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Structural basis of cell-surface signaling by a conserved sigma regulator in Gram-negative bacteria [Molecular Biophysics]

Cell-surface signaling (CSS) in Gram-negative bacteria involves highly conserved regulatory pathways that optimize gene expression by transducing extracellular environmental signals to the cytoplasm via inner-membrane sigma regulators. The molecular details of ferric siderophore-mediated activation of the iron import machinery through a sigma regulator are unclear. Here, we present the 1.56 Å resolution structure of the periplasmic complex of the C-terminal CSS domain (CCSSD) of PupR, the sigma regulator in the Pseudomonas capeferrum pseudobactin BN7/8 transport system, and the N-terminal signaling domain (NTSD) of PupB, an outer-membrane TonB-dependent transducer. The structure revealed that the CCSSD consists of two subdomains: a juxta-membrane subdomain, which has a novel all-β-fold, followed by a secretin/TonB, short N-terminal subdomain at the C terminus of the CCSSD, a previously unobserved topological arrangement of this domain. Using affinity pulldown assays, isothermal titration calorimetry, and thermal denaturation CD spectroscopy, we show that both subdomains are required for binding the NTSD with micromolar affinity and that NTSD binding improves CCSSD stability. Our findings prompt us to present a revised model of CSS wherein the CCSSD:NTSD complex forms prior to ferric-siderophore binding. Upon siderophore binding, conformational changes in the CCSSD enable regulated intramembrane proteolysis of the sigma regulator, ultimately resulting in transcriptional regulation.




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Structural and mutational analyses of the bifunctional arginine dihydrolase and ornithine cyclodeaminase AgrE from the cyanobacterium Anabaena [Enzymology]

In cyanobacteria, metabolic pathways that use the nitrogen-rich amino acid arginine play a pivotal role in nitrogen storage and mobilization. The N-terminal domains of two recently identified bacterial enzymes: ArgZ from Synechocystis and AgrE from Anabaena, have been found to contain an arginine dihydrolase. This enzyme provides catabolic activity that converts arginine to ornithine, resulting in concomitant release of CO2 and ammonia. In Synechocystis, the ArgZ-mediated ornithine–ammonia cycle plays a central role in nitrogen storage and remobilization. The C-terminal domain of AgrE contains an ornithine cyclodeaminase responsible for the formation of proline from ornithine and ammonia production, indicating that AgrE is a bifunctional enzyme catalyzing two sequential reactions in arginine catabolism. Here, the crystal structures of AgrE in three different ligation states revealed that it has a tetrameric conformation, possesses a binding site for the arginine dihydrolase substrate l-arginine and product l-ornithine, and contains a binding site for the coenzyme NAD(H) required for ornithine cyclodeaminase activity. Structure–function analyses indicated that the structure and catalytic mechanism of arginine dihydrolase in AgrE are highly homologous with those of a known bacterial arginine hydrolase. We found that in addition to other active-site residues, Asn-71 is essential for AgrE's dihydrolase activity. Further analysis suggested the presence of a passage for substrate channeling between the two distinct AgrE active sites, which are situated ∼45 Å apart. These results provide structural and functional insights into the bifunctional arginine dihydrolase–ornithine cyclodeaminase enzyme AgrE required for arginine catabolism in Anabaena.




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Structural basis of substrate recognition and catalysis by fucosyltransferase 8 [Protein Structure and Folding]

Fucosylation of the innermost GlcNAc of N-glycans by fucosyltransferase 8 (FUT8) is an important step in the maturation of complex and hybrid N-glycans. This simple modification can dramatically affect the activities and half-lives of glycoproteins, effects that are relevant to understanding the invasiveness of some cancers, development of mAb therapeutics, and the etiology of a congenital glycosylation disorder. The acceptor substrate preferences of FUT8 are well-characterized and provide a framework for understanding N-glycan maturation in the Golgi; however, the structural basis of these substrate preferences and the mechanism through which catalysis is achieved remain unknown. Here we describe several structures of mouse and human FUT8 in the apo state and in complex with GDP, a mimic of the donor substrate, and with a glycopeptide acceptor substrate at 1.80–2.50 Å resolution. These structures provide insights into a unique conformational change associated with donor substrate binding, common strategies employed by fucosyltransferases to coordinate GDP, features that define acceptor substrate preferences, and a likely mechanism for enzyme catalysis. Together with molecular dynamics simulations, the structures also revealed how FUT8 dimerization plays an important role in defining the acceptor substrate-binding site. Collectively, this information significantly builds on our understanding of the core fucosylation process.




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Type 2 Diabetes: Demystifying the Global Epidemic

Ranjit Unnikrishnan
Jun 1, 2017; 66:1432-1442
Perspectives in Diabetes




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Giants eager to see Bart during spring camp

It's been less than a year since the Giants selected Joey Bart with the second overall pick in the 2018 MLB Draft, but the 22-year-old catcher is already generating plenty of excitement within the organization.




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1 player (Bryce?) makes difference, Baer says

Twenty-seven years after signing Barry Bonds to a then-record free-agent contract, the Giants are in the market for yet another superstar outfielder. San Francisco's interest in Bryce Harper remained a prominent topic of conversation during Saturday's FanFest at Oracle Park, with CEO Larry Baer weighing in on the potential franchise-altering benefits of landing a marquee player.




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Uniform patch to mark 150 years of pro baseball

All 30 Major League teams will wear special "MLB 150" patches on their uniforms for the entire 2019 season in honor of the 150th anniversary of the 1869 Cincinnati Red Stockings, the first openly all-salaried professional baseball team.




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Bumgarner, Posey welcome Bart to camp

Less than two hours after meeting Madison Bumgarner, top Giants prospect Joey Bart found himself catching one of Bumgarner's bullpen sessions after the veteran left-hander approached him and said, "Let's go on No. 1."




