Larry Shover, Efficient Advisors

Larry Shover, Efficient Advisors

Two buildings collapsed on Hamilton’s Gore Park early Monday morning after being boarded up for over a decade. The fire department says no one was injured and the city has issued an emergency demolition order.

Toronto's redesigned vacant home tax rollout has begun, with over 59,000 people filing their paperwork in the first week. Some councillors say they were left responding to complaints about the rollout, after the city's online declaration portal experienced technical problems shortly after launch.

The Ontario Liberal Party is pledging to reduce the income tax rate for middle class families and eliminate provincial sales tax on hydro bills, if they win in the 2026 election.

The Toronto Police Services Board unanimously approved a new five-year hiring plan for the force on Tuesday.

The provincial government is seeking contractors to restore hundreds of kilometres of land where fireguards were created during the 2023 wildfire season.

Eyare died of injuries she sustained while moving between back of house spaces, Wilder Institute director of animal care, health and welfare, Colleen Baird said Tuesday.

Charlottetown-born curler Brett Gallant says competing in the Olympics will be a dream come true for him and his fiancée, Jocelyn Peterman, even if COVID-19 protocols will make it difficult for them to see each other.

After COVID-19 challenges forced the cancellation of Canada's mixed doubles trials, several top curlers are anxiously waiting to learn whether they will be chosen to represent the country in the discipline at the Beijing Games.

Laura Walker made a game-winning draw Sunday afternoon to win the Alberta women's curling playdowns and secure a berth in the upcoming national championship.

Canadian curler Kaitlyn Lawes looks back on her Olympic gold in mixed doubles at PyeongChang 2018, reflects on her disappointment in not qualifying with Team Jones in 2018, and her mentality heading into Beijing 2022, looking to add to her two Olympic gold medals.

CME Group, the world's leading derivatives marketplace, today declared a fourth-quarter dividend of $1.15 per share. The dividend is payable December 27, 2024, to shareholders of record as of...

Sleep is likely a whole-brain phenomenon, with most of the brain probably benefiting from this state of decreased arousal. Recent advances in our understanding of some potential sleep functions, such as metabolite clearance and synaptic homeostasis, make it evident why the whole brain is likely impacted by sleep: All neurons have synapses, and all neurons produce waste metabolites. Sleep experiments in the fly Drosophila melanogaster suggest that diverse sleep functions appear to be conserved across all animals. Studies of brain activity during sleep in humans typically involve multidimensional data sets, such as those acquired by electroencephalograms (EEGs) or functional magnetic resonance imaging (fMRI), and these whole-brain read-outs often reveal important qualities of different sleep stages, such as changes in frequency dynamics or connectivity. Recently, various techniques have been developed that allow for the recording of neural activity simultaneously across multiple regions of the fly brain. These whole-brain-recording approaches will be important for better understanding sleep physiology and function, as they provide a more comprehensive view of neural dynamics during sleep and wake in a relevant model system. Here, we present a brief summary of some of the findings derived from sleep activity recording studies in sleeping Drosophila flies and discuss the value of electrophysiological versus calcium imaging techniques. Although these involve very different preparations, they both highlight the value of multidimensional data for studying sleep in this model system, like the use of both EEG and fMRI in humans.

The establishment of neural connectivity is a major part of neural development. The central nervous system (CNS) midline is the most characterized axon guidance choice point, and work in Drosophila has played a pivotal role in understanding the molecular mechanisms responsible. Axons respond to attractive cues such as Netrin via the Frazzled receptor, and repulsive cues such as Slit via Robo receptors. Both signals are expressed at the CNS midline, affect pioneer axons, and have dramatic effects on the axon scaffold as a whole. Here, we focus on previous research analyzing classic mutants in the Slit/Robo pathway, which can readily be detected with a dissecting microscope. We also discuss analyzing these mutants in a teaching lab situation. The combination of sophisticated genetics and reliable axonal markers in Drosophila allows phenotypic analysis to be performed at the single-cell level. The elaborate architecture of neurons is very sensitive to disruption by genetic mutations, allowing the effects of novel mutations to be easily detected and assessed.

Although church planting has progressed at a slower pace than the team first expected, a few important milestones in Bar, Montenegro, have been reached.

No public playground exists in Bar, Montenegro. This year, OM Montenegro plans to build one with the help of an outreach team.

Four volunteers from Switzerland. One empty park. Ten days to build a playground. Could it be done?

With the help of two Scottish special-needs teachers, OM Montenegro passionately improves the lives of children with autism and the lives of their families.

OM Montenegro partners with Serbian singer-songwriter Dejan Milinov to bring worship music to believers in their own language.

Pioneering Technology Allows Surgeons to Cut Precisely and Control Bleeding Without Causing Heat Damage to Tissue

Centuries-old university standardizes on SolidWorks Education Edition software so students can learn CAD and design validation skills

Knee replacement doesn’t have to be ‘total’

Robotics programmers can now use SolidWorks 3D CAD models for more powerful simulations

R&D ‘Sandbox’ Previews Some Potential Capabilities for 3D CAD Software

Free SolidWorks 3D CAD Software, Training, and Certification will Build Valuable New Skills Employers Need

Leading elevator components supplier implements 550 licenses of the SolidWorks PDM solution

One Of Only Four Companies To Place Among Top Employers In Each Year Of The Publication’s Survey

Integrated Tools Make Mechatronics-Oriented Design and Seamless Deployment to Hardware Easy

367.382 mph in a Two-Wheeled Missile

SolidWorks Education Edition 2010-2011 Equips Students for Sustainable Design Careers

Donates $1 for Each Download of SolidWorks SustainabilityXpress Solution to Hybrid Auto Design Competition

SolidWorks CAD Software Enables Engineering Students to Fit ‘CubeSat’ Components Into a Four-Inch Square Box

Fabricators & Manufacturers Association teams with SolidWorks to encourage students to get formal manufacturing training

Formula SAE and Formula Student teams increasingly demand SolidWorks software for its ease of use and integrated design analysis

U.K.

Next month's annual user conference and expo only six weeks away

Company cites ease of use, localized languages, and data management capabilities in software

Power of One project's goal is perfecting solar technology for tomorrow's hybrid cars as high oil prices peak interest in alternative vehicles

SolidWorks 3D mechanical design and COSMOS design analysis software play key roles in developing regulator that reached more than 1,000 feet deep

Permasteelisa selects 1,200 licenses of SolidWorks 3D modeling software to more quickly satisfy clients' high expectations for beautiful and unparalleled function

Robust design helps withstand challenging competitive conditions as team takes first round in America 's Cup qualifying races

Students work with Chicago firefighters to design remote sensor systems in buildings and masks with heads-up displays

Aarhus purchases 500 licenses of SolidWorks 3D CAD and COSMOS design analysis software to teach students engineering fundamentals

U.K. firm designs smaller scale, more affordable custom test rigs for companies like Rolls Royce to help meet new regulations

3D mechanical design and analysis software dramatically increases productivity and reduces revision for precision optical manufacturer

Jewers Doors switched to SolidWorks to design products that enclose the world's largest hangars, protect against explosions at weapons depots, and mute sound at large plants