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Growth of microorganisms in an interfacially driven space bioreactor analog

npj Microgravity, Published online: 08 April 2020; doi:10.1038/s41526-020-0101-4

Growth of microorganisms in an interfacially driven space bioreactor analog




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Ex situ determination of freely dissolved concentrations of hydrophobic organic chemicals in sediments and soils: basis for interpreting toxicity and assessing bioavailability, risks and remediation necessity




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Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy




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High rate of durable remissions post autologous stem cell transplantation for core-binding factor acute myeloid leukaemia in second complete remission




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Donor-derived DNA variability in fingernails of acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation detected by direct PCR




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NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma




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Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells




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WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2




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Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent binding to neonatal Fc receptor

Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives.




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Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

Mouse studies suggest inhibiting PGF could help treat hypertension.




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Topoisomerase II binding protein 1 (TOPBP1)

Mouse and cell culture studies suggest inhibiting TOPBP1 could help treat cancer.




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Translational tidbits

Yabao and MRC Technology partner in PD; charities form Neuro-MAP to insource pharma's abandoned compounds; Singapore creates a diagnostic hub; a roundup of public-private partnerships.




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Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity




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Nature Cell Biology




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MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




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Oncolytic adenovirus encoding LIGHT (TNFSF14) inhibits tumor growth via activating anti-tumor immune responses in 4T1 mouse mammary tumor model in immune competent syngeneic mice




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TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials




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UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53




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High-purity orbital angular momentum states from a visible metasurface laser




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Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization




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An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9




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Compound LM9, a novel MyD88 inhibitor, efficiently mitigates inflammatory responses and fibrosis in obesity-induced cardiomyopathy




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Microbiota and colorectal cancer: colibactin makes its mark




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Colons or semi-colons: punctuating the regional variation of intestinal microbial–immune interactions




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Cannabinoid CB<sub>2</sub> receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear




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A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology




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Δ<sup>9</sup>-Tetrahydrocannabinol (THC) impairs visual working memory performance: a randomized crossover trial




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Combining radiolabelled therapies for neuroendocrine neoplasms




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Probing nanoscale fluctuation of ferromagnetic meta-atoms with a stochastic photonic spin Hall effect




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Decelerated epigenetic aging associated with mood stabilizers in the blood of patients with bipolar disorder




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The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro




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Expert opinion—management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors




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SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia




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Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke




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An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders




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NLRP3 inflammasome activity as biomarker for primary progressive multiple sclerosis




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Mining bacteria for biosensors




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Why Authoritarianism is Bad for Science, But Bigotry is Even Worse

There have been many protests against the Citizenship Amendment Bill (now Act), and there will be many more. This piece of legislation strikes at the heart of the Constitution, seeking to make India another country altogether. It is thus that so many people from so many different walks of life have raised their voices against [...]




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Possible consequences of the COVID-19 pandemic on the use of biospecimens from cancer biobanks for research in academia and bioindustry




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Next Moves on Climate Policy: A Conversation with Sue Biniaz

Sue Biniaz, former lead climate negotiator for the United States, shared her thoughts on the postponement of COP-26, and on the possible re-engagement of the U.S. in the international effort to address climate change in the newest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program,” a podcast produced by the Harvard Environmental Economics Program.




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Next Moves on Climate Policy: A Conversation with Sue Biniaz

Sue Biniaz, former lead climate negotiator for the United States, shared her thoughts on the postponement of COP-26, and on the possible re-engagement of the U.S. in the international effort to address climate change in the newest episode of “Environmental Insights: Discussions on Policy and Practice from the Harvard Environmental Economics Program,” a podcast produced by the Harvard Environmental Economics Program.




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Elevated sorbitol underlies a heritable neuropathy




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Biallelic mutations in <i>SORD</i> cause a common and potentially treatable hereditary neuropathy with implications for diabetes




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ZBP1 (DAI/DLM-1) promotes osteogenic differentiation while inhibiting adipogenic differentiation in mesenchymal stem cells through a positive feedback loop of Wnt/β-catenin signaling




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Accesibilidad informacional y diversidad funcional en el contexto universitario: el caso de la Universidad Complutense de Madrid

Cuevas-Cerveró, Aurora and Razquín-Zazpe, Pedro and Parra-Valero, Pablo and Barrios-Martínez, Cristina and Gómez-Hernández, José-Antonio . Accesibilidad informacional y diversidad funcional en el contexto universitario: el caso de la Universidad Complutense de Madrid., 2020 In: Competencia en Información y Políticas para Educación Superior: Estudos Hispano-Brasileiros. Universidad Complutense de Madrid, pp. 132-146. [Book chapter]




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El aspecto social de la biblioteca pública y la inclusión social de las minorías

Saurin-Parra, Julia . El aspecto social de la biblioteca pública y la inclusión social de las minorías., 2019 In: El libro y la lectura en recintos penitenciarios. Gráfica Nacional, pp. 73-81. [Book chapter]




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Leer, escribir y aprender con Internet. La función educativa de las bibliotecas y las tecnologías participativas de la web social

Gómez-Hernández, José-Antonio . Leer, escribir y aprender con Internet. La función educativa de las bibliotecas y las tecnologías participativas de la web social., 2008 In: Infodiversidad. La biblioteca como centro multicultural. Universidad de Guadalajara, pp. 55-74. [Book chapter]




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La medición de la satisfacción de usuarios como indicador de calidad en los sistemas bibliotecarios: el caso de las universidades públicas de noroeste de México

Verdugo-Sánchez, José-Alfredo La medición de la satisfacción de usuarios como indicador de calidad en los sistemas bibliotecarios: el caso de las universidades públicas de noroeste de México., 2015 PhD Thesis thesis, Universidad Complutense de Madrid. [Thesis]




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Retweeting Covid-19 disability issues: Risks, support and outrage

Thelwall, Mike and Levitt, Jonathan M. Retweeting Covid-19 disability issues: Risks, support and outrage. El profesional de la información, 2020, vol. 29, n. 2. [Journal article (Unpaginated)]




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Ritmo de crecimiento diario de la producción científica sobre Covid-19. Análisis en bases de datos y repositorios en acceso abierto

Torres-Salinas, Daniel Ritmo de crecimiento diario de la producción científica sobre Covid-19. Análisis en bases de datos y repositorios en acceso abierto. El profesional de la información, 2020, vol. 29, n. 2. [Journal article (Unpaginated)]