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The Giants' Spring Training battle to watch

The next five weeks will see lots of shuffling on Major League rosters. Here are the most intriguing positional battles on each of the 30 MLB clubs.




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Babies with microcephaly in Brazil are struggling to access care




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Melding the best of two worlds: Cecil Pickett's work on cellular oxidative stress and in drug discovery and development [Molecular Bases of Disease]

Many chemicals and cellular processes cause oxidative stress that can damage lipids, proteins, or DNA (1). To quickly sense and respond to this ubiquitous threat, organisms have evolved enzymes that neutralize harmful oxidants such as reactive oxygen species and electrophilic compounds (including xenobiotics and their breakdown products) in cells.These antioxidant enzymes include GSH S-transferase (GST),2 NADPH:quinone oxidoreductase 1, thioredoxin, hemeoxygenase-1, and others (2, 3). Many of these proteins are commonly expressed in cells exposed to oxidative stress.The antioxidant response element (ARE) is a major regulatory component of this cellular stress response. The ARE is a conserved, 11-nucleotide-long DNA motif present in the 5'-flanking regions of many genes encoding antioxidant proteins. The laboratory of Cecil Pickett (Fig. 1) at the Merck Frosst Centre for Therapeutic Research in Quebec discovered ARE, a finding reported in the early 1990s in two JBC papers recognized as Classics here (4, 5).jbc;295/12/3929/F1F1F1Figure 1.Cecil Pickett (pictured) and colleagues first described the ARE motif, present in the 5' regions of many genes whose expression is up-regulated by oxidative stress and xenobiotics. Photo courtesy of Cecil Pickett.ARE's discovery was spurred in large part by Pickett's career choice. After completing a PhD in biology and a 2-year postdoc at UCLA in the mid-1970s, he began to work in the pharmaceutical industry.Recruited to Merck in 1978 by its then head of research and development (and later CEO), Roy Vagelos, “I became interested in how drug-metabolizing enzymes were induced by various xenobiotics,” Pickett says.According to Pickett, Vagelos encouraged researchers at the company...




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Maritime security: the uncharted politics of the global sea

4 September 2019 , Volume 95, Number 5

A special section in the latest issue explores recent developments in maritime security and ocean governance.

Christian Bueger, Timothy Edmunds and Barry J. Ryan

In this introduction to a special section of the September 2019 issue of International Affairs, we revisit the main themes and arguments of our article ‘Beyond seablindness: a new agenda for maritime security studies’, published in this journal in November 2017. We reiterate our call for more scholarly attention to be paid to the maritime environment in international relations and security studies. We argue that the contemporary maritime security agenda should be understood as an interlinked set of challenges of growing global, regional and national significance, and comprising issues of national, environmental, economic and human security. We suggest that maritime security is characterized by four main characteristics, including its interconnected nature, its transnationality, its liminality—in the sense of implicating both land and sea—and its national and institutional cross-jurisdictionality. Each of the five articles in the special section explores aspects of the contemporary maritime security agenda, including themes of geopolitics, international law, interconnectivity, maritime security governance and the changing spatial order at sea.




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Michelle Bachelet: ‘Politics Is Getting Nastier’

12 December 2019

Gitika Bhardwaj

Editor, Communications & Publishing, Chatham House

Michelle Bachelet

United Nations High Commissioner for Human Rights; President of Chile (2006-10) and (2014-18)
In a series exploring women in international affairs, Michelle Bachelet speaks to Gitika Bhardwaj about her experiences of sexism in politics, her concerns about the pace of change for women’s rights and how to address the social inequalities driving people to protest around the world.

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UN High Commissioner for Human Rights, Michelle Bachelet, the first woman to become president of Chile in 2006, talks about her experiences as a woman in politics and her work realising human rights around the world. Photo: Chatham House.

Michelle Bachelet, as a young woman you became involved with political issues, supporting Chile’s transition to democracy following the Augusto Pinochet regime. What first sparked your interest in politics and what was it like for you as a young woman in Chile at this time?

I guess it’s related to the environment that I lived in as a child because none of my parents were involved in politics but they were people who were interested in what happened to other people. We would have interesting discussions about what was going on in Chile and around the world and I had grown up being a person who wanted to be part of finding solutions to different challenges.

When I was a student, there were lots of things happening in Chile that I became interested in even though I was in medical school at the time. Then came an important political moment in the 1970s for Chile and I thought that I needed to help make Chile a better place for everyone – that my voice alone would not be enough – so I wanted to meet other people who might have answers to the questions I had. That’s when I became politically active.

I always say that, in my milk bottle, the word responsibility was included because I always have felt responsible for things. My parents also always used to tell me that we’re all human beings and, although we might have differences, we should all have dignity and be respected and have the same rights and opportunities because it is the right thing to do. So that’s how I became what I became.

You became the first woman in Latin America to hold the post of minister of national defence in 2002 and pushed to include more women in conflict resolution. Given that the inclusion of women in peace processes increases the likelihood of agreements being reached, yet women are largely excluded from the negotiating tables, why should more women in peace and security be prioritized? 

I used to push hard to have more women as negotiators and mediators at different levels when I was minister of national defence but I was told ‘We don’t have enough women with the capacity’. Of course that was not true. So one of the tasks I set myself was to build a roster of capable women so that tomorrow nobody could use this excuse. 

We built a roster, but still, as you say, there was a tendency not to have women included at all levels. I think this is because there’s still machoism and sexism that exists at some levels. Some men feel that women are weaker, that they’re not capable enough, and that’s not true. Women are important because women have the right skills to be negotiators and mediators.

I have to say that UN Secretary-General António Guterres has done a great job by appointing women in half of all the posts for special envoys and special representatives in conflict places. But we still need to do more. 

