a Thiazolidinediones in the Treatment of Insulin Resistance and Type II Diabetes By diabetes.diabetesjournals.org Published On :: 1996-12-01 Alan R SaltielDec 1, 1996; 45:1661-1669Perspectives in Diabetes Full Article
a Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells By diabetes.diabetesjournals.org Published On :: 1997-11-01 Markus TiedgeNov 1, 1997; 46:1733-1742Original Article Full Article
a Are the {beta}-Cell Signaling Molecules Malonyl-CoA and Cystolic Long-Chain Acyl-CoA Implicated in Multiple Tissue Defects of Obesity and NIDDM? By diabetes.diabetesjournals.org Published On :: 1996-03-01 Marc PrentkiMar 1, 1996; 45:273-283Original Article Full Article
a Cell-Permeable Peptide Inhibitors of JNK: Novel Blockers of {beta}-Cell Death By diabetes.diabetesjournals.org Published On :: 2001-01-01 Christophe BonnyJan 1, 2001; 50:77-82Islet Studies Full Article
a Inflammatory Cytokines and the Risk to Develop Type 2 Diabetes: Results of the Prospective Population-Based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study By diabetes.diabetesjournals.org Published On :: 2003-03-01 Joachim SprangerMar 1, 2003; 52:812-817Pathophysiology Full Article
a A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm By diabetes.diabetesjournals.org Published On :: 1996-02-01 Franz M MatschinskyFeb 1, 1996; 45:223-241Banting Lecture 1995 Full Article
a Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H-13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents By diabetes.diabetesjournals.org Published On :: 1999-08-01 G PerseghinAug 1, 1999; 48:1600-1606Articles Full Article
a The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization By diabetes.diabetesjournals.org Published On :: 1981-12-01 R A DeFronzoDec 1, 1981; 30:1000-1007Original Contribution Full Article
a NCEP-Defined Metabolic Syndrome, Diabetes, and Prevalence of Coronary Heart Disease Among NHANES III Participants Age 50 Years and Older By diabetes.diabetesjournals.org Published On :: 2003-05-01 Charles M. AlexanderMay 1, 2003; 52:1210-1214Complications Full Article
a Mechanisms of Pancreatic {beta}-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities By diabetes.diabetesjournals.org Published On :: 2005-12-01 Miriam CnopDec 1, 2005; 54:S97-S107Section III: Inflammation and beta-Cell Death Full Article
a Nonalcoholic Fatty Liver Disease: A Feature of the Metabolic Syndrome By diabetes.diabetesjournals.org Published On :: 2001-08-01 Giulio MarchesiniAug 1, 2001; 50:1844-1850Pathophysiology Full Article
a Tumor Necrosis Factor {alpha}: A Key Component of the Obesity-Diabetes Link By diabetes.diabetesjournals.org Published On :: 1994-11-01 Gökhan S HotamisligilNov 1, 1994; 43:1271-1278Perspectives in Diabetes Full Article
a Intrauterine exposure to diabetes conveys risks for type 2 diabetes and obesity: a study of discordant sibships By diabetes.diabetesjournals.org Published On :: 2000-12-01 D DabeleaDec 1, 2000; 49:2208-2211Articles Full Article
a Evidence for 5'AMP-Activated Protein Kinase Mediation of the Effect of Muscle Contraction on Glucose Transport By diabetes.diabetesjournals.org Published On :: 1998-08-01 Tatsuya HayashiAug 1, 1998; 47:1369-1373Rapid Publications Full Article
a Insulin Action, Diabetogenes, and the Cause of Type II Diabetes By diabetes.diabetesjournals.org Published On :: 1994-08-01 C. Ronald KahnAug 1, 1994; 43:1066-1085Banting Lecture Full Article
a High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells By diabetes.diabetesjournals.org Published On :: 2000-11-01 T InoguchiNov 1, 2000; 49:1939-1945Articles Full Article
a Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance By diabetes.diabetesjournals.org Published On :: 1992-03-01 Eve Van CauterMar 1, 1992; 41:368-377Original Article Full Article
a From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus By diabetes.diabetesjournals.org Published On :: 2009-04-01 Ralph A. DeFronzoApr 1, 2009; 58:773-795Banting Lecture Full Article
a Skeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action By diabetes.diabetesjournals.org Published On :: 1997-06-01 D A PanJun 1, 1997; 46:983-988Original Article Full Article
a Protein kinase C activation and the development of diabetic complications By diabetes.diabetesjournals.org Published On :: 1998-06-01 D KoyaJun 1, 1998; 47:859-866Articles Full Article
a Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications By diabetes.diabetesjournals.org Published On :: 1995-08-01 Roger H UngerAug 1, 1995; 44:863-870Perspectives in Diabetes Full Article
a Diet-Induced Type II Diabetes in C57BL/6J Mice By diabetes.diabetesjournals.org Published On :: 1988-09-01 Richard S SurwitSep 1, 1988; 37:1163-1167Original Article Full Article
a Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and I{kappa}B-{alpha} By diabetes.diabetesjournals.org Published On :: 2002-07-01 Samar I. ItaniJul 1, 2002; 51:2005-2011Rapid Publications Full Article
a Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats By diabetes.diabetesjournals.org Published On :: 1999-12-01 G XuDec 1, 1999; 48:2270-2276Articles Full Article
a Banting Lecture 2001: Dysregulation of Fatty Acid Metabolism in the Etiology of Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2002-01-01 J. Denis McGarryJan 1, 2002; 51:7-18Banting Lecture 2001 Full Article
a Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas By diabetes.diabetesjournals.org Published On :: 1967-01-01 Paul E LacyJan 1, 1967; 16:35-39Original Contribution Full Article
a Elevated Levels of Acute-Phase Proteins and Plasminogen Activator Inhibitor-1 Predict the Development of Type 2 Diabetes: The Insulin Resistance Atherosclerosis Study By diabetes.diabetesjournals.org Published On :: 2002-04-01 Andreas FestaApr 1, 2002; 51:1131-1137Complications Full Article
a Hypoglycemia in the Diabetes Control and Complications Trial By diabetes.diabetesjournals.org Published On :: 1997-02-01 The Diabetes Control and Complications Trial Research GroupFeb 1, 1997; 46:271-286Original Article Full Article
a The Relationship of Glycemic Exposure (HbA1c) to the Risk of Development and Progression of Retinopathy in the Diabetes Control and Complications Trial By diabetes.diabetesjournals.org Published On :: 1995-08-01 The Diabetes Control and Complications Trial Research GroupAug 1, 1995; 44:968-983Original Article Full Article
a A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans By diabetes.diabetesjournals.org Published On :: 2001-08-01 David E. CummingsAug 1, 2001; 50:1714-1719Rapid Publications Full Article
a Role of oxidative stress in diabetic complications: a new perspective on an old paradigm By diabetes.diabetesjournals.org Published On :: 1999-01-01 JW BaynesJan 1, 1999; 48:1-9Articles Full Article
a PPAR{gamma} Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein By diabetes.diabetesjournals.org Published On :: 2001-09-01 Norikazu MaedaSep 1, 2001; 50:2094-2099Pathophysiology Full Article
a Preservation of Pancreatic {beta}-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women By diabetes.diabetesjournals.org Published On :: 2002-09-01 Thomas A. BuchananSep 1, 2002; 51:2796-2803Pathophysiology Full Article
a Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade By diabetes.diabetesjournals.org Published On :: 1999-06-01 ME GriffinJun 1, 1999; 48:1270-1274Articles Full Article
a Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM By diabetes.diabetesjournals.org Published On :: 1997-01-01 Guenther BodenJan 1, 1997; 46:3-10Perspectives in Diabetes Full Article
a U.K. Prospective Diabetes Study 16: Overview of 6 Years' Therapy of Type II Diabetes: A Progressive Disease By diabetes.diabetesjournals.org Published On :: 1995-11-01 U.K. Prospective Diabetes Study GroupNov 1, 1995; 44:1249-1258Perspectives in Diabetes Full Article
