchers in the Penn State College of Health and Human Development and Penn State College of Medicine. 

Loneliness and cognitive performance were related in the short term for older adults, according to a new study from researchers in the Penn State College of Health and Human Development.

The new U.S. Department of Education guidance creates a federal process for individuals and organizations to file complaints under the federal Religious Freedom Restoration Act.

God not only rescued Kamil and Klaudia's marriage but also transformed their relationships with Him.

Montevideo, Uruguay :: A Logos Hope crewmember relies on God for strength and the words to say to disruptive inmates at a prison.

The journey of a young Albanian girl from the Roma and Gypsy community who went from being a troubled teenager to excitedly following Jesus!

Anea's story is one of abandonment, misuse, tragedy and hurt. But through OM in Kosovo's House of Joy programme, she has found hope for her, and her daughter's, future.

Rosario, Argentina :: When their programme for the day gets cancelled, crew take to the streets to share their faith with those they meet.

An Albanian man's heart is forever changed after suffering a heart attack and meeting Jesus in his recuperation.

Rosario, Argentina :: Church members from a vulnerable community learn about human trafficking and experience care and respect.

An OM worker in Cambodia shares about how a new training she is attending is transforming the way she does ministry.

These four evidence-based suggestions can help educators offset learning loss for young English learners, write Leslie M. Babinski, Steven J. Amendum, Steven E. Knotek, and Marta Sánchez.

When teachers have experienced stressful events in their own childhoods, it could shape the way that they build classroom climate for their students, a study suggests.

All principals are dealing with COVID-19, and some are dealing with wildfires or hurricanes at the same time. Those issues, on top of increasing job demands, are pushing principals to the breaking point. We need to do something about that.

The consequences of reopening schools in Denmark, Israel, and South Korea offer valuable insights for U.S. schools.

A new survey examines which students want to be teachers and what's drawing them to—or driving them from—the profession.

The Department of Education has denied 99 percent of applications for public service loan forgiveness under a temporary expanded program funded by Congress, a report finds.

In a recent video message, transgender teachers urge school leaders to make schools more welcoming by examining their own biases and implementing inclusive policies.

Just 16 states require incoming teachers to provide evidence of successful prior job performance, a National Council on Teacher Quality analysis found.

From an increase in teacher activism to a decline in the number of people who want to be teachers, here are 10 of the biggest shifts in the profession over the past decade.

Education Week has teamed up with Roadtrip Nation to send a group of teachers across the country in a green RV. Here's what you need to know.

Here are five takeaways on the teaching profession from the newly released 2017-18 National Teacher and Principal Survey.

The Penn State College of IST Distinguished Lecture Series will host Wenke Lee from Georgia Tech at noon on Nov. 18 in E202 Westgate Building at University Park.

Working remotely and from in-person sites at the Harrisburg and University Park campuses, teams spent three focused days in June attending workshops and webinars, collaborating with coaches and each other, as they worked on their projects related to student success and providing opportunities for students in the higher education space.

Rick Brazier, senior associate dean for faculty and research in the Office of the Vice President for Commonwealth Campuses, has been named dean of Penn State’s 14-campus University College. Brazier served as interim dean of the University College since February 2022 and will begin the permanent appointment on Sept. 2, 2024.

A draft proposal of Penn State’s institutional strategic plan has been unveiled and shared with the community for feedback and discussion. All faculty, staff and students at all campuses are encouraged to visit the Strategic Plan website to review and provide feedback on the draft plans for four goal areas.

Kost Tire and Auto Service has partnered with Penn State Scranton to offer campus students, faculty and staff free winter safety checks of their vehicles during a special event on Tuesday, Oct. 1. In addition, representatives from State Farm Insurance will be offering car seat safety checks.

Penn State Scranton is set to host a job fair for students in its nursing degree program from noon to 2 p.m. on Monday, Oct. 14, in the Nursing Suite's lobby. The event aims to connect nursing students with local healthcare recruiters from major health systems.

Penn State Scranton has announced the establishment of the Lambda Omicron Chapter of Alpha Alpha Alpha (Tri-Alpha) Honor Society, a national organization dedicated to recognizing the achievements of first-generation college students.