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Delhi becomes world's most polluted city, overtakes Pakistan's Lahore, AQI recorded at...

At 9 am on Wednesday, the air quality was 'very poor' with a reading of 366 which later rose to 418.




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Chennai Rains: IMD predicts heavy showers for 2 days in Tamil Nadu; Are schools, colleges closed today?

The city experienced heavy rainfall on Wednesday night, and the IMD bulletin indicates that several isolated areas of the capital are expected to see heavy downpours on Thursday.




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Kerala lottery TODAY November 14: Karunya Plus KN- 547 result to be OUT at 3 PM, know how to check full winners list

The Kerala Lottery Result for Karunya Plus KN 547 is set to be drawn today (November 14, 2024). The draw is scheduled to be held at Gorky Bhavan near Bakery Junction in Thiruvananthapuram. The public can view the Winning Number post at 2.55 pm during the Kerala Lottery Today live broadcast.




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Meet Vivek Ramaswamy, Harvard-Yale graduate, son of immigrants, now part of Donald Trump's cabinet, his net worth is...

Born in the US to Indian immigrant parents, Ramaswamy gained wealth through his biotech company




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Practical photocatalytic hydroalkylation of alkenes with chloroacetates mediated by the formate ion

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00228H, Research Article
Ekaterina V. Malakhova, Vladislav S. Kostromitin, Vitalij V. Levin, Alexander D. Dilman
Commodity chemicals are used as alkylating and reducing agents for radical addition to alkenes. The method is based on activation of the strong C–Cl bond by the radical anion of carbon dioxide.
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Palladium-catalyzed [4 + 4] cycloaddition of 2-pyrones with 2-alkylidenetrimethylene carbonates: access to bridged eight-membered oxygen heterocycles

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00329B, Research Article
Huawei Lin, Biming Mao, Bing Han, Jiayi Luo, Yanqing Ge, Xuerui Zhang, Chang Wang, Hongchao Guo, Chunhao Yuan
A novel palladium-catalyzed [4 + 4] cycloaddition of 2-pyrones with 2-alkylidenetrimethylene carbonates has been developed for the synthesis of bridged eight-membered oxygen heterocycles in good yields and with excellent stereoselectivities.
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Chiral guanidine catalyzed cyclization reactions of 1,3-enynes for lactone synthesis: switchable H-bond catalysis

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00374H, Research Article
Yongyan Zhang, Lichao Ning, Tianxin Zhu, Zheng Xie, Shunxi Dong, Xiaoming Feng, Xiaohua Liu
Cyclization and 1,4-conjugate addition/cyclization between 2-activated 1,3-enynes and azlactones were achieved with chiral guanidine-amides for enol-type activation to yield a range of δ-lactone derivatives.
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Sustainable synthesis of long-acting local anesthetics ropivacaine and levobupivacaine under batch and continuous flow via asymmetric hydrogenation

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00072B, Research Article
Zhi Yang, Hanlin Chen, Linxi Wan, Xinyi Feng, Lingshuang Ma, Pei Tang, Fen-Er Chen
A sustainable synthesis method was developed for long-acting local anesthetics, ropivacaine and levobupivacaine, using both batch and continuous flow processes via asymmetric hydrogenation.
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Review of application of the I2 and dimethyl sulfoxide combined reagent system to aryl methyl ketones for diverse transformations

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00396A, Review Article
Dong-Sheng Yang, Xiang-Long Chen, An-Xin Wu
The synthesis of small molecules and complex scaffolds is one of the most important topics in organic synthesis.
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Asymmetric [3 + 2] cycloaddition of donor–acceptor cyclopropanes with azadienes enabled by Brønsted base catalysis

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00002A, Research Article
Shu Li, Zhi-Hong Dong, Si-Yu Dan, Mei-Jun Zheng, Teng Long, Jie Zhan, Qing Zhou, Wen-Dao Chu, Quan-Zhong Liu
A chiral bifunctional Brønsted base-catalyzed enantioselective [3 + 2] cycloaddition of D–A cyclopropanes and azadienes is reported. The protocol features broad substrate scope, mild reaction conditions and high functional group tolerance.
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Organocatalytic formal [4 + 2] cycloaddition of o-quinone-methyl derivatives and 2-isocyanatomalonate diesters for the construction of chroman derivatives with adjacent quaternary chiral centers

