ba Good Options Can Mask Bad Choices By www.washingtonpost.com Published On :: Mon, 14 Jan 2008 00:00:00 EST Take a step back from the Republican and Democratic presidential primary races and you will see a sharp difference between the two. Full Article Opinions Good Options Can Mask Bad Choices
ba Why Being the GOP's No. 2 Isn't So Bad By www.washingtonpost.com Published On :: Mon, 18 Feb 2008 00:00:00 EST Through much of the Republican presidential primary, Sen. John McCain and former Massachusetts governor Mitt Romney could barely restrain their contempt for each other. During one Republican debate in New Hampshire in early January, McCain landed a zinger that summed up Romney's opportunistic... Full Article Opinions Why Being the GOP's No. 2 Isn't So Bad
ba What Obama Might Learn From Emily Dickinson By www.washingtonpost.com Published On :: Mon, 21 Apr 2008 00:00:00 EDT Tell all the Truth but tell it slant/Success in Circuit lies/Too bright for our infirm Delight/The Truth's superb surprise . . . Full Article Opinions What Obama Might Learn From Emily Dickinson
ba Clinton, Obama and the Narcissist's Tale By www.washingtonpost.com Published On :: Mon, 28 Apr 2008 00:00:00 EDT Put yourself in the shoes of Sen. Barack Obama or Sen. Hillary Rodham Clinton. You are widely seen by Democratic voters as a transformational presidential candidate. Democrats are nearly evenly divided between you and your competitor, and you think you are the best candidate for your party -- and... Full Article Opinions Clinton Obama and the Narcissist's Tale
ba Does Your Subconscious Think Obama Is Foreign? By www.washingtonpost.com Published On :: Mon, 13 Oct 2008 00:00:00 EDT A few years ago, psychologists Mahzarin Banaji and Thierry Devos showed the names of a number of celebrities to a group of volunteers and asked them to classify the well-known personalities as American or non-American. The list included television personality Connie Chung and tennis star Michael ... Full Article Opinions Does Your Subconscious Think Obama Is Foreign?
ba Taking Stock of Refugee Resettlement: Policy Objectives, Practical Tradeoffs, and the Evidence Base By www.migrationpolicy.org Published On :: Mon, 22 May 2017 10:51:38 -0400 With displacement at a record high, governments around the world are looking for ways to jumpstart, expand, or maximize the impact of their refugee resettlement programs. Yet the evidence base regarding the effectiveness of such programs is particularly thin. This report maps the monitoring and evaluation gaps that exist and identifies areas where further research could help inform policymakers' actions. Full Article
ba Building an Evidence Base to Support Refugee Resettlement By www.migrationpolicy.org Published On :: Wed, 24 May 2017 12:16:08 -0400 Marking the release of an MPI Europe report commissioned as part of the EU-FRANK project, this webinar examines critical gaps in the research and evaluation of refugee resettlement programs and recommendations for improving evidence gathering and knowledge sharing between resettlement countries. Full Article
ba Reducing Integration Barriers Facing Foreign-Trained Immigrants: Policy and Practice Lessons from Across the United States By www.migrationpolicy.org Published On :: Thu, 16 Feb 2017 13:11:19 -0500 Marking the release of an MPI report, researchers and practitioners on this webinar discuss brain waste among college-educated immigrants and initiatives that ease the barriers foreign-educated newcomers confront with regards to credential recognition, employment, and relicensure, as well as recent policy developments and ongoing challenges in the field. Full Article
ba Reducing Integration Barriers Facing Foreign-Trained Immigrants: Policy and Practice Lessons from Across the United States By www.migrationpolicy.org Published On :: Tue, 28 Feb 2017 17:42:32 -0500 Marking the release of a report on the barriers foreign-trained high-skilled immigrants face in the United States, this webinar examines programs and initiatives that assist with credential recognition, employment, and relicensure, as well as recent policy developments. Discussants review recommendations for community-based organizations, employers, and policymakers to expand successful efforts aimed at preventing brain waste. Full Article
