Biomater. Sci., 2020, 8,2234-2244
DOI: 10.1039/C9BM01931F, Paper

Qiaojie Luo, Xiaojun Li, Ying Wang, Jianfang He, Qiao Zhang, Pengfei Ge, Xia Cai, Qiang Sun, Weipu Zhu, Zhiquan Shen, Xiaodong Li
A biodegradable CO₂-based polymeric nanodrug is obtained via a surfactant- and solvent-free miniemulsion preparation, which can be concentrated at tumor site by EPR and releases the encapsulated drug through pH responsiveness.
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Biomater. Sci., 2020, 8,2255-2263
DOI: 10.1039/D0BM00069H, Paper

Liting Zhang, Chengtao Jiang, Fanjun Zeng, Haiyu Zhou, Dongdong Li, Xinyu He, Song Shen, Xianzhu Yang, Jun Wang
The cell-penetrating function of R₉ peptide of DA@R₉-NP_DOX was masked in the blood circulation, while reactivated in tumor tissue for enhanced tumor cellular uptake.
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Biomater. Sci., 2020, 8,2274-2282
DOI: 10.1039/C9BM02036E, Paper

Yue Cai, Zhuomin Xu, Qi Shuai, Fangtao Zhu, Jiao Xu, Xin Gao, Xuanrong Sun
PEG-PLA micelles are modified with F3 peptides, thus endowing the micelles with active-targeting ability due to the nucleolin-binding ability of the F3 peptides.
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Biomater. Sci., 2020, 8,2264-2273
DOI: 10.1039/D0BM00112K, Paper

Jie Ding, Xu Zhang, Chuangqi Chen, Yuqiang Huang, Xingsu Yu, Xiaomao Li
An ultra pH-sensitive polymeric nanovesicle was constructed to co-deliver doxorubicin and navitoclax for highly efficient synergetic treatment of endometrial carcinoma.
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Biomater. Sci., 2020, 8,2283-2288
DOI: 10.1039/D0BM00088D, Paper

Guihong Lu, Liping Zuo, Jinfeng Zhang, Houshun Zhu, Wanru Zhuang, Wei Wei, Hai-Yan Xie
A highly efficient two-step targeting strategy integrating metabolic lipid-engineering with in situ click chemistry is developed, thus significantly improved the tumor theranostic performance of the red blood cells ghosts based drug delivery.
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Biomater. Sci., 2020, 8,2202-2211
DOI: 10.1039/C9BM01794A, Paper

Li Zhang, Shiyu Zhang, Huajian Chen, Yu Liang, Bingxia Zhao, Wanxian Luo, Qian Xiao, Jinheng Li, Junqiao Zhu, Chao Peng, Yaru Zhang, Zhe Hong, Ying Wang, Yingjia Li
Ultrasound-assisted fast extravasation and the following laser-triggered drug release of thermo-sensitive liposomes synergistically enhanced drug delivery in deep tumors.
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Biomater. Sci., 2020, 8,2308-2317
DOI: 10.1039/C9BM02007A, Paper

Xiuru Ji, Shuping Xie, Yan Jiao, Xiaojuan Zhang, Duxin Sun, Victor C. Yang, Mei Wang, Huining He, Lu Sun
A novel MT1-MMP activatable fluorogenic probe for tumor detection with enhanced specificity was developed via high-affinity and specific peptide conjugation.
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Biomater. Sci., 2020, 8,2318-2328
DOI: 10.1039/C9BM02000D, Paper

Bin Gao, Xiaoyu Wang, Meiyu Wang, Xiang-kui Ren, Jintang Guo, Shihai Xia, Wencheng Zhang, Yakai Feng
A dual-gene delivery system with coordinated expression function boosted the neovascularization.
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Biomater. Sci., 2020, 8,2245-2254
DOI: 10.1039/C9BM02010A, Paper

Gil Yeroslavsky, Masakazu Umezawa, Kyohei Okubo, Karina Nigoghossian, Doan Thi Kim Dung, Keiji Miyata, Masao Kamimura, Kohei Soga
Encapsulation of ICG and IR-1061 in PCL–PEG micelles producing agents with increased stability of ICG and tunable PTT and PDT activity. The micelles are also useful for NIR imaging and NIR nanothermometry.
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Biomater. Sci., 2020, 8,2289-2299
DOI: 10.1039/C9BM01474H, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Jefferson O. Abaricia, Arth H. Shah, Ryan M. Musselman, Rene Olivares-Navarrete
Neutrophils are sensitive to biomaterial surface properties, controlling activation and inflammatory microenvironment, revealing a novel target for enhancing biomaterial integration.
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Biomater. Sci., 2020, 8,2300-2307
DOI: 10.1039/D0BM00276C, Paper

