me Pre- and Postsynaptic MEF2C Promotes Experience-Dependent, Input-Specific Development of Cortical Layer 4 to Layer 2/3 Excitatory Synapses and Regulates Activity-Dependent Expression of Synaptic Cell Adhesion Molecules By www.jneurosci.org Published On :: 2024-11-06T09:30:07-08:00 Experience- and activity-dependent transcription is a candidate mechanism to mediate development and refinement of specific cortical circuits. Here, we demonstrate that the activity-dependent transcription factor myocyte enhancer factor 2C (MEF2C) is required in both presynaptic layer (L) 4 and postsynaptic L2/3 mouse (male and female) somatosensory (S1) cortical neurons for development of this specific synaptic connection. While postsynaptic deletion of Mef2c weakens L4 synaptic inputs, it has no effect on inputs from local L2/3, contralateral S1, or the ipsilateral frontal/motor cortex. Similarly, homozygous or heterozygous deletion of Mef2c in presynaptic L4 neurons weakens L4 to L2/3 excitatory synaptic inputs by decreasing presynaptic release probability. Postsynaptic MEF2C is specifically required during an early postnatal, experience-dependent, period for L4 to L2/3 synapse function, and expression of transcriptionally active MEF2C (MEF2C-VP16) rescues weak L4 to L2/3 synaptic strength in sensory-deprived mice. Together, these results suggest that experience- and/or activity-dependent transcriptional activation of MEF2C promotes development of L4 to L2/3 synapses. Additionally, MEF2C regulates the expression of many pre- and postsynaptic genes in postnatal cortical neurons. Interestingly, MEF2C was necessary for activity-dependent expression of many presynaptic genes, including those that function in transsynaptic adhesion and neurotransmitter release. This work provides mechanistic insight into the experience-dependent development of specific cortical circuits. Full Article
me Ants Farmed Fungi in the Wake of Dinosaurs’ Demise 66 Million Years Ago By www.smithsonianmag.com Published On :: Thu, 03 Oct 2024 18:04:00 +0000 A new study from Smithsonian scientists analyzes ant and fungus species, and uncovers the origins of their close partnership Full Article
me These 17 Pictures Tell the Stories of Black Athletes in America By www.smithsonianmag.com Published On :: Fri, 11 Oct 2024 19:20:13 +0000 A new book from the Smithsonian’s National Museum of African American History and Culture shows the images and impacts of athletes on and off the playing field Full Article
me See What Happened When One Museum Asked Artists to Define ‘Home’ By www.smithsonianmag.com Published On :: Mon, 04 Nov 2024 15:30:00 +0000 The Smithsonian Design Triennial presents 25 commissions that explore the physical and conceptual ideas of shelter and refuge Full Article
me Six months after disaster, Philippine farmers bring in the harvest By www.fao.org Published On :: Wed, 07 May 2014 00:00:00 GMT Tens of thousands of farmers are bringing in their first rice harvest just six months after one of the worst typhoons to ever hit the Philippines left their fields in [...] Full Article
me Latin America and the Caribbean redouble efforts to eradicate hunger By www.fao.org Published On :: Wed, 07 May 2014 00:00:00 GMT Representatives of all countries in Latin America and the Caribbean have gathered here this week to agree on the actions needed to definitively eradicate hunger in the region before 2025. [...] Full Article
me Crisis-hit farmers receive seeds and tools in Central African Republic By www.fao.org Published On :: Fri, 16 May 2014 00:00:00 GMT A major operation to distribute seeds and tools has been launched in the Central African Republic to support [...] Full Article
me FAO urges global commitment to tackle world's nutrition challenges By www.fao.org Published On :: Wed, 21 May 2014 00:00:00 GMT FAO Director-General José Graziano da Silva today called on countries to put nutrition high on their national and international agendas, and to take a lead role in the upcoming Second [...] Full Article
me Family farmers' market being held in FAO headquarters Atrium By www.fao.org Published On :: Mon, 16 Jun 2014 00:00:00 GMT Family farming is inextricably linked to national and global food security. Both in developing and developed countries, family farming is the leading form of agriculture in food production. Family farmers [...] Full Article