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00141A, Research Article
Tong Xiong, Yi-Zhao Xu, Yao Wang, You-Cai Xiao, Fen-Er Chen
An asymmetric organocatalytic formal [4 + 2] cycloaddition/annulation cascade of ortho-quinone methides with 2-isocyanatomalonate diesters has been reported.
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Vaska's complex–PMHS combination enabled mild and chemoselective reduction of sulfoxides to sulfides with low catalyst loading

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00312H, Research Article
Fang-Fang Xu, Zhong-Lei Ruan, Pei-Qiang Huang
We report a highly efficient, versatile, and chemoselective method for the catalytic reduction of sulfoxides to sulfides under mild conditions.
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Decarbonylative C(sp2)–C(sp2) reductive cross-coupling of aroyl fluorides with aryl bromides by palladium/cobalt co-catalysis

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00305E, Research Article
Chen He, Zhiyong Song, Wei Yao, Rui Lin, Yuanhong Ma
Herein, we report a decarbonylative C(sp2)–C(sp2) reductive cross-coupling of aroyl fluorides with aryl bromides by palladium and cobalt co-catalysis.
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Blue light-mediated carbene transfer reaction of thioesters with diazoesters: efficient synthesis of tetrasubstituted Z-enol esters

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00265B, Research Article
Shuncheng Wang, Hua Zhang, Jin Yang, Dongfang Zhang, Xin-Ping Hui
An efficient metal-free, blue light-mediated carbene transfer reaction of thioesters with diazoesters has been achieved. This protocol produced tetrasubstituted Z-enol esters containing arylsulfur groups in good yields under mild conditions.
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Iodine-catalyzed intermolecular 1,2-thio (seleno)amination of alkenes with 1,2,3-triazoles and disulfides (diselenides) in air

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00246F, Research Article
Jian Ji, Xuwen Chen, Zongjing Hu, Cong Guan, Jinhua Liu, Yaqi Deng, Shunying Liu
Iodine-catalyzed 1,2-thio (seleno)amination of alkenes via direct N- and C-centered radical cross-coupling was established to elicit highly regioselective β-triazolized thioalkyl compounds.
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Electrochemical switching in mechanically interlocked molecules (MIMs)

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00061G, Review Article
Ayush Bhadani, Murugavel Kathiresan
Mechanically interlocked molecules (MIMs) which include rotaxanes and catenanes are formed by the mechanical linking of two or more components and has the ability to switch between different states in the presence of an external stimuli.
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Three-component Friedel–Crafts-type difunctionalization of ynamides with (hetero)arenes and iodine(III) electrophile

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00489B, Research Article
Open Access
Jun Kikuchi, Toya Nagata, Shingo Ito, Naohiko Yoshikai
A three-component Friedel–Crafts type difunctionalization of ynamides with an iodine(III) electrophile and electron-rich (hetero)arenes has been developed, enabling regio- and stereoselective synthesis of densely functionalized enamides.
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Metal-Free Cascade O-H Double Insertion Between I(III)/S(VI)-Ylides, Carboxylic Acids, and Alcohols: Modular Access to Unsymmetrical α,α-O,O-Substituted Ketones

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00453A, Research Article
Shang-Shi Zhang, Jiaohang Wei, Wen-Xuan Zou, Qiong Hu, Mei-Zhu Bao, Dan-Ting Shen, Lin Xiao, Jia-Lin Song, Xiang Liu
The synthesis of unsymmetrical α,α-O,O-substituted ketones via O-H double insertion is appealing but remains constrained due to the lack of compatible coupling partners or uncontrollable selectivity. Herein, we present a...
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Synthesis of benzothiophenes via sulfonium-[3,3]-rearrangement of aryl sulfoxides with allenenitriles

Org. Chem. Front., 2024, 11,2208-2214
DOI: 10.1039/D4QO00121D, Research Article
Lei Zhang, Kun Wan, Huanhuan Wang, Mengyao Wang, Ao Cui, Xin Huang, Bo Peng
A facile synthesis of benzothiophenes from readily available aryl sulfoxides and allenenitriles has been established through sulfonium-rearrangement triggered cyclization.
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Iridium-catalyzed reductive γ-lactonization of ortho-acylbenzoic acids in water: sustainable access to phthalides

