ri Geology of Terrace map-area, British Columbia (103 I E1/2) By geoscan.nrcan.gc.ca Published On :: Tue, 21 Oct 2014 00:00:00 EDT Re-release; Duffell, S; Souther, J G. 329, 1964, 131 pages (3 sheets), https://doi.org/10.4095/100553 Full Article
ri Precambrian geology of Hecla-carroll map area, Manitoba-ontario (62p E1/2, 52m W1/2) By geoscan.nrcan.gc.ca Published On :: Fri, 11 Mar 2016 00:00:00 EDT Re-release; Ermanovics, I F. 69-42, 1970, 33 pages (2 sheets), https://doi.org/10.4095/102301 Full Article
ri Stratigraphy, facies and paleogeography of Mesozoic and Tertiary rocks of northern Yukon and northwest Mackenzie District, N.W.T. (NTS-107B, 106M, 117A, 116O (N1/2), 116I, 116H, 116J, 116K (E1/2)) By geoscan.nrcan.gc.ca Published On :: Fri, 27 Jan 2017 00:00:00 EDT Re-release; Jeletzky, J A. 1972, 72 pages (3 sheets), https://doi.org/10.4095/129163 Full Article
ri Geology of Fort Grahame E1/2 map-area, British Columbia By geoscan.nrcan.gc.ca Published On :: Tue, 15 Mar 2016 00:00:00 EDT Re-release; Gabrielse, H. 75-33, 1975, 28 pages (2 sheets), https://doi.org/10.4095/102605 Full Article
ri Surficial geology, Quyon, Quebec and Ontario 31F/9 E1/2 By geoscan.nrcan.gc.ca Published On :: Tue, 06 Jun 2017 00:00:00 EDT Re-release; Richard, S H. 1976, 1 sheet, https://doi.org/10.4095/129465<a href="https://geoscan.nrcan.gc.ca/images/geoscan/of0363.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/of0363.jpg" title=" 1976, 1 sheet, https://doi.org/10.4095/129465" height="150" border="1" /></a> Full Article
ri Airborne gamma ray spectrometric maps, Prosperous Lake - Hidden Lake area, Northwest Territories [85i/12, J/9 [E1/2], parts of 85i/11, 5, 6, 13, 14, J/8] By geoscan.nrcan.gc.ca Published On :: Tue, 09 Oct 2018 00:00:00 EDT Re-release; Geological Survey of Canada. 1989, 81 pages, https://doi.org/10.4095/130681<a href="https://geoscan.nrcan.gc.ca/images/geoscan/of_1978.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/of_1978.jpg" title=" 1989, 81 pages, https://doi.org/10.4095/130681" height="150" border="1" /></a> Full Article
ri Geology, Mount St. Elias map area [115B & C[E1/2]], Yukon Territory By geoscan.nrcan.gc.ca Published On :: Thu, 02 Oct 2014 00:00:00 EDT Re-release; Dodds, C J; Campbell, R B. 1992, 85 pages (1 sheet), https://doi.org/10.4095/133475<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gscof_2189_e_1992_mn01.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gscof_2189_e_1992_mn01.jpg" title=" 1992, 85 pages (1 sheet), https://doi.org/10.4095/133475" height="150" border="1" /></a> Full Article
ri Geology, SW Kluane Lake map area [115G & F [E1/2]], Yukon Territory By geoscan.nrcan.gc.ca Published On :: Thu, 02 Oct 2014 00:00:00 EDT Re-release; Dodds, C J; Campbell, R B. 1992, 85 pages (1 sheet), https://doi.org/10.4095/133474<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gscof_2188_e_1992_mn01.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gscof_2188_e_1992_mn01.jpg" title=" 1992, 85 pages (1 sheet), https://doi.org/10.4095/133474" height="150" border="1" /></a> Full Article
ri In a cancel culture, anonymity must be a civil right By www.washingtonexaminer.com Published On :: Tue, 06 Jul 2021 04:00:20 GMT Anonymity, in ordinary times, is a tough topic to wrestle with. These days, however, it’s easy: Dissent, and thus democracy, will only survive in today’s culture if anonymity is preserved. Full Article
ri Biden's embrace of Saudi prince shows that his only principle was defeating Trump By www.washingtonexaminer.com Published On :: Fri, 09 Jul 2021 04:00:47 GMT At this point, it may be fair to say President Joe Biden’s criticisms of his predecessor have nothing to do with principles. It was all politics, all the way down. Full Article
ri Yes, critical race theory is being taught in public schools By www.washingtonexaminer.com Published On :: Mon, 12 Jul 2021 04:01:47 GMT While we all debate what critical race theory is and whether lawmakers should ban it from public schools, every honest person should agree on one thing: This theory is behind the curricula in school districts all over the country, shaping the minds of unsuspecting, malleable children. Full Article
ri Climate hypocrites are all tell, no show By www.washingtonexaminer.com Published On :: Tue, 23 Aug 2022 11:14:57 GMT Many celebrities are full of sermons about how you need to save the planet. Often, they are the very same ones maximizing their own carbon footprints by flying on private jets. This has long been known, but the internet has now made it significantly easier to quantify their hypocrisy. Full Article