me Morocco's first South-South Cooperation agreement to benefit Guinea and other countries in Africa By www.fao.org Published On :: Tue, 17 Jun 2014 00:00:00 GMT Building on previous efforts, the Kingdom of Morocco will offer technical assistance to the Republic of Guinea through a South-South Cooperation Tripartite Agreement signed today at FAO headquarters by FAO [...] Full Article
me FAO appoints Prince Laurent of Belgium Special Ambassador for Forests and the Environment By www.fao.org Published On :: Mon, 23 Jun 2014 00:00:00 GMT Prince Laurent of Belgium was today appointed FAO Special Ambassador for Forests and the Environment. The announcement was made by FAO Director-General José Graziano da Silva at the Organization’s Committee on [...] Full Article
me FAO and China team up in SSC tripartite agreement to boost local farmers in Namibia By www.fao.org Published On :: Thu, 26 Jun 2014 00:00:00 GMT FAO and China have signed a two-year tripartite cooperation agreement worth about N$10.5 million (US$1.5 million) that will boost the efforts of local farmers in Namibia. The agreement, which is [...] Full Article
me MERCOSUR Government representatives praise FAO's support of family farming and hunger eradication efforts By www.fao.org Published On :: Thu, 03 Jul 2014 00:00:00 GMT Santiago, Chile- The declaration of the XXI Specialized Meeting on Family Farming of MERCOSUR (REAF, in Spanish) held last week in Argentina, acknowledged the advances promoted by FAO’s Director General, [...] Full Article
me Food security tops agenda of FAO Director-General's meeting with India's Prime Minister Modi By www.fao.org Published On :: Wed, 10 Sep 2014 00:00:00 GMT The [...] Full Article
me Ministers meet at FAO to discuss role of commodity markets By www.fao.org Published On :: Mon, 06 Oct 2014 00:00:00 GMT Rome - Governments ought to review the [...] Full Article
me Rome Based Agencies making an impact in Burkina Faso By www.fao.org Published On :: Tue, 07 Oct 2014 00:00:00 GMT FAO, IFAD and WFP/Burkina [...] Full Article
me Director General opens FAO Council meeting By www.fao.org Published On :: Mon, 01 Dec 2014 00:00:00 GMT FAO Director-General Graziano da Silva today opened the 150th session of the FAO Council, highlighting the successful conclusion of the Second International Conference on Nutrition (ICN2), held last month in [...] Full Article
me Euro-Mediterranean Conference on Agriculture welcomes FAO transformational changes By www.fao.org Published On :: Tue, 02 Dec 2014 00:00:00 GMT Rome, 2 December 2014 – The Ministers of Agriculture of the European Union and of other Mediterranean countries welcomed FAO’s transformational changes implemented in the last two years, and underlined [...] Full Article
me FAO Council closure: Director-General urges Members to focus on implementation early in 2015 By www.fao.org Published On :: Fri, 05 Dec 2014 00:00:00 GMT 5 December 2014, Rome – At the closure of the FAO Council held today, the [...] Full Article
me Register now and be part of the television audience: RAI3 documentary series at FAO By www.fao.org Published On :: Wed, 25 Feb 2015 00:00:00 GMT Scala Mercalli hosted by Italian environmentalist Luca Mercalli begins filming in the Sheikh Zayed Centre in FAO this week! Episodes will be shot in front of a live audience every Thursday [...] Full Article
me Main features of the Medium Term Plan 2014-17 (Reviewed) and Programme of Work and Budget 2016-17 are outlined By www.fao.org Published On :: Thu, 05 Mar 2015 00:00:00 GMT The 2016-17 Programme of Work and Budget will consolidate the existing actions within the Medium Term Plan and the Strategic Framework, emphasizing areas to reflect recent trends and developments, with [...] Full Article
me Internal documents now publically available By www.fao.org Published On :: Mon, 02 Nov 2015 00:00:00 GMT FAO is making publically available for the first time, a series of internal documents relating to programme and project management, among others. These documents range from the guidelines on the [...] Full Article
me THE HINDU: Agriculture can't remain the same, says FAO official By www.fao.org Published On :: Wed, 09 Dec 2015 00:00:00 GMT With rapid soil degradation, fast depletion of groundwater, excessive use of pesticides-fertilizers and extreme weather events all collectively putting stress on farming and forestry, it is time to recognise the [...] Full Article
me EL PAÍS, Maria Helena Semedo: “Agriculture should be integrated in climate change policies” By www.fao.org Published On :: Wed, 09 Dec 2015 00:00:00 GMT MANUEL PLANELLES, EL PAÍS, Paris- “Agriculture is seen as a threat in the fight against climate change,” Maria Helena Semedo warns. The Deputy Director-General of the Food and Agriculture Organization [...] Full Article
