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Intramolecular Csp3–H/C–C bond amination of alkyl azides for the selective synthesis of cyclic imines and tertiary amines

Chem. Sci., 2020, 11,4482-4487
DOI: 10.1039/C9SC05522C, Edge Article
Open Access
Xiaojin Wen, Xinyao Li, Xiao Luo, Weijin Wang, Song Song, Ning Jiao
A novel intramolecular cyclization of alkyl azides for the synthesis of cyclic imines and tertiary amines has been developed. The aliphatic C–H or C–C bond was selectively cleaved with the efficient formation of two C–N single bonds or a CN double bond.
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Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue

Chem. Sci., 2020, 11,4488-4498
DOI: 10.1039/D0SC00544D, Edge Article
Open Access
Carlo Pifferi, Ane Ruiz-de-Angulo, David Goyard, Claire Tiertant, Nagore Sacristán, Diego Barriales, Nathalie Berthet, Juan Anguita, Olivier Renaudet, Alberto Fernández-Tejada
A fully-synthetic anticancer vaccine candidate incorporating an hexadecavalent Tn antigen analogue display via oxime linkages induced tumor-specific IgG antibodies and cellular immune responses in mice coadministered with QS-21 as an adjuvant.
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Hydrogen peroxide reduction on single platinum nanoparticles

Chem. Sci., 2020, 11,4416-4421
DOI: 10.1039/D0SC00379D, Edge Article
Open Access
Xin Chang, Christopher Batchelor-McAuley, Richard G. Compton
At the single platinum nanoparticle scale the hydrogen peroxide reduction reaction is a surface limited process.
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The structures of ordered defects in thiocyanate analogues of Prussian Blue

Chem. Sci., 2020, 11,4430-4438
DOI: 10.1039/D0SC01246G, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Matthew J. Cliffe, Evan N. Keyzer, Andrew D. Bond, Maxwell A. Astle, Clare P. Grey
We report the structures of six new divalent transition metal hexathiocyanatobismuthate Prussian Blue analogues frameworks, which contain complex ordered defect structures.
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Self-assembly of reversed bilayer vesicles through pnictogen bonding: water-stable supramolecular nanocontainers for organic solvents

Chem. Sci., 2020, 11,4374-4380
DOI: 10.1039/D0SC00206B, Edge Article
Open Access
Shiva Moaven, Brandon T. Watson, Shelby B. Thompson, Veronica J. Lyons, Daniel K. Unruh, Dominick J. Casadonte, Dimitri Pappas, Anthony F. Cozzolino
A new air and moisture stable antimony thiolate compound has been prepared that spontaneously forms stable hollow vesicles.
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J-dimer emission in interwoven metal–organic frameworks

Chem. Sci., 2020, 11,4391-4396
DOI: 10.1039/D0SC00876A, Edge Article
Open Access
Wesley J. Newsome, Arnab Chakraborty, Richard T. Ly, Gavin S. Pour, David C. Fairchild, Amanda J. Morris, Fernando J. Uribe-Romo
J-dimer emission is an emergent property that occurs when pairs of ground-state fluorophores associate within multivariate MOFs producing tunable red shifted emission.
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Biocatalytic reversible control of the stiffness of DNA-modified responsive hydrogels: applications in shape-memory, self-healing and autonomous controlled release of insulin

Chem. Sci., 2020, 11,4516-4524
DOI: 10.1039/D0SC01319F, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Chen Wang, Amit Fischer, Avner Ehrlich, Yaakov Nahmias, Itamar Willner
Biocatalytic control over the stiffness of pH-responsive hydrogels is applied to develop shape-memory, self-healing and controlled release matrices.
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Metal-free carbon monoxide-releasing micelles undergo tandem photochemical reactions for cutaneous wound healing

Chem. Sci., 2020, 11,4499-4507
DOI: 10.1039/D0SC00135J, Edge Article
Open Access
Jian Cheng, Bin Zheng, Sheng Cheng, Guoying Zhang, Jinming Hu
Metal-free carbon monoxide-releasing polymers (CORPs) are synthesized via a direct polymerization approach, exhibiting not only improved stability but also accelerated wound healing performance as compared to CORM-3.
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Machine-enabled inverse design of inorganic solid materials: promises and challenges

