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CBD News: Ambassador Mary Seet-Cheng, Chair of the East Asian Seas Partnership Council, Viet Nam Deputy Minister of Natural Resources and Environment, Chu Pham Ngoc Hien, PEMSEA Executive Director, Stephen Adrian Ross, Dr. Chua Thia-Eng, Chair Emeritus of

By www.cbd.int
Published On :: Wed, 18 Nov 2015 00:00:00 GMT


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CBD News: Statement by Mr. Braulio F. de Souza Dias, CBD Executive Secretary, at the opening of the Biodiversity Indicator Partnership Technical Partner Meeting, Cambridge, United Kingdom, 25-27 January 2016

By www.cbd.int
Published On :: Mon, 25 Jan 2016 00:00:00 GMT


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CBD News: With the aim to encourage positive action for biodiversity and inspire others by showcasing the notable work of those it honours, nominations are now invited for the MIDORI Prize for Biodiversity 2016. The call for nominations remains open from

By www.cbd.int
Published On :: Mon, 15 Feb 2016 00:00:00 GMT


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CBD News: Ratifications by Togo and the United Kingdom of Great Britain and Northern Ireland has brought the total number of ratifications to the Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from th

By www.cbd.int
Published On :: Fri, 26 Feb 2016 00:00:00 GMT


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CBD News: Forests are crucial to the sustainable management of water ecosystems and resources, and water is essential for the sustainability of forest ecosystems. Let us work together and redouble our efforts to ensure that our forests remain healthy now

By www.cbd.int
Published On :: Sun, 20 Mar 2016 00:00:00 GMT


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CBD News: In anticipation of the discussions to take place at the thirteenth meeting of the Conference of Parties (COP 13) to the Convention on Biological Diversity (CBD) later this year, Latin American and Caribbean Ministers of Environment have adopted

By www.cbd.int
Published On :: Thu, 07 Apr 2016 00:00:00 GMT


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CBD News: The twentieth meeting of the Subsidiary Body on Scientific, Technical and Technological Advice (SBSTTA-20) of the Convention on Biological Diversity (CBD) came to a close on 30 April 2016 with the adoption of a number of key recommendations that

By www.cbd.int
Published On :: Wed, 04 May 2016 00:00:00 GMT


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CBD News: This year's World Day to Combat Desertification shows the importance of being inclusive as we cooperate to restore and rehabilitate degraded land. It also points to the convergence of international action and landmark agreements recently ado

By www.cbd.int
Published On :: Fri, 17 Jun 2016 00:00:00 GMT


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CBD News: The Food and Agriculture Organization of the United Nations (FAO) and the Secretariat of the Convention on Biological Diversity (CBD) have launched a technical guidance document which aims to promote mainstreaming of biodiversity and ecosystem s

By www.cbd.int
Published On :: Tue, 05 Jul 2016 00:00:00 GMT


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CBD News: The Subsidiary Body on Implementation at its first meeting urged Parties that have not yet done so to submit their financial reports where feasible by 31 August 2016, in time for the preparation of documentation for the thirteenth meeting of the

By chm.cbd.int
Published On :: Wed, 31 Aug 2016 00:00:00 GMT

f


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CBD News: France, Mali, the Netherlands, the Republic of Moldova and Sweden are the latest countries to ratify the Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization, bringing the t

By www.cbd.int
Published On :: Fri, 09 Sep 2016 00:00:00 GMT


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CBD News: The winners of the MIDORI Prize for Biodiversity 2016 have today been announced.

By www.cbd.int
Published On :: Mon, 31 Oct 2016 00:00:00 GMT


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CBD News: With the aim of raising public awareness about the importance of biodiversity, a documentary detailing what it is like to spend four weeks over two summers exploring the biodiversity of the Grand Lake protected natural area in the Canadian provi

By www.cbd.int
Published On :: Mon, 05 Dec 2016 00:00:00 GMT


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CBD News: The Food and Agriculture Organization of the United Nations (FAO), the Secretariat of the Pacific Regional Environment Programme (SPREP) and the Convention on Biological Diversity (CBD), today released a technical document that provides guidance

By www.cbd.int
Published On :: Fri, 09 Dec 2016 00:00:00 GMT


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CBD News: We, the Heads of State/Government of Brunei Darussalam, the Kingdom of Cambodia, the Republic of Indonesia, the Lao People's Democratic Republic, Malaysia, the Republic of the Union of Myanmar, the Republic of the Philippines, the Republic o

By www.cbd.int
Published On :: Mon, 19 Dec 2016 00:00:00 GMT


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CBD News: Reconnecting ourselves to nature is sometimes easier said than done. Many of us live in cities full of concrete and use devices such as smartphones and laptops that, while connecting us to other people, often serve to disconnect us from the simp

By www.cbd.int
Published On :: Fri, 02 Jun 2017 00:00:00 GMT


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CBD News: The ASEAN Biodiversity Outlook second edition was recently endorsed by the ASEAN Working Group on Nature Conservation and Biodiversity.