me LA REPÚBLICA, José Graziano da Silva: A new path to development By www.fao.org Published On :: Tue, 26 Jan 2016 00:00:00 GMT Bogotá- Latin America and the Caribbean is at a decisive juncture in its history. Thanks to its advancements in social, economic, and production-based terms, the region is on its way to [...] Full Article
me Statement of the FAO Secretariat under agenda item 12 “Proposal of the Republic of Korea for the establishment of an FAO World Fisheries University” By www.fao.org Published On :: Wed, 13 Jul 2016 00:00:00 GMT Mr Chairman, I wish to convey, through you, to the Committee on Fisheries, the considered views of the FAO Secretariat on the item on the proposed Fisheries University. So far, the [...] Full Article
me FAO and India's SEWA join efforts to empower rural women and youth By www.fao.org Published On :: Tue, 13 Sep 2016 00:00:00 GMT India's Self Employed Women's Association (SEWA) and FAO are strengthening their collaboration to boost rural development and reduce poverty in Asia and Africa via local initiatives focused on empowering rural [...] Full Article
me FAO urges strong and effective implementation of global anti-rogue fishing treaty By www.fao.org Published On :: Thu, 15 Sep 2016 00:00:00 GMT Washington, 15 September 2016 - The recent entry into force of a ground-breaking international accord on illegal fishing is a welcome development but it now requires "strong and effective implementation", FAO [...] Full Article
me Assessment shows technical capacity on the rise since 2012 By www.fao.org Published On :: Thu, 26 Jan 2017 00:00:00 GMT Further to Council-endorsed adjustments to the 2016-17 Programme of Work and Budget (PWB) made in 2015, an assessment of the technical capacity of the Organization by a team of independent [...] Full Article
me FAO Director-General listed among the most influential Latin Americans By www.fao.org Published On :: Thu, 09 Feb 2017 00:00:00 GMT FAO Director-General José Graziano da Silva has been selected as one of the world's most influential Latin Americans for his work against hunger and malnutrition in the world. In its [...] Full Article
me FAO welcomed as the Swiss Salon's international guest of honor By www.fao.org Published On :: Tue, 12 Dec 2017 00:00:00 GMT FAO was the international guest of honour at the 2017 Salon Goûts et Terroirs, a Swiss cultural and gastronomic exhibition that took place from 29 November - 3 December. Full Article
me Major outcomes and follow-ups of the Seventh Session of the Governing Body of the ITPGRFA By www.fao.org Published On :: Tue, 15 May 2018 00:00:00 GMT The Governing Body took a number of decisions that require action by Contracting Parties. This communication draws the attention of Contracting Parties to those decisions that are addressed to [...] Full Article
me Interview with Ambassador Hans Hoogeveen, Chair of the Programme Committee By www.fao.org Published On :: Thu, 31 May 2018 00:00:00 GMT Q: Ambassador, how did the Programme Committee in its recent session judge FAO's contribution to the eradication of hunger, food insecurity and malnutrition? Ambassador Hoogeveen: [...] Full Article
me UNGA Resolution A/RES/72/279 and related documentation available here By www.fao.org Published On :: Mon, 04 Jun 2018 00:00:00 GMT Further to the Director-General’s speech delivered to the 159th Session of the FAO Council this morning, Monday 4 June and specifically with reference to the letter from [...] Full Article
me The 159th session of the FAO Council came to a close last Friday, following intense week-long deliberations, concluding in consensus By www.fao.org Published On :: Mon, 11 Jun 2018 00:00:00 GMT Addressing the plenary meeting in the closing session of the 159th Session of the Council, the Director-General expressed his appreciation to delegates for their commitment and hard work to [...] Full Article
me FAO launches new space on FAO.org to showcase Member Countries By www.fao.org Published On :: Mon, 13 Jul 2020 00:00:00 GMT Over the last twenty years, the FAO corporate website has expanded to meet diverse Organizational needs and promote the work of divisions and country offices across FAO. When Director [...] Full Article