Why do I believe women make a difference? Conflicts matter to both women and men because they impact both, but usually, the experiences of women are invisible in the eyes of many who work in negotiating and mediating peace. That’s why you need people that can bring this perspective to the table. 

The other thing is that women can often get close to other women in conflict places, and in that case, they can get a lot of useful information from women on the ground because they don’t feel threatened by other women. This is particularly true of women who have been victims of sexual violence who are more willing to tell another woman what they have experienced. 

But, at the end of the day, women are half of the population of the world and I think we need them to be represented adequately.

In 2006, you became the first female president of Chile, what was this like for you and did you feel pressure taking up this mantle?

Yes of course. I mean, there were a lot of people who would say ‘I want to vote for you but I don’t think it’s a woman’s place’. Journalists would also ask you ‘You are divorced and don’t have a man by your side. How are you going to cope?’ and I would respond by saying ‘I have always done it myself.’

Sometimes if I took some time to make a decision, because I thought it needed a bit more time to reflect on what to do, they would say ‘She doesn’t take decisions’ but if you made a quick decision then they would say ‘She improvises’. I’m not complaining, I’m just describing the kinds of things that go on, and these are the things I have spoken about with other female leaders from around the world. For example, I once talked to Helle Thorning-Schmidt, the former prime minister of Denmark, and she would tell me that during the election campaign they would discuss the size of her purse and if she had a boyfriend. I mean, really, people tend to diminish women by talking about unsubstantial issues – there will be a lot of attempts to try to bring a woman’s self-esteem down. 

What I would say is, if you know exactly why you are there and what you want to do as a president, parliamentarian or whatever and you’re sure that what you want to do is the right thing – and the smart thing – then do it. Pick a team that is honest, that works with the same passion as you and that is loyal to you but is not afraid to tell you when things aren’t working. But it’s hard and difficult and politics is getting nastier every day.

You said politics is getting nastier. Julia Gillard recently spoke to me about the dark side of social media for women. In what ways do you think politics is changing for women in particular?

I remember seeing that, in the European Parliament, about 85 per cent of women have experienced psychological violence whether they have received death threats or threats of rape and all kinds of things just because they’re female.

There is also a bias against women during election campaigns where people say she cannot be elected because she’s not capable just because she’s a woman. 

Then there are those that, as I mentioned before, try to talk about personal things or spread fake news. Politics has always been about debate between people with different positions, and that’s fine, but I think sometimes you see it goes past the limit in terms of respect for the other person.

Then there is the language. Failing to understand that the other person is a competitor, not an enemy, and using language to, sort of, symbolically destroy the other one is not right. I see it everywhere and I think that’s not what politics is for – we came to serve the people and words matter. 

I think all of these things are making a lot of people not want to get involved in politics anymore because it’s not the kind of environment that we want to be in. But I hope, on the other hand, that if we have more women in politics, maybe we can turn that trend to a more positive and constructive one, where there can still be intense debate but in a way where everybody feels that we’re all part of the same country and we can all build the country together.

How did you find your male counterparts responding to you as leader? Was there a time, for example, your gender became an issue for you while you were in office?

When I was a student of medicine, what mattered was whether you were a good student or a good doctor, not if you were a man or a woman, but in politics, I found that when I appointed ministers, some of them struggled with me being a woman. For example, sometimes I would conclude a meeting by saying ‘We’re going to do this’ but there would be a male minister who would have to have the last word. Or some of them, particularly the more senior ones who had been in senior positions before, found it challenging to accept a secondary role to a woman.

On the other hand, with the military, I had no problem. Neither as minister of defence and neither as president because they understood the chain of command.

It’s interesting to look at women in other leadership positions too. For example, I remember a friend who worked in a place many years ago and she would tell me that she needed to swear and almost to spit on the ground so that men would respect her because the majority of the leaders there were men. I said to her ‘You don’t need to look like a man to be a leader.’

Perhaps sometimes it’s more difficult because strength is understood in different ways but my message would be that you can be a leader in your own way. 

Michelle Bachelet takes part in a ceremonial parade following her inauguration on 11 March 2006 outside the Congress in Valparaiso, Chile. Michelle Bachelet was sworn in as Chile's first woman president in the history of the socially conservative country. Photo: Getty Images.

While president of Chile, you introduced a number of policies aimed at addressing women’s rights issues notably on the gender pay gap and on sexual and reproductive rights for women.

How do you view your legacy on these issues? Were there other policies you wanted to implement but were unable to? And how would you like these initiatives to be furthered today in light of, for example, the rolling back of reproductive rights for women in some parts of the world?

We went from trying to improve the legal framework that applies to women to creating the Ministry of Women and Gender Equity. We also tried to push for changing the electoral roll with quotas for women which we got to an extent but not as much as I wanted. There was no appetite for having a quota for 40 per cent of all those elected to be women so we settled for 40 per cent of all candidates to be women. We still improved a little bit in terms of the number of women being elected from 14 per cent to 24 per cent through this but I didn’t get everything I wanted. Nevertheless, during my time in office, we were able to increase the representation of women in the Senate and the House which was positive. 

On sexual and reproductive rights, in Chile, abortion was criminalized so we were able to decriminalize abortion and we also advanced LGTBI rights and so on. We also developed a better legal framework for dealing with sexual violence but of course sexual violence is a complicated issue that cannot be solved in a short period of time and we need to continue working strongly on that.

The other thing I’m a believer of is the importance of early child development which is good for both boys and girls. So we set up a network of kindergartens free of charge, particularly for poorer people, because there are so many women who cannot afford to put their children in kindergartens while they study or work. So we tried to do lots of things to expand women’s opportunities and women’s rights during my time in office.

Women are increasingly making it to the top level of politics around the world, yet in Latin America, the number of female heads of states has dropped to 0 following a generation of female political leaders across the continent.

Why do you think this is the case and could we see this change again in the future? Do you think Chile is likely to see another female president soon, and if so, who do you think could take up the mantle?