ba When Good People Write Bad Sentences, by Robert Harris By brooklynbooktalk.blogspot.com Published On :: Fri, 16 May 2014 20:06:00 +0000 All great writing starts with a sentence. But what is it that makes a sentence great? Could it be grammar, syntax, style, word choice, information, meaning, common sense, passion etc? According to one author, there is only one rule for writing a great sentence. And this is the rule: "whether you're Christian, Jew, Muslim, or a disciple of the church of Penn Jillette, when you sit down to write, the Reader is thy god." The rule is certainly thought-provoking but one has to wonder if one rule would be enough for writing a great sentence. Robert Harris, in his book, "When Good People Write Bad Sentences," offers "12 Steps to Verbal Enlightenment" that can cure any eager to learn "bad writing addict." Besides, the 12 steps don’t just provide solutions to well-known problems in the categories of punctuation, syntax, diction, and style but also help bad writers understand the emotional foundations and psychological forces behind those problems. Harris argues, not without humor, that only with this deep understanding can permanent changes take place. He identifies nine types of ineffective sentences that arise from unexamined emotions and self-destructive needs, and offers an integrated approach which could help writers learn to take a broader and healthier perspective on sentence construction. When it comes to the malady of writing badly, which he calls "malescribism,"--an uncontrollable urge to write carelessly and unpersuasively--Harris warns that this malady "is no respecter of status, nor does it take into account social, ethnic, or religious orientation." He also notes that malescribes could be black and white, male and female, believer and nonbeliever, liberal and conservative.Since we all would like to write better sentences consistently, let's look at the advice offered by Robert Harris, and also share some of the great sentences that we have come across in our reading. Full Article
ba As Global Refugee Forum approaches, MPI Europe brief offers a road map for smart investment in refugee sponsorship programmes By www.migrationpolicy.org Published On :: Wed, 11 Dec 2019 22:29:14 -0500 BRUSSELS — Even as the number of refugees in need of protection has reached an all-time high, the resettlement spots offered by countries in 2018 were less than half the level in 2016—and future commitments may shrink further. With refugee needs high and generosity dimming, there is increasing urgency for humanitarian actors to find new ways to bring refugees to safety as well as to rebuild public interest and consensus around the importance of protection. Full Article
ba MPI Estimates No More than 167,000 Non-Citizens Could Be Ineligible for Green Cards Based on Current Public Benefits Use By www.migrationpolicy.org Published On :: Tue, 03 Mar 2020 18:12:47 -0500 WASHINGTON – While the new Trump administration public charge rule is likely to vastly reshape future legal immigration based on its test to assess if a person might ever use public benefits in the future, the universe of non-citizens who could be denied a green card based on current benefits use is quite small. Full Article
ba Global Demand for Medical Professionals Drives Indians Abroad Despite Acute Domestic Health-Care Worker Shortages By www.migrationpolicy.org Published On :: Tue, 21 Jan 2020 10:02:55 -0500 India is the world's largest source for immigrant physicians, and for Indian-trained doctors and nurses the allure of working abroad is strong despite an acute domestic shortage of health-care workers. Against this pull, the Indian government has enacted a number of policies to limit and regulate the emigration of health-care professionals, though these have been more ad hoc in nature and not part of a fully realized strategy. Full Article
ba Arancini balls By www.abc.net.au Published On :: Tue, 13 Oct 2015 11:43:00 +0800 Arancini balls are yummy way to use leftover rice, either for a party snack or dinner. Full Article ABC Local southwestwa Lifestyle and Leisure:Recipes:All Australia:WA:Bunbury 6230
