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WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2




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LncRNA <i>SNORD3A</i> specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression




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Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent binding to neonatal Fc receptor

Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives.




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Globohexaosylceramide (globo-H); stage-specific embryonic antigen-3 (SSEA-3); SSEA-4

Mouse studies suggest chemically modified carbohydrate conjugates could be useful as antigens for the development of cancer vaccines.




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SciBX: Science-Business eXchange




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Author Correction: Quantum wave–particle superposition in a delayed-choice experiment




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Ex vivo pulsed dendritic cell vaccination against cancer




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A novel multidimensional reinforcement task in mice elucidates sex-specific behavioral strategies




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Supporting sexual adjustment from the perspective of men living with spinal cord injury




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Age influences structural brain restoration during weight gain therapy in anorexia nervosa




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Expert opinion—management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors




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Pomalidomide, dexamethasone, and daratumumab in relapsed refractory multiple myeloma after lenalidomide treatment




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SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia




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Two Exemplary Twentieth Century Lives, The Telegraph

The 19th century Italian writer Emilio Salgari once remarked that ‘reading is travelling without the bother of baggage’. That is great advice, particularly in the time of COVID-19. Now that one is forcibly home-bound, works of literature and of scholarship can help transport one to different countries, different times. They can stimulate the mind, and [...]




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Tear analysis as the next routine body fluid test




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Impact of the COVID-19 lockdown on basic science research in ophthalmology: the experience of a highly specialized research facility in France




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Expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in human primary conjunctival and pterygium cell lines and in mouse cornea




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Protect against market exclusivity in the fight against COVID-19




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So Do Morals Matter in U.S. Foreign Policy? I Asked the Expert.

In his new book, Do Morals Matter? Presidents and Foreign Policy from FDR to Trump, Joseph S. Nye developed a scorecard to determine how U.S. presidents since 1945 factored questions of ethics and morality into their foreign policy. In an interview, Henry Farrell asked him a few questions to get to the heart of his findings.




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Placental expression of leptin: fetal sex-independent relation with human placental growth




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Next Moves on Climate Policy: A Conversation with Sue Biniaz

Sue Biniaz, former lead climate negotiator for the United States, shared her thoughts on the postponement of COP-26, and on the possible re-engagement of the U.S. in the international effort to address climate change in the newest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program,” a podcast produced by the Harvard Environmental Economics Program.




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Next Moves on Climate Policy: A Conversation with Sue Biniaz

Sue Biniaz, former lead climate negotiator for the United States, shared her thoughts on the postponement of COP-26, and on the possible re-engagement of the U.S. in the international effort to address climate change in the newest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program,” a podcast produced by the Harvard Environmental Economics Program.




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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease




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Accesibilidad informacional y diversidad funcional en el contexto universitario: el caso de la Universidad Complutense de Madrid

Cuevas-Cerveró, Aurora and Razquín-Zazpe, Pedro and Parra-Valero, Pablo and Barrios-Martínez, Cristina and Gómez-Hernández, José-Antonio . Accesibilidad informacional y diversidad funcional en el contexto universitario: el caso de la Universidad Complutense de Madrid., 2020 In: Competencia en Información y Políticas para Educación Superior: Estudos Hispano-Brasileiros. Universidad Complutense de Madrid, pp. 132-146. [Book chapter]




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Analyses of breakpoint junctions of complex genomic rearrangements comprising multiple consecutive microdeletions by nanopore sequencing




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Accumulating Evidence Using Crowdsourcing and Machine Learning: A Living Bibliography about Existential Risk and Global Catastrophic Risk

The study of existential risk — the risk of human extinction or the collapse of human civilization — has only recently emerged as an integrated field of research, and yet an overwhelming volume of relevant research has already been published. To provide an evidence base for policy and risk analysis, this research should be systematically reviewed. In a systematic review, one of many time-consuming tasks is to read the titles and abstracts of research publications, to see if they meet the inclusion criteria. The authors show how this task can be shared between multiple people (using crowdsourcing) and partially automated (using machine learning), as methods of handling an overwhelming volume of research.




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So Do Morals Matter in U.S. Foreign Policy? I Asked the Expert.

In his new book, Do Morals Matter? Presidents and Foreign Policy from FDR to Trump, Joseph S. Nye developed a scorecard to determine how U.S. presidents since 1945 factored questions of ethics and morality into their foreign policy. In an interview, Henry Farrell asked him a few questions to get to the heart of his findings.




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Exploring the cost-effectiveness of child dental caries prevention programmes. Are we comparing apples and oranges?




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Dental caries experience, care index and restorative index in children with learning disabilities and children without learning disabilities: a systematic review and meta-analysis




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How do we decide? Knowledge? Experience? Research?