The truth is that there was a moment that I think the region had four or so female heads of states, and although there are currently some female vice presidents, the number of presidents is 0 but I wouldn't be able to say that this is necessarily a bad thing. There doesn’t need to be a female president every time. We need to have female leaders where their citizens believe that they’re the best people to lead their countries.

But we do need to do more to support women making it to the top so they can have all the skills needed to be a president or a prime minister and work more with young women too so that they can think of themselves as being able to take up such positions of leadership in the future. 

In Chile, I hope, of course, there will be another woman president one day but I have no idea when. I will not run again, I can tell you that, but I hope when the time comes, the people of Chile will believe in them.

In your current role, you have said that ‘The climate crisis is the greatest threat to human rights’ and that climate change and gender equality are inextricably linked. How do you see this link and what does that mean for how these issues should be addressed?

Climate change is the biggest threat to human rights because it affects the right to life, to food, to health and to live without violence, and if we are not able to tackle it, it will lead to water scarcity, food insecurity, forced migration and conflict – all of which we are seeing already.

Why is it linked to gender equality? There are many reasons. One of them is that women, who make up half the global population, are usually among the most vulnerable people in the world. Today there are billions of people who don’t have access to water, sanitation or housing with women having less access to all of these tools that would permit them to adapt [to a changing climate].

For example, women will be more affected by food insecurity because imagine a woman who is pregnant without food. She will likely end up being underweight, and then afterwards, this will impact her child who will be at risk of malnourishment. We see it everywhere where women avoid eating so that their children can eat.

Furthermore, if we have water scarcity, that will also affect women because today, in many parts of the world, women and girls fetch the water for their families. If water becomes increasingly scarce, they will have to walk longer to fetch it, and today we already see women and girls who are subject to sexual gender-based violence as they carry out their day-to-day tasks. 

That’s why we need to provide women with the tools to empower them and to devise gender-responsive policies to climate change. 

Throughout your career, have you seen the scale and pace of change for human rights, particularly women’s rights, around the world that you would have wanted?

It depends on how you look at things. It has been over 70 years since the Universal Declaration of Human Rights was written when maternal mortality was incredibly high in many parts of the world and women did not have the vote everywhere.

If you look from that time to now, of course, women’s rights have seen a lot of progress. Maternal mortality has reduced and women can vote I think [in almost every democracy].

But over the last few years, we have seen a pushback on women’s rights, particularly in some areas like sexual and reproductive health rights, and that it something that concerns me a lot.

So I would say we’re not there yet. I hope we will be able to push back the pushback and move forward. Because if we go on along the same trajectory as we are now, we will have economic equality for women in 120 years, which is too long. I mean, nobody wants your great, great, great grandchildren to have to wait so long for equality. We need to stand up for women’s rights – and for all human rights – now and accelerate the progress we’ve been making.

In the past couple of months, there have been ongoing protests in Chile and around the world. What in your estimation is driving the protests and in what ways should governments, civil society and others respond to help address their demands?

I think it’s a phenomenon we are seeing in Chile and many places around the world. It’s a new process where young people are voicing their grievances but with no particular leaders. It’s what some people are calling a ‘new power’ and I think the situation in Chile is very similar to what’s happening in Lebanon, Hong Kong and elsewhere but with different triggers. 

In some places, people are challenging the outcome of an election; in other places, they are protesting because leaders want to change the constitution to be re-elected again; in other places, it can be, like in the case of Chile, a result of economic issues following the increase of the price of what you would call the Underground here. These inequalities lead to a mistrust in our institutions and in traditional leaders and I think this is a universal experience at the moment.

The current political and economic system is not delivering and it’s failing to meet people’s needs. So these young people protesting don’t see, in the current political and economic system, the solutions to the concerns they have.

The other thing that is interesting is the role social media has played in many of these recent protests. Social media has become a different way to allow people to learn from each other. When the students in Chile decided to protest against the increasing price of public transport, they went to the Metro and jumped over the barriers and then, two weeks’ later, I saw it in New York. Hundreds of students, for different reasons – against police brutality – doing exactly the same thing. So they learn from each other and they see what works in one place. 

So I think there is something in the world that is making people go to the streets. If it’s peacefully done then that’s fine. The problem is that sometimes it has triggered a harsh response from governments and that leads to more violence. 

I believe what needs to be done is to try to set up a national dialogue that includes all sectors of all societies where governments listen to the grievances that people have. You cannot change things in a day but I think people are reasonable enough to understand if you are committed to change. 

That’s why the UN has developed the Agenda 2030 on Sustainable Development to leave no one behind. It probably won’t solve everything, but it will, I guess, if we are able to achieve the goals, help us have a planet that’s for everyone. 




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China and Russia in R2P debates at the UN Security Council

7 May 2020 , Volume 96, Number 3

Zheng Chen and Hang Yin

While China and Russia's general policies towards the Responsibility to Protect (R2P) are similar, the two reveal nuanced differences in addressing specific emergencies. Both express support for the first two pillars of R2P while resisting coercive intervention under its aegis, as they share anxieties of domestic political security and concerns about their international image. Nonetheless, addressing cases like the Syrian crisis, Russian statements are more assertive and even aggressive while Chinese ones are usually vague and reactive. This article highlights the two states’ different tones through computer-assisted text analyses. It argues that diplomatic styles reflect Russian and Chinese perceptions of their own place in the evolving international order. Experiences in past decades create divergent reference points and status prospects for them, which leads to their different strategies in signalling Great Power status. As Beijing is optimistic about its status-rising prospects, it exercises more self-restraint in order to avoid external containments and is reluctant to act as an independent ‘spoiler’. Meanwhile, Moscow interprets its Great Power status more from a frame of ‘loss’ and therefore is inclined to adopt a sterner approach to signal its status. Although their policies complement each other on many occasions, there is nothing akin to a Sino–Russian ‘bloc’.