Ruru Li, Xiaoyu Huang, Guolin Lu, Chun Feng
A PEG₄₅-b-PVPOP₁₄ diblock copolymer with pendant levulinate-protected phenol groups exhibited a highly specific response toward sulfites.
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Biomater. Sci., 2020, 8,2102-2110
DOI: 10.1039/D0BM00027B, Minireview

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

T. Ahlfeld, V. Guduric, S. Duin, A. R. Akkineni, K. Schütz, D. Kilian, J. Emmermacher, N. Cubo-Mateo, S. Dani, M. v. Witzleben, J. Spangenberg, R. Abdelgaber, R. F. Richter, A. Lode, M. Gelinsky
This minireview highlights the use of the polysaccharide methylcellulose for biofabrication applications. Its properties are useful for printing of dissolvable support structures as well as the development of novel bioinks.
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Biomater. Sci., 2020, 8,2129-2142
DOI: 10.1039/D0BM00171F, Paper

Xiaoshuang Guo, Zihan Yuan, Yang Xu, Minyan Wei, Zhiwei Fang, Wei-En Yuan
RNAi technology targeting HIF-1α could benefit hemangioma therapy effectively and FPEI polyplexes which could inhibit the expression of HIF-1α at the translational level can provide a practicable strategy for clinical hemangioma treatment in the future.
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Biomater. Sci., 2020, 8,2143-2155
DOI: 10.1039/C9BM01691K, Paper

Open Access

  This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Katharina Schuhladen, Lena Stich, Jochen Schmidt, Alexander Steinkasserer, Aldo R. Boccaccini, Elisabeth Zinser
Bioactive borate glasses additionally doped with copper and/or zinc have enthralling immune-modulatory effects on immune cells.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00453G, Paper

Zhongzheng Yu, Yong Yao Chun, Jingwen Xue, Jodie Zu Yi Tan, Wen Kiat Chan, Weizheng Cai, Yan Zhang, Timothy Thatt Yang Tan
Balancing the thickness of sensitizing and inert layers in neodymium-sensitized tetralayer nanoconstructs for optimal ultraviolet upconversion.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00424C, Paper

Nianqiang Jin, Nuo Jin, Zilin Wang, Lili Liu, Lin Meng, Daowei Li, Xing Li, Dabo Zhou, Jie Liu, Wenhuan Bu, Hongchen Sun, Bai Yang
Novel carbon dots induced ER stress and activated PERK-eIF2α-ATF4 pathway promote bone regeneration.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01879D, Paper

Guohua Wu, Di Wu, James Lo, Yimin Wang, Jianguo Wu, Siming Lu, Han Xu, Xin Zhao, Yong He, Jun Li, Utkan Demirci, Shuqi Wang
The developed bioartificial liver support system integrated with the decellularized liver matrix/GelMA-based bioengineered whole liver can potentially help elevate liver functions and prevent hepatic encephalopathy via enhanced ammonia reduction.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00269K, Review Article

Lu Wang, Cunyang Wang, Shuai Wu, Yubo Fan, Xiaoming Li
We have clarified the influence of the mechanical properties of biomaterials on degradability and cell response, and also mechanical design targets and approaches.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00323A, Paper

Bunty Sharma, Gurpreet Kaur, Ganga Ram Chaudhary, Santosh L. Gawali, P. A. Hassan
Developments in the field of photodynamic therapy (PDT) are being made by investigating appropriate photosensitizers (PSs) and enhancing the penetration effect of light by developing new metallocatanionic vesicles.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM02056J, Paper

Yadu N. Vakkipurath Kodakkadan, Kristyna Idzakovicova, Josef Sepitka, Daniël ten Napel, Eric Safai, Petr Cigler, Frantisek Štěpánek, Ivan Rehor
We introduce a method for photolithographic synthesis of arbitrarily shaped microgels composed purely of a biopolymer of choice.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00187B, Paper

