ac Correction: Anti-schistosomal activity and ADMET properties of 1,2,5-oxadiazinane-containing compound synthesized by visible-light photoredox catalysis By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD90044H, Correction Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Kennosuke Itoh, Hiroki Nakahara, Atsushi Takashino, Aya Hara, Akiho Katsuno, Yuriko Abe, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Kenichiro Nagai, Reiko Seki, Noriko Sato, Kazuki Okuyama, Masashi Hashimoto, Ken Tokunaga, Hitoshi Ishida, Fusako Mikami, Kofi Dadzie Kwofie, Hayato Kawada, Bangzhong Lin, Kazuto Nunomura, Toshio Kanai, Takeshi Hatta, Naotoshi Tsuji, Junichi Haruta, Hideaki FujiiTo cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Human microbiome derived synthetic antimicrobial peptides with activity against Gram-negative, Gram-positive, and antibiotic resistant bacteria By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00383G, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Walaa K. Mousa, Ashif Y. Shaikh, Rose Ghemrawi, Mohammed Aldulaimi, Aya Al Ali, Nour Sammani, Mostafa Khair, Mohamed I. Helal, Farah Al-Marzooq, Emilia OueisAn AMP-derived short 15-mer peptide and its cyclic derivatives have low micromolar broad spectrum antibacterial activity, with rapid onset of bactericidal effect and a membrane-targeting mode of action.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Amides of moronic acid and morolic acid with the tripeptides MAG and GAM targeting antimicrobial, antiviral and cytotoxic effects By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00742E, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Uladzimir Bildziukevich, Lucie Cerna, Jana Trylčová, Marie Kvasnicova, Lucie Rárová, David Šaman, Petra Lovecká, Jan Weber, Zdenek WimmerA series of amides of the selected plant triterpenoids, moronic acid and morolic acid, with the tripeptides MAG and GAM was designed and synthesized. Two required tripeptides 5 and 10...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Novel benzenesulfonamides containing a dual triazole moiety with selective carbonic anhydrase inhibition and anticancer activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00617H, Research ArticleAida Buza, Cüneyt Türkeş, Mustafa Arslan, Yeliz Demir, Busra Dincer, Arleta Rifati Nixha, Şükrü BeydemirIn this research, a series of sulfonamides incorporating a 1,2,3-triazolyloxime substituted 1,2,3-triazolyl moiety was conceptualized, synthesized, and investigated as carbonic anhydrase inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Azo derivatives of monoterpenes as anti-Helicobacter pylori agents: from synthesis to structure-based target investigation By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00511B, Research Article Open Access   This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.Francesco Melfi, Marialuigia Fantacuzzi, Simone Carradori, Ilaria D'Agostino, Alessandra Ammazzalorso, Noemi Mencarelli, Marialucia Gallorini, Mattia Spano, Paolo Guglielmi, Mariangela Agamennone, Sazan Haji Ali, Ali Al-Samydai, Francesca SistoMonoterpene-derived azo benzenes showed selective antibacterial activity against Helicobacter pylori with a safe profile. An in silico investigation highlighted the inosine 5'-monophosphate dehydrogenase enzyme as the putative target.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Synthesis and anti-tumor activity of new benzofuran-based chalcone derivatives as potent VEGFR-2 inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00621F, Research ArticleChunfei Zhang, Yixin Liu, Xiao Zhang, Chunping Wan, Zewei MaoA series of novel benzofuran-based chalcone derivatives could be considered as potent VEGFR-2 inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Miniaturized click chemistry and direct screening facilitate the discovery of triazole piperazine SARS-CoV-2 Mpro inhibitors with improved metabolic stability By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00555D, Research ArticleShenghua Gao, Letian Song, Bing Ye, Mianling Yang, Junyi Li, Manyu Gu, Ann E. Tollefson, Karoly Toth, Peng Zhan, Xinyong LiuThe continuous mutational nature of SARS-CoV-2 and its inter-species' similarities emphasize the urgent need to design and develop more direct-acting antiviral agents against highly infectious variants.