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC00594K, Minireview
Open Access
Juhwan Noh, Geun Ho Gu, Sungwon Kim, Yousung Jung
The grand challenge of materials science, discovery of novel materials with target properties, can be greatly accelerated by machine-learned inverse design strategies.
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Correction: Metal complexes as a promising source for new antibiotics

Chem. Sci., 2020, 11,4531-4531
DOI: 10.1039/D0SC90075C, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Angelo Frei, Johannes Zuegg, Alysha G. Elliott, Murray Baker, Stefan Braese, Christopher Brown, Feng Chen, Christopher G. Dowson, Gilles Dujardin, Nicole Jung, A. Paden King, Ahmed M. Mansour, Massimiliano Massi, John Moat, Heba A. Mohamed, Anna K. Renfrew, Peter J. Rutledge, Peter J. Sadler, Matthew H. Todd, Charlotte E. Willans, Justin J. Wilson, Matthew A. Cooper, Mark A. T. Blaskovich
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Mapping the multi-step mechanism of a photoredox catalyzed atom-transfer radical polymerization reaction by direct observation of the reactive intermediates

Chem. Sci., 2020, 11,4475-4481
DOI: 10.1039/D0SC01194K, Edge Article
Open Access
Luke Lewis-Borrell, Mahima Sneha, Aditi Bhattacherjee, Ian P. Clark, Andrew J. Orr-Ewing
Short-lived intermediates are tracked in real-time by transient absorption spectroscopy during a multi-step photoredox catalysed polymerization reaction.
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Chemical control of competing electron transfer pathways in iron tetracyano-polypyridyl photosensitizers

Chem. Sci., 2020, 11,4360-4373
DOI: 10.1039/C9SC06272F, Edge Article
Open Access
Kristjan Kunnus, Lin Li, Charles J. Titus, Sang Jun Lee, Marco E. Reinhard, Sergey Koroidov, Kasper S. Kjær, Kiryong Hong, Kathryn Ledbetter, William B. Doriese, Galen C. O'Neil, Daniel S. Swetz, Joel N. Ullom, Dale Li, Kent Irwin, Dennis Nordlund, Amy A. Cordones, Kelly J. Gaffney
Photoinduced intramolecular electron transfer in Fe tetracyano-polypyridyl complexes was investigated with static and time-resolved UV-visible absorption and resonant inelastic X-ray scattering which revealed a competition of two relaxation pathways.
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Self-enhanced multicolor electrochemiluminescence by competitive electron-transfer processes

Chem. Sci., 2020, 11,4508-4515
DOI: 10.1039/D0SC00853B, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Silvia Voci, Romain Duwald, Stéphane Grass, David J. Hayne, Laurent Bouffier, Paul S. Francis, Jérôme Lacour, Neso Sojic
Controlling electrochemiluminescence (ECL) color(s) is crucial for many applications ranging from multiplexed bioassays to ECL microscopy.
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Designing naphthopyran mechanophores with tunable mechanochromic behavior

Chem. Sci., 2020, 11,4525-4530
DOI: 10.1039/D0SC01359E, Edge Article
Open Access
Brooke A. Versaw, Molly E. McFadden, Corey C. Husic, Maxwell J. Robb
Structure–activity relationships for strategic substitution of the naphthopyran mechanophore scaffold enable polymeric materials with tunable mechanochromic behavior.
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Small-molecule fluorescent probes for imaging gaseous signaling molecules: current progress and future implications

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC01482F, Perspective
Open Access
Mingwang Yang, Jiangli Fan, Jianjun Du, Xiaojun Peng
This perspective article aims to introduce the design principles and recognition strategies of small-molecule fluorescent probes which are applied for the detection of gas signaling molecules including NO, CO and H2S in biological systems.
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Enantioselective total synthesis of (−)-myrifabral A and B

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC01141J, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Tyler J. Fulton, Anthony Y. Chen, Michael D. Bartberger, Brian M. Stoltz
A catalytic enantioselective approach to the Myrioneuron alkaloids (−)-myrifabral A and (−)-myrifabral B is described.
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Synthesis and properties of hypervalent electron-rich pentacoordinate nitrogen compounds