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US–China Strategic Competition: The Quest for Global Technological Leadership

7 November 2019

The current dispute between the US and China goes far beyond trade tariffs and tit-for-tat reprisals: the underlying driver is a race for global technological supremacy. This paper examines the risks of greater strategic competition as well as potential solutions for mitigating the impacts of the US–China economic confrontation.

Marianne Schneider-Petsinger

Senior Research Fellow, US and the Americas Programme

Dr Jue Wang

Associate Fellow, Asia-Pacific Programme (based in Holland)

Dr Yu Jie

Senior Research Fellow on China, Asia-Pacific Programme

James Crabtree

Associate Fellow, Asia-Pacific Programme

Video: Marianne Schneider-Petsinger and Dr Yu Jie discuss key themes from the research paper

Summary

  • The underlying driver of the ongoing US–China trade war is a race for global technological dominance. President Trump has raised a number of issues regarding trade with China – including the US’s trade deficit with China and the naming of China as a currency manipulator. But at the heart of the ongoing tariff escalation are China’s policies and practices regarding forced technology transfer, intellectual property theft and non-market distortions.
  • As China’s international influence has expanded it has always been unlikely that Beijing would continue to accept existing global standards and institutions established and widely practised by developed countries based on ‘the Washington Consensus’.
  • China’s desire to be an alternative champion of technology standard-setting remains unfulfilled. Its ample innovation talent is a solid foundation in its quest for global technology supremacy but tightening controls over personal freedoms could undermine it and deter potential global partners.
  • It is unclear if Chinese government interventions will achieve the technological self-sufficiency Beijing has long desired. China’s approach to macroeconomic management diverges significantly from that of the US and other real market economies, particularly in its policy towards nurturing innovation.
  • Chinese actors are engaged in the globalization of technological innovation through exports and imports of high-tech goods and services; cross-border investments in technology companies and research and development (R&D) activities; cross-border R&D collaboration; and international techno-scientific research collaboration.
  • While the Chinese state pushes domestic companies and research institutes to engage in the globalization of technological innovation, its interventions in the high-tech sector have caused uneasiness in the West.
  • The current US response to its competition with China for technological supremacy, which leans towards decoupling, is unlikely to prove successful. The US has better chances of success if it focuses on America’s own competitiveness, works on common approaches to technology policy with like-minded partners around the globe and strengthens the international trading system.
  • A technically sound screening mechanism of foreign investment can prevent normal cross-border collaboration in technological innovation from being misused by geopolitical rival superpowers.




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Global Trade Policy Forum

This multi-year initiative is the focal point for Chatham House research, partnerships and events concerning global trade.

The forum aims to develop substantive and actionable policy recommendations for the future direction of global trade in a context of changing geopolitical dynamics and rapid technological transformations.

At the core of the Chatham House Global Trade Policy Forum will be the Chatham House Global Trade Conference, a series of roundtable meetings which address the range of regional and systemic trade matters, and a series of written outputs. The activities will culminate in an annual Global Trade Policy Review Briefing paper.

Our unique position in London, and as a world-leading source of independent analysis and with unparalleled convening capacity, enables Chatham House to engage with a committed network of action-oriented policymakers, business leaders, academics, and representatives from the media and civil society to develop trade policy insights. We are committed to the promotion of sustainable growth and more inclusive governance.

The forum’s work is supported by AIG (founding partner), Clifford Chance LLP, Diageo plc, and EY (supporting partners).

View our current work on International Trade and the World Trade Organization (WTO).

 

Department contact

US and Americas Programme

More on the Global Trade Policy Forum




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Iran Crisis Pushes Foreign Policy to Top of 2020 Election Debate

14 January 2020

Dr Lindsay Newman

Senior Research Fellow, US and the Americas Programme
Democrats would be wise to communicate a clear alternative to Trump’s ‘America First’ policy in the Middle East.

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Donald Trump speaks to the media in front of the White House on Monday. Photo: Getty Images.

Conventional wisdom says that foreign policy takes a backseat role in US elections. But last autumn’s Democratic primary debates suggest a potential shift is taking place in the conventional view. While healthcare dominated the discussion (Democrats attribute their 2018 midterm gains to the issue), through November foreign policy followed closely behind in second place in terms of minutes devoted to the discussion.

This trend is consistent with President Donald Trump’s America First approach to foreign policy, in which an eye is always kept on how decisions abroad play for the domestic audience. One former Trump administration official has called this dynamic the ‘recoupling’ of foreign policy with domestic policy.

The US–China trade conflict, which commanded headlines throughout 2019, is perhaps the best example of this recoupling, tying trade imbalances less with the geopolitical than with domestic impact on farmers. Immigration is another policy area in which Trump has linked domestic implications and indeed domestic opinion with foreign policy. It’s in the title: America First.

Now, for better or worse, the targeted killing of Qassem Soleimani, Iran’s response and the subsequent fallout may make US foreign policy towards Iran and the US role in the Middle East a central issue for the 2020 US elections. As it comes just ahead of the Democratic presidential primaries, voters will be looking to the candidates to differentiate their foreign policy experience and proposals for America’s Middle East policy.

To President Donald Trump, Soleimani’s assassination represents a campaign promise kept to confront Iran’s aggression.

The Trump administration initially justified the action by citing intelligence of an imminent threat to US personnel and targets, but after Defense Secretary Mark Esper called this into question, Trump tweeted that ‘it doesn’t really matter because of [Soleimani’s] horrible past’. Ultimately, Trump’s message, on the campaign trail and any general debate stage he agrees to be on, is that he has overseen a new national security strategy for Iran.