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Advances in antibacterial agents for Mycobacterium fortuitum By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00508B, Review ArticleCarlos Roberto Tavolari Jortieke, Angélica Rocha Joaquim, Fernando FumagalliThis review presents the recent findings on antibacterial agents against Mycobacterium fortuitum and reveals the most promising and effective chemical frameworks to inspire the development of new drugs.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac A novel approach for the synthesis of the cyclic lipopeptide globomycin By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00685B, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Samantha J. Bann, Stephen A. CochraneLipid swapping: a new approach for the synthesis of globomycin that allows for facile lipid diversification.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against Staphylococcus aureus By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00623B, Research ArticleOjaswitha Ommi, Priyanka Sudhir Dhopat, Shashikanta Sau, Madhu Rekha Estharla, Srinivas Nanduri, Nitin Pal Kalia, Venkata Madhavi YaddanapudiA series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, and Mycobacterium tuberculosis, aiming to combat antibiotic resistance.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Novel quinoxaline-derived derivatives: design, synthesis, bioactive evaluation, SARs and preliminary antibacterial mechanism By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00670D, Research ArticleYuting Liu, Pengju Yang, Yunyun Zhou, Zhiwen ZhouIn the current study, we have designed and prepared a series of quinoxaline-based compounds, which were derived from o-phenylenediamine. Among which, compounds 5m-p displayed good to moderate antibacterial activity with...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Enhancing the antimycobacterial efficacy of pyridine-4-carbohydrazide: linkage to additional antimicrobial agents via oxocarboxylic acids By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00663A, Research Article Open Access   This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Václav Pflégr, Klára Konečná, Jiřina Stolaříková, Jan Ősterreicher, Ondřej Janďourek, Martin KrátkýLinking pyridine-4-carbohydrazide to other antimicrobial agents via oxocarboxylic acids significantly enhances efficacy against mycobacteria with promising selectivity and safety profiles.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Synthesis of cationic N-acylated thiazolidine for selective activity against Gram-positive bacteria and evaluation of N-acylation's role in membrane-disrupting activity By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00626G, Research ArticleAleena Pious, Vignesh Venkatasubramanian, Dharshini Karnan Singaravelu, Subburethinam Ramesh, Fuad Ameen, Anbazhagan VeerappanLipidation modulates the Gram-selective antibacterial activity of QPyNATh.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Property-based optimisation of PROTACs By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00769G, OpinionJames Scott, Iacovos Michaelides, Markus SchadePROTACs are an emerging therapeutic approach towards targeted protein degradation. This article examines the leading examples of this modality that are in clinical development through the prism of their physicochemical...