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC00002G, Edge Article
Open Access
Chenting Yan, Masato Takeshita, Jun-ya Nakatsuji, Akihiro Kurosaki, Kaoko Sato, Rong Shang, Masaaki Nakamoto, Yohsuke Yamamoto, Yohei Adachi, Ko Furukawa, Ryohei Kishi, Masayoshi Nakano
Structural characterization of hypervalent electron-rich pentacoordinate nitrogen species has long been a synthetic challenge. Here we report the first nitrogen cationic radical (11-N-5) species featuring a weak hypervalent 3c-5e interaction.
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Selective electrochemical reduction of carbon dioxide to ethanol via a relay catalytic platform

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC01133A, Edge Article
Open Access
Juan Du, Shaopeng Li, Shulin Liu, Yu Xin, Bingfeng Chen, Huizhen Liu, Buxing Han
The relay catalytic platform is very efficient and selective for CO2 electroreduction to ethanol.
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Geometric landscapes for material discovery within energy–structure–function maps

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC00049C, Edge Article
Open Access
Seyed Mohamad Moosavi, Henglu Xu, Linjiang Chen, Andrew I. Cooper, Berend Smit
We introduce a representation for the geometric features of the pores of porous molecular crystals. This representation provides a good basis for supervised (predict adsorption properties) and unsupervised (polymorph classification) tasks.
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Ultraviolet photochemistry of ethane: implications for the atmospheric chemistry of the gas giants

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC01746A, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yao Chang, Jiayue Yang, Zhichao Chen, Zhiguo Zhang, Yong Yu, Qingming Li, Zhigang He, Weiqing Zhang, Guorong Wu, Rebecca A. Ingle, Matthew Bain, Michael N. R. Ashfold, Kaijun Yuan, Xueming Yang, Christopher S. Hansen
The vacuum ultraviolet photodissociation dynamics of ethane provide clues for modelling the atmospheric chemistry of the gas giants.
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Determination of protein-ligand binding modes using fast multi-dimensional NMR with hyperpolarization

Chem. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0SC00266F, Edge Article
Open Access
Yunyi Wang, Jihyun Kim, Christian Hilty
Elucidation of small molecule-protein interactions provides essential information for understanding biological processes such as cellular signaling, as well as for rational drug development. Here, multi-dimensional NMR with sensitivity enhancement by...
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Enlightening advances in polymer bioconjugate chemistry: light-based techniques for grafting to and from biomacromolecules

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC01544J, Perspective
Open Access
Rebecca A. Olson, Angie B. Korpusik, Brent S. Sumerlin
Light-driven synthetic techniques have revolutionized polymer–biomacromolecule conjugation. This Perspective discusses the benefits of photochemistry for polymer–protein ligation and considerations when designing a new light-driven conjugation approach.
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Quinone Methide Dimers Lacking Labile Hydrogen Atoms Are Surprisingly Excellent Radical-Trapping Antioxidants

Chem. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0SC02020F, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Derek A. Pratt, Mark A R Raycroft, Jean-Philippe R Chauvin, Matthew Galliher, Kevin Romero, Corey Stephenson
Hydrogen atom transfer (HAT) is the mechanism by which the vast majority of radical-trapping antioxidants (RTAs), such as hindered phenols, inhibit autoxidation. As such, at least one weak O–H bond...
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Correction: Enantioselective synthesis of isochromans and tetrahydroisoquinolines by C–H insertion of donor/donor carbenes

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC90081H, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Leslie A. Nickerson, Benjamin D. Bergstrom, Mingchun Gao, Yuan-Shin Shiue, Croix J. Laconsay, Matthew R. Culberson, Walker A. Knauss, James C. Fettinger, Dean J. Tantillo, Jared T. Shaw
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Synthesis of unstrained Criegee intermediates: inverse α-effect and other protective stereoelectronic forces can stop Baeyer-Villiger rearrangement of γ-hydroperoxy-γ-peroxylactones

