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Geology of Terrace map-area, British Columbia (103 I E1/2)

Re-release; Duffell, S; Souther, J G. 329, 1964, 131 pages (3 sheets), https://doi.org/10.4095/100553




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Precambrian geology of Hecla-carroll map area, Manitoba-ontario (62p E1/2, 52m W1/2)

Re-release; Ermanovics, I F. 69-42, 1970, 33 pages (2 sheets), https://doi.org/10.4095/102301




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Stratigraphy, facies and paleogeography of Mesozoic and Tertiary rocks of northern Yukon and northwest Mackenzie District, N.W.T. (NTS-107B, 106M, 117A, 116O (N1/2), 116I, 116H, 116J, 116K (E1/2))

Re-release; Jeletzky, J A. 1972, 72 pages (3 sheets), https://doi.org/10.4095/129163




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Geology of Fort Grahame E1/2 map-area, British Columbia

Re-release; Gabrielse, H. 75-33, 1975, 28 pages (2 sheets), https://doi.org/10.4095/102605




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Surficial geology, Quyon, Quebec and Ontario 31F/9 E1/2

Re-release; Richard, S H. 1976, 1 sheet, https://doi.org/10.4095/129465
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/of0363.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/of0363.jpg" title=" 1976, 1 sheet, https://doi.org/10.4095/129465" height="150" border="1" /></a>




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Airborne gamma ray spectrometric maps, Prosperous Lake - Hidden Lake area, Northwest Territories [85i/12, J/9 [E1/2], parts of 85i/11, 5, 6, 13, 14, J/8]

Re-release; Geological Survey of Canada. 1989, 81 pages, https://doi.org/10.4095/130681
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/of_1978.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/of_1978.jpg" title=" 1989, 81 pages, https://doi.org/10.4095/130681" height="150" border="1" /></a>




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Geology, Mount St. Elias map area [115B & C[E1/2]], Yukon Territory

Re-release; Dodds, C J; Campbell, R B. 1992, 85 pages (1 sheet), https://doi.org/10.4095/133475
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gscof_2189_e_1992_mn01.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gscof_2189_e_1992_mn01.jpg" title=" 1992, 85 pages (1 sheet), https://doi.org/10.4095/133475" height="150" border="1" /></a>




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Geology, SW Kluane Lake map area [115G & F [E1/2]], Yukon Territory

Re-release; Dodds, C J; Campbell, R B. 1992, 85 pages (1 sheet), https://doi.org/10.4095/133474
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gscof_2188_e_1992_mn01.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gscof_2188_e_1992_mn01.jpg" title=" 1992, 85 pages (1 sheet), https://doi.org/10.4095/133474" height="150" border="1" /></a>




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In a cancel culture, anonymity must be a civil right

Anonymity, in ordinary times, is a tough topic to wrestle with. These days, however, it’s easy: Dissent, and thus democracy, will only survive in today’s culture if anonymity is preserved.




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Biden's embrace of Saudi prince shows that his only principle was defeating Trump

At this point, it may be fair to say President Joe Biden’s criticisms of his predecessor have nothing to do with principles. It was all politics, all the way down.




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Yes, critical race theory is being taught in public schools

While we all debate what critical race theory is and whether lawmakers should ban it from public schools, every honest person should agree on one thing: This theory is behind the curricula in school districts all over the country, shaping the minds of unsuspecting, malleable children.




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Climate hypocrites are all tell, no show

Many celebrities are full of sermons about how you need to save the planet. Often, they are the very same ones maximizing their own carbon footprints by flying on private jets. This has long been known, but the internet has now made it significantly easier to quantify their hypocrisy.




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CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

In the first-ever (sanctioned) investigational use of multiple edits to the human genome, a study found that cells edited in three specific ways and then removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion.

This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients' immune cells. The ongoing study is a cooperative between Tmunity Therapeutics, the Parker Institute for Cancer Immunotherapy, and the University of Pennsylvania. 

Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, co-lead author on the study. The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient's T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell's natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job. 

Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months. 

Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors. 

The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events. 