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac 3-Thio-3,4,5-Trisubstituted-1,2,4-Triazoles: High Affinity Somatostatin Receptor-4 Agonist Synthesis and Structure-Activity Relationships By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Accepted ManuscriptDOI: 10.1039/D4MD00597J, Research ArticleAlbert Michael Crider, Audrey Hospital, Karin Sandoval, William Neumann, Stephen Kukielski, Lejla Garic, Kristen Ingold, Matthew Dunahoo, Khush Srabony, Rafael Frare, Olivia Slater, Nathan Peel, Maria Kontoyianni, Ken WittSomatostatin receptor-4 (SST4) is a therapeutic target for several conditions, including Alzheimer’s disease, seizures, neuropsychiatric disorders, and pain. Our previous work on 1,2,4-triazole derivatives led to enhanced SST4 binding affinity,...The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac A practical guide for the assay-dependent characterisation of irreversible inhibitors By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00707G, Review ArticleLavleen K. Mader, Jessica E. Borean, Jeffrey W. KeillorKinetic evaluations for assay dependent characterization of irreversible inhibitors.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Adjuvant strategies to tackle mcr-mediated polymyxin resistance By pubs.rsc.org Published On :: RSC Med. Chem., 2024, Advance ArticleDOI: 10.1039/D4MD00654B, Review ArticleMadison R. Nuske, Junlang Zhong, Renjie Huang, Vijayalekshmi Sarojini, Jack L. Y. Chen, Christopher J. Squire, Mark A. T. Blaskovich, Ivanhoe K. H. LeungThe emergence of the mobile colistin resistance (mcr) gene is a significant threat contributing to the worldwide antibiotic resistance crisis. This review discusses adjuvant strategies to restore polymyxin sensitivity in these resistant bacteria.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry Full Article
ac Will decide on sharing stage with actor Vijay in consultation with VCK leaders: Thirumavalavan By www.thehindu.com Published On :: Tue, 05 Nov 2024 17:44:09 +0530 Mr. Thirumavalavan told reporters in Tiruchi that the book release event was not something that was planned recently, and that he had consented to take part in it almost a year ago Full Article Tamil Nadu
ac Duo arrested for possession of banned tobacco products worth ₹3 lakh in Tiruchi By www.thehindu.com Published On :: Wed, 06 Nov 2024 18:23:30 +0530 Full Article Tiruchirapalli
ac Case filed against actor Kasthuri over remarks on Telugu community By www.thehindu.com Published On :: Wed, 06 Nov 2024 19:46:03 +0530 Full Article Tiruchirapalli
ac Urban Primary Health Centre stuck in cramped, temporary facility By www.thehindu.com Published On :: Wed, 06 Nov 2024 20:31:50 +0530 Full Article Tiruchirapalli
ac HC directs authorities to maintain park and ensure no encroachment By www.thehindu.com Published On :: Wed, 06 Nov 2024 21:09:52 +0530 Full Article Madurai
ac Farmers demand withdrawal of Tamil Nadu Land Consolidation Act By www.thehindu.com Published On :: Thu, 07 Nov 2024 17:59:18 +0530 The Coordination Committee of All Farmers’ Associations of Tamil Nadu says the State government has created a situation where industries can acquire fertile lands Full Article Tiruchirapalli
ac Railways using treated water from its STP for maintaining green spaces By www.thehindu.com Published On :: Thu, 07 Nov 2024 20:46:00 +0530 The treated water is stored in an overhead tank and used in gardens at the two railway rest houses meant for officers at Kallukuzhi near Tiruchi Railway Junction Full Article Tiruchirapalli
ac High-level committee formed to facilitate clearances for companies that signed MoU, says Minister By www.thehindu.com Published On :: Fri, 08 Nov 2024 18:56:40 +0530 Constant monitoring was being done now from the time of signing of MoUs to providing employment in new industrial units, says Industries Minister T.R.B. Rajaa Full Article Tiruchirapalli
ac Fishermen seek healthcare and cold storage facilities By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:03:17 +0530 Full Article Tiruchirapalli
ac Uppiliyapuram, gateway to scenic Pachamalai, lacks bus stand with passengers left to fight the elements By www.thehindu.com Published On :: Fri, 08 Nov 2024 19:20:03 +0530 Buses stop at a busy junction making it difficult for commuters as well as local businessmen; a site is yet to be identified for the bus stand Full Article Tiruchirapalli
ac EPS’s dream of AIADMK staging a comeback in 2026 election will not materialise: Law Minister Regupathy By www.thehindu.com Published On :: Fri, 08 Nov 2024 20:25:59 +0530 Full Article Tiruchirapalli