ri CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients By scienceblogs.com Published On :: Thu, 06 Feb 2020 19:52:53 +0000 CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients In the first-ever (sanctioned) investigational use of multiple edits to the human genome, a study found that cells edited in three specific ways and then removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion. This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients' immune cells. The ongoing study is a cooperative between Tmunity Therapeutics, the Parker Institute for Cancer Immunotherapy, and the University of Pennsylvania. Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, co-lead author on the study. The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient's T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell's natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job. Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months. Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors. The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events. CRISPR technology has not previously been tested in humans in the U.S. so the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health's Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn's institutional review board and institutional biosafety committee. The entire process required more than two years. Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn. sb admin Thu, 02/06/2020 - 14:52 Categories Life Sciences Full Article
ri Terrifying the public about COVID or other health concerns is bad for their health By www.washingtonexaminer.com Published On :: Wed, 27 Dec 2023 17:33:39 GMT Back around 2010, just before Halloween, a reporter friend retweeted a local police department’s warning to check your kids’ candy for drugs or razor blades or something like that. I asked, “Is there any evidence of something like that ever happening?” Full Article
ri Federal judge blocks Idaho child gender transition law, claiming parental rights By www.washingtonexaminer.com Published On :: Thu, 28 Dec 2023 23:07:09 GMT A federal judge in Idaho issued a block on a state law that would ban gender transitions for children before it was set to go into effect Jan. 1. Full Article
ri Are we on the cusp of historic medical breakthroughs? By www.washingtonexaminer.com Published On :: Sun, 31 Dec 2023 13:18:48 GMT During my lifetime, there have been numerous seminal breakthroughs in medicine that greatly changed our ability to prevent or treat disease. I have a good idea of what the next ones will be. Full Article
ri Home economics: The human cost of the affordability crisis By www.washingtonexaminer.com Published On :: Tue, 05 Dec 2023 11:00:37 GMT Soaring mortgage rates have combined with high housing prices to push homebuying out of reach for many people, causing major knock-on effects on their lives. Full Article
ri Gov. Josh Green threatens to bring down 'hammer' on landlords in fallout from Hawaii fire By www.washingtonexaminer.com Published On :: Sat, 16 Dec 2023 18:03:07 GMT Gov. Josh Green (D-HI) has threatened to use the "hammer" of emergency orders to convert 3,000 temporary vacation rentals into longer-term housing for survivors displaced by the wildfire that swept across the island of Maui in August. Full Article
ri Existing home sales rise for first time in six months as mortgage rates moderate By www.washingtonexaminer.com Published On :: Wed, 20 Dec 2023 15:03:50 GMT Last month, existing home sales increased for the first time since May as mortgage rates began to moderate. Full Article
ri Historic Langston to enter National Black Golf Hall of Fame By www.washingtonexaminer.com Published On :: Fri, 25 Jan 2013 05:00:00 GMT Langston Golf Course in Washington, D.C., the first golf course built specifically for African-American golfers, will be inducted into the National Black Golf Hall of Fame. The ceremony will take place March 23 in Tampa. Full Article
ri Sheedy wins IJGT event in Arizona By www.washingtonexaminer.com Published On :: Tue, 02 Apr 2013 04:00:00 GMT Will Sheedy of the District shot 80-76 – 156 on Friday and Saturday to win the 14-and-under division of an International Junior Golf Tour event at Wigwam Golf Resort in Litchfield Park, Ariz. Sheedy came from four strokes back in the final round to edge Remington Hirano of Honolulu by one stroke. Full Article
ri Why do the Washington Wizards keep honoring a Chinese Communist? By www.washingtonexaminer.com Published On :: Thu, 29 Dec 2022 14:59:57 GMT The NBA’s groveling to China has slipped from public view in recent months, but the Washington Wizards are doing what they can to remind everyone that the league is in bed with a genocidal regime. Full Article