By chm.aseanbiodiversity.org
Published On :: Thu, 20 Jul 2017 00:00:00 GMT


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CBD News: 10 official working documents and 14 information documents for the twenty-first meeting of the Subsidiary Body on Scientific, Technical and Technological Advice (SBSTTA-21), being held in Montreal, Canada, 11 - 14 December 2017, are now availabl

By www.cbd.int
Published On :: Mon, 04 Dec 2017 00:00:00 GMT


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CBD News: Nominations are now invited for the MIDORI Prize for Biodiversity 2018. The call for nominations remains open until 15 June 2018.

By www.cbd.int
Published On :: Mon, 19 Feb 2018 00:00:00 GMT


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CBD News: The winners of the MIDORI Prize for Biodiversity 2018 were announced today. The MIDORI Prize is a prestigious biennial international prize organized by the AEON Environmental Foundation and the Secretariat of the Convention on Biological Diversi

By www.cbd.int
Published On :: Thu, 11 Oct 2018 00:00:00 GMT


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CBD News: In 1992, at the landmark Rio Earth Summit, the international community, in its wisdom, created three interrelated conventions to safeguard the future of the planet, all peoples, and indeed all life on earth: the United Nations Framework Conventi

By www.cbd.int
Published On :: Thu, 22 Aug 2019 00:00:00 GMT


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CBD News: Nominations are now invited for The MIDORI Prize for Biodiversity 2020. The call for nominations remains open until 30 March 2020.

By www.cbd.int
Published On :: Wed, 27 Nov 2019 00:00:00 GMT


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CBD Notification SCBD/OES/DC/KM/88539 (2019-108): Submission of views on possible targets, indicators and baselines for the post-2020 global biodiversity framework and peer review of a document on indicators

By www.cbd.int
Published On :: Tue, 03 Dec 2019 00:00:00 GMT


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CBD News: The nature that surrounds us, sustains us. Ensuring that it can continue to do so for future generations is a trust bestowed on us all.

By www.cbd.int
Published On :: Wed, 11 Dec 2019 00:00:00 GMT


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CBD Notification SCBD/IMS/JMF/NVW/86292 (2019-117): Follow-up invitation to participate in and/or contribute to the piloting and further development of a methodology for the voluntary peer review of national biodiversity strategies and action plans

By www.cbd.int
Published On :: Wed, 18 Dec 2019 00:00:00 GMT


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CBD Notification SCBD/IMS/JMF/JBM/88603 (2020-004): Documentation for the Second Meeting of the Open-Ended Working Group on the Post-2020 Global Biodiversity Framework

By www.cbd.int
Published On :: Tue, 14 Jan 2020 00:00:00 GMT


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CBD News: Twenty years ago, on 29 January 2000, Parties to the Convention on Biological Diversity (CBD) adopted the Cartagena Protocol on Biosafety. The Cartagena Protocol entered into force on 11 September 2003.

By www.cbd.int
Published On :: Wed, 29 Jan 2020 00:00:00 GMT


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CBD Notification SCBD/IMS/JMF/KNM/88699 (2020-019): Peer review of documents for the third meeting of the Subsidiary Body on Implementation

By www.cbd.int
Published On :: Fri, 14 Feb 2020 00:00:00 GMT


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CBD Notification SCBD/SSSF/AS/SBG/CC/VA/88724 (2020-024): Peer review of draft documents for the twenty-fourth meeting of the Subsidiary Body on Scientific, Technical and Technological Advice (SBSTTA 24)

By www.cbd.int
Published On :: Tue, 25 Feb 2020 00:00:00 GMT


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CBD Notification SCBD/IMS/JMF/NP/CR/IH/88710 (2020-027): Final Call for Nominations for the MIDORI Prize for Biodiversity 2020

By www.cbd.int
Published On :: Fri, 06 Mar 2020 00:00:00 GMT


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Stability, analyticity, and maximal regularity for parabolic finite element problems on smooth domains

By www.ams.org
Published On :: Tue, 07 Apr 2020 14:09 EDT

Takahito Kashiwabara and Tomoya Kemmochi
Math. Comp. 89 (2020), 1647-1679.
Abstract, references and article information


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Remote working: Is it doing more harm than good?

By www.techworld.com
Published On :: Thu, 27 Feb 2020 09:00:00 GMT

As 1 in 6 UK adults struggle with their mental health, is the rise in remote working making employees happier or creating a workforce racked by loneliness?