Org. Chem. Front., 2024, 11,2220-2230
DOI: 10.1039/D3QO02019C, Research Article
Yang Chen, Jingyu Zhang, Hongguang Du, Renshi Luo, Jiaxi Xu, Zhanhui Yang
Iridium-catalyzed reductive γ-lactonization of ortho-acylbenzoic acids in water provides a practical and sustainable route to phthalides.
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Visible light/copper catalysis enabled Heck-like coupling between alkenes and cyclic sulfonium salts via selective C–S bond cleavage

Org. Chem. Front., 2024, 11,2195-2200
DOI: 10.1039/D3QO02009F, Research Article
Xianqin Liu, Xufeng Li, Linyuan Wang, Yongjia Shi, Jian Lv, Daoshan Yang
A Heck-like coupling of cyclic sulfonium salts with alkenes via selective C–S bond cleavage using a copper complex as a photosensitizer through a visible-light-driven redox-neutral process has been developed.
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Electrode-switchable: exploring this new strategy to achieve regiodivergent azidoiodination of alkenes

Org. Chem. Front., 2024, 11,2189-2194
DOI: 10.1039/D3QO01935G, Research Article
Xin-Lei Sun, Chen-Xi Xia, Yue Ren, Yu-Jin Li, Zhi-Qian Cao, Ling-Guo Meng
An “electrode-switchable” organic electrochemistry method for the azidoiodination of alkenes, where the choice of anode dictates the regiodivergent alkene azidoiodination, reveals a novel pathway for controlled regioisomers.
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Frustrated Lewis pair chemistry of alkynes

Org. Chem. Front., 2024, 11,2375-2396
DOI: 10.1039/D4QO00217B, Review Article
Jing Guo, Maying Yan, Douglas W. Stephan
This review is focused on the chemistry of frustrated Lewis pairs (FLPs) with alkynes and surveys the range of stoichiometric and catalytic reactions enabled by this concept.
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Palladium-catalyzed asymmetric [4 + 3] cycloaddition of acyclic α,β-unsaturated imines with trimethylenemethane donors: access to chiral non-fused azepines

Org. Chem. Front., 2024, 11,2326-2331
DOI: 10.1039/D4QO00064A, Research Article
Ting-Peng Li, Shuixiu Su, Jia-Huan Shen, Meng Zang, Yang-Zi Liu, Quannan Wang, Wei-Ping Deng
An efficient approach for the construction of non-fused azepines in good yields with high enantioselectivity via Pd-catalyzed asymmetric [4 + 3] cycloaddition was developed.
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Correction: Cu-catalyzed arylation of S-tosyl peptides with arylboronic acids

Org. Chem. Front., 2024, 11,2418-2418
DOI: 10.1039/D4QO90029D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Junjie Ying, Jingrong Huang, Chenguang Liu, Fa-Jie Chen, Chunfa Xu, Fen-Er Chen
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Aculeatones A and B, epimeric lovastatin derivatives with a 6/6/3-tricyclic carbon skeleton from Aspergillus aculeatus and their chemical transformation

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00351A, Research Article
Fei Liu, Fengqing Wang, Qin Li, Bingbing Dai, Weiguang Sun, Jianguo Li, Chunmei Chen, Yonghui Zhang, Hucheng Zhu
Lovastatin derivatives aculeatones A–F (1–6) with lipid-lowering activity were isolated from Aspergillus aculeatus. 1 and 2 represent the first examples with a 6/6/3-tricyclic scaffold and the biomimetic formation of 1 was achieved starting from 3.
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Cr-mediated Photocatalytic Decarboxylative Coupling of alpha-Oxo Acids with Benzylic Pyridinium Salts

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00475B, Research Article
Jia Cao, Yan Liu, Zhixiang Wang, Le Liu
Herein, we report the chromium/photoredox dual catalytic synthesis of ketones using α-oxo acids with benzylic pyridinium salts. This reaction proceeded by photocatalytic generation of acyl radical from α-oxo acids and...
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Visible-light Induced [1, 3]-Brook Rearrangements of α-Ketoacylsilanes and Its Subsequent Trapping in a Tandem Annulation with 1, 3, 5-Triazinanes and Azomethine Imines

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00463A, Research Article
Zhong Zhang, Sirui Wu, Yuqiao Zhou, Bao-Lin Li, Siyue Xiao, Xiaohu Zhao, Zhipeng Yu
An unusual visible light-induced [1, 3]-Brook rearrangement of α-ketoacylsilanes for cascade cyclization with 1,3,5-triazinanes and C,N-cyclic azomethine imines has been developed under catalyst-free and mild reaction conditions. The strategy offers...
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Cobalt-catalysed Csp3–Csp3 cross-coupling of benzyl Katritzky pyridinium salts with Callyl–O electrophiles