Soleimani’s removal from the Iranian calculus is just a part of this broader policy, which also includes neutralizing the Iranian government’s destabilizing influence in the Middle East, denying Iran and especially the Islamic Revolutionary Guard Corps’ access to funding for its malign activities, and rallying the international community against domestic human rights violations and unjust detentions.

To counter Trump, Democrats and democratic presidential candidates would be best-served by offering a simple argument that too links domestic interests and foreign policy: the killing of Soleimani and Trump’s national security strategy for Iran have not made the US or its interests safer.

Iran’s ballistic missile attack on US forces in Iraq, which Iran’s Supreme Leader Ayatollah Ali Khamenei called a ‘slap in the face’ for the US, makes the risks to US assets and personnel abundantly clear. Even if Iran reverts entirely to covert, proxy efforts to counter US interests, the current US–Iran tensions remain unresolved and will likely continue to persist through the 2020 elections in November.

As a matter of the first order, Soleimani was replaced by his deputy Brigadier General Esmail Ghaani within a day of the former’s death, with Khamenei saying that the Quds Force will be ‘unchanged’.

At the second order, Iraq’s parliament voted in favour of a nonbinding resolution to rescind the invitation to US forces, which led Trump to threaten sanctions and demands for reimbursement. Whether US troops will ultimately leave Iraq (following a ‘mistaken’ report that the US was preparing to depart) remains to be seen, but the destabilization of the US military presence in Iraq fulfils a key Iranian objective.

In the interim, the US-led coalition in Iraq and Syria fighting ISIS announced that it would at least temporarily cease its counterterrorism efforts to instead fortify its outposts and prepare for Iranian retaliation, opening a wider door for the resurgence of the terror group.

By arguing that the US, its troops and interest have not been made safer by Trump’s Middle East policy – from withdrawing from the Iran nuclear deal to the imposition of a ‘maximum pressure campaign’ to Soleimani’s killing – Democrats will be able to point to every post-Soleimani US injury, death, regional terrorism attack, asset compromise, cyberattack and shipping disruption as evidence.

Democratic presidential candidates also ought to be explicit about how they plan to manage tensions with Iran – strategic, diplomatic and military – particularly their position on the future of the nuclear deal.

Iran has made clear that the path to de-escalation is through sanctions relief. Asserting leverage need not always involve taking away all of your counterparty’s options (‘maximum pressure’). It also involves knowing what your adversary wants (sanctions relief) and showing a willingness to offer it (especially where it means less to you) in exchange for something of greater worth (avoiding war/a non-nuclear Iran).

Clarity around future policy of a potential Democratic president may bring de-escalation forward in a way that Trump’s statement of Iran standing down are unlikely to do.




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Virtual Roundtable: The End of Globalism? Remaining Interconnected While Under Increased Pressure to Isolate

Invitation Only Research Event

30 March 2020 - 1:00pm to 2:00pm

Zoom Audio Call

Event participants

Fred Hochberg, Chairman and President, Export-Import Bank of the United States, 2009 -17
Chair: Dr Leslie Vinjamuri, Director, US and the Americas Programme, Chatham House

This event is part of the Chatham House Global Trade Policy Forum. We would like to take this opportunity to to thank founding partner AIG and supporting partners Clifford Chance LLP, Diageo plc and EY for their generous support of the forum. 

US and Americas Programme




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Virtual Roundtable: US-China Geopolitics and the Global Pandemic

Invitation Only Research Event

2 April 2020 - 2:00pm to 3:00pm

Event participants

Dr Kurt Campbell, Chairman, CEO and Co-Founder, The Asia Group; Assistant Secretary of State for East Asian and Pacific Affairs, 2009-13
Chair: Dr Leslie Vinjamuri, Director, US and the Americas Programme, Chatham House

This event is part of the Inaugural Virtual Roundtable Series on the US, Americas and the State of the World and will take place virtually only. Participants should not come to Chatham House for these events.

Department/project

US and Americas Programme




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Virtual Roundtable: Global Cities and the Response to Coronavirus

Research Event

8 April 2020 - 4:00pm to 5:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Penny Abeywardena, Commissioner, International Affairs, City of New York
Ambassador Nina Hachigian, Deputy Mayor for International Affairs, City of Los Angeles; US Ambassador to the Association of Southeast Asian Nations (2014-17)
Steven Erlanger, Chief Diplomatic Correspondent, Europe, The New York Times  
Chair: Dr Leslie Vinjamuri, Director, US and the Americas Programme, Chatham House

This event is part of the Inaugural Virtual Roundtable Series on the US, Americas and the State of the World and will take place virtually only.  Participants should not come to Chatham House for these events.

Department/project

US and Americas Programme




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Virtual Roundtable: US Global Leadership After COVID-19

Research Event

20 April 2020 - 2:00pm to 3:00pm

Event participants

Michèle Flournoy, Co-Founder and Managing Partner, Westexec Advisors; US Under Secretary of Defense for Policy, 2009 - 12
Chair: Dr Leslie Vinjamuri, Director, US and the Americas Programme; Dean, Queen Elizabeth II Academy for Leadership in International Affairs, Chatham House

The COVID-19 pandemic highlights the absence of US global leadership. Michèle Flournoy talks with Dr Leslie Vinjamuri about the impact of COVID-19 on US domestic priorities and foreign policy commitments.

Flournoy discusses current US strategy towards China and the Middle East and how this might change under a Democratic administration.

This event is part of the Inaugural Virtual Roundtable Series on the US, Americas and the State of the World and will take place virtually only.

Department/project

US and Americas Programme




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Webinar: Does COVID-19 Spell the End of America's Interest in Globalization?

Research Event

19 May 2020 - 2:00pm to 3:00pm
Add to Calendar
Dr Anne-Marie Slaughter, CEO, New America
Professor Stephen Walt, Robert and Renee Belfer Professor of International Affairs, Harvard Kennedy School
Chair: Dr Leslie Vinjamuri, Director, US and Americas Programme, Chatham House
This  event is  part of the US and Americas Programme Inaugural Virtual Roundtable Series on the US and the State of the World and will take place virtually only.
 