ba Badrijani - Grilled Eggplants with a coriander and garlic Aioli By www.abc.net.au Published On :: Tue, 13 Oct 2015 15:50:00 +1100 This recipe was featured on Foodie Tuesday, a weekly segment with Raf Epstein on Drive, 774 ABC Melbourne, 3:30 PM, courtesy of Alice in Frames. www.aliceinframes.com Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ba Handmade egg noodles Hunan-style with smoked bacon and chilli By www.abc.net.au Published On :: Tue, 27 Oct 2015 19:47:00 +1100 This recipe was featured on Foodie Tuesday, a weekly segment with Raf Epstein on Drive, 774 ABC Melbourne, 3:30 PM, courtesy of Neil Perry. Neil's new book is "Spice Temple." Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ba Bacon wrapped mozzarella chicken breasts By www.abc.net.au Published On :: Tue, 03 Nov 2015 16:05:00 +0800 When it comes to bacon, it's everything in moderation... This recipe uses bacon as a seasoning. Full Article ABC Local southwestwa Lifestyle and Leisure:Recipes:All Health:Diet and Nutrition:Healthy recipes Australia:WA:Bunbury 6230
ba Balsamic Walnuts By www.abc.net.au Published On :: Fri, 13 Nov 2015 14:13:00 +1100 Make these a few days before gifting - unless you decide to keep them! Walnuts will remain crisp for a few days only but that shouldn't be a problem. Serve walnuts as a nibble, sprinkle over a leafy green salad or roast vegetables, use to decorate panna cotta, cheesecakes, a frozen dessert, or serve on a cheese board. Full Article ABC Local shepparton goulburnmurray Lifestyle and Leisure:Recipes:All Australia:VIC:Shepparton 3630 Australia:VIC:Wodonga 3690
ba Bbq barramundi, Jamon, minted peas, Dijon mustard dressing & Danish fetta By www.abc.net.au Published On :: Mon, 23 Nov 2015 12:16:00 +1000 Delicious fish dish for a summer night. Full Article ABC Local brisbane Lifestyle and Leisure:Food and Cooking:All Australia:QLD:Brisbane 4000
ba Chickpea Bake By www.abc.net.au Published On :: Tue, 15 Dec 2015 14:22:00 +1100 This recipe was featured on Foodie Tuesday, a weekly segment with Richelle Hunt on Drive, 774 ABC Melbourne, 3:30 PM, courtesy of Hana Assafiri. Hana's new book is called "Moroccan Soup Bar: Recipes of a Spoken Menu." Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ba ZUCCHINI, BASIL AND GOAT'S CHEESE FRITTATA By www.abc.net.au Published On :: Thu, 24 Dec 2015 11:06:00 +1100 A good frittata is really simple to make, but it does need a little TLC to make sure that the eggs don't overcook. At its best the eggs are softly set and still really tender and the whole thing is such a pleasure to eat. So do take just a little extra care with this, it's really worth it. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ba Babushka's Borsch By www.abc.net.au Published On :: Tue, 08 Mar 2016 18:16:00 +1100 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of Alice Zaslavsky aka Alice in Frames. Alice's latest book is "Alice's Food A-Z: Edible Adventures". Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ba Baked figs stuffed with goat's cheese, black garlic and herbs, mint and purple basil salad By www.abc.net.au Published On :: Thu, 10 Mar 2016 05:43:00 +1100 Figs are such a versatile fruit, they can be eaten raw, cooked, and sweet or savoury. Here I am baking them with goat's curd which is truly delicious. Wrapping them in prosciutto adds texture and saltiness and the mint salad adds a lovely freshness to the dish. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ba Charred cabbage with olive and truffle tapenade By www.abc.net.au Published On :: Mon, 16 May 2016 12:44:00 +1000 Cabbage at its best. Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ba Banana Choc chip cake By www.abc.net.au Published On :: Thu, 09 Jun 2016 10:28:00 +1000 A luscious light chocolate banana cake for any occasion. Do you have overripe bananas in the fruit bowl? Pop them into a freezer bag and freeze. Then when you have time to whip up this easy and delicious cake, just thaw bananas a few hours ahead at room temperature then mash them. Full Article ABC Local shepparton goulburnmurray Lifestyle and Leisure:All:All Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Australia:VIC:Shepparton 3630 Australia:VIC:Wodonga 3690
ba Bouillabaisse By www.abc.net.au Published On :: Tue, 14 Jun 2016 14:45:00 +1000 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, courtesy of Tony Twitchett, Taxi Kitchen Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ba Mushroom and pearl barley soup with parmesan By www.abc.net.au Published On :: Tue, 21 Jun 2016 10:27:00 +0800 Cold damp weather prompts all manner of mushrooms and fungi to emerge from the forest floor. Having neighbours willing to share their regular harvest of field mushrooms is one of the many great privileges of living in the Southern Forests. However, this hearty winter soup can be equally delicious when made with cultivated mushrooms easily purchased from supermarkets and independent grocers. Full Article ABC Local southwestwa Lifestyle and Leisure:Recipes:Soups Australia:WA:Pemberton 6260