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Soldo supports COVID-19 'digital foodstamps' response

By www.techworld.com
Published On :: Thu, 23 Apr 2020 07:00:00 GMT

The London-headquartered fintech startup Soldo has repurposed its spend management tools for local authorities in Italy to support its COVID-19 emergency response measures


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Uniqueness for the inverse boundary value problem of piecewise homogeneous anisotropic elasticity in the time domain

By www.ams.org
Published On :: Wed, 08 Apr 2020 11:21 EDT

Cătălin I. Cârstea, Gen Nakamura and Lauri Oksanen
Trans. Amer. Math. Soc. 373 (2020), 3423-3443.
Abstract, references and article information


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Wyandotte Douglas DC-2

By www.flickr.com
Published On :: Sat, 09 May 2020 10:10:49 -0700

dlberek posted a photo:


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Tootsietoy Douglas DC-2s

By www.flickr.com
Published On :: Sat, 09 May 2020 10:10:50 -0700

dlberek posted a photo:


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Wyandotte Boeing 247

By www.flickr.com
Published On :: Sat, 09 May 2020 10:10:45 -0700

dlberek posted a photo:


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Wyandotte and Tootsietoy Douglas DC-2s

By www.flickr.com
Published On :: Sat, 09 May 2020 10:10:50 -0700

dlberek posted a photo:


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Ehrenfest–Brillouin-type correlated continuous time random walk and fractional Jacobi diffusion

By www.ams.org
Published On :: Mon, 02 Mar 2020 06:58 EST

N. N. Leonenko, I. Papić, A. Sikorskii and N. Šuvak
Theor. Probability and Math. Statist. 99 (2020), 137-147.
Abstract, references and article information


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Estimation of the rate of convergence in the central limit theorem for a sequence of series in terms of averaged pseudomoments

By www.ams.org
Published On :: Mon, 02 Mar 2020 06:58 EST

M. M. Kapustei and P. V. Slyusarchuk
Theor. Probability and Math. Statist. 99 (2020), 101-111.
Abstract, references and article information


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Best free software downloads for your laptop

By www.techworld.com
Published On :: Mon, 08 Jul 2019 13:20:00 GMT


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Google Docs tips everyone should know

By www.techworld.com
Published On :: Thu, 01 Aug 2019 14:48:00 GMT


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Seven things developers should do before going freelance

By www.techworld.com
Published On :: Wed, 07 Aug 2019 09:00:00 GMT


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The best meetups for startups in London

By www.techworld.com
Published On :: Mon, 09 Dec 2019 12:11:00 GMT


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Non-Periodontal Oral Manifestations of Diabetes: A Framework for Medical Care Providers

By spectrum.diabetesjournals.org
Published On :: 2011-11-01

Beatrice K. Gandara
Nov 1, 2011; 24:199-205
From Research to Practice


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Diabetic Ketoacidosis and Hyperglycemic Hyperosmolar Syndrome

By spectrum.diabetesjournals.org
Published On :: 2002-01-01

Guillermo E. Umpierrez
Jan 1, 2002; 15:
Articles


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How Onfido raised $100 million at the peak of a pandemic

By www.techworld.com
Published On :: Wed, 15 Apr 2020 09:01:00 GMT

The UK-based digital identity specialist managed to raise a bumper round during the peak of the COVID-19 pandemic, and is looking at ways to apply its technology to help combat the global crisis


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The FKH domain in FOXP3 mRNA frequently contains mutations in hepatocellular carcinoma that influence the subcellular localization and functions of FOXP3 [Molecular Bases of Disease]

By www.jbc.org
Published On :: 2020-04-17T00:06:05-07:00

The transcription factor forkhead box P3 (FOXP3) is a biomarker for regulatory T cells and can also be expressed in cancer cells, but its function in cancer appears to be divergent. The role of hepatocyte-expressed FOXP3 in hepatocellular carcinoma (HCC) is unknown. Here, we collected tumor samples and clinical information from 115 HCC patients and used five human cancer cell lines. We examined FOXP3 mRNA sequences for mutations, used a luciferase assay to assess promoter activities of FOXP3's target genes, and employed mouse tumor models to confirm in vitro results. We detected mutations in the FKH domain of FOXP3 mRNAs in 33% of the HCC tumor tissues, but in none of the adjacent nontumor tissues. None of the mutations occurred at high frequency, indicating that they occurred randomly. Notably, the mutations were not detected in the corresponding regions of FOXP3 genomic DNA, and many of them resulted in amino acid substitutions in the FKH region, altering FOXP3's subcellular localization. FOXP3 delocalization from the nucleus to the cytoplasm caused loss of transcriptional regulation of its target genes, inactivated its tumor-inhibitory capability, and changed cellular responses to histone deacetylase (HDAC) inhibitors. More complex FKH mutations appeared to be associated with worse prognosis in HCC patients. We conclude that mutations in the FKH domain of FOXP3 mRNA frequently occur in HCC and that these mutations are caused by errors in transcription and are not derived from genomic DNA mutations. Our results suggest that transcriptional mutagenesis of FOXP3 plays a role in HCC.


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