ac Lack of signboards indicating bus timings at Chathiram Bus Stand in Tiruchi irks passengers By www.thehindu.com Published On :: Mon, 11 Nov 2024 17:08:51 +0530 Passengers also say some buses leave earlier than scheduled or don’t pass certain rural areas, leading to schoolchildren not being able to board on time Full Article Tiruchirapalli
ac 543: Zach Leatherman on Eleventy, Mastodon, Twitter, and is-land By shoptalkshow.com Published On :: Tue, 29 Nov 2022 16:30:32 +0000 Zach Leatherman talks with us about what's new with Eleventy, setting up on Mastodon, what's happened with Twitter, and is-land. Full Article All Episodes eleventy mastodon Twitter Web Components
ac 544: Feedback, RSS Talk, Arc Brower, and Product Talk By shoptalkshow.com Published On :: Mon, 05 Dec 2022 08:15:42 +0000 Getting feedback for what you're building or writing, RSS feed reminiscing, Arc browser thoughts, products that didn't make that should have. Full Article All Episodes browsers Feedback rss
ac 554: Jamstack Thoughts with Brian Rinaldi By shoptalkshow.com Published On :: Mon, 27 Feb 2023 20:50:01 +0000 Brian Rinaldi joins us to talk about the state of Jamstack in 2023, acronym confusion, SPA confusion, developing common tools of understanding, why Netlify bought Gatsby, and the state of developer conferences. Full Article All Episodes jamstack
ac 555: React Documentary, Front of the Front End, Fast Fallacy, and Best Practices By shoptalkshow.com Published On :: Mon, 06 Mar 2023 09:39:37 +0000 Reacting to the React.js documentary, is there still jobs for front of the front end anymore? The fast fallacy in frameworks, best practices, dealing with too much or too little isolation, and AI test generation. Full Article All Episodes applying for a job React Tests
ac 567: Full Stack Dev, Load Bearing Developer, and Being Zod Curious By shoptalkshow.com Published On :: Mon, 29 May 2023 09:00:16 +0000 What do you do if your computer dies? Chris applies to work at Luro, Dave applies at CodePen, Dave's Zod curious, TypeScript, sorting out a 10MB blog post, and how much do you miss jQuery? Full Article All Episodes full stack Jquery Zod
ac 585: Blog Redesign, Sounds on a Website, Accessibility Tests, and Safari 17 By shoptalkshow.com Published On :: Mon, 02 Oct 2023 08:30:29 +0000 Chris redesigned his blog, using sounds on your website to make it seem fancy, what can't automated accessibility tests test, and what's new in Safari 17. Full Article All Episodes accessibilty sounds
ac 597: How Many VS Code Plugins, Poor Charlie’s Almanack, and Where to Start in 2024? By shoptalkshow.com Published On :: Mon, 08 Jan 2024 10:06:30 +0000 We're closing in on episode 600 and need your help to celebrate! Listen in to learn how to contribute to the episode. We're also talking GitHub desktop apps and code editors, how many VS Code plugins are needed, reading long form like Poor Charlie's Almanack, InVision shutting down, and answering our first Q of the year: how would you approach learning web development in 2024? Full Article All Episodes Education episode 600 Github vs code
ac 602: What Does Accessibility Really Mean? By shoptalkshow.com Published On :: Mon, 12 Feb 2024 10:20:51 +0000 Voiceover pays us a visit, we talk about what accessibility really means, the difficulty of closing a dialogue element, web components at work, and jQuery 4 is out. Full Article All Episodes accessibilty Jquery
ac 603: Deno, React Alternatives, and Copilot Concerns with Triple Threat Josh Collinsworth By shoptalkshow.com Published On :: Mon, 19 Feb 2024 09:22:07 +0000 Josh (or Jsoh) stops by to talk about his work at Deno, recent blog posts on Copilot, why Svelte is awesome and React is not, Apple and PWA, and building word games on the web. Full Article All Episodes Deno GitHub copilot pwa