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Low Prices, Full Storage Tanks: What's Next for the Oil Industry

When the economy slows, so does the demand for oil. Prices have plummeted and storage tanks are filled to capacity. We look at the future of the oil industry.




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Deadline Extended: MEI Summer Funding for HKS Students

Deadline Extended: MEI Summer Funding for HKS Students. Apply now. Priority will be given to applications received by April 15th. Applications received after this date may be considered on a rolling basis through May 5th




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So Do Morals Matter in U.S. Foreign Policy? I Asked the Expert.

In his new book, Do Morals Matter? Presidents and Foreign Policy from FDR to Trump, Joseph S. Nye developed a scorecard to determine how U.S. presidents since 1945 factored questions of ethics and morality into their foreign policy. In an interview, Henry Farrell asked him a few questions to get to the heart of his findings.




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Implication of gut microbiota in the association between infant antibiotic exposure and childhood obesity and adiposity accumulation




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Deadline Extended: MEI Summer Funding for HKS Students

Deadline Extended: MEI Summer Funding for HKS Students. Apply now. Priority will be given to applications received by April 15th. Applications received after this date may be considered on a rolling basis through May 5th




ex

So Do Morals Matter in U.S. Foreign Policy? I Asked the Expert.

In his new book, Do Morals Matter? Presidents and Foreign Policy from FDR to Trump, Joseph S. Nye developed a scorecard to determine how U.S. presidents since 1945 factored questions of ethics and morality into their foreign policy. In an interview, Henry Farrell asked him a few questions to get to the heart of his findings.




ex

So Do Morals Matter in U.S. Foreign Policy? I Asked the Expert.

In his new book, Do Morals Matter? Presidents and Foreign Policy from FDR to Trump, Joseph S. Nye developed a scorecard to determine how U.S. presidents since 1945 factored questions of ethics and morality into their foreign policy. In an interview, Henry Farrell asked him a few questions to get to the heart of his findings.




ex

Next Moves on Climate Policy: A Conversation with Sue Biniaz

Sue Biniaz, former lead climate negotiator for the United States, shared her thoughts on the postponement of COP-26, and on the possible re-engagement of the U.S. in the international effort to address climate change in the newest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program,” a podcast produced by the Harvard Environmental Economics Program.




ex

Low Prices, Full Storage Tanks: What's Next for the Oil Industry

When the economy slows, so does the demand for oil. Prices have plummeted and storage tanks are filled to capacity. We look at the future of the oil industry.




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The regulation and functions of DNA and RNA G-quadruplexes




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The expanding regulatory mechanisms and cellular functions of circular RNAs




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So Do Morals Matter in U.S. Foreign Policy? I Asked the Expert.

In his new book, Do Morals Matter? Presidents and Foreign Policy from FDR to Trump, Joseph S. Nye developed a scorecard to determine how U.S. presidents since 1945 factored questions of ethics and morality into their foreign policy. In an interview, Henry Farrell asked him a few questions to get to the heart of his findings.




ex

So Do Morals Matter in U.S. Foreign Policy? I Asked the Expert.

In his new book, Do Morals Matter? Presidents and Foreign Policy from FDR to Trump, Joseph S. Nye developed a scorecard to determine how U.S. presidents since 1945 factored questions of ethics and morality into their foreign policy. In an interview, Henry Farrell asked him a few questions to get to the heart of his findings.




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Lebanon has formed a controversial new government in a polarised, charged atmosphere, and protesters are not going to be easily pacified by its promises, explains Rami Khoury.

The fourth consecutive month of Lebanon's unprecedented political and economic crisis kicked off this week with three dramatic developments that will interplay in the coming months to define the country's direction for years to come: Escalating protests on the streets, heightened security measures by an increasingly militarising state, and now, a new cabinet of controversial so-called "independent technocrats" led by Prime Minister-designate Hassan Diab.

Seeking to increase pressure on the political elite to act responsibly amid inaction vis-a-vis the slow collapse of the economy, the protesters had launched the fourth month of their protest movement, which had begun on 17 October last year, with a 'Week of Anger', stepping up their tactics and targeting banks and government institutions.




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Molecular architecture of the luminal ring of the <i>Xenopus laevis</i> nuclear pore complex




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Structure of the cytoplasmic ring of the <i>Xenopus laevis</i> nuclear pore complex by cryo-electron microscopy single particle analysis




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Low Prices, Full Storage Tanks: What's Next for the Oil Industry

When the economy slows, so does the demand for oil. Prices have plummeted and storage tanks are filled to capacity. We look at the future of the oil industry.




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Comparisons of simple and complex methods for quantifying exposure to individual point source air pollution emissions




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Can respirator face masks in a developing country reduce exposure to ambient particulate matter?




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The COVID-19 pandemic: a moment for exposure science