l Ex situ determination of freely dissolved concentrations of hydrophobic organic chemicals in sediments and soils: basis for interpreting toxicity and assessing bioavailability, risks and remediation necessity By feeds.nature.com Published On :: 2020-04-20 Full Article
l Simultaneous noninvasive recording of electrocardiogram and skin sympathetic nerve activity (neuECG) By feeds.nature.com Published On :: 2020-04-20 Full Article
l Author Correction: Guidance for quantitative confocal microscopy By feeds.nature.com Published On :: 2020-04-20 Full Article
l Cellular thermal shift assay for the identification of drug–target interactions in the <i>Plasmodium falciparum</i> proteome By feeds.nature.com Published On :: 2020-04-27 Full Article
l Simultaneous quantification of protein–DNA interactions and transcriptomes in single cells with scDam&T-seq By feeds.nature.com Published On :: 2020-04-29 Full Article
l Tissue-specific alteration of gene expression and function by RU486 and the GeneSwitch system By feeds.nature.com Published On :: 2019-05-21 Full Article
l Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy By feeds.nature.com Published On :: 2019-10-02 Full Article
l Daily blue-light exposure shortens lifespan and causes brain neurodegeneration in <i>Drosophila</i> By feeds.nature.com Published On :: 2019-10-17 Full Article
l Short-term NAD<sup>+</sup> supplementation prevents hearing loss in mouse models of Cockayne syndrome By feeds.nature.com Published On :: 2020-01-07 Full Article
l Repository of proposed pathways and protein–protein interaction networks in age-related macular degeneration By feeds.nature.com Published On :: 2020-01-07 Full Article
l CMV-independent increase in CD27−CD28+ CD8+ EMRA T cells is inversely related to mortality in octogenarians By feeds.nature.com Published On :: 2020-01-21 Full Article
l Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging By feeds.nature.com Published On :: 2020-03-06 Full Article
l COVID-19 outcomes in patients with hematologic disease By feeds.nature.com Published On :: 2020-05-06 Full Article
l High rate of durable remissions post autologous stem cell transplantation for core-binding factor acute myeloid leukaemia in second complete remission By feeds.nature.com Published On :: 2020-05-06 Full Article
l Phase I trial of maintenance selinexor after allogeneic hematopoietic stem cell transplantation for patients with acute myeloid leukemia and myelodysplastic syndrome By feeds.nature.com Published On :: 2020-05-06 Full Article
l Oral health in allogeneic hematopoietic stem cells transplantation survivors By feeds.nature.com Published On :: 2020-05-07 Full Article
l Rituximab for desensitization during HLA-mismatched stem cell transplantation in patients with a positive donor-specific anti-HLA antibody By feeds.nature.com Published On :: 2020-05-08 Full Article
l Donor-derived DNA variability in fingernails of acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation detected by direct PCR By feeds.nature.com Published On :: 2020-05-09 Full Article
l Safety and efficacy of chimeric antigen receptor T-cell therapy in relapsed/refractory multiple myeloma with renal impairment By feeds.nature.com Published On :: 2020-05-09 Full Article
l NT5DC2 promotes tumor cell proliferation by stabilizing EGFR in hepatocellular carcinoma By feeds.nature.com Published On :: 2020-05-07 Full Article
l Irradiation induces cancer lung metastasis through activation of the cGAS–STING–CCL5 pathway in mesenchymal stromal cells By feeds.nature.com Published On :: 2020-05-07 Full Article
l Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells By feeds.nature.com Published On :: 2020-05-07 Full Article
l The HMGB1-RAGE axis modulates the growth of autophagy-deficient hepatic tumors By feeds.nature.com Published On :: 2020-05-07 Full Article
l QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism By feeds.nature.com Published On :: 2020-05-07 Full Article
l WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2 By feeds.nature.com Published On :: 2020-05-07 Full Article
l LncRNA <i>SNORD3A</i> specifically sensitizes breast cancer cells to 5-FU by sponging miR-185-5p to enhance UMPS expression By feeds.nature.com Published On :: 2020-05-07 Full Article
l NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas By feeds.nature.com Published On :: 2020-05-07 Full Article
l MicroRNA let-7c (MIRLET7C; let-7c), miR-99a and miR-125b as prognostic markers of luminal breast cancer By feeds.nature.com Published On :: 2014-12-18 Studies in patient samples and cell culture suggest let-7c, miR-99a and miR-125b could serve as prognostic markers in patients with estrogen receptor–positive luminal breast cancers. Full Article
l Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE) By feeds.nature.com Published On :: 2014-12-18 Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE. Full Article