Please note this event is taking place between 2pm to 3pm BST.

US and Americas Programme

Department/project




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Virtual Roundtable: As COVID-19 Hits the Developing World, Where is the American-led Global Response?

Research Event

9 June 2020 - 2:00pm to 3:00pm
Add to Calendar

Lord Mark Malloch-Brown, Chairman, SGO; Former Deputy Secretary-General and Chief of Staff, United Nations
Dr Elizabeth Cousens, President and CEO, United Nations Foundation
Ambassador Nicholas Burns, Roy and Barbara Goodman Family Professor of the Practice of Diplomacy and International Relations at the Harvard Kennedy School; US Under Secretary of State for Political Affairs, 2005 – 2008
Chair: Dr Leslie Vinjamuri, Director, US and the Americas Programme, Chatham House

This event is part of the US and Americas Programme Inaugural Virtual Roundtable Series on the US and the State of the World and will take place virtually only.

This event will take place from 14:00 – 15:00 BST.

US and Americas Programme

Department/project




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Cow’s milk allergy guidelines are not evidence based and are beset by conflicts of interest, researchers warn




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Obat Pemerah Bibir Gel Herbal Cepat Alami - Rahasia Pria

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Thirty Years of Armenian-Azerbaijani Rivalry: Dynamics, Problems and Prospects

Invitation Only Research Event

20 November 2019 - 10:00am to 11:30am

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Laurence Broers, Associate Fellow, Russia and Eurasia Programme, Chatham House
Chair: Lubica Pollakova, Senior Programme Manager, Russia and Eurasia Programme

The Armenian–Azerbaijani conflict for control of the mountainous territory of Nagorny Karabakh is the longest-running dispute in post-Soviet Eurasia.

Laurence Broers, author of Armenia and Azerbaijan: Anatomy of a Rivalry, will discuss how decades of dynamic territorial politics, shifting power relations, international diffusion and unsuccessful mediation efforts have contributed to the resilience of this stubbornly unresolved dispute.

Department/project

Anna Morgan

Administrator, Ukraine Forum
+44 (0)20 7389 3274




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Zelenskyy Finds That There Are No Easy Solutions in Donbas

23 October 2019

Duncan Allan

Associate Fellow, Russia and Eurasia Programme

Leo Litra

Senior Research Fellow, New Europe Center
The president has attempted to use the so-called Steinmeier Formula to find a compromise on holding elections in the east of Ukraine. But he has run into a stark reality: Moscow and Kyiv’s interests remain irreconcilable.

2019-10-23-Ukraine.jpg

A banner reading 'No capitulation!' is unfurled above the entrance to the city hall in Kyiv as part of protests against implementation of the so-called Steinmeier Formula. Photo: Getty Images.

In 2016, the then-German foreign minister, Frank-Walter Steinmeier, suggested a way around the impasse in east Ukraine.

He proposed that elections in the areas held by Russian-backed insurgents – the ‘Donetsk People’s Republic’ (DNR) and the ‘Luhansk People’s Republic’ (LNR) –   could be held under Ukrainian legislation, with Kyiv adopting a temporary law on ‘special status’, the main disagreement between Russia and Ukraine in the Minsk Agreements. This law would become permanent once the Organization for Security and Cooperation in Europe (OSCE) had declared that elections correspond with OSCE standards.

The reaction in Ukraine was strongly negative. The so-called Steinmeier Formula contradicted Kyiv’s position that elections in the occupied Donbas should only go ahead in a secure environment – requiring the prior withdrawal of Russian forces and the return of the eastern border to Ukraine’s control. It also did not address the differing views of ‘special status’; Russia demands a much greater devolution of constitutional powers to the DNR and LNR regimes than Ukraine will grant.

But on 1 October, Volodymyr Zelenskyy, the new Ukrainian president, announced that he was signing up to the Steinmeier Formula. He also announced a conditional withdrawal of Ukrainian forces from two frontline areas in the east.

Quick reversal

During the 2019 presidential election campaign, Zelenskyy repeatedly promised that, if elected, he would re-energize efforts to end the war. This appealed to many Ukrainians, who understandably want the conflict over, although Zelenskyy’s eventual electoral victory was largely won on domestic issues.

But his initiative quickly ran into two problems.

First, following a major prisoner swap in September, Russian President Vladimir Putin appeared to judge that Zelenskyy was in a hurry to deliver his election promises and was acting without consulting France and Germany. Russia had earlier demanded that Ukraine formally agree to elections in the Donbas as the precondition for a summit of the ‘Normandy’ powers (the diplomatic format comprising leaders of Ukraine, Russia, Germany and France, which has not met since 2016).

Moreover, the US, which is not part of the ‘Normandy’ group, has seemed disengaged because of domestic controversies. Concluding that Zelenskyy was vulnerable, the Kremlin welcomed his announcement about the Steinmeier Formula but declined to assent to a summit, hoping to extract further concessions.

Second, Zelenskyy’s action triggered protests in Kyiv and other Ukrainian cities. Critics feared that he intended to make unilateral concessions over ‘special status’. Though he tried to assure Ukrainians that ‘there won't be any elections there if the [Russian] troops are still there’, concerns were fuelled by what many saw as his lack of openness about what the Steinmeier Formula really meant. Ukrainian public opinion wants an end to the war, but apparently not at any price.

Zelenskyy duly rowed back. During a marathon 14-hour press conference on 10 October, he emphasized that he would not surrender Ukraine’s vital interests. He also acknowledged that he had been insufficiently open with the Ukrainian public. For the time being at least, he seems to have been given pause.