ba STEAK BALMORAL (Oyster Mushroom and Leek Sauce Balmoral) By www.abc.net.au Published On :: Thu, 23 Jun 2016 10:30:00 +1000 WHERE IS WINTER WITHOUT A GUTSY SAUCE TO ACCOMPANY A JUICY STEAK OR EVEN A ROAST CHICKEN? THIS IS MORE OF A RAGOUT TYPE SAUCE Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ba Swedish meatballs By www.abc.net.au Published On :: Fri, 22 Jul 2016 10:47:00 +1000 400g pork/beef mince 1 egg 1 onion, grated 1/4 cups fresh breadcrumbs 1/2 tsp. allspice 1/4 tsp. ground cloves Pinch of nutmeg 1 tbsp. olive oil 20g butter 150ml beef stock 2 tbsp. brown sugar Lingonberry sauce, sour cream, dill and parsley potatoes, baby cos leaves and cucumber wedges to serve Full Article ABC Local widebay Lifestyle and Leisure:All:All Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
ba Roasted Baby Carrot Moroccan Style By www.abc.net.au Published On :: Tue, 23 Aug 2016 15:43:00 +1000 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by Jad Choucair of Mankoushe. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ba Big Batch of Cookies of ANY Flavour By www.abc.net.au Published On :: Mon, 05 Sep 2016 11:10:00 +1000 Lovely sweet and easy to bake cookies. Full Article ABC Local brisbane Lifestyle and Leisure:All:All Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ba Vanilla-scented Baked Rice Pudding By www.abc.net.au Published On :: Tue, 13 Sep 2016 11:44:00 +1000 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by the Dinner Ladies (Katherine Westwood & Sophie Gilliatt) Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ba Murwillmbah Asparagus with a Blood Orange Hollandaise sauce By www.abc.net.au Published On :: Thu, 15 Sep 2016 10:54:00 +1000 Spring has definitely in the air well and truly. Loving the produce, country aromas, and appearance as I cycle through the country side. I love asparagus... this local stuff growing by a great friend and awesome farmer. Side dishes are often overlooked but are a very important part to a great meal. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ba Calamari and fermented celeriac, barbecued peas and beef fat By www.abc.net.au Published On :: Tue, 20 Sep 2016 12:17:00 +1000 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by Dan Hunter, chef and owner of Otways' restaurant Brae. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ba Medallions of Beef, with pan juice sauce, wilted cherry tomatoes, wine and basil By www.abc.net.au Published On :: Thu, 06 Oct 2016 10:07:00 +1100 Medallions of Beef, with pan juice sauce, wilted cherry tomatoes, any old wine and basil. Really nice with a potato salad, with fresh spring peas and crispy bacon pieces. Something I do very often is knock up quick tasty dinner utilising your favourite heavy-based frying pan. Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ba BBQ Moreton Bay bugs with asparagus, butter, lemon and capers By www.abc.net.au Published On :: Mon, 10 Oct 2016 10:56:00 +1000 A simple summer seafood dish! Full Article ABC Local brisbane Lifestyle and Leisure:Recipes:All Australia:QLD:Brisbane 4000
ba Barramundi with crushed peas and sour cream By www.abc.net.au Published On :: Tue, 08 Nov 2016 11:29:00 +1100 This recipe features on Foodie Tuesday, a weekly segment on 774 Drive with Raf Epstein, 3.30PM, shared by John Susman. Full Article ABC Local melbourne Lifestyle and Leisure:Recipes:All Australia:VIC:Melbourne 3000
ba Parmesan and Herby Crumbed Pork Loin with raw cabbage salad and lemon By www.abc.net.au Published On :: Thu, 02 Mar 2017 07:55:00 +1100 4 x 150 x g of pork loin steaks as your butcher to cut 3 x cup (210 g) Panko Breadcrumbs (Japanese bread crumb) 1/2 cup (80g) Plain flour Chopped flat leaf parsley, thyme, rosemary 2 Eggs, lightly beaten 1/2cup (80g) finely grated Parmesan CABBAGE SLAW 500 grams of Cabbage finely shredded Squeezed of Lemon juice 1/4 cup (60 ml) quality cider vinegar add to taste. May need less. 2 Tablespoon of Macadamia Oil 1 Tablespoon chop parsley Aioli just a little bit to bind Sea salt and cracked pepper 100 ml Macadamia oil for cooking 4 juicy lemon wedges to squeeze over Pork Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ba Japanese sweet ginger meatballs By www.abc.net.au Published On :: Thu, 15 Jun 2017 13:41:00 +1000 1 bunch of spring onions, finely chopped 250 g minced beef 250 g minced pork 20 g grated ginger 1 egg 2 tsps. roasted sesame oil 1 tbsp. cornflour, plus extra for dusting sunflower oil, for shallow frying 1 tbsp. white sesame seeds salt and ground white pepper For the sweet ginger sauce: 30 g grated ginger 3 tbsps. soy sauce 125 ml dashi stock or 1 tsp instant dashi powder mixed with water 2 tbsps. sugar 3 tbsps. mirin 3 tbsps. rice vinegar 1 tsp cornflour Full Article ABC Local widebay Lifestyle and Leisure:Recipes:All Australia:QLD:Bundaberg 4670