CRISPR technology has not previously been tested in humans in the U.S. so the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health's Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn's institutional review board and institutional biosafety committee. The entire process required more than two years.

 Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn.

sb admin Thu, 02/06/2020 - 14:52
Categories




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Terrifying the public about COVID or other health concerns is bad for their health

Back around 2010, just before Halloween, a reporter friend retweeted a local police department’s warning to check your kids’ candy for drugs or razor blades or something like that. I asked, “Is there any evidence of something like that ever happening?”




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Federal judge blocks Idaho child gender transition law, claiming parental rights

A federal judge in Idaho issued a block on a state law that would ban gender transitions for children before it was set to go into effect Jan. 1.




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Are we on the cusp of historic medical breakthroughs?

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Home economics: The human cost of the affordability crisis

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Existing home sales rise for first time in six months as mortgage rates moderate

Last month, existing home sales increased for the first time since May as mortgage rates began to moderate.




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Historic Langston to enter National Black Golf Hall of Fame

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Sheedy wins IJGT event in Arizona

Will Sheedy of the District shot 80-76 – 156 on Friday and Saturday to win the 14-and-under division of an International Junior Golf Tour event at Wigwam Golf Resort in Litchfield Park, Ariz. Sheedy came from four strokes back in the final round to edge Remington Hirano of Honolulu by one stroke.




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Why do the Washington Wizards keep honoring a Chinese Communist?

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WATCH LIVE: Glenn Youngkin announces sports arena project in Alexandria, Virginia

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DC Mayor Muriel Bowser forgets which Metro lines service arena stop while defending keeping teams downtown

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Winsome Sears says crime in DC was 'issue' in Capitals-Wizards arena move

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The Debrief with Conn Carroll: Why Wizards and Capitals are leaving DC

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Majority of Virginians are against electric vehicle mandate: Poll

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Youngkin seeks to aid cake pop makers over state policy restriction

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Army removes Confederate Memorial put up in 1914 from Arlington National Cemetery

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Glenn Youngkin’s popularity at record high, approval throughout Virginia

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What Elmo — and his human friends — learned by asking Americans about their mental health

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Fast, wet and furious: How the North American monsoon floods the California desert

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COVID and bird flu are rising. Here's how to keep yourself safe

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SpaceX will bring Boeing's Starliner astronauts home from the International Space Station

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Earthquake risks and rising costs: The price of operating California's last nuclear plant

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Growing need. Glaring gaps. Why mental health care can be a struggle for autistic youth

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Climate warriors fighting some of the 'greatest crises humanity has ever seen'

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How to rediscover hope during election season

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A huge deposit of marine fossils found under San Pedro High School

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Cedars-Sinai terminates OB-GYN's hospital privileges after complaint investigation

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An industrial chemical is showing up in fentanyl in the U.S., troubling scientists

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'Grief into action.' Philanthropists give historic $150 million donation to City of Hope for pancreatic cancer research

Entrepreneur Emmet Stephenson and his daughter are giving $150 million to City of Hope to fund an award for innovation research in pancreatic cancer. It's the largest single gift the center has received.




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Tortured by regret? Here's a trick to make peace with the past

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Number of California dairy herds infected with H5N1 bird flu rises to 17

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New genetic research points to Wuhan animal market as origin of COVID pandemic, study says

Samples taken in the pandemic's early weeks reinforce hypothesis that coronavirus emerged from live animal market, not a laboratory, new study says.




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Virus that can cause paralysis in children is on the rise in California: A few safeguards

Enterovirus D68, which in rare cases can cause polio-like paralysis in children, is on the rise in California and across the nation, analyses show.




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Concern grows as bird flu outbreaks continue to rise among California dairy herds

The number of dairy herds infected with H5N1 Bird Flu doubled over the weekend. The count is now 34.




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Brett Favre, testifying at welfare fraud hearing, reveals he has Parkinson's

Brett Favre, 54, says he has Parkinson's disease while testifying before a House committee about welfare fraud in which he was allegedly involved in Mississippi.




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Depression was rising among young people in Southern California. COVID made it worse

New data from Southern California children, teens and young adults show that rising rates of depression and anxiety increased further during the pandemic.