Chem. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0SC01025A, Edge Article
Open Access
Vera A. Vil', Yana Barsegyan, Leah Kuhn, Maria V. Ekimova, Egor A. Semenov, Alexander Korlyukov, Alexander Olegovich Terent'ev, Igor Alabugin
How far can we push the limits in removing stereoelectronic protection from an unstable intermediate? We address this question by exploring the interplay between the primary and secondary stereoelectronic effects...
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Regioselective Molybdenum-catalyzed allylic substitution of tertiary allylic electrophiles: methodology development and applications

Chem. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0SC01763A, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Muhammad Salman, Yaoyao Xu, Shahid Khan, Junjie Zhang, Ajmal Khan
The first molybdenum-catalyzed allylic sulfonylation of tertiary allylic electrophile is described. The method utilizes a readily accesable catalyst (Mo(CO)6/2,2'-bipyridine, both are commercially available) and represent the first example of the...
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Direct and quantitative monitoring of catalytic organic reactions under heterogeneous conditions using direct analysis in real time mass spectrometry

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC00021C, Edge Article
Open Access
Koichiro Masuda, Shū Kobayashi
A direct and quantitative method for monitoring heterogeneous organic reactions has been developed by using direct analysis in real time mass spectrometry (DART-MS) with an isotope-labeled reaction product as an internal standard.
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Cancer cell discrimination and dynamic viability monitoring through wash-free bioimaging using AIEgens

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC01213K, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ruoyao Zhang, Guangle Niu, Qing Lu, Xiaolin Huang, Joe H. C. Chau, Ryan T. K. Kwok, Xiaoqiang Yu, Min-Hui Li, Jacky W. Y. Lam, Ben Zhong Tang
We present a series of AIEgens for cancer cell discrimination and dynamic viability monitoring.
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Near-infrared light-activated membrane fusion for cancer cell therapeutic applications

Chem. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0SC00863J, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Fujian Huang, Ruilin Duan, Zhixin Zhou, Margarita Vázquez-González, fan xia, Itamar Willner
The spatiotemporal stimulation of liposome-liposome or liposome-membrane fusion processes attracts growing interest as a means to mimic cell-cell interactions in nature and for using these processes for biomedical applications. We...
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Observations of tetrel bonding between sp3–carbon and THF

Chem. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0SC01559H, Edge Article
Open Access
Victoria V. L. Heywood, T. P. J. Alford, Julius J.J. Roeleveld, Siebe S. J. Lekanne-Deprez, Abraham A. Verhoofstad, Jarl Ivar van der Vlugt, Melanie Schnell, Sérgio R Domingos, Anthony P. Davis, Tiddo Jonathan Mooibroek
We report the direct observation of tetrel bonding interactions between sp3-carbons of the supramolecular synthon 3,3-dimethyl-tetracyanocyclopropane (1) and tetrahydrofuran in the gas and crystalline phase. The intermolecular contact is established...
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N2Phos – an easily made, highly effective ligand designed for ppm level Pd-catalyzed Suzuki–Miyaura cross couplings in water

Chem. Sci., 2020, Advance Article
DOI: 10.1039/D0SC00968G, Edge Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Nnamdi Akporji, Ruchita R. Thakore, Margery Cortes-Clerget, Joel Andersen, Evan Landstrom, Donald H. Aue, Fabrice Gallou, Bruce H. Lipshutz
A new, biaryl phosphine-containing ligand, N2Phos, forms a 1 : 1 complex with Pd resulting in an active catalyst at the ppm level for Suzuki–Miyaura couplings in water, enabled by an aqueous micellar medium. Notably, aryl chlorides are shown to be amenable substrates.
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Enhancing catalytic alkane hydroxylation by tuning the outer coordination sphere in a heme-containing metal–organic framework

Chem. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0SC01796E, Edge Article
Open Access
David Zhi Hong Zee, T. David Harris
Catalytic heme active sites of enzymes are sequestered by the protein superstructure and are regulated by precisely defined outer coordination spheres. Here, we emulate both of these protective functions in...
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A time-domain view of charge carriers in semiconductor nanocrystal solids