ba Goat's Curd Bavarois with Cardamom Apples By www.abc.net.au Published On :: Thu, 29 Jun 2017 06:38:00 +1000 Exotic, different, really cool flavours, pared-back dessert and it's not too sweet. Enjoy! Full Article ABC Local northcoast Lifestyle and Leisure:Food and Cooking:All Lifestyle and Leisure:Recipes:All Lifestyle and Leisure:Recipes:Main Australia:NSW:Lismore 2480
ba Refugee Sponsorship Programs: A Global State of Play and Opportunities for Investment By www.migrationpolicy.org Published On :: Wed, 11 Dec 2019 12:01:25 -0500 From Argentina to New Zealand and points beyond, a growing number of countries have begun exploring refugee sponsorship as a way to expand protection capacity at a time of rising need, involving individuals and communities more directly in resettlement. This brief takes stock of what both new and well-established programs need to succeed, and outlines opportunities for private philanthropic actors to support them. Full Article
ba Federer charges to fifth Basel title By www.abc.net.au Published On :: Mon, 07 Nov 2011 09:09:00 +1100 Roger Federer has returned to winning mode 10 months after his last title, as the home tennis hero schooled Japanese wild card Kei Nishikori 6-1, 6-3 to win a fifth Swiss Indoors title in Basel. Full Article
ba Bangkok floods force Socceroos switch By www.abc.net.au Published On :: Tue, 08 Nov 2011 12:57:00 +1100 Australia's World Cup qualifier against Thailand next week has been moved to another stadium in Bangkok because of flooding in the city, Football Federation Australia said. Full Article
ba Glycated Hemoglobin, Prediabetes, and the Links to Cardiovascular Disease: Data From UK Biobank By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE HbA1c levels are increasingly measured in screening for diabetes; we investigated whether HbA1c may simultaneously improve cardiovascular disease (CVD) risk assessment, using QRISK3, American College of Cardiology/American Heart Association (ACC/AHA), and Systematic COronary Risk Evaluation (SCORE) scoring systems. RESEARCH DESIGN AND METHODS UK Biobank participants without baseline CVD or known diabetes (n = 357,833) were included. Associations of HbA1c with CVD was assessed using Cox models adjusting for classical risk factors. Predictive utility was determined by the C-index and net reclassification index (NRI). A separate analysis was conducted in 16,596 participants with known baseline diabetes. RESULTS Incident fatal or nonfatal CVD, as defined in the QRISK3 prediction model, occurred in 12,877 participants over 8.9 years. Of participants, 3.3% (n = 11,665) had prediabetes (42.0–47.9 mmol/mol [6.0–6.4%]) and 0.7% (n = 2,573) had undiagnosed diabetes (≥48.0 mmol/mol [≥6.5%]). In unadjusted models, compared with the reference group (<42.0 mmol/mol [<6.0%]), those with prediabetes and undiagnosed diabetes were at higher CVD risk: hazard ratio (HR) 1.83 (95% CI 1.69–1.97) and 2.26 (95% CI 1.96–2.60), respectively. After adjustment for classical risk factors, these attenuated to HR 1.11 (95% CI 1.03–1.20) and 1.20 (1.04–1.38), respectively. Adding HbA1c to the QRISK3 CVD risk prediction model (C-index 0.7392) yielded a small improvement in discrimination (C-index increase of 0.0004 [95% CI 0.0001–0.0007]). The NRI showed no improvement. Results were similar for models based on the ACC/AHA and SCORE risk models. CONCLUSIONS The near twofold higher unadjusted risk for CVD in people with prediabetes is driven mainly by abnormal levels of conventional CVD risk factors. While HbA1c adds minimally to cardiovascular risk prediction, those with prediabetes should have their conventional cardiovascular risk factors appropriately measured and managed. Full Article