A situation resistant to compromise

Instead, Zelenskyy may now attempt to ‘freeze’ the conflict by ending active operations. This is not Ukraine’s favoured outcome but could be the most realistic one in current conditions.  

Russia still calculates that time is on its side. It believes that Western support for Ukraine is lukewarm and that Kyiv will eventually have to give it what it wants. Russia clearly felt no pressure to respond positively to Zelenskyy’s overture, which it probably read as a weakness to be exploited.    

For these reasons, Zelenskyy now appears less optimistic that rapid progress to end the war is possible. A new summit of the ‘Normandy’ powers may happen but looks unlikely in the near future. This may act as an incentive for further bilateral negotiations between Ukraine and Russia, such as those which delivered the prisoner swap. However, a diplomatic process managed by Zelenskyy and Putin alone risks reducing Ukraine’s leverage. 

Finally, the main obstacles to implementation of the Minsk Agreements – radically different views of elections in, and ‘special status’ for, the DNR and LNR – remain. The Kremlin’s versions of both would gravely limit Ukraine’s sovereignty; Kyiv’s would facilitate the re-establishment of its control over the east. It is hard to see how this gap can be bridged.

Tellingly, the Steinmeier Formula offers no answer to this conundrum. Some conflicts, it seems, are resistant to diplomatic compromises that aim to satisfy everyone equally.




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Screening Room: Parts of a Circle - History of the Karabakh Conflict

Members Event

18 February 2020 - 6:00pm to 8:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Jenny Norton, Producer, Parts of a Circle: History of the Karabakh Conflict
Famil Ismayilov, Journalist
Leon Aslanov, Middle East Analyst, Integrity UK
Chair: Laurence Broers, Associate Fellow, Russia and Eurasia Programme, Chatham House; Director, Caucasus Programme, Conciliation Resources

Once an autonomous region populated mainly by Armenians in Soviet Azerbaijan, Nagorny Karabakh, is a contested territory in the Caucasus. Since the late 1980s, its contested status has driven popular mobilization among Armenians and Azerbaijanis and an all-out war between 1992-94. After a quarter-century of enmity and military build-up, in 2019, Armenian and Azerbaijani leaders agreed to ‘prepare their populations for peace’ but how would this work in practice?

Parts of a Circle: History of the Karabakh Conflict (2019) chronicles the disputed history of the decades-old conflict between Armenians and Azerbaijanis. Supported by the European Union and based on a series of three documentary films jointly produced over four years by Armenian and Azerbaijani production teams, the film showcases journalistic cooperation in bridging societies in conflict.

The screening was followed by a panel discussion that will explore the state of the conflict and the efforts to end it. Why have efforts to resolve the conflict between Azerbaijan and Armenia not been successful? How can both sides build grassroot support for peace after years of fomenting hatred? And what can the international community do in support?

A short film about the making of the documentary can be seen here.

Members Events Team




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Ukraine Beyond Donbas: Is Social Cohesion at Risk?

Invitation Only Research Event

28 February 2020 - 9:30am to 1:00pm

Chatham House | 10 St James's Square | London | SW1Y 4LE

Event participants

Iryna Brunova-Kalisetska, Independent Researcher, Trainer and Dialogue Facilitator
Maxim Ieligulashvili, Independent Researcher, Trainer and Dialogue Facilitator
Volodymyr Lupatsy, Co-founder, National Platform on Dialogue for Peace and Secure Reintegration; Board Member, Centre for Security and Development Research, Ukraine
Orysia Lutsevych, Research Fellow and Manager, Ukraine Forum, Chatham House

Six years after the annexation of Crimea and the start of the armed conflict in Donbas, the process of coalescing the Ukrainian society around a common civic identity remains complex. Ukraine comprises many ethno-linguistic identities, and various internal and external actors have been able to exploit old and new grievances to increase tensions at the regional and local level.

The panellists will discuss the conflict dynamics along parts of Ukraine’s international border and the line of contact with Crimea. The speakers will review the internal political, social and economic trends that cause friction and suggest ways to strengthen cohesion.

The event will build upon key findings from International Alert’s analysis of the south of Odesa, Kherson and Zakarpattia oblasts and on the reintegration of veterans in Ukraine.

This event is organized in partnership with International Alert, supported by UK aid from the UK government as part of the Peace Research Partnership programme.

 

Anna Morgan

Administrator, Ukraine Forum
+44 (0)20 7389 3274




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Virtual Roundtable: Re-integration or Dis-integration: What Does the Future Hold for Occupied Donbas?

Invitation Only Research Event

28 April 2020 - 4:00pm to 5:30pm

Event participants

Paul D’anieri, Professor of Public Policy and Political Science, University of California, Riverside
Vlad Mykhnenko, Associate Professor of Sustainable Urban Development, St Peter’s College, University of Oxford
Chair: Orysia Lutsevych, Research Fellow and Manager, Ukraine Forum, Chatham House

The armed conflict in Donbas has now entered its seventh year. President Zelenskyy, who came to power in May 2019, promised to end the war with Russia and bring peace to Ukraine.

Since assuming office, Zelenskyy has managed to revive the Normandy Format talks, complete military disengagement at three points along the line of contact and negotiate the release of over a hundred Ukrainians held as prisoners of war in Russia. However, ceasefire violations continue to occur frequently.

Looking at the origins of the armed conflict in Donbas and the region’s economic role in Ukraine’s economy, this event discusses the prospects for conflict resolution. Do the recent events signify an opportunity for peace? Does Zelenskyy have a viable plan for re-integrating Donbas or will the region be cut off from mainland Ukraine for the foreseeable future?

The speakers assess the strategy and track record of the Ukrainian government and its Western allies in bringing parts of the occupied Donbas under Kyiv’s control. They also review possible policy implications of the COVID-19 pandemic for the conflict.

Anna Morgan

Administrator, Ukraine Forum
+44 (0)20 7389 3274




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