l Tumor-selective delivery of antisense oligomers (antimiRs) against oncogenic microRNAs By feeds.nature.com Published On :: 2014-12-18 miRNA-targeted antimiRs conjugated to a peptide with a low pH–induced transmembrane structure (pHLIP) could help treat solid tumors. Full Article
l RNAi against therapeutic targets with short interfering ribonucleic neutrals (siRNNs) By feeds.nature.com Published On :: 2014-12-18 siRNNs could enable RNAi knockdown of therapeutic targets in a broader range of cells and tissue types than siRNA. Full Article
l Extending therapeutic protein half-lives via fusion to affibodies with pH-dependent binding to neonatal Fc receptor By feeds.nature.com Published On :: 2014-12-18 Fusing therapeutic proteins to affibodies with pH-dependent binding to neonatal Fc receptor could improve the proteins' half-lives. Full Article
l Nanomolar-scale, high throughput chemical synthesis of drug-like molecules By feeds.nature.com Published On :: 2014-12-18 A high throughput, miniaturized chemical synthesis platform could enable rapid discovery of lead compounds. Full Article
l Influenza A virus hemagglutinin By feeds.nature.com Published On :: 2014-12-18 Cell and mouse studies have identified pentacyclic triterpenoid analogs that could help treat influenza infections and have lower risk for resistance than amantadine. Full Article
l Glutathione peroxidase 4 (GPX4) By feeds.nature.com Published On :: 2014-12-18 Mouse studies suggest inhibiting ferroptosis could help treat ischemia/reperfusion injury in the liver and kidney. Full Article
l Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3) By feeds.nature.com Published On :: 2014-12-18 Mouse studies suggest inhibiting PGF could help treat hypertension. Full Article
l c-jun N-terminal kinase (JNK); MAP kinase 1 (MAPK1; ERK-2); MAPK3 (ERK-1) By feeds.nature.com Published On :: 2014-12-18 In vitro and rodent studies suggest ophiopogonin D could help prevent doxorubicin-induced cardiotoxicity. Full Article
l Sortilin 1 (SORT1) By feeds.nature.com Published On :: 2014-12-18 Mouse studies suggest inhibiting SORT1 in macrophages and T cells could help treat atherosclerosis. Full Article
l Globohexaosylceramide (globo-H); stage-specific embryonic antigen-3 (SSEA-3); SSEA-4 By feeds.nature.com Published On :: 2014-12-18 Mouse studies suggest chemically modified carbohydrate conjugates could be useful as antigens for the development of cancer vaccines. Full Article
l Epidermal growth factor receptor 1 (EGFR1; ErbB1; HER1); HER2 (EGFR2; ErbB2; neu); HER3 (EGFR3; ErbB3); VEGF By feeds.nature.com Published On :: 2014-12-18 Tumor cell and mouse studies suggest tetravalent antibodies that target four different antigens could help treat cancers resistant to HER-targeted therapies. Full Article
l Cyclin dependent kinase 7 (CDK7); v-myc myelocytomatosis viral related oncogene neuroblastoma derived (MYCN; NMYC) By feeds.nature.com Published On :: 2014-12-18 In vitro and mouse studies suggest THZ1, a covalent CDK7 inhibitor, could help treat neuroblastoma and other cancers driven by MYCN and other c-MYC (MYC)-family oncoproteins. Full Article
l Estrogen receptor; LYN kinase (LYN); phosphoinositide 3-kinase (PI3K) By feeds.nature.com Published On :: 2014-12-18 Studies in mice and human samples suggest inhibiting LYN could help treat estrogen receptor–positive breast cancers resistant to anti-estrogen therapy. Full Article
l Genocea's mark on malaria By feeds.nature.com Published On :: 2014-12-18 Genocea has identified an immunological imprint in patients with malaria and is using a $1.2 million grant from the Gates Foundation to turn the findings into a vaccine. Full Article
l Resurrecting a magic bullet By feeds.nature.com Published On :: 2014-12-18 Heidelberg Pharma has resuscitated a long-dead ADC toxin with updated conjugation techniques, and its partner Roche has thrown the company a lifeline that could help validate the platform. Full Article
l Translational tidbits By feeds.nature.com Published On :: 2014-12-18 Yabao and MRC Technology partner in PD; charities form Neuro-MAP to insource pharma's abandoned compounds; Singapore creates a diagnostic hub; a roundup of public-private partnerships. Full Article
l Translational balance By feeds.nature.com Published On :: 2014-12-18 Moving discoveries from academia to industry requires a delicate balance of risk, reward, skill sets and personalities, according to a translational panel held at BIO-Europe's partnering conference. Full Article
l Neutralizing the negatives of RNAi By feeds.nature.com Published On :: 2014-12-18 The siRNN technology that Solstice licensed from UCSD could take RNAi-based therapies to tissues outside the liver and expand their use to a host of new diseases. Full Article