ac 611: React! TypeScript! Jobification! Drupal! By shoptalkshow.com Published On :: Mon, 15 Apr 2024 08:30:37 +0000 Dave & Chris and thoughts on career advice that worked 3 years ago but isn't as helpful now, marking tests with ChatGPT, is taking a Drupal job in 2024 a good idea, Chris got #gear sniped, P3 color follow up, the confusing File System APIs, and where did all the lightboxes go? Full Article All Episodes Career Advice Drupal File System API p3
ac 616: Strum Machine with Luke Abbott By shoptalkshow.com Published On :: Mon, 20 May 2024 08:09:58 +0000 Luke Abbott is the creator of Strum Machine, an app that simulates backing tracks by stitching together individual notes, chords, and strums recorded on guitar, standup bass, and mandolin. We talk about what Strum Machine does, why he decided to build it, how bringing on a professional designer helped, pricing thoughts, and the "fun" of building a version on iOS. Full Article All Episodes app banjo music
ac 618: Matt Visiwig on SVGBackgrounds By shoptalkshow.com Published On :: Mon, 03 Jun 2024 08:08:44 +0000 Matt Visiwig stops by to chat with us about his site, SVGBackgrounds.com, a membership site for copy-and-paste website graphics built around SVG. We talk about why he built the site, how he decided to monetize it, competing with AI garbage on the web, pricing membership options, and how he's running the site. Full Article All Episodes ecommerce Making Money SEO SVG
ac 621: Setting Up Prettier and Linting, Comparing Colors, and Accessibility Overlays By shoptalkshow.com Published On :: Mon, 24 Jun 2024 08:05:22 +0000 We've got follow up on Cloudflare and Cara from last episode, a question about setting up Prettier and auto linting, a cool tool from a listener on comparing colors, a question about using tooling like Craft or more user friendly apps like Webflow when working with clients, and our takes on accessibility overlays. Full Article All Episodes Accessibility prettier webflow
ac 624: Blogging, In App Browsers are Bad, and Teaching CSS from Scratch By shoptalkshow.com Published On :: Mon, 15 Jul 2024 08:37:37 +0000 On this epsiode we're talking about the current state of blogging and social media, the polyfill hack, whether in app browsers should be banned, web components and the difficulty of front end web dev, and how we would go about teaching CSS from scratch in 2024. Full Article All Episodes Blogging CSS Education polyfill
ac 637: Approachable Open Source with Brian Muenzenmeyer By shoptalkshow.com Published On :: Mon, 14 Oct 2024 08:28:34 +0000 Brian Muenzenmeyer joins the show to talk about his book, Approachable Open Source, ways we can make open source easier to get in, important conversations around funding and supporting open source, and whether money helps maintainers deal with burnout or not? Full Article All Episodes books Money Open Source
ac ‘Edible’ terraces By www.thehindu.com Published On :: Fri, 05 Dec 2014 15:33:52 +0530 In pursuit of organic food, Bengaluru residents are growing vegetables on open terraces. Full Article Property Plus
ac Building practices for the future By www.thehindu.com Published On :: Fri, 05 Dec 2014 16:08:44 +0530 Sacred Groves in Auroville is being built using ecologically sensitive construction methods and material. Full Article Property Plus
ac Your space, your right By www.thehindu.com Published On :: Fri, 17 Apr 2015 14:58:35 +0530 Ask for specified parking slots in your new home. Full Article Property Plus
ac The fight against encroachment By www.thehindu.com Published On :: Fri, 04 Sep 2015 16:58:16 +0530 No one has the right to use precious road space as their private storage yard. Full Article Property Plus
ac Gunning for a slice of billion-dollar defence contracts By www.thehindubusinessline.com Published On :: Sun, 29 Sep 2024 20:36:00 +0530 How a college project birthed a bootstrapped manufacturer of components for the armed forces Full Article Emerging Entrepreneurs
ac Balrampur Chini hopes success of polylactic acid plant will be sweet By www.thehindubusinessline.com Published On :: Sun, 29 Sep 2024 20:46:00 +0530 In conversation with Avantika Saraogi, ED, and Stefan Barot, President, Chemicals Division, Balrampur Chini Mills Full Article Corporate File