Yuping Hu, Xuechun Wang, Peng Zhao, Hao Wang, Wei Gu, Ling Ye
The accelerated O₂ release from CaO₂ catalyzed by MnO₂ nanozyme leads to a rapid and efficient hypoxia relief, an increased yield of ¹O₂, a down-regulated HIF-1α and VEGF, and eventually a super-efficient PDT.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00175A, Paper

Mohamed F. Attia, Meenakshi Ranasinghe, Roman Akasov, Jeffrey N. Anker, Daniel C. Whitehead, Frank Alexis
Hybrid gold-polyester nanoparticles were synthesized by UV irradiation of a gold salt and photoinitiator encapsulated in a polyester nanoparticle. The resulting materials exhibit excellent cellular imaging and surface plasmon resonance properties.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00015A, Paper

Manisha Ahir, Priyanka Upadhyay, Avijit Ghosh, Sushmita Sarker, Saurav Bhattacharya, Payal Gupta, Swatilekha Ghosh, Sreya Chattopadhyay, Arghya Adhikary
Cationic Mesoporous silica Nanoparticle coated with hyaluronic acid conjugated polymer (HA-Dual miRNA Np) facilitated enhanced dual miRNA loading, efficient delivery and significantly inhibited tumor growth as well as retarded metastasis in triple-negative breast cancer.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00331J, Communication

Yihang Wu, Yue Xiong, Ling Wang, Quanming Zhou, Linxian Li, Pavel A. Levkin, Gary Davidson, Liqian Gao, Wenbin Deng
A library of lipidoids self-assembling to liposomes exhibits excellent transfection efficiency in HEK 293T cells and mESCs with low cytotoxicity.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00372G, Paper

Yongbin Cao, Boshu Ouyang, Xiaowei Yang, Qin Jiang, Lin Yu, Shun Shen, Jiandong Ding, Wuli Yang
Tumors were effectively destroyed by a mild photothermal effect and the subsequent gas mechanical damage triggered by NIR-II light.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM90037K, Correction

Open Access

  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Zhilin Liu, Na Shen, Zhaohui Tang, Dawei Zhang, Lili Ma, Chenguang Yang, Xuesi Chen
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01990A, Paper

Taufiq Ahmad, Hayeon Byun, Hyeok Jun Shin, Jinkyu Lee, Sajeesh Kumar Madhurakkat Perikamana, Eun Mi Kim, Young Min Shin, Heungsoo Shin
Adenosine and its receptors have emerged as alternative targets to control cellular functions for bone healing.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00318B, Communication

Pengyuan Qi, Qianyuan Chen, Dong Tu, Songhuan Yao, Yupeng Zhang, Jike Wang, Conghua Xie, Chunxu Pan, Hao Peng
The potential role of borophene as a radiosensitizer in PT and BNCT was investigated.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00155D, Paper

Sergio Acosta, Arturo Ibañez-Fonseca, Conrado Aparicio, J. Carlos Rodríguez-Cabello
Protein-engineered polymers can be used as multivalent platforms for AMP tethering on implant surfaces as cytocompatible coatings with strong antibiofilm properties.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00466A, Paper

Peng Zhang, Yu Zhang, Xiaoya Ding, Chunsheng Xiao, Xuesi Chen
An efficient strategy to selectively promote nanoparticle accumulation in solid tumors was developed by encapsulating sildenafil in cisplatin-incorporated polymeric micelles.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00063A, Paper

Yuyang Xia, Hongying Bao, Jie Huang, Xiaodi Li, Chenggong Yu, Zhijun Zhang, Haishui Wang
A dual-labeling strategy integrating near-infrared-persistent luminescence and RfLuc-based bioluminescence imaging techniques has been developed to track the transplanted stem cells, deepening the understanding of the role played by stem cells in PF treatment.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00076K, Paper

Jungju Oh, Sang-Mi Kim, Eun-Hye Lee, Minkyung Kim, Youngki Lee, Seung Hwan Ko, Ji Hoon Jeong, Chang-Hwan Park, Minhyung Lee
Heme oxygenase-1 messenger RNA (HO1-mRNA) was delivered into the post-ischemic brain, using a polymeric carrier. Therapeutic efficacy of HO1-mRNA delivery was compared with that of HO1-plasmid DNA (HO1-pDNA) in ischemia-reperfusion rat models.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00395F, Communication