ba Visit-to-Visit HbA1c Variability Is Associated With Cardiovascular Disease and Microvascular Complications in Patients With Newly Diagnosed Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE To investigate the association between visit-to-visit HbA1c variability and cardiovascular events and microvascular complications in patients with newly diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS This retrospective cohort study analyzed patients from Tayside and Fife in the Scottish Care Information–Diabetes Collaboration (SCI-DC) who were observable from the diagnosis of diabetes and had at least five HbA1c measurements before the outcomes were evaluated. We used the previously reported HbA1c variability score (HVS), calculated as the percentage of the number of changes in HbA1c >0.5% (5.5 mmol/mol) among all HbA1c measurements within an individual. The association between HVS and 10 outcomes was assessed using Cox proportional hazards models. RESULTS We included 13,111–19,883 patients in the analyses of each outcome. The patients with HVS >60% were associated with elevated risks of all outcomes compared with the lowest quintile (for example, HVS >80 to ≤100 vs. HVS ≥0 to ≤20, hazard ratio 2.38 [95% CI 1.61–3.53] for major adverse cardiovascular events, 2.4 [1.72–3.33] for all-cause mortality, 2.4 [1.13–5.11] for atherosclerotic cardiovascular death, 2.63 [1.81–3.84] for coronary artery disease, 2.04 [1.12–3.73] for ischemic stroke, 3.23 [1.76–5.93] for heart failure, 7.4 [3.84–14.27] for diabetic retinopathy, 3.07 [2.23–4.22] for diabetic peripheral neuropathy, 5.24 [2.61–10.49] for diabetic foot ulcer, and 3.49 [2.47–4.95] for new-onset chronic kidney disease). Four sensitivity analyses, including adjustment for time-weighted average HbA1c, confirmed the robustness of the results. CONCLUSIONS Our study shows that higher HbA1c variability is associated with increased risks of all-cause mortality, cardiovascular events, and microvascular complications of diabetes independently of high HbA1c. Full Article
ba Reduction in Global Myocardial Glucose Metabolism in Subjects With 1-Hour Postload Hyperglycemia and Impaired Glucose Tolerance By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Impaired insulin-stimulated myocardial glucose uptake has occurred in patients with type 2 diabetes with or without coronary artery disease. Whether cardiac insulin resistance is present remains uncertain in subjects at risk for type 2 diabetes, such as individuals with impaired glucose tolerance (IGT) or those with normal glucose tolerance (NGT) and 1-h postload glucose ≥155 mg/dL during an oral glucose tolerance test (NGT 1-h high). This issue was examined in this study. RESEARCH DESIGN AND METHODS The myocardial metabolic rate of glucose (MRGlu) was measured by using dynamic 18F-fluorodeoxyglucose positron emission tomography combined with a euglycemic-hyperinsulinemic clamp in 30 volunteers without coronary artery disease. Three groups were studied: 1) those with 1-h postload glucose <155 mg/dL (NGT 1-h low) (n = 10), 2) those with NGT 1-h high (n = 10), 3) and those with IGT (n = 10). RESULTS After adjusting for age, sex, and BMI, both subjects with NGT 1-h high (23.7 ± 6.4 mmol/min/100 mg; P = 0.024) and those with IGT (16.4 ± 6.0 mmol/min/100 mg; P < 0.0001) exhibited a significant reduction in global myocardial MRGlu; this value was 32.8 ± 9.7 mmol/min/100 mg in subjects with NGT 1-h low. Univariate correlations showed that MRGlu was positively correlated with insulin-stimulated whole-body glucose disposal (r = 0.441; P = 0.019) and negatively correlated with 1-h (r = –0.422; P = 0.025) and 2-h (r = –0.374; P = 0.05) postload glucose levels, but not with fasting glucose. CONCLUSIONS This study shows that myocardial insulin resistance is an early defect that is already detectable in individuals with dysglycemic conditions associated with an increased risk of type 2 diabetes, such as IGT and NGT 1-h high. Full Article
ba Association Between the Use of Antidepressants and the Risk of Type 2 Diabetes: A Large, Population-Based Cohort Study in Japan By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE This study aimed to reveal the associations between the risk of new-onset type 2 diabetes and the duration of antidepressant use and the antidepressant dose, and between antidepressant use after diabetes onset and clinical outcomes. RESEARCH DESIGN AND METHODS In this large-scale retrospective cohort study in Japan, new users of antidepressants (exposure group) and nonusers (nonexposure group), aged 20–79 years, were included between 1 April 2006 and 31 May 2015. Patients with a history of diabetes or receipt of antidiabetes treatment were excluded. Covariates were adjusted by using propensity score matching; the associations