ri WATCH LIVE: Glenn Youngkin announces sports arena project in Alexandria, Virginia By www.washingtonexaminer.com Published On :: Wed, 13 Dec 2023 14:00:38 GMT Gov. Glenn Youngkin (R-VA) and Monumental Sports are announcing a $2 billion sports arena and entertainment district set to be built in the Potomac Yard neighborhood of Alexandria, Virginia. Full Article
ri DC Mayor Muriel Bowser forgets which Metro lines service arena stop while defending keeping teams downtown By www.washingtonexaminer.com Published On :: Wed, 13 Dec 2023 20:58:49 GMT Washington, D.C., Mayor Muriel Bowser forgot which lines on the D.C. Metro service Capital One Arena while trying to argue against the NBA's Washington Wizards and the NHL's Washington Capitals moving to a new arena in Virginia. Full Article
ri Winsome Sears says crime in DC was 'issue' in Capitals-Wizards arena move By www.washingtonexaminer.com Published On :: Thu, 14 Dec 2023 03:47:37 GMT Virginia Republican Lt. Gov. Winsome Sears cheered on the historic tentative move of the Washington Wizards and Washington Capitals teams to Potomac Yard in Alexandria, Virginia, while also lamenting that Washington, D.C.'s crime wave and safety concerns were a factor in the location change. Full Article
ri The Debrief with Conn Carroll: Why Wizards and Capitals are leaving DC By www.washingtonexaminer.com Published On :: Sun, 17 Dec 2023 17:00:33 GMT Washington Examiner Commentary Editor Conn Carroll joins Investigations Editor Sarah Bedford to discuss how Washington, D.C., has been wrecked by crime and why the Wizards and Capitals are moving out of the district, as well as the border talks occurring in the Senate. Full Article
ri Majority of Virginians are against electric vehicle mandate: Poll By www.washingtonexaminer.com Published On :: Thu, 04 Jan 2024 16:48:42 GMT While some Virginians weren't previously aware of their state's mandate to only sell electric vehicles after 2035, most are against it. Full Article
ri Youngkin seeks to aid cake pop makers over state policy restriction By www.washingtonexaminer.com Published On :: Thu, 04 Jan 2024 21:50:57 GMT Gov. Glenn Youngkin (R-VA) is seeking to address food safety concerns within Virginia, which have become an obstruction for some small-business owners. Full Article
ri Army removes Confederate Memorial put up in 1914 from Arlington National Cemetery By www.washingtonexaminer.com Published On :: Fri, 05 Jan 2024 00:10:44 GMT Army removes Confederate Memorial from Arlington National Cemetery as Civil War-era controversies continue to roil national and local politics. Full Article
ri Glenn Youngkin’s popularity at record high, approval throughout Virginia By www.washingtonexaminer.com Published On :: Fri, 05 Jan 2024 18:03:32 GMT Virginia Gov. Glenn Youngkin’s popularity continues to soar, even after voters turned the commonwealth’s general assembly over to Democrats. Full Article
ri Power-hungry AI data centers are raising electric bills and blackout risk By www.latimes.com Published On :: Mon, 12 Aug 2024 10:00:28 GMT Experts warn that a frenzy of data center construction could delay California's transition away from fossil fuels, raise electric bills and increase risk of blackouts Full Article
ri What Elmo — and his human friends — learned by asking Americans about their mental health By www.latimes.com Published On :: Thu, 15 Aug 2024 10:00:49 GMT Mental and emotional health is on a par with physical health and financial security when it comes to negative impacts on overall well-being, researchers say. Full Article
ri Fast, wet and furious: How the North American monsoon floods the California desert By www.latimes.com Published On :: Sat, 17 Aug 2024 10:00:46 GMT The North American monsoon plays an important role in the climate of the Four Corners states, bringing crucial moisture to areas that would otherwise be dry. Full Article
ri COVID and bird flu are rising. Here's how to keep yourself safe By www.latimes.com Published On :: Tue, 20 Aug 2024 10:00:43 GMT Doctors urge people who are experiencing respiratory problems to see a medical professional who can check their symptoms and test to determine what their illness is. Full Article
ri SpaceX will bring Boeing's Starliner astronauts home from the International Space Station By www.latimes.com Published On :: Sat, 24 Aug 2024 18:00:21 GMT NASA Administrator Bill Nelson said the decision was driven by the agency's commitment to safety, especially after the disasters that beset the space shuttle program. Full Article