me A lifetime of fighting hunger By www.fao.org Published On :: Wed, 28 Oct 2020 00:00:00 GMT To celebrate FAO’s 75th anniversary, a new publication chronicles the history of the Organization and shares its vision for the future. FAO at 75 – Grow, nourish, sustain. Together provides a snapshot of [...] Full Article
me High-level event commemorating the Fifth Anniversary of the Paris Agreement By www.fao.org Published On :: Wed, 09 Dec 2020 00:00:00 GMT On the occasion of the fifth anniversary of the Paris Agreement, the event will highlight the key role of the agricultural sectors in supporting the Paris Agreement. The Paris Agreement, [...] Full Article
me Global consultation on the implementation of the UN Decade of Family farming (UNDFF) in 2019-2020 By www.fao.org Published On :: Fri, 09 Apr 2021 00:00:00 GMT In December 2017, the United Nations General Assembly proclaimed the UN Decade of Family Farming 2019-2028 (UNDFF) to serve as a framework for developing public policies and investments to [...] Full Article
me FAO - Globally Important Agricultural Heritage Systems Programme call for experts By www.fao.org Published On :: Tue, 01 Jun 2021 00:00:00 GMT Rome - The FAO - Globally Important Agricultural Heritage Systems Programme opens the process of establishing a new Scientific Advisory Groupfor the 2021-2022 term. The Programme is seeking for [...] Full Article
me Recommended reads ahead of the 42nd session of the FAO Conference By www.fao.org Published On :: Mon, 07 Jun 2021 00:00:00 GMT The FAO Conference meets every two years to determine the policies of the Organization, approve the budget, and make recommendations to its Members. If you would like to dig deeper into [...] Full Article
me Global Dialogue and High-level Segment on the Role of Food and Agriculture in the Global Biodiversity Framework 6-7 July 2021 By www.fao.org Published On :: Fri, 18 Jun 2021 00:00:00 GMT The Food and Agriculture Organization of the United Nations (FAO), in collaboration with the Secretariat of the Convention on Biological Diversity (CBD), will hold a Global Dialogue on the [...] Full Article
me Follow the Director-General's meetings at the Pre-Summit By www.fao.org Published On :: Sun, 25 Jul 2021 00:00:00 GMT The Pre-Summit will bring together the global efforts to shape the transformation of agri-food systems. Full Article
me The Pre-Summit of the UN Food Systems Summit, 26-28 July 2021, Rome By www.fao.org Published On :: Mon, 26 Jul 2021 00:00:00 GMT Delivering the latest evidence-based and scientific approaches, launching new commitments for food systems transformation. Full Article
me AMR Multi-Stakeholder Partnership Platform - Creating a movement for change through engaging multiple actors and voices By www.fao.org Published On :: Wed, 18 Aug 2021 00:00:00 GMT The Tripartite organizations (FAO, OIE, WHO) invite partners to join public discussion on the establishment of the AMR Multi-Stakeholder Partnership Platform. Full Article
me Report on the implementation of the United Nations Decade of Family Farming (2019–2028) By www.fao.org Published On :: Thu, 23 Sep 2021 00:00:00 GMT In December 2017, the United Nations General Assembly proclaimed the UN Decade of Family Farming 2019-2028 (UNDFF) to serve as a framework for developing public policies and investments to [...] Full Article
me Programme Implementation Report 2020-21 By www.fao.org Published On :: Thu, 19 May 2022 00:00:00 GMT In an exceptionally challenging biennium, see how FAO rose to the challenge, implementing a global, holistic and multipronged strategy to support Members. Full Article
me FAO promotes innovation and action to reshape management of aquatic biodiversity By www.fao.org Published On :: Fri, 27 May 2022 00:00:00 GMT FAO is pleased to announce the release of the Global Plan of Action for the Conservation, Sustainable Use and Development of Aquatic Genetic Resources for Food [...] Full Article
me Annual Report on Private Sector Engagement, 2021 By www.fao.org Published On :: Tue, 31 May 2022 00:00:00 GMT This newly-released report highlights the progress made since FAO’s Strategy for Private Sector Engagement 2021-2025 was approved during the 165th session of the Council in December 2020. It discusses important [...] Full Article
me FAO Technical Briefing “Integrated Water Resources Management for Food Security and Climate Resilience" By www.fao.org Published On :: Mon, 17 Oct 2022 00:00:00 GMT 26 October 2022, 09.00-16.00 (CEST) Water is a fundamental resource enabling the production of over 95% of food on land as well the progress of all sustainable development goals [...] Full Article