were analyzed between risk of new-onset type 2 diabetes and the duration of antidepressant use/dose of antidepressant in the exposure and nonexposure groups by using Cox proportional hazards models. Changes in glycated hemoglobin (HbA1c) level were examined in groups with continuous use, discontinuation, or a reduction in the dose of antidepressants. RESULTS Of 90,530 subjects, 45,265 were in both the exposure and the nonexposure group after propensity score matching; 5,225 patients (5.8%) developed diabetes. Antidepressant use was associated with the risk of diabetes onset in a time- and dose-dependent manner. The adjusted hazard ratio was 1.27 (95% CI 1.16–1.39) for short-term low-dose and 3.95 (95% CI 3.31–4.72) for long-term high-dose antidepressant use. HbA1c levels were lower in patients who discontinued or reduced the dose of antidepressants (F[2,49] = 8.17; P < 0.001). CONCLUSIONS Long-term antidepressant use increased the risk of type 2 diabetes onset in a time- and dose-dependent manner. Glucose tolerance improved when antidepressants were discontinued or the dose was reduced after diabetes onset. Full Article
ba Effects of Bariatric Surgery in Early- and Adult-Onset Obesity in the Prospective Controlled Swedish Obese Subjects Study By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE Bariatric surgery is an effective treatment for obesity, but it is unknown if outcomes differ between adults with early- versus adult-onset obesity. We investigated how obesity status at 20 years of age affects outcomes after bariatric surgery later in life. RESEARCH DESIGN AND METHODS The Swedish Obese Subjects study is a prospective matched study performed at 25 surgical departments and 480 primary health care centers. Participants aged 37–60 years with BMI ≥34 kg/m2 (men) or ≥38 kg/m2 (women) were recruited between 1987 and 2001; 2,007 participants received bariatric surgery and 2,040 usual care. Self-reported body weight at 20 years of age was used to stratify patients into subgroups with normal BMI (<25 kg/m2), overweight (BMI 25–29.9 kg/m2), or obesity (BMI ≥30 kg/m2). Body weight, energy intake, and type 2 diabetes status were examined over 10 years, and incidence of cardiovascular and microvascular disease was determined over up to 26 years using data from health registers. RESULTS There were small but statistically significant differences in reduction of body weight among the subgroups after bariatric surgery (interaction P = 0.032), with the largest reductions among those with obesity aged 20 years. Bariatric surgery increased type 2 diabetes remission (odds ratios 4.51, 4.90, and 5.58 in subgroups with normal BMI, overweight, or obesity at 20 years of age, respectively; interaction P = 0.951), reduced type 2 diabetes incidence (odds ratios 0.15, 0.13, and 0.15, respectively; interaction P = 0.972), and reduced microvascular complications independent of obesity status at 20 years of age (interaction P = 0.650). The association between bariatric surgery and cardiovascular disease was similar in the subgroups (interaction P = 0.674). Surgical complications were similar in the subgroups. CONCLUSIONS The treatment benefits of bariatric surgery in adults are similar regardless of obesity status at 20 years of age. Full Article
ba In the Age of Trump: Populist Backlash and Progressive Resistance Create Divergent State Immigrant Integration Contexts By www.migrationpolicy.org Published On :: Wed, 17 Jan 2018 10:26:51 -0500 As long-simmering passions related to federal immigration policies have come to a full boil, less noted but no less important debates are taking place at state and local levels with regards to policies affecting immigrants and their children. As states are increasingly diverging in their responses, this report examines how some of the key policies and programs that support long-term integration success are faring in this volatile era. Full Article
ba Through the Back Door: Remaking the Immigration System via the Expected “Public-Charge” Rule By www.migrationpolicy.org Published On :: Thu, 23 Aug 2018 11:11:59 -0400 A Trump administration “public-charge” rule expected to be unveiled soon could create the potential to significantly reshape family-based legal immigration to the United States—and reduce arrivals from Asia, Latin America, and Africa—by imposing a de facto financial test that 40 percent of the U.S. born themselves would fail, as this commentary explains. Full Article