ri Earthquake risks and rising costs: The price of operating California's last nuclear plant By www.latimes.com Published On :: Sun, 25 Aug 2024 10:00:13 GMT The plant supplies 6% of California's power, yet critics charge the facility is too expensive and too dangerous to continue operating. Full Article
ri Growing need. Glaring gaps. Why mental health care can be a struggle for autistic youth By www.latimes.com Published On :: Tue, 27 Aug 2024 10:00:08 GMT Autistic people and their families say they can't find adequate help in their communities before they reach a crisis point. Full Article
ri Climate warriors fighting some of the 'greatest crises humanity has ever seen' By www.latimes.com Published On :: Tue, 10 Sep 2024 10:00:31 GMT 'Something that Sunrise has taught me, and that I've learned from the world around me, is that hope comes through collective action but is also something that you need to practice.' Full Article
ri How to rediscover hope during election season By www.latimes.com Published On :: Thu, 12 Sep 2024 10:00:42 GMT In his new book 'Hope for Cynics,' Stanford psychology professor Jamil Zaki explains how cynicism became an American epidemic — and how to cure it. Full Article
ri A huge deposit of marine fossils found under San Pedro High School By www.latimes.com Published On :: Fri, 13 Sep 2024 10:00:28 GMT San Pedro High School discovered a deposit of marine fossils on campus in 2022 and began collaborating with local paleontologists to uncover secrets from the Palos Verdes Peninsula's geological past. Full Article
ri Cedars-Sinai terminates OB-GYN's hospital privileges after complaint investigation By www.latimes.com Published On :: Sat, 14 Sep 2024 10:00:28 GMT An obstetrician-gynecologist has been barred from practicing at Cedars-Sinai following an investigation into complaints. The doctor has denied wrongdoing. Full Article
ri An industrial chemical is showing up in fentanyl in the U.S., troubling scientists By www.latimes.com Published On :: Mon, 16 Sep 2024 18:32:17 GMT An industrial chemical used in plastic products has been cropping up in illegal drugs from California to Maine. Full Article
ri 'Grief into action.' Philanthropists give historic $150 million donation to City of Hope for pancreatic cancer research By www.latimes.com Published On :: Tue, 17 Sep 2024 09:30:06 GMT Entrepreneur Emmet Stephenson and his daughter are giving $150 million to City of Hope to fund an award for innovation research in pancreatic cancer. It's the largest single gift the center has received. Full Article
ri Tortured by regret? Here's a trick to make peace with the past By www.latimes.com Published On :: Wed, 18 Sep 2024 10:00:30 GMT A new study from Temple University offers an easy road map for how to reframe and conquer regrets, no matter how big or small. Full Article
ri Number of California dairy herds infected with H5N1 bird flu rises to 17 By www.latimes.com Published On :: Fri, 20 Sep 2024 20:20:02 GMT With 17 dairy herds in California now infected with bird flu, the state is upping its surveillance. Full Article
ri New genetic research points to Wuhan animal market as origin of COVID pandemic, study says By www.latimes.com Published On :: Sat, 21 Sep 2024 10:00:36 GMT Samples taken in the pandemic's early weeks reinforce hypothesis that coronavirus emerged from live animal market, not a laboratory, new study says. Full Article
ri Virus that can cause paralysis in children is on the rise in California: A few safeguards By www.latimes.com Published On :: Tue, 24 Sep 2024 10:00:39 GMT Enterovirus D68, which in rare cases can cause polio-like paralysis in children, is on the rise in California and across the nation, analyses show. Full Article
ri Concern grows as bird flu outbreaks continue to rise among California dairy herds By www.latimes.com Published On :: Tue, 24 Sep 2024 10:00:54 GMT The number of dairy herds infected with H5N1 Bird Flu doubled over the weekend. The count is now 34. Full Article
ri Brett Favre, testifying at welfare fraud hearing, reveals he has Parkinson's By www.latimes.com Published On :: Tue, 24 Sep 2024 17:38:19 GMT Brett Favre, 54, says he has Parkinson's disease while testifying before a House committee about welfare fraud in which he was allegedly involved in Mississippi. Full Article
ri Depression was rising among young people in Southern California. COVID made it worse By www.latimes.com Published On :: Tue, 1 Oct 2024 15:00:24 GMT New data from Southern California children, teens and young adults show that rising rates of depression and anxiety increased further during the pandemic. Full Article