a Role of Oxidative Stress in Development of Complications in Diabetes By diabetes.diabetesjournals.org Published On :: 1991-04-01 John W BaynesApr 1, 1991; 40:405-412Perspectives in Diabetes Full Article
a The Triumvirate: {beta}-Cell, Muscle, Liver: A Collusion Responsible for NIDDM By diabetes.diabetesjournals.org Published On :: 1988-06-01 Ralph A DeFronzoJun 1, 1988; 37:667-687Lilly Lecture 1987 Full Article
a Quantification of the Relationship Between Insulin Sensitivity and {beta}-Cell Function in Human Subjects: Evidence for a Hyperbolic Function By diabetes.diabetesjournals.org Published On :: 1993-11-01 Steven E KahnNov 1, 1993; 42:1663-1672Original Article Full Article
a Triggering and amplifying pathways of regulation of insulin secretion by glucose By diabetes.diabetesjournals.org Published On :: 2000-11-01 JC HenquinNov 1, 2000; 49:1751-1760Articles Full Article
a Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2002-10-01 David E. KelleyOct 1, 2002; 51:2944-2950Metabolism and Signal Transduction Full Article
a PPAR-gamma: adipogenic regulator and thiazolidinedione receptor By diabetes.diabetesjournals.org Published On :: 1998-04-01 BM SpiegelmanApr 1, 1998; 47:507-514Articles Full Article
a Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion By diabetes.diabetesjournals.org Published On :: 2000-03-01 HE HohmeierMar 1, 2000; 49:424-430Articles Full Article
a Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice By diabetes.diabetesjournals.org Published On :: 2008-06-01 Patrice D. CaniJun 1, 2008; 57:1470-1481Metabolism Full Article
a The Pathobiology of Diabetic Complications: A Unifying Mechanism By diabetes.diabetesjournals.org Published On :: 2005-06-01 Michael BrownleeJun 1, 2005; 54:1615-1625Banting Lecture 2004 Full Article
a Metabolic Endotoxemia Initiates Obesity and Insulin Resistance By diabetes.diabetesjournals.org Published On :: 2007-07-01 Patrice D. CaniJul 1, 2007; 56:1761-1772Obesity Studies Full Article
a Classification and Diagnosis of Diabetes Mellitus and Other Categories of Glucose Intolerance By diabetes.diabetesjournals.org Published On :: 1979-12-01 National Diabetes Data GroupDec 1, 1979; 28:1039-1057Articles Full Article
a {beta}-Cell Deficit and Increased {beta}-Cell Apoptosis in Humans With Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2003-01-01 Alexandra E. ButlerJan 1, 2003; 52:102-110Islet Studies Full Article
a Role of Insulin Resistance in Human Disease By diabetes.diabetesjournals.org Published On :: 1988-12-01 Gerald M ReavenDec 1, 1988; 37:1595-1607Banting Lecture 1988 Full Article
a Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank By diabetes.diabetesjournals.org Published On :: 2020-01-20T12:00:26-08:00 Night shift work, behavioral rhythms, and the common MTNR1B risk single nucleotide polymorphism (SNP), rs10830963, associate with type 2 diabetes; however, whether they exert joint effects to exacerbate type 2 diabetes risk is unknown. Among employed participants of European ancestry in the UK Biobank (N = 189,488), we aimed to test the cross-sectional independent associations and joint interaction effects of these risk factors on odds of type 2 diabetes (n = 5,042 cases) and HbA1c levels (n = 175,156). Current shift work, definite morning or evening preference, and MTNR1B rs10830963 risk allele associated with type 2 diabetes and HbA1c levels. The effect of rs10830963 was not modified by shift work schedules. While marginal evidence of interaction between self-reported morningness-eveningness preference and rs10830963 on risk of type 2 diabetes was seen, this interaction did not persist when analysis was expanded to include all participants regardless of employment status and when accelerometer-derived sleep midpoint was used as an objective measure of morningness-eveningness preference. Our findings suggest that MTNR1B risk allele carriers who carry out shift work or have more extreme morningness-eveningness preference may not have enhanced risk of type 2 diabetes. Full Article