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00402G, Research Article
Mengyu Gao, Corinne Gosmini
Different allylbenzyl derivatives are synthesized by Co-catalyzed reductive cross-coupling from functionalized benzyl Katritzky pyridinium salts and various allylic acetates, ethers or carbonates in moderate to good yields under mild conditions.
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Metal-free photoinduced denitrogenative alkylation of vinyl azides with alkyl radicals toward ketones

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00280F, Research Article
Hui Yin, Siqi Jian, Xiujuan Feng, Ming Bao, Xuan Zhang
A metal-free method for the synthesis of ketones via a visible-light induced denitrogenative alkylation of vinyl azides with alkyl radicals is presented.
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Base- and metal-free visible-light driven site-selective α-C(sp3)–H functionalization reaction of glycine derivatives with hydroxamic acid derivatives

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00425F, Research Article
Shiyun He, Hongying Fan, Xue Zhang, Meiling Ye, Jian Chen, Jinyu Hou, Tianle Huang, Li Guo, Guanghui Lv, Yong Wu
A visible-light-mediated radical–radical cross-coupling reaction between hydroxamic acid and N-phenyl glycine derivatives under base and metal free conditions is reported. A series of unnatural amino acids and peptides were obtained in good to excellent yields with good chemo-selectivity.
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Photochemical [2 + 2 + 1] annulation of 2-vinyloxy arylalkynes with bromomalonates via energy transfer

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00249K, Research Article
Shuo Tang, Jiupeng Liu, Min Zhang, Dan Wang, Yong Wang, Jingjing Zhao, Pan Li
A transition-metal-free, oxidant-free and base-free photochemical [2 + 2 + 1] radical annulation of 2-vinyloxy arylalkynes with bromomalonates has been developed.
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Halogen-Bond-Promoted Direct Cross-Coupling of Ethyl 3-bromo-3-alkyl-2,2-difluoropropanoate with Coumarins/Quinolinones

Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00484A, Research Article
Guoliang Pu, Shi-Yuan Song, Jian Yang, Peng Guo, Jia Jia, Peijun Liu, Xuefei Li, Ping Liu, Chun-Yang He
Herein, we developed a practical method for the direct cross-coupling of ethyl 3-bromo-3-alkyl-2,2-difluoropropanoate with coumarins/quinolinones, leveraging a halogen bond as the pivotal non-covalent interaction. Employing this protocol, a library of...
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Palladium-catalyzed and ligand-controlled divergent cycloadditions of vinylidenecyclopropane-diesters with para-quinone methides enabled by zwitterionic π-propargyl palladium species

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00368C, Research Article
Jia-Hao Shen, Yong-Jie Long, Min Shi, Yin Wei
A palladium-catalyzed and ligand-controlled divergent synthesis of spiro-cyclohexadienones from p-quinone methides and VDCP-diesters was realized via zwitterionic π-propargyl palladium species and the mechanism was clarified by DFT calculations.
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Selective nickel-catalyzed disulfuration of alkyl halides with di/trithiosulfonates

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00411F, Research Article
Lulu Liu, Jiaqi Hou, Yingying Ma, Hongwei Wang, Yu Zhong, Fangcan Liang, Luyao Wang, Qingling Wang, Ji-Quan Liu, Wen-Hua Xu, Dianhu Zhu
Selective reductive disulfuration of alkyl halides with di/trithiosulfonate reagents was developed through ligand regulation, with key features of broad substrate scope, good tolerance and excellent selectivity to disulfides over trisulfides.
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Iridium-catalyzed asymmetric hydrogenation of 5-hydroxypicolinate pyridinium salts under batch and flow: stereodefined access to cis-configurated hydroxypiperidine esters

Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00322E, Research Article
Zhi Yang, Shangxian Luan, Linxi Wan, Jingxi Chen, Xiaofang Wei, Pei Tang, Fen-Er Chen
An iridium-catalyzed asymmetric hydrogenation of 2-esteryl-5-hydroxypyridinium salts is reported, providing chiral cis-5-hydroxypiperidine-2-carboxylates in excellent yields with high levels of enantioselectivities and diastereoselectivities.
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Integrating continuous flow reaction and work-up: chiral amine resolution, separation and purification using a novel coalescing filter system