Chem. Sci., 2020, Advance Article
DOI: 10.1039/C9SC05925C, Perspective
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Wenbi Shcherbakov-Wu, William A. Tisdale
Time-domain spectroscopy and transient photocurrent techniques have revealed new understanding of mesoscale carrier dynamics in nanocrystal solids, including the role of energetic disorder, interactions with trap states, and nonequilibrium dynamics
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Electrochemical Radical Reactions of Alkyl Iodides: A Highly Efficient, Clean, Green Alternative to Tin Reagents

Chem. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0SC01694B, Edge Article
Open Access
diyuan Li, Tsz-Kan Ma, Reuben J Scott, Jonathan David Wilden
An electrochemical ‘redox-relay’ system has been developed which allows the generation of C-centered radicals. Intermolecular ‘tin-like’ radical reactions can subsequently be conducted under the most benign of conditions. The yields...
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an

It's not the right stage to put differential premium on banks: Finance Secy

Finance minister had announced hiking the deposit insurance limit to Rs 5 lakh for each bank depositor




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BS Insurance Round Table 2020: No major impact of tax change, say experts

Six top life insurance executives brainstorm on the impact of tax exemption removal and the upcoming IPO of Life Insurance Corporation. Edited Excerpts:




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BS Insurance Round Table: Sandbox opens up avenues for bundling services

A power-packed panel said that AI is the game changer in the non-life insurance business and underlined the need to generate underwriting profits and rely less on investment gains




an

YES Bank okays board reconstitution; Prashant Kumar to be new MD & CEO

The other board members will be Sunil Mehta, former non-executive chairman of Punjab National Bank, as the non executive chairman of YES Bank




an

Issue closing stats for any repo

tl;dr: If you just want to quickly get stats for a repo, you can find the app here. The rest of this post explains how it’s built with Mavo HTML, CSS, and 0 lines of JS. Or, if you’d prefer, you can just View Source — it’s all there! One of the cool things about […]




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LCH colors in CSS: what, why, and how?

I was always interested in color science. In 2014, I gave a talk about CSS Color 4 at various conferences around the world called “The Chroma Zone”. Even before that, in 2009, I wrote a color picker that used a hidden Java applet to support ICC color profiles to do CMYK properly, a first on […]




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Weather Warnings for Queensland - land areas. Issued by the Australian Bureau of Meteorology




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Lockdown: Blood banks run ‘dry’ in Patna

Blood banks in the city are facing an acute shortage of blood as regular donors are not showing up due to the lockdown. While some donors said they avoid going to blood bank as it would amount to violation of lockdown, others are apprehensive of getting infected by Covid-19.




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Many electronics shops defy DM’s order in Patna

A day after the state home department issued an order allowing certain categories of shops to reopen, some electronics, electrical and vehicle spare parts shops reopened in the city on Thursday.




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Wife dead, man held on dowry charges in Patna

A 30-year-old man was arrested in Patna after his wife was found dead at their home in Shivpuri under Shastri Nagar police station area on Thursday. The couple, Manish Kumar and Anita Devi, were marred in 2017.




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Bihar hands over 68-bed AES ward to SKMCH

A fully-equipped 68-bed AES ward was formally handed over to the Sri Krishna Medical College and Hospital (SKMCH) at Muzaffarpur by the state government on Thursday.




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Bihar to go for 1,000 random Covid tests a day

With the increase in inflow of migrants to Bihar, the state government has decided to go for a new strategy to contain the spread of Covid-19 pandemic — random samplings of 1,000 migrants in a day with focus on those coming from red zones.




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Monitor kitchens at quarantine centres: Bihar CM

CM Nitish Kumar on Friday asked chief secretary Deepak Kumar to increase the number of kitchens proportionate to people staying at each quarantine centre so that they could get quality meals on time.




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Bihar man held, stolen gold biscuits seized

Police arrested one Mohan Kumar (30) from Shivaji Nagar Bagicha under the Digha police station area in Patna on Friday and recovered stolen gold biscuits, jewellery and cash worth around Rs 20 lakh from his possession.




an

Is it possible to enter an IPO bid below floor price?

Floor price is the minimum price at which bids can be made for offer.




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For how many days is an IPO open?

At present, it takes six days for a stock to get listed on the exchanges after a successful bidding process.