Yue Hu, Yuyin Tang, Xiao-Jing Zhang, Xiao-Tong Yang, Ying-Ying Tang, Su Li, Linyu Hu, Peng Chen, Dong Zhu
Multi-functional and hierarchically structured silica nanospheres are rationally designed and fabricated, which encapsulate quantum dots to permit near infrared deep tissue imaging and are loaded with carcinoembryonic antigen messenger RNA (CEAmRNA) to enable stable and abundant antigen expression in DCs.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM02017A, Paper

Teresa Dean, Nancy T. Li, Jose L. Cadavid, Laurie Ailles, Alison P. McGuigan
A novel 3D in vitro co-culture platform to explore the interactions between cancer-associated fibroblasts and tumour cells that drive increased tumour cell invasion and the impact of matrix density.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00003E, Paper

Jia Qu, Dengke Teng, Guoqing Sui, Shihui Guan, Yang Wang, Qimeihui Wang, Yuanqiang Lin, Haitao Ran, Zhigang Wang, Hui Wang
The advantages of PCM@Lip/IT NPs include mitochondrial-targeting, on-demand drug release, and prodrug activation by hypoxia with guidance/monitoring by PA and FL imaging.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00376J, Paper

Dawei Li, Jin Zhou, Mingming Zhang, Yuanzheng Ma, Yanyu Yang, Xue Han, Xing Wang
An alendronate-loaded tetra-PEG hydrogel, as an injectable and effective drug carrier, regulates the optimized release of therapeutic cargoes to promote osteoporosis therapy and bone regeneration.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01872G, Review Article

Ratchapol Jenjob, Treethip Phakkeeree, Daniel Crespy
Core–shell particles offer significant advantages in their use for bioimaging and biosensors.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM01968E, Paper

Teng Zhang, Qingguang Wei, Hua Zhou, Wenhao Zhou, Daoyang Fan, Xinhong Lin, Zehao Jing, Hong Cai, Yan Cheng, Xiaoguang Liu, Weishi Li, Chunli Song, Yun Tian, Nanfang Xu, Yufeng Zheng, Zhongjun Liu
Sustainable release of vancomycin from micro-arc oxidised 3D-printed porous Ti6A14V for treating MRSA bone infection and enhancing osteogenesis.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00134A, Paper

Kiheon Baek, Alexander David Noblett, Pengyu Ren, Laura J. Suggs
Doxorubicin is intercalated within the nanofibril structure of self-assembled nucleo-peptide hydrogels and injection leads to decrease in tumor volume and greater concentration of chemotherapeutic relative to soluble form.
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Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00204F, Paper

Yongju He, Linjie Shao, Ibrahim Usman, Yao Hu, Anqiang Pan, Shuquan Liang, Hui Xu
The dilemma between tumor accumulation and renal clearance has severely limited the efficacy of mesoporous silica-based drug nanocarrier in cancer therapy. Herein, a pH-responsive dissociable mesoporous silica-based nanoplatform with efficient...
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00222D, Review Article

Natanael Fernandes, Carolina F. Rodrigues, André F. Moreira, Ilídio J. Correia
Cancer photothermal therapy (PTT) has captured the attention of researchers worldwide due to its localized and trigger-activated therapeutic effect.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00549E, Paper

Tianhong Teng, Ronggui Lin, Ziguo Lin, Kun Ke, Xianchao Lin, Maoen Pan, Da Zhang, Heguang Huang
Preparation of Abraxane@MoSe₂ and its PTT effect augment stromal disrupting effects for enhanced Abraxane synergy chemotherapy in pancreatic cancer PDX mode.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00278J, Paper

Qinghua Li, Zujian Feng, Huijuan Song, Jianhua Zhang, Anjie Dong, Deling Kong, Weiwei Wang, Pingsheng Huang
¹⁹ F MRI is able to precisely monitor the localization and quantify the degradation rate of implantable/injectable hydrogels in real-time and noninvasive manner, with no interference of endogenous background signals and limitation of penetration depth.
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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00188K, Paper

Ning Han, Ziyang Xu, Chunyan Cui, Yuan Li, Dongfei Zhang, Meng Xiao, Chuanchuan Fan, Tengling Wu, Jianhai Yang, Wenguang Liu
A tunicate-inspired gelatin-based hydrogel prepared by a simple mixing method, exhibits strong adhesion and antibacterial capacity, and facilitates wound healing.
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