React. Chem. Eng., 2024, Accepted Manuscript
DOI: 10.1039/D4RE00442F, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Bethan May Rowley, Lisa Alice Thompson, Luke Power, James Daglish, Emma Parks, James Birbeck, Stephen P Marsden, Nikil Kapur, John Blacker
To maximize the benefits of a continuous flow reaction, a continuous work-up is also needed. Herein, we present a process design and novel equipment for a continuous amine resolution reaction,...
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Efficient Fully Textured Perovskite Silicon Tandems with Thermally Evaporated Hole Transporting Materials

Energy Environ. Sci., 2024, Accepted Manuscript
DOI: 10.1039/D4EE03899A, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Bhushan Kore, Oussama Er-raji, Oliver Fischer, Adrian Callies, Oliver Schultz-Wittmann, Patricia Samia Cerian Schulze, Martin Bivour, Stefaan De Wolf, Stefan W Glunz, Juliane Borchert
Fully textured perovskite silicon tandem solar cells effectively minimize the reflection losses and are compatible with industrial silicon production lines. To facilitate scalability and industrial deployment of perovskite silicon tandems...
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Contribution of an instructional module incorporating PhET simulations to Rwandan students' knowledge of chemical reactions, acids, and bases through social interactions

Chem. Educ. Res. Pract., 2024, Advance Article
DOI: 10.1039/D4RP00105B, Paper
Jean-Baptiste Ndagijimana, Jeannette Musengimana, Henriette Mushimiyimana, Evode Mukama, Olivier Habimana, Paulin Manirakiza, Jean Claude Dushimimana, Jean Pierre Alpha Munyaruhengeri, Samia Khan, Elizabeth Lakin
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New treatment option for young women with hormone-sensitive breast cancer

A drug used for treating breast cancer, known as exemestane, is more effective than a common breast cancer prevention drug, tamoxifen, in preventing breast cancer recurrence in young women who also receive post-surgical treatment to suppress ovarian function. The combined results of the Tamoxifen and Exemestane Trial and Suppression of Ovarian Function Trial were presented at the 2014 ASCO Annual Meeting in Chicago.




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Inference with Gemma using Dataflow and vLLM

vLLM's continuous batching and Dataflow's model manager optimizes LLM serving and simplifies the deployment process, delivering a powerful combination for developers to build high-performance LLM inference pipelines more efficiently.




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Farewell and thank you for the continued partnership, Francois Chollet!

Today, we're announcing that Francois Chollet, the creator of Keras and a leading figure in the AI world, is embarking on a new chapter in his career outside of Google.




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Stocks that will see action today: November 14, 2024

Buzzing stocks: Tata Power, India Glycols, Hero MotoCorp, BDL, Firstcry, Mamaearth, MTNL, HAL, Nazara Tech, Sobha, Glenmark Pharma, GVK Power, Medi Assist, Grasim, PNB Housing Fin, Samhi Hotels, Inox Green Energy, Varun Beverages, Piccadilly Agro, 




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IIT Kharagpur-led study says tropical rainforests could survive global warming

The study, published online in the Elsevier journal, was conducted on records of rainforests in sediments from Gujarat’s Vastan coal mines deposited in coastal lagoons around 56 million years ago




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Let's ensure resounding victory together: Rahul Gandhi to Wayanad voters

‘She [Priyanka Gandhi Vadra] will be more than just a representative – she will be your sister, your daughter, and your advocate’, says Rahul Gandhi in a post on X on bypoll day




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Row over CPI(M) leader E.P. Jayarajan’s yet to be published autobiography

Jayarajan clarifies that though he is working on an autobiography, it remains unfinished, and no one has been authorised to publish or distribute it




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A.J. Raghavan, former ISRO scientist, passes away




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E.P. Jayarajan’s ‘autobiography’ row: publishing house remains tight lipped, refuses to clear the air

Jayarajan claims that circulating excerpts from his ‘autobiography’ are baseless nonsense and asserts that he had not granted publishing rights for his autobiography to any establishment




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Wayanad bypoll turns out to be a reunion for landslides survivors

Their tearful reunion touches many, as they witness the heartbreak of lost connections. We celebrated the previous election, but many who participated then are no longer with us, says a survivor. District administration designated three polling stations for the survivors, two at Neelicappu and one at Meppadi




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Thiruvananthapuram Zoo welcomes new species from Shivamogga

Arrival of hyenas, jackals, marsh crocodiles, and palm civets raise species count to 94